LOCUS       NM_001415805            4130 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus transcription factor 7 like 2 (Tcf7l2), mRNA.
ACCESSION   NM_001415805 XM_039090252
VERSION     NM_001415805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4130)
  AUTHORS   Yuan J and Yuan G.
  TITLE     miR-212 Promotes Cardiomyocyte Hypertrophy through Regulating
            Transcription Factor 7 Like 2
  JOURNAL   Mediators Inflamm 2022, 5187218 (2022)
   PUBMED   36060928
  REMARK    GeneRIF: miR-212 Promotes Cardiomyocyte Hypertrophy through
            Regulating Transcription Factor 7 Like 2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4130)
  AUTHORS   Ye Y, Barghouth M, Luan C, Kazim A, Zhou Y, Eliasson L, Zhang E,
            Hansson O, Thevenin T and Renstrom E.
  TITLE     The TCF7L2-dependent high-voltage activated calcium channel subunit
            alpha2delta-1 controls calcium signaling in rodent pancreatic
            beta-cells
  JOURNAL   Mol Cell Endocrinol 502, 110673 (2020)
   PUBMED   31805307
  REMARK    GeneRIF: The TCF7L2-dependent high-voltage activated calcium
            channel subunit alpha2delta-1 controls calcium signaling in rodent
            pancreatic beta-cells.
REFERENCE   3  (bases 1 to 4130)
  AUTHORS   Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z,
            Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P,
            Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM,
            Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM and Kenny PJ.
  TITLE     Habenular TCF7L2 links nicotine addiction to diabetes
  JOURNAL   Nature 574 (7778), 372-377 (2019)
   PUBMED   31619789
  REMARK    GeneRIF: Findings reveal a crucial role for the diabetes-associated
            transcription factor TCF7L2 in regulating the function of nicotinic
            acetylcholine receptors in the habenula and in controlling nicotine
            intake.
REFERENCE   4  (bases 1 to 4130)
  AUTHORS   Li H, Ma Y, Chen B and Shi J.
  TITLE     miR-182 enhances acute kidney injury by promoting apoptosis
            involving the targeting and regulation of TCF7L2/Wnt/beta-catenins
            pathway
  JOURNAL   Eur J Pharmacol 831, 20-27 (2018)
   PUBMED   29733821
  REMARK    GeneRIF: miR-182 exacerbated acute kidney injury by targeting and
            regulation of TCF7L2/Wnt/beta-catenin signaling.
REFERENCE   5  (bases 1 to 4130)
  AUTHORS   Wilson R, Geyer SH, Reissig L, Rose J, Szumska D, Hardman E, Prin
            F, McGuire C, Ramirez-Solis R, White J, Galli A, Tudor C, Tuck E,
            Mazzeo CI, Smith JC, Robertson E, Adams DJ, Mohun T and Weninger
            WJ.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4130)
  AUTHORS   He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin
            PJ, Vogelstein B and Kinzler KW.
  TITLE     Identification of c-MYC as a target of the APC pathway
  JOURNAL   Science 281 (5382), 1509-1512 (1998)
   PUBMED   9727977
REFERENCE   7  (bases 1 to 4130)
  AUTHORS   Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ
            and Clevers H.
  TITLE     Depletion of epithelial stem-cell compartments in the small
            intestine of mice lacking Tcf-4
  JOURNAL   Nat Genet 19 (4), 379-383 (1998)
   PUBMED   9697701
REFERENCE   8  (bases 1 to 4130)
  AUTHORS   Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G,
            Markman M, Lamers W, Destree O and Clevers H.
  TITLE     Two members of the Tcf family implicated in Wnt/beta-catenin
            signaling during embryogenesis in the mouse
  JOURNAL   Mol Cell Biol 18 (3), 1248-1256 (1998)
   PUBMED   9488439
REFERENCE   9  (bases 1 to 4130)
  AUTHORS   Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B
            and Kinzler KW.
  TITLE     Activation of beta-catenin-Tcf signaling in colon cancer by
            mutations in beta-catenin or APC
  JOURNAL   Science 275 (5307), 1787-1790 (1997)
   PUBMED   9065402
REFERENCE   10 (bases 1 to 4130)
  AUTHORS   Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler
            KW, Vogelstein B and Clevers H.
  TITLE     Constitutive transcriptional activation by a beta-catenin-Tcf
            complex in APC-/- colon carcinoma
  JOURNAL   Science 275 (5307), 1784-1787 (1997)
   PUBMED   9065401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000054.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001415805.2.
            
            On Dec 30, 2022 this sequence version replaced XM_039090252.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-704               JACYVU010000054.1  15880089-15880792
            705-771             JACYVU010000054.1  15881034-15881100
            772-896             JACYVU010000054.1  15881331-15881455
            897-965             JACYVU010000054.1  15893077-15893145
            966-1067            JACYVU010000054.1  15954537-15954638
            1068-1200           JACYVU010000054.1  16048446-16048578
            1201-1303           JACYVU010000054.1  16050565-16050667
            1304-1390           JACYVU010000054.1  16052592-16052678
            1391-1516           JACYVU010000054.1  16057560-16057685
            1517-1676           JACYVU010000054.1  16058280-16058439
            1677-1784           JACYVU010000054.1  16058843-16058950
            1785-1833           JACYVU010000054.1  16063245-16063293
            1834-1884           JACYVU010000054.1  16063863-16063913
            1885-1957           JACYVU010000054.1  16065294-16065366
            1958-4130           JACYVU010000054.1  16070836-16073008
FEATURES             Location/Qualifiers
     source          1..4130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4130
                     /gene="Tcf7l2"
                     /note="transcription factor 7 like 2"
                     /db_xref="GeneID:679869"
                     /db_xref="RGD:1583621"
     exon            1..704
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..2381
                     /gene="Tcf7l2"
                     /note="transcription factor 7-like 2 (T-cell specific,
                     HMG-box)"
                     /codon_start=1
                     /product="transcription factor 7-like 2"
                     /protein_id="NP_001402734.1"
                     /db_xref="GeneID:679869"
                     /db_xref="RGD:1583621"
                     /translation="MPQLNGGGGDDLGANDELISFKDEGEQEEKNSENSSAERDLADV
                     KSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPG
                     YPFIMIPDLTSPYLPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAIQYLQMKWPLLD
                     VQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPP
                     HLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGF
                     RHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSS
                     KHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALS
                     REEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCL
                     SLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLD
                     SPPPSPHLLGSPPQDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEAAHGKAS
                     ALCPNGALDLPPATLQPSMVPSSSLAQPSTSSLHSHNSLAGTQPQPLSLVTKSLE"
     exon            705..771
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..896
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..965
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1067
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1200
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1303
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1390
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1516
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1676
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1784
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1833
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1884
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1957
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..4130
                     /gene="Tcf7l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcaataatc tccgctccca gactactccg ttcctccgga tttcgatccc cctttttcta
       61 tctgtcaatc agcgccgcct ttgaactgaa aagctcagtc taacttcaac tcactcaaat
      121 ccgagcggca cgagctcctt cggtgtcttc ggcttccccc cccctttgct cttatatctg
      181 acttcttctt gttgttgttt ttttttttta cccccccttt ttttatttat tatttttttg
      241 cacattgatc ggatccttgg gaacgagaga aaaaagaaac ccaaactcac gcgtgcagaa
      301 gatctccccc ttcccctccc ctcctccctc ttttcccctc cccaggagag aaagacccca
      361 aagcaggaaa aaaagttaac cttggactcg tctttttctt gcagtatttt ttttgggggg
      421 gactcgcaaa acttttttct ttttttttct ttttttttcc ttttcttcct ccttcatttt
      481 tcttccaaaa ttgctgctgg tgggtgaaaa aaaaaatgcc gcagttgaac ggcggtggag
      541 gagatgacct aggcgctaac gacgaactga tctccttcaa agacgaaggc gagcaggagg
      601 agaagaactc ggaaaactcc tcggcggaga gggatttagc cgatgtcaag tcgtcgttgg
      661 tcaatgaatc agagacgaat caaaacagct cctccgattc cgaggcggaa agacggcctc
      721 cgcctcgctc cgaaagtttc cgagataaat cccgggaaag tttggaagaa gcggccaaga
      781 ggcaagatgg agggctcttt aaggggccac cgtatcccgg ctaccccttc atcatgatcc
      841 ccgacctgac gagcccctac ctccccaacg gatcgctctc gcccaccgcc cgaaccctcc
      901 attttcaatc cggcagcact cattactctg cgtacaaaac gattgaacac cagattgcaa
      961 ttcagtatct tcagatgaaa tggcctctgc tcgatgtcca agcaggaagc ctccagagca
     1021 gacaagccct caaggatgcc cgctcacctt cgccagcaca catcgtttcg aacaaagtgc
     1081 cggtggtgca gcacccccac catgtccacc cactcacacc tctcatcacg tacagcaatg
     1141 aacacttcac cccgggaaat ccacctccgc acttaccagc tgacgtagac cccaaaacag
     1201 gaattccacg gcctccgcac cctccagata tctctccata ttacccgctg tcgcccggca
     1261 ccgtaggaca aatcccccat ccgctaggat ggttagtacc acagcaaggt cagcctgtgt
     1321 acccaatcac gacaggagga ttcagacacc cctaccccac agcgctgaca gtcaacgcgt
     1381 ctatgtctag gttccctccc cacatggtcc ctccccatca cactctgcac acgaccggaa
     1441 tcccccaccc ggccattgtc acaccgacag tcaagcagga gtcctcacag agtgacgtcg
     1501 gctcactcca tagctcaaag catcaggact ccaagaagga agaagagaag aaaaagcccc
     1561 acataaagaa gccccttaat gcattcatgt tgtatatgaa ggagatgaga gcgaaggtgg
     1621 tggctgagtg cacattgaaa gagagtgcag ccatcaacca gatcctcggg cgcaggtggc
     1681 acgccctgtc cagggaagaa caggcaaagt actacgagct agcccggaag gaacgacagc
     1741 ttcacatgca gctgtaccct ggctggtctg cacgggataa ctatggaaag aagaagaaga
     1801 gaaaaagaga caagcagccg ggggagacca atgaacacag cgaatgtttc ctaaatcctt
     1861 gcctttcgct tcctccgatc acagacctga gcgctcctaa gaaatgccga gcgcgctttg
     1921 gccttgatca acagaataac tggtgcggcc cctgcaggag aaaaaaaaag tgcgttcgct
     1981 acatacaagg tgaaggcagc tgcctcagcc caccctcttc agatggaagc ttactagact
     2041 cacctccccc ctcaccgcat ctgctaggct cccctcccca agacgccaag tcacagactg
     2101 agcagacaca gccgctctcg ctgtccctga agcctgatcc tctggcccac ctgtccatga
     2161 tgcctccacc acccgcgctc ctgctggctg aagctgccca cggcaaggcc tctgccctct
     2221 gtcccaacgg ggccctggac ctgccacctg ccactttgca gccgtccatg gtcccttcct
     2281 catcgctcgc acaaccatca acttcttcct tacattccca caactcgctg gctgggacgc
     2341 aaccccagcc tctgtctctg gtgaccaagt ctttagaata gcttcgcctc ctcgtcttcc
     2401 gtgcccctgc ttgattgaag tgtttccttc tggttcttgg ttcgcccttc ccccgcttgg
     2461 aaagcctttt ttcttgttct ttaattttgt gccactgtgg ctacatgagt taatgtttat
     2521 ggagttcatt ggtcaatatt tgacccattc ttatttcaat ttctcctttt aaatatgtag
     2581 atgagagaaa cctcatgatt ctaccaaaat ttttatcaac agctgtttaa agtctttgta
     2641 gcgtttaaaa aaatatataa atatatatat acataactgt tatgtagttc ggatagctta
     2701 gttttaaaag actgatttaa ggaacaaaaa gaaaaagaaa agagagagaa gcaactttga
     2761 agcaccctcc agaaggagtt ggttctgtat tatttgtatt aaatacgagc ttgcgaacca
     2821 atcatttcca tcttggtatt taaaccgcga gggcacgatg aatgcagtgc cgtttctttc
     2881 tttctttttt cctcccatgt gaaacaactt ttattgtgat gttacttgtt attgtttaaa
     2941 tgtacagaaa caaagggtta aaatgtgtta atataccttt ttccatggtg ttgttctttt
     3001 tggggggagg ggacgctact caacatgaat ggaatcaaca ctgttggacc agtagtattt
     3061 attactttag aggttgcttg tccgtacctg tccgtccgtc caattttaaa tattgtttcc
     3121 cttttttttt tgaaactgta taaagtcaac ccccccaaca taagcatctt atatacaaca
     3181 actcatttgt acaaggtttt taagtttata tataaattgt gtatatattt ttttgtttcc
     3241 ttttcttgac ttttcgtttg tttgtttgtt tctgtataaa acccagatgc caccaaatgg
     3301 acattgatag ctgcattaag gatcagtagc attaacaaaa gttgctttaa aagccattac
     3361 gtaaaacaag acttgaacat tagcgagagg gtcgagcaga gcagccgtgg gaaccacccc
     3421 gtttcccctt ggacctccta gtcaattacc ctgtgctctt agaacatgga ctgaccgtgt
     3481 gcaaaacttt ttatgtgcca aaattctcag tgactttagc tttctccctc ctttttgatg
     3541 ccgtactttc tgttcgccat gttttgctgt gatgttacat agatagattt gtatgtagtt
     3601 ttaatgtcac ctataacaaa atgtgtttgg tagcagactg tccagaaagc attttaaatg
     3661 aagaggtcta aacccttaag ggccaaaaat tctgtatatt agattactct taaaatgaaa
     3721 aagaaaaaaa gtaaaaaaaa aaaaaaaccc agctgccgct tctgtgtaca agtatgacat
     3781 acgagtaggt agcgaacttt aaaaacaaga gaacctaggc atgccgatgt tgtaaaatgc
     3841 tgtataaagc cgagacctgt cttttcagtg ccatcgtagt tgacatgaag cgattgtaaa
     3901 actgtctccg gttttctctg gtttattaaa atgctaacta taacaatttt tttttgtgaa
     3961 tactttgaat gtttcctaac agttgtggtg ttaccgttct gtttgatgct tattccaagt
     4021 tcatttttgg atggtttgga agccattttg taatgaataa atgtccatgc tgtacagtat
     4081 ctgtagcatg ccgttctgga ttaataaaag caacttagta tgtgcagaaa
//
