LOCUS       NM_001107390            4366 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus transcription elongation regulator 1 (Tcerg1),
            mRNA.
ACCESSION   NM_001107390 XM_001068365 XM_225983
VERSION     NM_001107390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4366)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 4366)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 4366)
  AUTHORS   Zhou,J., Liu,Y., Zhang,W., Popov,V.M., Wang,M., Pattabiraman,N.,
            Sune,C., Cvekl,A., Wu,K., Jiang,J., Wang,C. and Pestell,R.G.
  TITLE     Transcription elongation regulator 1 is a co-integrator of the cell
            fate determination factor Dachshund homolog 1
  JOURNAL   J Biol Chem 285 (51), 40342-40350 (2010)
   PUBMED   20956529
REFERENCE   4  (bases 1 to 4366)
  AUTHORS   Ramirez-Espain,X., Ruiz,L., Martin-Malpartida,P., Oschkinat,H. and
            Macias,M.J.
  TITLE     Structural characterization of a new binding motif and a novel
            binding mode in group 2 WW domains
  JOURNAL   J Mol Biol 373 (5), 1255-1268 (2007)
   PUBMED   17915251
REFERENCE   5  (bases 1 to 4366)
  AUTHORS   Ferguson,N., Becker,J., Tidow,H., Tremmel,S., Sharpe,T.D.,
            Krause,G., Flinders,J., Petrovich,M., Berriman,J., Oschkinat,H. and
            Fersht,A.R.
  TITLE     General structural motifs of amyloid protofilaments
  JOURNAL   Proc Natl Acad Sci U S A 103 (44), 16248-16253 (2006)
   PUBMED   17060612
REFERENCE   6  (bases 1 to 4366)
  AUTHORS   Arango,M., Holbert,S., Zala,D., Brouillet,E., Pearson,J.,
            Regulier,E., Thakur,A.K., Aebischer,P., Wetzel,R., Deglon,N. and
            Neri,C.
  TITLE     CA150 expression delays striatal cell death in overexpression and
            knock-in conditions for mutant huntingtin neurotoxicity
  JOURNAL   J Neurosci 26 (17), 4649-4659 (2006)
   PUBMED   16641246
  REMARK    GeneRIF: Together, our data indicate that mutant htt may induce
            CA150 dysfunction in striatal neurons and suggest that the
            restoration of nuclear protein cooperativity may be
            neuroprotective.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jan 25, 2008 this sequence version replaced NM_001107390.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.62657.1,
                                           SRR26643298.73891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000018.1  34756725-34756823
            100-325             JAXUCZ010000018.1  34763325-34763550
            326-478             JAXUCZ010000018.1  34766326-34766478
            479-881             JAXUCZ010000018.1  34767287-34767689
            882-1124            JAXUCZ010000018.1  34773810-34774052
            1125-1187           JAXUCZ010000018.1  34778059-34778121
            1188-1388           JAXUCZ010000018.1  34779112-34779312
            1389-1501           JAXUCZ010000018.1  34779787-34779899
            1502-1590           JAXUCZ010000018.1  34780870-34780958
            1591-1751           JAXUCZ010000018.1  34791965-34792125
            1752-1808           JAXUCZ010000018.1  34793495-34793551
            1809-1875           JAXUCZ010000018.1  34793697-34793763
            1876-2011           JAXUCZ010000018.1  34796117-34796252
            2012-2101           JAXUCZ010000018.1  34797028-34797117
            2102-2220           JAXUCZ010000018.1  34802688-34802806
            2221-2371           JAXUCZ010000018.1  34805908-34806058
            2372-2536           JAXUCZ010000018.1  34809467-34809631
            2537-2719           JAXUCZ010000018.1  34810045-34810227
            2720-2899           JAXUCZ010000018.1  34812573-34812752
            2900-2983           JAXUCZ010000018.1  34813384-34813467
            2984-3084           JAXUCZ010000018.1  34814865-34814965
            3085-4366           JAXUCZ010000018.1  34816160-34817441
FEATURES             Location/Qualifiers
     source          1..4366
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..4366
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /note="transcription elongation regulator 1"
                     /db_xref="GeneID:307474"
                     /db_xref="RGD:1311748"
     exon            1..99
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..3286
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /note="coactivator of 150 kD"
                     /codon_start=1
                     /product="transcription elongation regulator 1"
                     /protein_id="NP_001100860.2"
                     /db_xref="GeneID:307474"
                     /db_xref="RGD:1311748"
                     /translation="MAERGGDGGEGERFNPGELRMAQQQALRFRGPAPPPNAVMRGPP
                     PLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPP
                     PMGAMPPPPGMMFPPGMPPGTAPGAPALPPTEEIWVENKTPDGKVYYYNARTRESAWT
                     KPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAAQAQAQA
                     QAQAQAQAQAQAQAQVQAQAVGAPTPTTSSPAPAVSTSAPTSTPSSTTATTTTATSVA
                     QTVSTPTTQDQTPSSAVSVATPTVSVSAPAPTATPVQTVPQPHPQTLPPAVPHSVPQP
                     AAAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPI
                     VPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKE
                     KLDEKIKEPIKEASEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVA
                     TTPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGLED
                     MKKLRHPAPTMLSIQKWQFSMSAIKEEQELMEEMNEDEPIKAKKRKRDDNKDIDSEKE
                     AAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNP
                     KERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKD
                     SRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWS
                     KVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLRERE
                     REVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRW
                     ESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPR
                     CIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDV
                     EKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK"
     exon            100..325
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            326..478
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            479..881
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1124
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1187
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1388
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1501
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1590
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1751
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1808
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1875
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2011
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2101
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2220
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2371
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2536
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2719
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2899
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2983
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3084
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..4366
                     /gene="Tcerg1"
                     /gene_synonym="Ca150"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacgccggg tcggcgggtg gatgaacgcg gctgtctgta atggcggagc gtggcgggga
       61 cggaggggaa ggcgagcgct tcaacccggg ggagctgagg atggctcaac agcaggcctt
      121 gagattccga ggcccagctc ccccaccaaa tgcagtgatg cgcggcccac cacctcttat
      181 gagaccacct cctcctttcg gcatgatgag aggccctcct ccaccaccca ggcccccctt
      241 tggacggcct ccttttgatc ctaatatgcc accaatgcct cccccaggag gaatacctcc
      301 acccatgggc ccaccacacc tccagagacc accattcatg cctccaccca tgggagctat
      361 gcctcctcct ccgggcatga tgttcccacc aggaatgcct ccggggactg ctcctggtgc
      421 tccagcactg ccccccactg aggagatatg ggtagaaaat aagactccag atgggaaggt
      481 ttattactat aatgctcgga ctcgtgaatc tgcatggacc aagccagatg gagttaaggt
      541 tattcagcag tcagaactaa cacctatgct tgcagctcaa gcacaggtcc aggctcaggc
      601 ccaggcccag gctcaggctc aggcacaggc acaggctcag gcccaggccc aggcccaggc
      661 ccaggctcag gcagcccagg ctcaggccca agcgcaagca caagctcagg cccaggctca
      721 ggcccaggcc caggctcagg tccaagcaca agcagtaggc gctcccaccc ctaccaccag
      781 tagcccagca cctgcagtgt ccacgtcagc accaacatct accccgtcct ccaccacagc
      841 taccacaaca actgctactt cagttgcaca gacagtatca acacccacaa cacaagacca
      901 gaccccaagt tctgctgttt cagttgccac gcctacagtt agtgtttcag ctcctgctcc
      961 tacagccaca cctgtgcaaa ctgtacccca gccgcaccca cagacgttac ctcctgctgt
     1021 tcctcactca gtccctcagc cggcagcagc aatacctgct ttcccaccag taatggtgcc
     1081 tccgttccgt gtgccccttc ctggcatgcc aattccactt ccaggtgtag caatgatgca
     1141 aatagtcagc tgcccgtatg taaagacagt cgctaccacc aagaccggtg tattaccagg
     1201 aatggcccct cctatagtac ccatgataca tccccaggtt gctattgcag cttcacctgc
     1261 taccttagct ggagccaccg cagtttctga gtggactgaa tataaaacag cagatgggaa
     1321 gacgtactat tataataata gaacacttga atcaacgtgg gaaaagcccc aagaactgaa
     1381 ggaaaaagaa aaattagatg agaagattaa agaaccaatt aaggaggcat ctgaagagcc
     1441 attgccaatg gagacagagg aggaagatcc taaggaagaa cctataaagg agataaagga
     1501 ggaacccaaa gaagaagaga tgactgaaga agaaaaggct gcccagaagg caaagccagt
     1561 agctactact cctattcctg gtactccatg gtgtgttgtt tggactggcg atgagagggt
     1621 cttcttttac aatcccacca ctcgtctttc tatgtgggac cgacctgatg atttaattgg
     1681 aagggcagat gttgacaaaa ttattcaaga gccccctcat aaaaaaggat tagaagacat
     1741 gaagaaacta aggcacccgg ctccgacaat gctgtccatc caaaagtggc agttctcgat
     1801 gagtgcaatt aaagaagaac aagaattaat ggaagaaatg aatgaagatg agcctattaa
     1861 agcaaaaaag cggaagagag atgataataa agacattgat tcagagaaag aagctgccat
     1921 ggaagctgaa attaaagctg cccgagaaag ggccattgtc cctctggagg ctcgaatgaa
     1981 gcagttcaag gacatgctgc tagagagagg ggtgtcagct ttttcaacat gggagaagga
     2041 gttgcacaag atagtgtttg accctcggta cttgcttctc aatcctaaag aaaggaaaca
     2101 ggtgtttgat caatatgtca agaccagagc agaggaagaa cgcagggaaa agaaaaacaa
     2161 aataatgcaa gccaaggaag atttcaaaaa aatgatggaa gaagcaaagt ttaatccaag
     2221 agctactttt agtgaatttg ctgccaaaca tgctaaagat tcaagattca aagcaattga
     2281 aaagatgaaa gatagagaag cattgtttaa tgaattcgtg gcagctgcaa ggaagaaaga
     2341 aaaagaagat tcgaagacga gaggtgagaa gattaaatca gatttcttcg aactgttatc
     2401 taatcatcac ttggacagtc aatctcggtg gagcaaagta aaagacaaag tagaaagcga
     2461 cccacgatac aaagcagtgg atagttcgtc aatgagagaa gaccttttca aacagtacat
     2521 agagaaaata gctaagaatt tagactcaga aaaagaaaaa gagctggaga gacaagcccg
     2581 cattgaggca agccttcgag aacgtgaaag agaagttcaa aaggcacgtt ctgagcaaac
     2641 taaagaaatt gatcgagaga gagagcagca caaacgagaa gaagctatcc agaatttcaa
     2701 ggctcttctg tctgacatgg tacgttcttc agatgtgtcc tggtctgata ctaggaggac
     2761 cctccggaag gaccaccgtt gggagtctgg ttccttattg gaaagagagg agaaagagaa
     2821 actctttaat gaacatattg aagcgcttac caaaaagaaa agggagcact ttaggcagct
     2881 tctggatgag acttccgcga ttaccttaac atccacgtgg aaagaagtga agaaaataat
     2941 taaggaagat cctcgctgca ttaagttctc ctccagtgac aggaaaaaac aaagggagtt
     3001 tgaagaatac atcagagaca aatacatcac tgccaaagct gacttcagga cacttttgaa
     3061 agagaccaaa ttcattacgt acagatccaa aaagctaatc caagaatctg atcagcacct
     3121 gaaagatgta gaaaaaattt tgcagaatga caaacggtat ctagtactgg actgtgtacc
     3181 agaggagagg aggaaactca tcgtggcata tgttgatgac ctggatcgcc gaggtccacc
     3241 tccacctccc acagcatcag agcccactag acgatcaaca aaataattct aaatgccctt
     3301 ccctgggggt tgctgttaat tgaaaatgct tgcatgagcc aaattttcag gtttttacat
     3361 atatgtgcat tagtcaacct attgcaaaac cacctgatga cagaaggaga agcaattgcg
     3421 ggcagtctct gaacagaaca ctttgaaaat atttaatgct tttctttgtg tggcatgact
     3481 gacatacata ctcaaatata gactgtctct agtaaattta aaatcttgaa gctaaaaaaa
     3541 tcatcctttt ctaaggtgtg gaagccagtg acttggtgat atttttacta gcagtgttac
     3601 tcagcaagac aggagaattt gtggtaggag cttggaaata gcacagactc caggaaaact
     3661 gaagttggag tctgtttttg attttgtttt ttaagcgggt aaaagaggaa acactgaatt
     3721 ggattcttcc agagactatg aatattataa cggacacact tttacctttg tctctgaagc
     3781 acagtttagt tgtgtttgtt catgtaagct ttgattctcc ccctcttggt tataggccaa
     3841 gtcttgttta gcccaggaga agatgtattt agtaatttct tctcaggtat gaaccacatt
     3901 cataaataac atgttggcca gaatggaatc ctggtttaaa cattctttat tctccactga
     3961 atgatctcta ccaatattct caattagaca acaaaactcc ctttctgggc gttccctgga
     4021 aactacttct gtttgaatgt ttgaactttt gtttctaaaa agtttaattt taagatgttt
     4081 gaatgttgaa tttatgtatt tgaactacaa taaaccaacc cttttatata tgtggattgt
     4141 aaatgattat tgttacacaa tatatttttt aaaaaccctt agacatgttt ttttgtttgt
     4201 ttgtttgctt gcttgcttgc ttgcttgctc gtttggttcg ttggtttttg ttttgtttta
     4261 ttttttgaaa aaaagcatgt gataatttga ggcaactgaa tcttagaata tagtttttaa
     4321 aggcttgact ataatgtatt tctaatataa aagatacatt ttttag
//
