LOCUS       NM_001398736            5885 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus trichohyalin (Tchh), mRNA.
ACCESSION   NM_001398736 XM_006232820
VERSION     NM_001398736.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5885)
  AUTHORS   Yamamoto,S., Hirai,K., Hasegawa-Oka,Y. and Hirai,Y.
  TITLE     Molecular elements of the regulatory control of keratin filament
            modulator AHF/trichohyalin in the hair follicle
  JOURNAL   Exp Dermatol 18 (2), 152-159 (2009)
   PUBMED   18643848
  REMARK    GeneRIF: BMP-4 signalling activates AHF/THH transcription in hair
            follicles.
REFERENCE   2  (bases 1 to 5885)
  AUTHORS   Steinert,P.M., Parry,D.A. and Marekov,L.N.
  TITLE     Trichohyalin mechanically strengthens the hair follicle: multiple
            cross-bridging roles in the inner root shealth
  JOURNAL   J Biol Chem 278 (42), 41409-41419 (2003)
   PUBMED   12853460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006232820.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345330
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000002.1  181787109-181787160
            53-215              JAXUCZ010000002.1  181788687-181788849
            216-5885            JAXUCZ010000002.1  181789794-181795463
FEATURES             Location/Qualifiers
     source          1..5885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5885
                     /gene="Tchh"
                     /gene_synonym="Thh"
                     /note="trichohyalin"
                     /db_xref="GeneID:310588"
                     /db_xref="RGD:1309635"
     exon            1..52
                     /gene="Tchh"
                     /gene_synonym="Thh"
                     /inference="alignment:Splign:2.1.0"
     exon            53..215
                     /gene="Tchh"
                     /gene_synonym="Thh"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..4856
                     /gene="Tchh"
                     /gene_synonym="Thh"
                     /codon_start=1
                     /product="trichohyalin"
                     /protein_id="NP_001385665.1"
                     /db_xref="GeneID:310588"
                     /db_xref="RGD:1309635"
                     /translation="MSPLIRSIVDITEVFNQYASQSCDGASLSKRELKNLLERELGDV
                     LQKPHDPETVDLTLELLDRDCNGRVDFNEFLLFLFKIAQACYYALDQAAELGEKRTLT
                     KEKRSLSQDRRQEDQRRFEPRDRQLDEEPGRGSWQKRREQEERAEELRLEQRDRQHRD
                     EEQQLQRRELQELEERLAEKEPLSWSKGRDAEEFSEVEEQQRQERQELKGKGQTEERR
                     LQRRRQEELREPLLRREQDLNRRQELRQELRREPELRREQELSRGQEQRREQELRQEL
                     RREQELRREQVLRREQELRQEQRREQELRHEQELRQELRREQALAEEDEQTRVREPDQ
                     SITQRWQWQLESEAEARQNKVYSRPRRQEQRLRQELEERQLREEEGQRRDLQRQRPAE
                     EARQRYQWERPQRAEERLEQEQRFRDREEQRFREERLQRAELQDSLLEEEQRRRQAER
                     REPNASWELREESQRRHTLYTKPSLRQRREEELREERLLQEEQRQQRERKYRREEDLQ
                     QEEERLQQDEEQLQREKRRLQQERQYQEEDLQLEEERLQQEEERLQRERRRLQQERQY
                     QEEDLQRLQDEDRRRDLKWQWQPRKEVEVRSNRLFTKRREDEETIQQLEDSREQGRRQ
                     DRRPLQNEQEERRELEQERRRLQQRDRQILEEEQLQREQQREARRRDETFQEEEQLLE
                     ESRRQQQEREGKFLEEERQLQTEREEQRRHQEQEREFREEEEERLQEPEKELRQERDR
                     KSREEQERRQQREEEQLRRQERDRRFRREQEQRQETEEEQLRDRPFRREQERRQEREE
                     EQLRDRKFRREQEPRQEREEEQLRDRKFRREQEPRQEREEEQLRDRKFRREQEPRQER
                     VEEQLRDRKFRREQERFQEREEEQLRDRPFRREQERRQEREEEQLRDRPFRREQELRQ
                     EREEEQLRDRKFRREQERRREREEEQLRDRKFRREQERRREREEEQLRDRPFRREQER
                     LQEREEEQLRDRPFHREQERRQEERDRPSRREQELLRELEEEQLRDRKFRREQELRRD
                     RKLREEEERRPELEEEQLRGQERDRLRVEEQLRQEREEEQRRRQERDRKSREEQELRQ
                     ELEEEQLRDRKFRREQELRRDRKLHDEERRQELEERQLSGQERERKFRLEQELRRERE
                     EEERRQQRDRKFRREEELRQELEEEQLRDRKIRREQELRRDRKFREEEERRQEEFEEK
                     QLRLQEPDRRFRREQELRREREEEQRRRQERDRKSREEQELRQELEEEQLRDRRIRQE
                     LQEEELRRQERDSKFLEEQEIRRALQEEELRRQERDRKFREEQELRQELEEERLRDRK
                     IPREQEFRRPREEEQLRDRKFRREQEFRREPGVEQRRRQEREEEQIRFEEQQQRRQER
                     EQQLRQERDRRVREEEELRQEREELLHREVGGRKFREEERFRQEREEQRRHLQERDNR
                     RFREEVELRQEREEQQLRQERQERERKFREVEELRQEEEQRRRQEFDRKFREEKRLRE
                     EREGQQLRREKRDGQYPAEEQFARDKIRRQEQELRQEEEQRRRQERERKFQEEQIRRR
                     QEEQRRRPILEPGTRQFANVPVRSSPLYEYIQEQRSQYRP"
     exon            216..5885
                     /gene="Tchh"
                     /gene_synonym="Thh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacttgcca gcagtgtcag cgagcacttg acttcttcct ctggtgaagt gggtttactt
       61 gaattttaag aaaaaaaatg tctccactta taagaagcat tgttgatatc actgaagttt
      121 tcaatcaata tgcatcacaa agttgtgatg gagcatcgct tagcaagaga gaactgaaaa
      181 acctccttga gagagaactt ggagatgtcc ttcagaaacc acatgatccg gagactgtag
      241 atctgaccct agaacttctg gatcgtgact gcaacgggcg tgttgatttc aacgaattcc
      301 tcctgttcct tttcaagatt gctcaagctt gctattatgc tctcgatcag gctgcagagt
      361 taggcgagaa gagaacccta accaaggaaa agaggagcct gtcacaagat cgcaggcaag
      421 aagatcaaag gagattcgag ccccgggaca gacaactgga cgaagaacct gggcgcggaa
      481 gctggcagaa gagacgtgag caggaggagc gcgctgagga gctgaggctg gagcagcgcg
      541 acaggcagca ccgcgacgaa gagcagcaac tgcaaaggag agaactgcaa gaactggagg
      601 agcgccttgc agaaaaagag cctctaagct ggagtaaggg tcgtgacgct gaggagtttt
      661 ctgaggtaga ggaacagcaa aggcaagaga gacaggaact caagggcaag ggccagacag
      721 aggagagaag gttgcagagg cgccggcaag aagagctacg cgaacccctg ctgaggcgcg
      781 agcaggatct gaatcgtaga caggagctga ggcaggaact gaggcgcgaa ccagagctaa
      841 ggcgcgaaca ggagctgagt agaggacagg aacagaggcg cgagcaggag ctgaggcagg
      901 aactgagacg cgagcaggag ctaaggcgcg agcaggtgct gaggcgcgag caggagctga
      961 ggcaggaaca gagacgcgag caggagctaa gacacgagca ggagctgagg caggagctca
     1021 ggcgcgagca ggcgctggct gaggaggatg agcagacgcg agtccgggaa cccgaccaga
     1081 gcatcaccca gaggtggcag tggcagctcg aaagcgaggc agaagcccgt cagaacaagg
     1141 tctactctag gcctcgcagg caagagcaga ggcttcgcca ggagctggag gagcgtcagc
     1201 tccgggagga ggaggggcaa cgccgcgacc tccaacggca gcgtcccgct gaggaggctc
     1261 gccagcgtta ccaatgggag aggccgcaac gggcggagga gcgcctggag caggagcagc
     1321 ggttccgcga ccgggaggag cagcgcttcc gggaagagag gctgcaaaga gctgagctcc
     1381 aggacagcct ccttgaggaa gaacagaggc gacgtcaggc ggagcgccga gagccaaacg
     1441 cgagctggga gcttcgggaa gaaagccaga gacgccacac actgtacacc aaacccagcc
     1501 tgaggcagcg tagggaggaa gagctacgcg aggagcggtt gttgcaagaa gagcagcgcc
     1561 agcagcggga gaggaaatac cgcagggagg aggatctgca gcaggaggaa gagcggctgc
     1621 agcaagatga agagcaactg cagcgggaaa agaggcgcct gcagcaggag aggcagtatc
     1681 aagaggagga cctgcagctg gaggaagagc ggctgcagca ggaggaagag cggctgcaga
     1741 gagaaaggag gcgcctgcag caggagaggc agtatcaaga ggaggacctg cagcggctgc
     1801 aggatgaaga tcggcgcagg gatctgaaat ggcagtggca acctaggaaa gaagtcgaag
     1861 ttcgtagtaa caggcttttc accaaacgca gagaggatga ggaaacgatc cagcagctgg
     1921 aagactctcg agagcaaggg agacgtcagg atcggcggcc tctgcaaaac gaacaggaag
     1981 agagaagaga gctggagcag gagaggaggc gcctacagca gcgcgaccgg cagatcctag
     2041 aggaagagca gctgcagcga gagcagcaac gggaagccag aagacgagat gagacgttcc
     2101 aggaggaaga acagctcctg gaagaatcga gaagacagca acaggagaga gagggcaaat
     2161 tccttgagga agaaaggcag ctgcagacgg aacgggaaga acagaggcgg catcaagaac
     2221 aagagagaga attccgagaa gaggaggagg agcgcctcca agaacctgag aaagaacttc
     2281 ggcaggagcg tgacagaaaa tcccgtgaag aacaagagcg ccgccagcag cgtgaggaag
     2341 agcagctgag gcgccaggag cgggacagaa gattccgccg ggaacaagaa caacgccagg
     2401 agactgagga agagcagctg cgagacagac cattccgccg ggaacaagaa cgccgccagg
     2461 agcgcgagga agagcagctg cgggacagaa agttccgtcg agaacaagaa ccccgtcagg
     2521 agcgcgagga agagcagctg cgggacagaa agttccgtcg ggaacaagaa ccccgtcagg
     2581 agcgcgagga agagcagctg cgggacagaa agttccgccg ggaacaagaa ccccgccagg
     2641 agcgtgtgga agagcagctg cgggacagaa agttccgccg ggaacaagaa cgcttccagg
     2701 agcgtgagga agagcagctg agggacagac cattccgccg ggaacaagaa cgccgccagg
     2761 agcgtgagga agagcagctg cgggatagac ctttccgccg ggaacaagaa ctccgtcagg
     2821 agcgtgagga agagcagctg agggacagaa agttccgccg ggaacaagaa cgccgccggg
     2881 agcgtgaaga agagcagctg agggacagaa agttccgccg ggaacaagaa cgccgccggg
     2941 agcgtgagga agagcagctg agggacagac cattccgcag ggaacaagaa cgcctccagg
     3001 agcgtgagga agagcagttg agggataggc cattccaccg agaacaagaa cgccgccagg
     3061 aggagcgcga cagaccatcc cgccgggaac aagagctcct ccgggaactc gaggaagagc
     3121 agctgcggga cagaaagttc cgccgggagc aagagctcag acgcgacaga aaactccgtg
     3181 aggaagaaga gcgccgcccg gaactggagg aagagcagct gcgtggccaa gagcgagacc
     3241 gtttaagggt ggaagagcaa cttcgccagg agcgcgagga agagcagcgg cgccgccagg
     3301 aacgtgacag aaaatcccgt gaggaacaag agctccgcca ggaactcgag gaagagcagc
     3361 tgagggacag aaagttccgc cgggaacaag agctcaggcg cgacagaaaa ctccacgacg
     3421 aagagcgccg ccaggagcta gaggaaaggc agctgagcgg gcaagaacga gagagaaagt
     3481 tccgcttgga acaagagctt cgccgggagc gcgaggaaga ggagcgccgc cagcagcgtg
     3541 acagaaagtt ccgccgggaa gaggagctcc gccaggaact ggaggaagag caactgcggg
     3601 acagaaagat ccgcagggaa caagagctca ggcgggacag aaaattccgt gaggaagaag
     3661 agcgccgcca ggaggagttc gaggaaaagc agctgcggct ccaggaacca gacagaagat
     3721 tccgccggga acaagagctc cgccgggaac gcgaagaaga gcagaggagg cgccaagaac
     3781 gtgacagaaa atctcgtgag gaacaagagc tccgccagga actggaggaa gagcagctga
     3841 gggacagaag gattcgccag gaactccagg aagaagagct aaggcgccag gaacgtgaca
     3901 gtaagttcct tgaggaacaa gaaatccgcc gggcactcca ggaagaagag ctaaggcgcc
     3961 aggaacgtga cagaaagttc cgtgaggaac aagagctccg ccaagaactg gaggaagagc
     4021 ggctgaggga cagaaagatc ccccgagaac aagagttccg ccggccgcga gaggaagagc
     4081 agctgcggga cagaaagttc cgcagggaac aagaattccg ccgagagccg ggggtagagc
     4141 agcggcgccg ccaggagcgc gaagaggaac aaattcgctt tgaggagcaa cagcagcgcc
     4201 gccaggagcg cgagcaacag ttaagacaag aacgcgacag gagagtccgg gaggaagaag
     4261 agcttcgtca ggaaagggag gagctgctac accgtgaggt gggtggcagg aaattccggg
     4321 aagaggagcg attccgccag gaaagagagg aacagcggcg tcacctccag gagcgggaca
     4381 acagaagatt ccgcgaggaa gtagagctca ggcaagaaag ggaagagcag cagctgcgtc
     4441 aagagcgcca agagcgtgag agaaaattcc gtgaggtaga agagcttcgc caggaagaag
     4501 agcagcgccg ccgccaggag tttgacagga aattccggga agagaaacgc ctgcgtgagg
     4561 aacgcgaggg ccagcaactg cggagggaga agcgagatgg tcagtacccg gctgaggagc
     4621 aatttgccag ggataagatt cgtcgccagg aacaagaact acgtcaagaa gaggaacaaa
     4681 gacgtcgcca agagcgggag agaaaattcc aagaagagca gatccgtcgt aggcaagagg
     4741 agcagaggcg ccgcccaatc ctagagcctg gcacacgcca gtttgccaac gtcccagtgc
     4801 gttccagtcc tctctacgag tacatccaag agcagaggtc tcaataccgc ccttaaaaga
     4861 tgctgcgaaa atcctggcac cagccaaacc ttcaagcaaa agaaaatgag aaacactggg
     4921 gtatccagcg ataactcacg tgtttctggt tgtgggaaaa ctctctgatc ttagaatgtg
     4981 tcttttctta cagaatctta aactataccc atttcatttc tttcaattcc tgtctttcat
     5041 tcttcctcag gtagtccttt tttgcaagat gtcattgttc tttagtgcag atatgatgtg
     5101 cacttttaaa agtaagtcat ttaatttttt gaaaaaattt gtttgagaag cacattgatt
     5161 tatggtcttc ataaataaca agaataatgt agcactctgg tattcaaagt aattgggtca
     5221 ttatttttag tggtggatca ttttgtctag agctttcatt ttataagttc aagttggcat
     5281 tttgtttggc ctaattccat ttgtcttgac ctccaaatgg ttttctcagg ttttgttgca
     5341 taattgtgac agattccatc agcaggctga aattttacag ccctcaaata atgcaggggg
     5401 agaatgattt atgcagaaaa taccatatga aatcaattca taactgaaac aaatctttat
     5461 taagagaaat gcttggtaga caattataat ttggcattat atttttatat tttgcatcac
     5521 ctaaaacaat ctcatgaagc aaaagcaaag tgcttctcaa acaactcaaa tttaaaactg
     5581 taattgtagc attctgttcc atttccccaa gttttgttgg gtttgagaat ttttctactt
     5641 ttgtatattt tggtttgcag gaaacctact caagattctg taaacatttg tcttgtttgg
     5701 gtccaataag aactcacaga gtgatggaag aaggaaaggg ggaaatgtat aaacagatga
     5761 caaaattcta gaggtctctt gattatactt atcagctcac aatcctttga ggccttatac
     5821 tacctggaag acattcttgt tcaaataatt tgactgttaa aaatcaataa atgtttggca
     5881 aataa
//
