LOCUS       NM_001035237            2562 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus transcription factor 3 (Tcf3), transcript variant
            2, mRNA.
ACCESSION   NM_001035237 XM_001076440
VERSION     NM_001035237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2562)
  AUTHORS   Guo,Q., Liu,Y., Sun,R., Yang,F., Qiao,P., Zhang,R., Song,L., E,L.
            and Liu,H.
  TITLE     Mechanical stimulation induced osteogenic differentiation of BMSCs
            through TWIST/E2A/p21 axis
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32309849
  REMARK    GeneRIF: Mechanical stimulation induced osteogenic differentiation
            of BMSCs through TWIST/E2A/p21 axis.
REFERENCE   2  (bases 1 to 2562)
  AUTHORS   Siu,M.K., Chen,W.Y., Tsai,H.Y., Chen,H.Y., Yin,J.J., Chen,C.L.,
            Tsai,Y.C. and Liu,Y.N.
  TITLE     TCF7 is suppressed by the androgen receptor via microRNA-1-mediated
            downregulation and is involved in the development of resistance to
            androgen deprivation in prostate cancer
  JOURNAL   Prostate Cancer Prostatic Dis 20 (2), 172-178 (2017)
   PUBMED   28220803
REFERENCE   3  (bases 1 to 2562)
  AUTHORS   Wang,Z., Kim,J., Teng,Y., Ding,H.F., Zhang,J., Hai,T., Cowell,J.K.
            and Yan,C.
  TITLE     Loss of ATF3 promotes hormone-induced prostate carcinogenesis and
            the emergence of CK5(+)CK8(+) epithelial cells
  JOURNAL   Oncogene 35 (27), 3555-3564 (2016)
   PUBMED   26522727
REFERENCE   4  (bases 1 to 2562)
  AUTHORS   Udayakumar,T.S., Stoyanova,R., Shareef,M.M., Mu,Z., Philip,S.,
            Burnstein,K.L. and Pollack,A.
  TITLE     Edelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors
            by Increasing ATF3 and Inhibiting Androgen Receptor Activity
  JOURNAL   Mol Cancer Ther 15 (6), 1353-1363 (2016)
   PUBMED   26944919
REFERENCE   5  (bases 1 to 2562)
  AUTHORS   Zhu,G., Li,X., Guo,B., Ke,Q., Dong,M. and Li,F.
  TITLE     PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal
            transition and metastasis of colon cancer
  JOURNAL   Oncogene 35 (15), 1943-1954 (2016)
   PUBMED   26212009
REFERENCE   6  (bases 1 to 2562)
  AUTHORS   Metz,R. and Ziff,E.
  TITLE     The helix-loop-helix protein rE12 and the C/EBP-related factor
            rNFIL-6 bind to neighboring sites within the c-fos serum response
            element
  JOURNAL   Oncogene 6 (12), 2165-2178 (1991)
   PUBMED   1766666
REFERENCE   7  (bases 1 to 2562)
  AUTHORS   Sommer,L., Hagenbuchle,O., Wellauer,P.K. and Strubin,M.
  TITLE     Nuclear targeting of the transcription factor PTF1 is mediated by a
            protein subunit that does not bind to the PTF1 cognate sequence
  JOURNAL   Cell 67 (5), 987-994 (1991)
   PUBMED   1720355
REFERENCE   8  (bases 1 to 2562)
  AUTHORS   Nelson,C., Shen,L.P., Meister,A., Fodor,E. and Rutter,W.J.
  TITLE     Pan: a transcriptional regulator that binds chymotrypsin, insulin,
            and AP-4 enhancer motifs
  JOURNAL   Genes Dev 4 (6), 1035-1043 (1990)
   PUBMED   2200736
REFERENCE   9  (bases 1 to 2562)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
REFERENCE   10 (bases 1 to 2562)
  AUTHORS   Murre,C., McCaw,P.S., Vaessin,H., Caudy,M., Jan,L.Y., Jan,Y.N.,
            Cabrera,C.V., Buskin,J.N., Hauschka,S.D., Lassar,A.B. et al.
  TITLE     Interactions between heterologous helix-loop-helix proteins
            generate complexes that bind specifically to a common DNA sequence
  JOURNAL   Cell 58 (3), 537-544 (1989)
   PUBMED   2503252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X54549.1, BC078750.1 and BQ192196.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001076440.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               X54549.1           1-245
            246-2521            BC078750.1         174-2449
            2522-2562           BQ192196.1         1-41                c
FEATURES             Location/Qualifiers
     source          1..2562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2562
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /note="transcription factor 3"
                     /db_xref="GeneID:171046"
                     /db_xref="RGD:620914"
     exon            1..148
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2014
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /note="isoform b is encoded by transcript variant 2;
                     transcription factor E2-alpha; TCF-3; transcription
                     regulator Pan; pancreas specific transcription factor 1c;
                     immunoglobulin enhancer-binding factor E12/E47;
                     transcription factor E2a; transcription factor E2a-like"
                     /codon_start=1
                     /product="transcription factor E2-alpha isoform b"
                     /protein_id="NP_001030314.1"
                     /db_xref="GeneID:171046"
                     /db_xref="RGD:620914"
                     /translation="MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGT
                     QFAGSGLEDRPSSGSWGNSEQNSSSFDPSRAYSEGAHFSDSHSSLPPSTFLGAGLGGK
                     GSERNAYATFGRDTSVGTLSQAGFLPGELGLSSPGPLSPSGVKSSSQYYTSFPSNPRR
                     RAADGGLDTQPKKVRKVPPGLPSSVYPSSSGDNYSRDATAYPSAKTPSSAYPSPFYVA
                     DGSLHPSAELWSPPGQVGFGPMLGDGSAPLPLAPGSSSVSSGAFGGLQQQDRMGYQLH
                     GSEVNGTLPAVSSFSAAPGTYSGTSGHTPPVSGADSLLGTRGTTASSSGDALGKALAS
                     IYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRL
                     DEAIHVLRSHAVGTASELHGLLPGHSTLTTSFAGPMSLGGRHAGLVSGSHPEDGLTSG
                     ASLLHNHASLPSQPSSLPDLSQRPPDSFSGLGRAGVTAGASEIKREEKEDEEVTSVAD
                     AEEDKKDLKVPRTRTSSTDEVLSLEEKDLRDRERRMANNARERVRVRDINEAFRELGR
                     MCQLHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPKAACLKRREEEKVSGVVGD
                     PQLALSAAHPGLGEAHNPAGHL"
     exon            149..221
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            222..295
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            296..374
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            375..442
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            443..575
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            576..625
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            626..728
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            729..886
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1016
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1075
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1154
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1228
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1384
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1511
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1644
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1871
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2545
                     /gene="Tcf3"
                     /gene_synonym="Pan2; Tcfe2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgtcact acacagggct gcctctaggc ctggggaacg caccccagtt ccgacacctg
       61 ctgccctggc tggatgatga accagtctca gagaatggca cctgttggct cggacaaaga
      121 actgagtgac ctcctggact tcagtatgat gttcccgcta cctgtggcca atggcaaggg
      181 ccggcccgcc tccctagctg gaacccagtt cgcaggctca ggactggagg accgacccag
      241 ctcagggtcc tggggcaaca gtgaacagaa cagttcttcc tttgacccta gccgggcata
      301 cagcgaaggt gcccacttca gtgactccca cagcagcctg ccgccttcca cgttcctagg
      361 agctgggctt ggaggcaagg gcagtgaacg gaatgcctat gccaccttcg ggagagacac
      421 cagtgttggc accctgagtc aggctggctt cctaccaggt gagctgggcc tcagcagtcc
      481 cgggccactg tccccatcag gcgtcaagag cagctcccag tattacacct cattccccag
      541 caaccctcgg cggagagctg cagatggtgg cctggatact cagcccaaga aggtccggaa
      601 ggttccgcct ggtcttcctt cctcggtata tccatccagc tcaggtgata actacagcag
      661 ggacgccaca gcctacccct ccgccaagac ccccagcagc gcttacccct cccccttcta
      721 cgtggcagac ggcagcctgc acccctcagc ggagctctgg agtccccctg gccaggtggg
      781 ctttgggccc atgctaggtg atggctcggc ccccctgccg cttgcaccgg gcagcagttc
      841 cgtgagcagt ggtgcctttg ggggcctcca gcagcaggat cgcatgggct accagctgca
      901 tgggtctgag gtcaatggca cgctcccagc tgtatccagc ttctcagctg cccctggcac
      961 ttacagtggg acttctggcc acacgccacc cgtgagcggg gccgacagcc tcttaggcac
     1021 ccgagggact acagccagca gctcagggga tgcccttggg aaggcactgg cctccatcta
     1081 ctccccggat cactccagca ataatttctc gcccagcccc tcaacgcctg tgggttcacc
     1141 ccagggcctg ccagggacat cacagtggcc ccgggcagga gcgcccagtg ccttatcccc
     1201 caactacgat gcaggtctcc atggcctgag taaaatggaa gatcgcttgg acgaggccat
     1261 ccacgtcctc cgcagtcacg ctgtcggcac tgcaagcgag ctccatggac tgctgcctgg
     1321 ccacagcacg ttgaccacaa gctttgcggg ccccatgtca ctgggcgggc ggcatgcagg
     1381 cctggtcagc ggaagccacc ctgaggatgg cctcacaagt ggtgccagtc ttttgcataa
     1441 ccatgccagc cttcccagcc agcccagctc cctccctgac ctctcacaga ggccacccga
     1501 ctcctttagt ggactcggga gggcaggcgt gactgcaggc gccagtgaga tcaagcggga
     1561 ggagaaagag gacgaggagg tcacatcagt ggcagacgct gaggaagaca agaaggacct
     1621 gaaggtccca cgcacacgta ccagcagtac agatgaggtg ctgtccctgg aggagaagga
     1681 cctgagggac cgggagaggc gcatggccaa taacgctcgg gagcgggtgc gcgtgcggga
     1741 cattaacgag gccttccggg agctgggccg catgtgccag ctgcacctca agtcggataa
     1801 ggcgcagacc aagctgctga tcctgcagca ggcggtgcag gttatcctgg gcctggagca
     1861 gcaggtgcga gaacgcaacc tgaaccccaa agcagcctgc ttgaagcggc gggaggagga
     1921 gaaggtatct ggcgtggtcg gggatccgca gctggcgctg tcagccgccc acccgggcct
     1981 gggtgaggcc cacaatccag ctgggcacct gtgagccgtc acagggtctt cgttggacca
     2041 gggaccacca catctctgcc cggggtgcac ccaggatggt cctggatgag acatctccat
     2101 cgaggcatgg gcagagggct ctggggacac ttcagggcct gggggagttg gcacggagca
     2161 gcccacctgt cttggcccag taaccaagct gaagagcggc tcctcctctc gattagcggg
     2221 aactggaaac aaagcagcat gcccacttat cagaaaggaa aaaagatgcc ttaactatgt
     2281 cagacggaag agtcggaccg cgccctggca aggggcggcc tggtactggc ttctagttca
     2341 gagccacagc acattgtgcc taagcatttt tcgtttttta aaaggagaat aaaggaacat
     2401 tagttttcag attttttttt taatgtagac aaaagttagc aagaacgagg ccttccgtgt
     2461 cttttttttc ccttaacttt cttttccgta tgttttgtaa gcaacaaatt tttgtataaa
     2521 agtctcatgt ctgtttctgt ttctaaaaaa aaaaaaaaaa aa
//
