LOCUS       NM_053369               2194 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), mRNA.
ACCESSION   NM_053369
VERSION     NM_053369.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 2194)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 2194)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 2194)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 2194)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 2194)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 2194)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 2194)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 2194)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 2194)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 7, 2020 this sequence version replaced NM_053369.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000018.1  65219645-65219736
            93-165              JAXUCZ010000018.1  65221421-65221493
            166-227             JAXUCZ010000018.1  65334541-65334602
            228-324             JAXUCZ010000018.1  65337982-65338078
            325-386             JAXUCZ010000018.1  65391770-65391831
            387-513             JAXUCZ010000018.1  65437942-65438068
            514-563             JAXUCZ010000018.1  65438528-65438577
            564-669             JAXUCZ010000018.1  65507173-65507278
            670-800             JAXUCZ010000018.1  65511025-65511155
            801-933             JAXUCZ010000018.1  65516916-65517048
            934-1001            JAXUCZ010000018.1  65525175-65525242
            1002-1080           JAXUCZ010000018.1  65526319-65526397
            1081-1157           JAXUCZ010000018.1  65528841-65528917
            1158-1361           JAXUCZ010000018.1  65531547-65531750
            1362-1497           JAXUCZ010000018.1  65551334-65551469
            1498-1648           JAXUCZ010000018.1  65553405-65553555
            1649-1878           JAXUCZ010000018.1  65556812-65557041
            1879-2019           JAXUCZ010000018.1  65557878-65558018
            2020-2194           JAXUCZ010000018.1  65558233-65558407
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2194
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..92
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2015
                     /gene="Tcf4"
                     /note="ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4"
                     /protein_id="NP_445821.2"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLH
                     SSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDG
                     HHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPP
                     MSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHT
                     NNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDD
                     AIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGA
                     HREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSS
                     EIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMAN
                     NARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLN
                     PKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     exon            93..165
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            166..227
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            228..324
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            325..386
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            387..513
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..563
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            564..669
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            670..800
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            801..933
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1001
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1080
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1157
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1361
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1497
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1648
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1878
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2019
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2194
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttgtgtga ttttgctaaa atgcatcacc aacagcgaat ggctgcctta gggacggaca
       61 aagagctgag tgatttactg gatttcagtg cgatgttttc gcctcctgta agcagtggga
      121 aaaatggacc aacttctttg gcgagtggac attttacggg ctcaaatgta gaagacagaa
      181 gtagctcagg gtcctggggg aatggaggtc atccaagccc gtccaggaac tatggagatg
      241 ggactcccta tgaccacatg actagcaggg atcttgggtc acatgacaat ctctctccac
      301 cttttgtcaa ttccagaata caaagtaaaa cagaaagggg ttcatactca tcttatggga
      361 gagaaaacgt acagggttgc caccagagtc tcctcggagg ggacatggat atgggcaacc
      421 caggaaccct ttcgcccacc aaacctggct cccagtacta cccatattcc agcaataacg
      481 cccgacggag gcctcttcac agtagtacca tggaggtgca gacaaagaaa gtcagaaaag
      541 ttcctccagg cttgccatct tcagtctacg ctccttcagc cagcactgcc gactacaaca
      601 gggactcacc aggctattct tcctccaagc cagcagccag cactttctcc agctccttct
      661 tcatgcaaga tggccatcac agcagtgacc cttggagctc ctccagtgga atgaatcagc
      721 ccggctatgg agggatgcta ggcaactctc atatcccaca gtctagcagc tactgtagcc
      781 tgcatccaca tgaacgtctg agctatccat cgcactcctc ggcagacatc aactccagtc
      841 ttcctccgat gtccacgttc catcgaagtg gcacaaacca ttacagcacc tcttcctgca
      901 cacctcctgc caacggaaca gacagtataa tggcaaacag aggaactggg gcagcaggca
      961 gctcccagac tggagacgct ctggggaaag ccctggcttc gatctattct cctgatcaca
     1021 cgaacaacag cttctcctcc aacccttcaa ctcctgttgg ctcccctcct tcactctcag
     1081 caggcacagc tgtttggtct cgaaacggag gacaggcctc gtcatctccc aattacgaag
     1141 gacccttgca ctccttgcag agccgaattg aagaccgttt agaaagactg gacgacgcga
     1201 ttcatgttct ccggaaccac gcggtgggcc catccacagc tgtgcccggt ggccatgggg
     1261 acatgcatgg gatcatcgga ccctctcaca atggagcaat gggcagtctg ggctcaggat
     1321 atggaactgg ccttctctca gccaacagac attcactcat ggtcggggcc caccgtgaag
     1381 atggcgtggc actgagaggc agccattctc tcctgccaaa ccaggttccg gttccacagc
     1441 ttccagtcca gtctgcaact tcccctgact tgaacccacc ccaagaccct tacagaggga
     1501 tgccaccagg cctccaggga cagagtgtgt cttccggcag ctctgagatc aagtccgacg
     1561 acgagggcga tgagaaccta caggacacaa aatcttccga ggacaagaaa ctagacgacg
     1621 acaagaagga tatcaaatca attactagca ataacgatga tgaggacctg accccggagc
     1681 agaaggccga gcgtgagaag gagcggagga tggccaataa cgcccgtgag cgcctgaggg
     1741 tccgtgatat caacgaggct ttcaaggagc tgggccgcat ggtacagctc cacctgaaga
     1801 gcgacaagcc ccagaccaag ctcctgattc tccaccaggc agtggctgtc atcctcagcc
     1861 tggagcagca agtgcgagaa aggaacctga acccaaaagc tgcctgtctg aaaagaaggg
     1921 aggaagagaa ggtgtcctca gagcctcccc cgctctcctt ggctggccca caccctggga
     1981 tgggagacgc agcgaatcac atgggtcaga tgtgaaaggg tccaagttgc caccttgctt
     2041 cattaaaaca agagaccact tccttaacag ctgtattatc ctaaacccac ataaacactg
     2101 ctccttaacc ccgttttttt tgtaatataa gacaagtctg agtagttatg aatcgcagac
     2161 gcaagaggtt tcagcattcc caattatcaa aaaa
//
