LOCUS       NM_001271277             997 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus titin-cap (Tcap), mRNA.
ACCESSION   NM_001271277 XM_001081394
VERSION     NM_001271277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 997)
  AUTHORS   Candasamy AJ, Haworth RS, Cuello F, Ibrahim M, Aravamudhan S,
            Kruger M, Holt MR, Terracciano CM, Mayr M, Gautel M and Avkiran M.
  TITLE     Phosphoregulation of the titin-cap protein telethonin in cardiac
            myocytes
  JOURNAL   J Biol Chem 289 (3), 1282-1293 (2014)
   PUBMED   24280220
  REMARK    GeneRIF: cardiac telethonin is constitutively bis-phosphorylated
            and suggest that such phosphorylation is critical for normal
            telethonin function, which may include maintenance of transverse
            tubule organization and intracellular Ca(2+) transients.
REFERENCE   2  (bases 1 to 997)
  AUTHORS   Heng AE, Ventadour S, Jarzaguet M, Pouch-Pelissier MN, Guezennec
            CY, Bigard X, Attaix D and Taillandier D.
  TITLE     Coordinate expression of the 19S regulatory complex and evidence
            for ubiquitin-dependent telethonin degradation in the unloaded
            soleus muscle
  JOURNAL   Int J Biochem Cell Biol 40 (11), 2544-2552 (2008)
   PUBMED   18565784
  REMARK    GeneRIF: data suggest that telethonin is a substrate of the
            ubiquitin-proteasome system during soleus muscle atrophy.
REFERENCE   3  (bases 1 to 997)
  AUTHORS   Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M,
            Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara
            T, Doi Y, Izumi T and Kimura A.
  TITLE     Interaction of BMP10 with Tcap may modulate the course of
            hypertensive cardiac hypertrophy
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (6), H3396-H3403 (2007)
   PUBMED   17921333
REFERENCE   4  (bases 1 to 997)
  AUTHORS   Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N,
            Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H,
            Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knoll R,
            Hoshijima M, Chien KR and Kimura A.
  TITLE     Tcap gene mutations in hypertrophic cardiomyopathy and dilated
            cardiomyopathy
  JOURNAL   J Am Coll Cardiol 44 (11), 2192-2201 (2004)
   PUBMED   15582318
REFERENCE   5  (bases 1 to 997)
  AUTHORS   Knoll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I,
            Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W,
            Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio
            CC, Poller W, Schaper J, Schultheiss HP and Chien KR.
  TITLE     The cardiac mechanical stretch sensor machinery involves a Z disc
            complex that is defective in a subset of human dilated
            cardiomyopathy
  JOURNAL   Cell 111 (7), 943-955 (2002)
   PUBMED   12507422
REFERENCE   6  (bases 1 to 997)
  AUTHORS   Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Koyanagi T,
            Takahashi M, Hohda S, Ueda K, Nouchi T, Hiroe M, Marumo F, Imaizumi
            T, Yasunami M and Kimura A.
  TITLE     Titin mutations as the molecular basis for dilated cardiomyopathy
  JOURNAL   Biochem Biophys Res Commun 291 (2), 385-393 (2002)
   PUBMED   11846417
REFERENCE   7  (bases 1 to 997)
  AUTHORS   Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang ML, Labeit D,
            Labeit S, Inagaki N and Gregorio CC.
  TITLE     Specific interaction of the potassium channel beta-subunit minK
            with the sarcomeric protein T-cap suggests a T-tubule-myofibril
            linking system
  JOURNAL   J Mol Biol 313 (4), 775-784 (2001)
   PUBMED   11697903
REFERENCE   8  (bases 1 to 997)
  AUTHORS   Gregorio CC, Trombitas K, Centner T, Kolmerer B, Stier G, Kunke K,
            Suzuki K, Obermayr F, Herrmann B, Granzier H, Sorimachi H and
            Labeit S.
  TITLE     The NH2 terminus of titin spans the Z-disc: its interaction with a
            novel 19-kD ligand (T-cap) is required for sarcomeric integrity
  JOURNAL   J Cell Biol 143 (4), 1013-1027 (1998)
   PUBMED   9817758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ216780.1 and BM384635.1.
            
            On Sep 13, 2012 this sequence version replaced XM_001081394.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216780.1, FQ215695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMD00132302
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-778               FQ216780.1         1-778
            779-997             BM384635.1         1-219               c
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..997
                     /gene="Tcap"
                     /note="titin-cap"
                     /db_xref="GeneID:688173"
                     /db_xref="RGD:1592387"
     exon            1..135
                     /gene="Tcap"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..529
                     /gene="Tcap"
                     /note="titin cap protein"
                     /codon_start=1
                     /product="telethonin"
                     /protein_id="NP_001258206.1"
                     /db_xref="GeneID:688173"
                     /db_xref="RGD:1592387"
                     /translation="MATSELSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEED
                     TQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGAT
                     KEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGPLRRTLSRSM
                     SQEAQRG"
     exon            136..979
                     /gene="Tcap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagcagagg gatcaagaag gaataatggc cacttcagag ctgagctgtc aagtgtctga
       61 ggagaaccag gagcgcaggg aagccttctg ggccgagtgg aaagacctga ctctgtctac
      121 ccggccggaa gagggatgct ccctgcatga ggaggataca cagaggcatg agacctacca
      181 ccggcaggga cagtgtcagg ccgtggtaca gcgctcgcca tggctggtga tgcgcctggg
      241 tatcctcggc cgtgggctgc aggaatacca gctgccgtac cagcgggtgc tgccgctacc
      301 catcttcacc cctaccaagg tgggggccac caaggaggaa cgcgaggaga cccccattca
      361 gctgcgggag ctgctggccc tggagacagc cctgggcggc cagtgcgtgg agcgccagga
      421 cgtggctgag atcaccaagc agcttccccc ggtggtgcca gtcagcaaac ctgggcccct
      481 gcggcgtacc ctgtctcggt ccatgtctca ggaagctcag agaggctgag atgactgcga
      541 ccgatgcaga ctctgatgtg tctgccttgg gctgggcact tcctgcctag gacgatgggg
      601 gagagctgct ggccaaggct gctttgtagt ttgcccagag gtgcgggcca tgggaggagg
      661 gagccagagg ccaggatgcc taggtgtcct gggtccccac agggagggga acaaggatgg
      721 tggacactag gagtggagag ctgagtaccc tcagccccag aagaagggac aagagattct
      781 gttgagagcc agaggccccg tgagaggccc tggaacacgc ctgtgcggtt acagcgatgg
      841 agtaggagaa ggaaggatgt agaatgctcc ggaaggatgc ttggagaccg gaaggagggg
      901 gatgtaaaga gggtgaaagc agggcaggcc cccagcaccc tctgttagca ctgcaataaa
      961 cgctcagcca tgtcccagga aaaaaaaaaa aaaaaaa
//
