LOCUS       NM_001110838            1789 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus T cell activation inhibitor, mitochondrial
            (Tcaim), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001110838 XM_001078761 XM_343508
VERSION     NM_001110838.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Keeren,K., Friedrich,M., Gebuhr,I., Philipp,S., Sabat,R.,
            Sterry,W., Brandt,C., Meisel,C., Grutz,G., Volk,H.D. and
            Sawitzki,B.
  TITLE     Expression of tolerance associated gene-1, a mitochondrial protein
            inhibiting T cell activation, can be used to predict response to
            immune modulating therapies
  JOURNAL   J Immunol 183 (6), 4077-4087 (2009)
   PUBMED   19684086
REFERENCE   2  (bases 1 to 1789)
  AUTHORS   Sawitzki,B., Bushell,A., Steger,U., Jones,N., Risch,K., Siepert,A.,
            Lehmann,M., Schmitt-Knosalla,I., Vogt,K., Gebuhr,I., Wood,K. and
            Volk,H.D.
  TITLE     Identification of gene markers for the prediction of allograft
            rejection or permanent acceptance
  JOURNAL   Am J Transplant 7 (5), 1091-1102 (2007)
   PUBMED   17456197
  REMARK    GeneRIF: Downregulation of TOAG-1 and alpha-1,2-mannosidase
            expression occurred in graft infiltrating cells and expression of
            both genes was also downregulated after T-cell activation in vitro.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            [WARNING] On Oct 15, 2024 this sequence was replaced by
            NM_001110838.2.
            
            On or before Nov 26, 2007 this sequence version replaced
            XM_343508.3, XM_001078761.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132295,
                              SAMD00155336 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1789
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /note="T cell activation inhibitor, mitochondrial"
                     /db_xref="GeneID:363169"
                     /db_xref="RGD:1560717"
     exon            1..67
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..137
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1596
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /note="tolerance-associated gene 1; Tolerance-associated
                     gene-1"
                     /codon_start=1
                     /product="T-cell activation inhibitor, mitochondrial"
                     /protein_id="NP_001104308.1"
                     /db_xref="GeneID:363169"
                     /db_xref="RGD:1560717"
                     /translation="MLGSWRAFSEMFCHLRPWRRFCLRKVLPPWLHYSRALSGAEAIN
                     ALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREK
                     TAQNSSEGQEPVSTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQP
                     LKEATGMPDRPIKWHRSYYSFTGFKDPDEDLEHVSRVETTLTSWLGSNGKGAVKKLKN
                     SLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNLEPLQNAKG
                     CTIVFTDRSGMSALGHVMLGTMDVHHHWTRLFESLPNYFDLQRRMSALEDQISHLLGG
                     IQVVYIEELQPALTLDEYYSLLDTFYNQLQRSRAPPRPQSLSGLQMILSRYAPSLHEL
                     GHFNIPALSDPASLQSFMRTKAQQARENMRRREKLKVIENELIQASTRKFSLEKLYKE
                     PSISSRQMVDCCKRLLEQSLPYLHGMHLCVSHFYSVMQDGDLCIPWNWKKGEAMK"
     exon            138..273
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..430
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..683
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..806
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..904
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..996
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1229
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1355
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1789
                     /gene="Tcaim"
                     /gene_synonym="RGD1560717; TOAG-1; Toag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctagtcgg cgggaagaac ctgcttgtgt ctcccgaagc tcccctcgga aacccgcaga
       61 tagcggggca gttgatggat gcttggaagc tggcgtgctt tttcggaaat gttttgccac
      121 ctgaggcctt ggaggaggtt ctgcctgagg aaggtcctcc ctccttggct tcactactct
      181 cgagctttat caggggcaga agccatcaat gccttgaggc ctttctactt tgcagttcat
      241 cctgatttct ttggacagca ccccagggaa agggaagtca atgaaaattc tcttaagaga
      301 ttaagtgtct atttagaaaa tctccagaaa ccaggcttca agtctctgaa accaactcag
      361 cttacatttt atataagaga aaaaacagcg cagaattcct ctgaaggaca ggagcctgtc
      421 agtactaccg gattccgagc agtcagattt actttgcaca gcagcgatct gctaagcaca
      481 gtattatata ttctcaactc ctgcagtttg cctgttgaac acgtccaaag cttgaacact
      541 aatgtgcatt cccagcctct caaggaagct acagggatgc ctgacagacc catcaaatgg
      601 cataggtcct attattcctt tactgggttc aaggaccctg acgaagacct tgaacatgtc
      661 tcaagagtgg aaacaaccct cacgtcctgg ttaggtagca atggcaaagg tgctgttaaa
      721 aagctgaaga acagtctgcc acttaggaag gagctggatc gtctcaagaa cgagctatct
      781 gagcttctac aactgtcaga catcaggtgg cagagaggct ggggagtcgc ccatcgctgc
      841 agccagctac atagtcttag ccgcctagca cagcagaatc tggagccgct tcagaatgca
      901 aaagggtgca ccattgtatt cacagaccgc tctggtatga gtgcactggg ccacgtgatg
      961 ctggggacca tggatgtcca ccatcactgg acacggcttt ttgaaagctt gccaaactat
     1021 tttgaccttc agaggagaat gtcagcctta gaagaccaaa taagccatct cctaggggga
     1081 atccaggtgg tttatatcga agagctgcag cctgcactca cgctggacga gtattactcg
     1141 ctccttgaca ccttctacaa ccagctgcag cggagcaggg cacctccccg ccctcagagt
     1201 ctgagtggtt tgcagatgat cctcagcagg tatgcaccaa gcttgcatga acttgggcat
     1261 tttaatatcc cagccctctc ggatccagca agcctgcagt catttatgag aaccaaagcc
     1321 cagcaggcaa gagaaaatat gagaagaaga gagaagttaa aagttattga aaatgaattg
     1381 atacaggctt caacaaggaa attttctctg gagaagttat ataaagaacc cagcatttct
     1441 agtagacaga tggtagattg ctgtaagaga cttctagaac agtcgctgcc ttatctgcat
     1501 gggatgcacc tgtgtgtttc acatttctat tctgttatgc aagatggaga cctgtgcatc
     1561 ccatggaact ggaagaaagg agaagccatg aagtaacaca gatctgtttt attttctgaa
     1621 gaaatgaaaa actgttgaat ttatttaaat tcagtttgat ataacgttag tatttacatg
     1681 ttagaacaaa gtgtctaact gctgctataa aaaagtgggt tttcttttta gtgatcttat
     1741 gctaagaaac ttgcttttaa aaggttttat ccgtatgatg ctgatggca
//
