LOCUS       NM_013176               2531 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus transcription factor 12 (Tcf12), mRNA.
ACCESSION   NM_013176 XM_346829
VERSION     NM_013176.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2531)
  AUTHORS   Wu,K., Li,S., Bodhinathan,K., Meyers,C., Chen,W.,
            Campbell-Thompson,M., McIntyre,L., Foster,T.C., Muzyczka,N. and
            Kumar,A.
  TITLE     Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of
            rats: Impact on cognitive function, synaptic plasticity and
            pathology
  JOURNAL   Neurobiol Learn Mem 97 (1), 69-80 (2012)
   PUBMED   21982980
  REMARK    GeneRIF: The learning and memory deficits in Tcf12 animals are
            likely due to neuropathology associated with Tcf12 gene expression.
REFERENCE   2  (bases 1 to 2531)
  AUTHORS   Yoon,S.J., Wills,A.E., Chuong,E., Gupta,R. and Baker,J.C.
  TITLE     HEB and E2A function as SMAD/FOXH1 cofactors
  JOURNAL   Genes Dev 25 (15), 1654-1661 (2011)
   PUBMED   21828274
REFERENCE   3  (bases 1 to 2531)
  AUTHORS   Jia,J., Dai,M. and Zhuang,Y.
  TITLE     E proteins are required to activate germline transcription of the
            TCR Vbeta8.2 gene
  JOURNAL   Eur J Immunol 38 (10), 2806-2820 (2008)
   PUBMED   18958875
REFERENCE   4  (bases 1 to 2531)
  AUTHORS   Ravanpay,A.C. and Olson,J.M.
  TITLE     E protein dosage influences brain development more than family
            member identity
  JOURNAL   J Neurosci Res 86 (7), 1472-1481 (2008)
   PUBMED   18214987
REFERENCE   5  (bases 1 to 2531)
  AUTHORS   Wissmuller,S., Kosian,T., Wolf,M., Finzsch,M. and Wegner,M.
  TITLE     The high-mobility-group domain of Sox proteins interacts with
            DNA-binding domains of many transcription factors
  JOURNAL   Nucleic Acids Res 34 (6), 1735-1744 (2006)
   PUBMED   16582099
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2531)
  AUTHORS   Lin,H.H., Li,W.Y. and Ann,D.K.
  TITLE     The helix-loop-helix proteins (salivary-specific cAMP response
            element-binding proteins) can modulate cAMP-inducible RP4 gene
            expression in salivary cells
  JOURNAL   J Biol Chem 268 (14), 10214-10220 (1993)
   PUBMED   7683670
REFERENCE   7  (bases 1 to 2531)
  AUTHORS   Klein,E.S., Simmons,D.M., Swanson,L.W. and Rosenfeld,M.G.
  TITLE     Tissue-specific RNA splicing generates an ankyrin-like domain that
            affects the dimerization and DNA-binding properties of a bHLH
            protein
  JOURNAL   Genes Dev 7 (1), 55-71 (1993)
   PUBMED   8422988
REFERENCE   8  (bases 1 to 2531)
  AUTHORS   Nielsen,A.L., Pallisgaard,N., Pedersen,F.S. and Jorgensen,P.
  TITLE     Murine helix-loop-helix transcriptional activator proteins binding
            to the E-box motif of the Akv murine leukemia virus enhancer
            identified by cDNA cloning
  JOURNAL   Mol Cell Biol 12 (8), 3449-3459 (1992)
   PUBMED   1321336
REFERENCE   9  (bases 1 to 2531)
  AUTHORS   Sommer,L., Hagenbuchle,O., Wellauer,P.K. and Strubin,M.
  TITLE     Nuclear targeting of the transcription factor PTF1 is mediated by a
            protein subunit that does not bind to the PTF1 cognate sequence
  JOURNAL   Cell 67 (5), 987-994 (1991)
   PUBMED   1720355
REFERENCE   10 (bases 1 to 2531)
  AUTHORS   Sun,X.H., Copeland,N.G., Jenkins,N.A. and Baltimore,D.
  TITLE     Id proteins Id1 and Id2 selectively inhibit DNA binding by one
            class of helix-loop-helix proteins
  JOURNAL   Mol Cell Biol 11 (11), 5603-5611 (1991)
   PUBMED   1922066
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L09656.1.
            
            On Feb 21, 2013 this sequence version replaced NM_013176.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09656.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2531              L09656.1           1-2531
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2531
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /note="transcription factor 12"
                     /db_xref="GeneID:25720"
                     /db_xref="RGD:3829"
     exon            1..181
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            182..278
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2327
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /note="E-box-binding protein; DNA-binding protein HTF4;
                     transcription factor HTF-4; salivary-specific cAMP
                     response element-binding protein alpha; TCF-12;
                     SCBP-alpha"
                     /codon_start=1
                     /product="transcription factor 12"
                     /protein_id="NP_037308.1"
                     /db_xref="GeneID:25720"
                     /db_xref="RGD:3829"
                     /translation="MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSS
                     QFSGSGMDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPF
                     MNSNLIGKTSERGSFSLYSRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFS
                     ATSSRRRPLHDSVALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPT
                     SMFASTFFMQDGTHSSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLS
                     YPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQ
                     TGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTAGTSQWPRAGGQAPSSPSYEN
                     SLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSL
                     PTSHSDIHSLLGPSHNAPIGNLNSNYGGSSLVTNSRSASMVGTHREDSVSLNGNHSVL
                     SSTVAASNTELNHKTPESFRGGVQNQSGSVVPTEIKTENKEKDENLHEPPSSDDMKSD
                     DESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKE
                     LGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAA
                     SAEPPTTLPGTHPGLSETTNPMGHL"
     exon            279..351
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            352..425
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            426..528
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            529..593
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            594..729
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            730..782
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            783..888
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1028
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1173
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1238
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1317
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1394
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1466
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1673
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1788
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1951
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2184
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2338
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2531
                     /gene="Tcf12"
                     /gene_synonym="SCBP alpha; SCBPA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccgggga gccacgggcg gccaagcccg agagccgccc gagccgctcg gactcaagcg
       61 ctcgcgcggg cccgaggcag cccagccgcc ggcggcgcgt ggggaggggg aagcccgagc
      121 ccgcgctccc gaccaaagtg aactttaatc gggaaggttg gatgcggagc ccgggcggca
      181 ggacctgcta gaagtagctg aagatgaatc cccagcagca gcgcatggcc gcgataggga
      241 ccgacaagga gctgagcgac ctgctggact tcagtgcgat gttttctcca cctgttaata
      301 gtgggaaaac gagaccaacg acactgggaa gtagtcagtt cagcgggtca ggtatggatg
      361 agcgtggagg aacaacgtct tggggaacaa gcggtcaacc aagcccctcc tatgattcat
      421 ctagaggttt tacagacagc cctcattaca gtgatcactt gaatgacagt cgattaggaa
      481 cccatgaagg cttgtcccca acacctttca tgaactcaaa tctgataggg aaaacctcag
      541 agagaggctc attttccctg tacagcagag actctggatt atcaggctgt cagtctagtc
      601 tcctgagaca agatctagga ctcgggagcc cagcacagtt gtcttcttca ggaaaacctg
      661 gaacaccata ctactcattc tctgccacaa gttctagaag aagaccgctc catgattctg
      721 tagctctaga tcctttacaa gcaaagaaag taagaaaggt gcctcctggc ctaccttctt
      781 ctgtgtatgc accatcccca aattctgacg atttcaaccg tgaatctcct agttacccat
      841 ctcccaagcc accaaccagt atgttcgcta gcactttctt tatgcaagat ggcactcaca
      901 gttcttctga cctttggagt tcatcgaatg ggatgagcca gcctggtttt ggtggaattc
      961 tggggacctc cacttcccac atgtctcagt ccagtagtta tggcagtctt cattcacatg
     1021 accgcttgag ttatcctcca cactcagtgt caccaacaga cataaacaca agtcttccgc
     1081 caatgtccag cttccaccgt ggtagtacca gcagctcacc atatgttgcc gcctcacata
     1141 ctcctcccat caatggatca gatagcatcc tgggaacccg agggaatgct gctggaagct
     1201 cacagaccgg tgatgcactt gggaaggcct tggcatctat ttattctcct gaccacacaa
     1261 gcagtagttt tccatcaaac ccatcaacac cagtaggatc tccttcacct ctcacagcag
     1321 gtaccagtca gtggcccaga gctggagggc aagctccttc atccccaagc tatgaaaact
     1381 cacttcactc cctgaaaaat cgagttgagc agcaacttca cgagcatttg caagatgcaa
     1441 tgtccttctt aaaggatgtc tgtgagcagt ctcgaatgga agaccgttta gacaggctgg
     1501 atgatgctat ccatgtgcta cggaaccatg cagttggacc ttctaccagt ctgcctacta
     1561 gccacagtga tatacacagt ttattgggac catcccataa tgcaccaatt ggaaacctca
     1621 attcaaacta tggaggatca agccttgtta caaatagtcg atcagcttcg atggtcggaa
     1681 ctcatcggga agattcggtc agtctcaatg gcaatcattc ggtcctgtct agtactgttg
     1741 ctgcctcaaa cacagaactg aaccataaaa caccagaaag tttcagaggt ggtgtacaaa
     1801 atcagtctgg aagtgttgtt ccaacagaaa tcaagactga aaacaaagaa aaagatgaaa
     1861 accttcatga acctccttca tcagatgaca tgaaatcaga tgatgagtcc tcccagaaag
     1921 acatcaaagt ctcatctaga ggcagaacaa gcagtaccaa tgaagatgag gatctgaatc
     1981 cagaacagaa aatcgaaagg gagaaggaaa ggcggatggc taacaatgcc agagagcgct
     2041 tgcgtgtgcg ggatatcaat gaggcattca aggagctcgg ccgaatgtgt cagcttcatt
     2101 tgaagagtga gaaaccacag acaaaacttc tcattcttca tcaagccgtg gcagtcatcc
     2161 ttagtctaga acagcaagtc agagagagga acctcaaccc caaagcagcc tgccttaaga
     2221 gaagagaaga agaaaaggtc tctgctgcgt cagcagagcc gcccaccacg ttgccaggaa
     2281 cccatcctgg gcttagtgag acaaccaacc ctatgggtca tctgtaaaca tcagccagtt
     2341 ccagagtcat cagtaggcta gatagaaggt gacctctcct cataaagatt tggagaactc
     2401 agattatctg aagacacaaa cctggcagga gggagaagaa aaagcaaaac acttgaaaca
     2461 agaaactcat atgtaatcct atgatcaaag caactggtca acacttccat cagaagtgag
     2521 gataggaagc t
//
