LOCUS       NP_001385665            1592 aa            linear   ROD 31-MAR-2024
DEFINITION  trichohyalin [Rattus norvegicus].
ACCESSION   NP_001385665 XP_006232882
VERSION     NP_001385665.1
DBSOURCE    REFSEQ: accession NM_001398736.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1592)
  AUTHORS   Yamamoto,S., Hirai,K., Hasegawa-Oka,Y. and Hirai,Y.
  TITLE     Molecular elements of the regulatory control of keratin filament
            modulator AHF/trichohyalin in the hair follicle
  JOURNAL   Exp Dermatol 18 (2), 152-159 (2009)
   PUBMED   18643848
  REMARK    GeneRIF: BMP-4 signalling activates AHF/THH transcription in hair
            follicles.
REFERENCE   2  (residues 1 to 1592)
  AUTHORS   Steinert,P.M., Parry,D.A. and Marekov,L.N.
  TITLE     Trichohyalin mechanically strengthens the hair follicle: multiple
            cross-bridging roles in the inner root shealth
  JOURNAL   J Biol Chem 278 (42), 41409-41419 (2003)
   PUBMED   12853460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 22, 2021 this sequence version replaced XP_006232882.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345330
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..1592
                     /product="trichohyalin"
                     /calculated_mol_wt=207586
     Region          2..89
                     /region_name="S-100"
                     /note="S-100 domain, which represents the largest family
                     within the superfamily of proteins carrying the Ca-binding
                     EF-hand motif. Note that this S-100 hierarchy contains
                     only S-100 EF-hand domains, other EF-hands have been
                     modeled separately. S100 proteins are...; cd00213"
                     /db_xref="CDD:238131"
     Site            order(2..19,25..27,36..37,39..41,69..72,74..75,77..80,
                     82..89)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238131"
     Site            order(19,24,27,32..33,62,64,66,68,70,73)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238131"
     Region          <91..>586
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1592
                     /gene="Tchh"
                     /gene_synonym="Thh"
                     /coded_by="NM_001398736.1:78..4856"
                     /db_xref="GeneID:310588"
                     /db_xref="RGD:1309635"
ORIGIN      
        1 msplirsivd itevfnqyas qscdgaslsk relknllere lgdvlqkphd petvdltlel
       61 ldrdcngrvd fnefllflfk iaqacyyald qaaelgekrt ltkekrslsq drrqedqrrf
      121 eprdrqldee pgrgswqkrr eqeeraeelr leqrdrqhrd eeqqlqrrel qeleerlaek
      181 eplswskgrd aeefseveeq qrqerqelkg kgqteerrlq rrrqeelrep llrreqdlnr
      241 rqelrqelrr epelrreqel srgqeqrreq elrqelrreq elrreqvlrr eqelrqeqrr
      301 eqelrheqel rqelrreqal aeedeqtrvr epdqsitqrw qwqleseaea rqnkvysrpr
      361 rqeqrlrqel eerqlreeeg qrrdlqrqrp aeearqryqw erpqraeerl eqeqrfrdre
      421 eqrfreerlq raelqdslle eeqrrrqaer repnaswelr eesqrrhtly tkpslrqrre
      481 eelreerllq eeqrqqrerk yrreedlqqe eerlqqdeeq lqrekrrlqq erqyqeedlq
      541 leeerlqqee erlqrerrrl qqerqyqeed lqrlqdedrr rdlkwqwqpr kevevrsnrl
      601 ftkrredeet iqqledsreq grrqdrrplq neqeerrele qerrrlqqrd rqileeeqlq
      661 reqqrearrr detfqeeeql leesrrqqqe regkfleeer qlqtereeqr rhqeqerefr
      721 eeeeerlqep ekelrqerdr ksreeqerrq qreeeqlrrq erdrrfrreq eqrqeteeeq
      781 lrdrpfrreq errqereeeq lrdrkfrreq eprqereeeq lrdrkfrreq eprqereeeq
      841 lrdrkfrreq eprqerveeq lrdrkfrreq erfqereeeq lrdrpfrreq errqereeeq
      901 lrdrpfrreq elrqereeeq lrdrkfrreq errrereeeq lrdrkfrreq errrereeeq
      961 lrdrpfrreq erlqereeeq lrdrpfhreq errqeerdrp srreqellre leeeqlrdrk
     1021 frreqelrrd rklreeeerr peleeeqlrg qerdrlrvee qlrqereeeq rrrqerdrks
     1081 reeqelrqel eeeqlrdrkf rreqelrrdr klhdeerrqe leerqlsgqe rerkfrleqe
     1141 lrrereeeer rqqrdrkfrr eeelrqelee eqlrdrkirr eqelrrdrkf reeeerrqee
     1201 feekqlrlqe pdrrfrreqe lrrereeeqr rrqerdrksr eeqelrqele eeqlrdrrir
     1261 qelqeeelrr qerdskflee qeirralqee elrrqerdrk freeqelrqe leeerlrdrk
     1321 ipreqefrrp reeeqlrdrk frreqefrre pgveqrrrqe reeeqirfee qqqrrqereq
     1381 qlrqerdrrv reeeelrqer eellhrevgg rkfreeerfr qereeqrrhl qerdnrrfre
     1441 evelrqeree qqlrqerqer erkfreveel rqeeeqrrrq efdrkfreek rlreeregqq
     1501 lrrekrdgqy paeeqfardk irrqeqelrq eeeqrrrqer erkfqeeqir rrqeeqrrrp
     1561 ilepgtrqfa nvpvrssply eyiqeqrsqy rp
//
