LOCUS       NM_001107865            2736 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus transcription factor 7 like 1 (Tcf7l1), mRNA.
ACCESSION   NM_001107865 XM_001065007 XM_001065059 XM_232064
VERSION     NM_001107865.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2736)
  AUTHORS   Furumatsu T, Shukunami C, Amemiya-Kudo M, Shimano H and Ozaki T.
  TITLE     Scleraxis and E47 cooperatively regulate the Sox9-dependent
            transcription
  JOURNAL   Int J Biochem Cell Biol 42 (1), 148-156 (2010)
   PUBMED   19828133
  REMARK    GeneRIF: Scx and E47 might modulate the primary chondrogenesis by
            associating with the Sox9-related transcriptional complex, and by
            binding to the conserved E-box on Col2a1 promoter.
REFERENCE   2  (bases 1 to 2736)
  AUTHORS   Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM,
            Pasolli HA and Fuchs E.
  TITLE     Tcf3 and Tcf4 are essential for long-term homeostasis of skin
            epithelia
  JOURNAL   Nat Genet 41 (10), 1068-1075 (2009)
   PUBMED   19718027
REFERENCE   3  (bases 1 to 2736)
  AUTHORS   Mehmood R, Yasuhara N, Oe S, Nagai M and Yoneda Y.
  TITLE     Synergistic nuclear import of NeuroD1 and its partner transcription
            factor, E47, via heterodimerization
  JOURNAL   Exp Cell Res 315 (10), 1639-1652 (2009)
   PUBMED   19272376
  REMARK    GeneRIF: The nuclear import of NeuroD1 and E47 is energy-dependent
            and involves the Ran-mediated pathway.
REFERENCE   4  (bases 1 to 2736)
  AUTHORS   Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H and Lim B.
  TITLE     T-cell factor 3 regulates embryonic stem cell pluripotency and
            self-renewal by the transcriptional control of multiple lineage
            pathways
  JOURNAL   Stem Cells 26 (8), 2019-2031 (2008)
   PUBMED   18467660
REFERENCE   5  (bases 1 to 2736)
  AUTHORS   Cole MF, Johnstone SE, Newman JJ, Kagey MH and Young RA.
  TITLE     Tcf3 is an integral component of the core regulatory circuitry of
            embryonic stem cells
  JOURNAL   Genes Dev 22 (6), 746-755 (2008)
   PUBMED   18347094
REFERENCE   6  (bases 1 to 2736)
  AUTHORS   Shu W, Guttentag S, Wang Z, Andl T, Ballard P, Lu MM, Piccolo S,
            Birchmeier W, Whitsett JA, Millar SE and Morrisey EE.
  TITLE     Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF
            signaling to regulate proximal-distal patterning in the lung
  JOURNAL   Dev Biol 283 (1), 226-239 (2005)
   PUBMED   15907834
REFERENCE   7  (bases 1 to 2736)
  AUTHORS   Merrill BJ, Pasolli HA, Polak L, Rendl M, Garcia-Garcia MJ,
            Anderson KV and Fuchs E.
  TITLE     Tcf3: a transcriptional regulator of axis induction in the early
            embryo
  JOURNAL   Development 131 (2), 263-274 (2004)
   PUBMED   14668413
REFERENCE   8  (bases 1 to 2736)
  AUTHORS   Roose J and Clevers H.
  TITLE     TCF transcription factors: molecular switches in carcinogenesis
  JOURNAL   Biochim Biophys Acta 1424 (2-3), M23-M37 (1999)
   PUBMED   10528152
  REMARK    Review article
REFERENCE   9  (bases 1 to 2736)
  AUTHORS   DasGupta R and Fuchs E.
  TITLE     Multiple roles for activated LEF/TCF transcription complexes during
            hair follicle development and differentiation
  JOURNAL   Development 126 (20), 4557-4568 (1999)
   PUBMED   10498690
REFERENCE   10 (bases 1 to 2736)
  AUTHORS   Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G,
            Markman M, Lamers W, Destree O and Clevers H.
  TITLE     Two members of the Tcf family implicated in Wnt/beta-catenin
            signaling during embryogenesis in the mouse
  JOURNAL   Mol Cell Biol 18 (3), 1248-1256 (1998)
   PUBMED   9488439
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001065059.1, XM_232064.4, XM_001065007.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132285, SAMD00155332
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..2736
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /note="transcription factor 7 like 1"
                     /db_xref="GeneID:312451"
                     /db_xref="RGD:1311671"
     exon            1..248
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1769
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /note="transcription factor 3; transcription factor 7-like
                     1 (T-cell specific, HMG-box)"
                     /codon_start=1
                     /product="transcription factor 7-like 1"
                     /protein_id="NP_001101335.1"
                     /db_xref="GeneID:312451"
                     /db_xref="RGD:1311671"
                     /translation="MPQLGGGRGGGAGGGGGGSGAGATSGGDDLGANDELIPFQDEGG
                     EEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPARDAFQKPRDYFAE
                     VRRPQDGAFFKGPAYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSA
                     TVKDTRSPSPAHLSNKVPVLQHPHHLQHPLTPLITYSNDHFSPASPPTHLSPEIDPKT
                     GIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMN
                     ASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSAKSPVT
                     VKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQA
                     KYYELARKERQLHAQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQIQEAEGALVSKS
                     KKPCIQYLPPEKPCDSPASSHGSTLDSPATPSAALASPAAPAATHSEQAQPLSLTTKP
                     ETRAQLALHSAAFLSAKATASNSSQMGSQPPLLSRPLPLGSMPTALLTSPPSFPATLH
                     AHQTLPVLQAQPLSLVTKSAH"
     exon            249..312
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            313..440
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..524
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..660
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..763
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..847
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..991
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1151
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1259
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1335
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..2736
                     /gene="Tcf7l1"
                     /gene_synonym="Tcf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaccatgcc ccagctcggt ggtggccgcg gtggcggcgc cggcggggga ggcggtggct
       61 ccggagccgg ggcaaccagt ggaggggacg acctcggagc gaacgacgag ctgatcccct
      121 tccaggacga ggggggcgaa gagcaggagc cgagcagcga cagcgcttcg gcgcagaggg
      181 atctggatga ggtcaagtcg tccctggtca acgaatcgga gaatcagagc agtagctcgg
      241 actccgaggc ggagaggcgc ccgcagcccg cccgggacgc tttccagaag ccgcgcgact
      301 atttcgccga agtgagaagg ccccaggacg gcgctttctt taagggacct gcgtaccctg
      361 ggtacccctt cctgatgatt ccagacctga gcagcccata cctctccaat ggacccctgt
      421 ctcctggtgg agcgcgcacc tacctgcaga tgaaatggcc cctcctcgat gtcccctcca
      481 gcgctacagt caaggacaca agatcaccat ctccagcaca cttgtccaac aaagtccctg
      541 ttcttcagca tcctcatcac ctacagcacc cgctgacccc tctcatcacc tacagcaacg
      601 accacttctc ccccgcgtcc cctcccacac atctgtcccc agagatcgac ccaaagacag
      661 gtatcccccg gccccctcac ccatctgagc tgtcaccgta ttacccactg tctccaggag
      721 ctgttggaca aatcccccat cccctcggct ggctcgtccc acagcaagga cagcccatgt
      781 actcactccc tcctggtggt ttccggcacc cttaccctgc ccttgccatg aatgcttcaa
      841 tgtccagcct ggtctcaagt cggttctccc cacacatggt ggctcctgcc catcctggtc
      901 tgcccacctc aggaatcccc caccctgcca tcgtctcccc cattgtgaag caggagccag
      961 cgccccccag cctgagccct gcagtgagtg cgaaatcccc cgttaccgtg aaaaaggaag
     1021 aggagaagaa gcctcacgtg aaaaagcctc tcaatgcctt catgttgtat atgaaggaga
     1081 tgagggcaaa ggtggtggcc gagtgtaccc tgaaggaaag tgcagccatt aaccaaatcc
     1141 tgggaagaaa gtggcacaac ctgtcaagag aagaacaggc caaatactat gaacttgccc
     1201 ggaaagaacg gcagcttcac gcgcagctct acccaacctg gtcagcccgg gacaactatg
     1261 gtaagaagaa gaagaggaag agggaaaagc agctgtcaca gacacagtct cagcagcaaa
     1321 tccaggaggc agagggtgct ctggtctcta agagcaagaa gccatgcatt cagtacctgc
     1381 cccctgagaa gccttgtgat agccctgcgt cttcccatgg cagcacgttg gactcccctg
     1441 cgactccctc cgcagccctg gcgtcaccag ctgcccctgc ggctactcac tccgagcaag
     1501 cccagcccct gtcactcacc accaaaccgg agacccgggc ccagctggct ctccactcag
     1561 ctgccttcct gtcagctaag gccacagcca gcaactccag ccagatgggc agccagcccc
     1621 cactcctatc caggcccttg cccttgggct ctatgcccac cgctctgctg acctctcccc
     1681 cttctttccc agccacgctc catgcccacc agaccctccc cgtgctacag gcccagcctc
     1741 tttccttggt caccaagtct gcccactaag ctgcccccgt tctacgcagg ctgtctcggg
     1801 actccaagta gtagtgattc agaagagagg aagggggaaa cacacaaagc aaacattatt
     1861 ggtcaatatt tgaccactct ggactgttct ataaagtaac tggtaacagc agtgctttac
     1921 cagtgtagat gtaaccagta gctgatcttc aggcattttt tttttaaaaa ggagaaaaca
     1981 aaaacaaaac aaaacctgtc cctccctccc aaaagaatct tcacaggaaa gcactgaaaa
     2041 gcagtgtgtt gctctctccc cttgtgctgt ggtaggtata cctgggcagg agatacctct
     2101 ctacctcttc tcttcctgac tctctgccct ccttttcgtt gctgccagcc cccacctgcc
     2161 ctagcttccc caccgtatct gcaatgtgac ctggcctgga gttctagcct tggtaccctt
     2221 tcctccaggt cattcctgtt ccctcaccca agtatttgtc atgtgttcaa caccagttca
     2281 tgcccctttg tcctctgccc agtgtaaggc cgtggccgtg tgattatcct ctcccaccag
     2341 catcccccct ccctcttcag gtcccaatgg cctggcctcc agcttggggt ggggaaagag
     2401 gtccttctga tacgatcccc cccaaccctg catttaaagg gactcaaggt gcctaccact
     2461 gccttcaaga agtctgtgtt cctctcccct gcccagtcaa gttttctttc ccacctcgac
     2521 gtctcagagt ggcaggcagg ccccaggccc actgtctggc tcctgtcacc tccgactatg
     2581 ctagtacaat ctgcagaagt tccaagaccc tctgctctcc ccaccaccac cacctcacaa
     2641 gctttttctg tgtgtatttc attttgtttt tatggttttt ggaacatttt aaactcccag
     2701 tttattttca caaaagaaaa taaaattaca gttgca
//
