LOCUS       NM_001106209            2118 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus T-box transcription factor T (Tbxt), mRNA.
ACCESSION   NM_001106209 XM_001069590 XM_217890
VERSION     NM_001106209.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Xia,Y., Wu,Y., Gong,Y., Yue,C., Tao,L., Xin,T., Shen,C., Zhu,Y.,
            Shen,M. and Shen,J.
  TITLE     Brachyury promotes extracellular matrix synthesis through
            transcriptional regulation of Smad3 in nucleus pulposus
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1384-C1397 (2024)
   PUBMED   38690917
  REMARK    GeneRIF: Brachyury promotes extracellular matrix synthesis through
            transcriptional regulation of Smad3 in nucleus pulposus.
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Postma,A.V., Alders,M., Sylva,M., Bilardo,C.M., Pajkrt,E., van
            Rijn,R.R., Schulte-Merker,S., Bulk,S., Stefanovic,S., Ilgun,A.,
            Barnett,P., Mannens,M.M., Moorman,A.F., Oostra,R.J. and van
            Maarle,M.C.
  TITLE     Mutations in the T (brachyury) gene cause a novel syndrome
            consisting of sacral agenesis, abnormal ossification of the
            vertebral bodies and a persistent notochordal canal
  JOURNAL   J Med Genet 51 (2), 90-97 (2014)
   PUBMED   24253444
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Roselli,M., Fernando,R.I., Guadagni,F., Spila,A., Alessandroni,J.,
            Palmirotta,R., Costarelli,L., Litzinger,M., Hamilton,D., Huang,B.,
            Tucker,J., Tsang,K.Y., Schlom,J. and Palena,C.
  TITLE     Brachyury, a driver of the epithelial-mesenchymal transition, is
            overexpressed in human lung tumors: an opportunity for novel
            interventions against lung cancer
  JOURNAL   Clin Cancer Res 18 (14), 3868-3879 (2012)
   PUBMED   22611028
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   David,R., Jarsch,V.B., Schwarz,F., Nathan,P., Gegg,M., Lickert,H.
            and Franz,W.M.
  TITLE     Induction of MesP1 by Brachyury(T) generates the common multipotent
            cardiovascular stem cell
  JOURNAL   Cardiovasc Res 92 (1), 115-122 (2011)
   PUBMED   21632880
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   Pereira,L.A., Wong,M.S., Lim,S.M., Sides,A., Stanley,E.G. and
            Elefanty,A.G.
  TITLE     Brachyury and related Tbx proteins interact with the Mixl1
            homeodomain protein and negatively regulate Mixl1 transcriptional
            activity
  JOURNAL   PLoS One 6 (12), e28394 (2011)
   PUBMED   22164283
REFERENCE   6  (bases 1 to 2118)
  AUTHORS   Rennebeck,G.M., Lader,E., Chen,Q., Bohm,R.A., Cai,Z.S., Faust,C.,
            Magnuson,T., Pease,L.R. and Artzt,K.
  TITLE     Is there a Brachyury the Second? Analysis of a transgenic mutation
            involved in notochord maintenance in mice
  JOURNAL   Dev Biol 172 (1), 206-217 (1995)
   PUBMED   7589801
REFERENCE   7  (bases 1 to 2118)
  AUTHORS   Kispert,A., Koschorz,B. and Herrmann,B.G.
  TITLE     The T protein encoded by Brachyury is a tissue-specific
            transcription factor
  JOURNAL   EMBO J 14 (19), 4763-4772 (1995)
   PUBMED   7588606
REFERENCE   8  (bases 1 to 2118)
  AUTHORS   Johnson,L.R., Pilder,S.H., Bailey,J.L. and Olds-Clarke,P.
  TITLE     Sperm from mice carrying one or two t haplotypes are deficient in
            investment and oocyte penetration
  JOURNAL   Dev Biol 168 (1), 138-149 (1995)
   PUBMED   7883069
REFERENCE   9  (bases 1 to 2118)
  AUTHORS   Wilson,V., Manson,L., Skarnes,W.C. and Beddington,R.S.
  TITLE     The T gene is necessary for normal mesodermal morphogenetic cell
            movements during gastrulation
  JOURNAL   Development 121 (3), 877-886 (1995)
   PUBMED   7720590
REFERENCE   10 (bases 1 to 2118)
  AUTHORS   Lyon,M.F. and Bechtol,K.B.
  TITLE     Derivation of mutant t-haplotypes of the mouse by presumed
            duplication or deletion
  JOURNAL   Genet Res 30 (1), 63-76 (1977)
   PUBMED   924142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 22, 2022 this sequence version replaced NM_001106209.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676789,
                              SAMN16676808 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               JAXUCZ010000001.1  54853121-54853583   c
            464-728             JAXUCZ010000001.1  54852436-54852700   c
            729-863             JAXUCZ010000001.1  54851644-54851778   c
            864-925             JAXUCZ010000001.1  54850860-54850921   c
            926-987             JAXUCZ010000001.1  54850692-54850753   c
            988-1161            JAXUCZ010000001.1  54849246-54849419   c
            1162-1291           JAXUCZ010000001.1  54848080-54848209   c
            1292-2118           JAXUCZ010000001.1  54845674-54846500   c
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2118
                     /gene="Tbxt"
                     /note="T-box transcription factor T"
                     /db_xref="GeneID:292301"
                     /db_xref="RGD:1310141"
     exon            1..463
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1568
                     /gene="Tbxt"
                     /note="brachyury protein; brachyury homolog; T brachyury
                     transcription factor"
                     /codon_start=1
                     /product="T-box transcription factor T"
                     /protein_id="NP_001099679.1"
                     /db_xref="GeneID:292301"
                     /db_xref="RGD:1310141"
                     /translation="MSSPGTESAGKSLQYRVDHLLSAVESELQAGSEKGDPTERELRV
                     GLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRW
                     KYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIML
                     NSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFL
                     DAKERNDHKDVMEEPGDCQQPGYSQWGWLVPGAGTLCPPASSHPQFGGSLSLPSTHGC
                     ERYPTLRNHRSSPYPSPYAHRNNSPTYADNSSACLSMLQSHDNWSSLGVPAHTSMLPV
                     SHNASPPTGSSQYPSLWSVSNGTITPGSQTAGVSNGLGAQFFRGSPAHYAPLTHTVSA
                     ATSSSSGSPMYEGAATVTDISDSQYDTAQSLLIASWTPVSPPSL"
     exon            464..728
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
     exon            729..863
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
     exon            864..925
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
     exon            926..987
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1161
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1291
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..2118
                     /gene="Tbxt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccagagac ttactcttgt cgcgccttgc gggagttcaa gtggaaccac ggctccccag
       61 gcccttaccc ccatccccgc ccccttcccc ccacatctcg gtcccggtcc tcctttggcg
      121 aatgtgctgg gacccaggtg tgatctttgg gctccgcaga gtgatccttt ttcttggaaa
      181 agtggtggcg agagaagtga aggtggctgt tgggtaggga gtcaagactc cagggcggtg
      241 gagagggtgg cgggaggatg agctccccgg gcacagagag cgcagggaag agcctgcagt
      301 accgagtgga tcacctgctc agcgccgtgg agagcgagct gcaggcgggc agcgagaagg
      361 gcgaccccac cgaacgtgaa ctgcgagtgg gtctggaaga gagcgagctg tggctgcgct
      421 tcaaggagct aactaatgag atgattgtga ccaagaacgg caggaggatg ttcccggtgc
      481 tgaaggtaaa tgtgtcaggt ctggacccca atgccatgta ttccttcctg ctggacttcg
      541 tggcggctga caaccaccgc tggaagtatg tgaatgggga gtgggtacct gggggcaaac
      601 cagagcctca ggcgcccagc tgcgtctaca tccacccaga ctcgcccaat ttcggggccc
      661 actggatgaa ggcccctgtg tctttcagca aagtcaaact caccaacaaa ctcaatggag
      721 gaggacagat catgttgaac tccttgcata agtacgaacc tcggattcac atcgtgagag
      781 ttgggggccc gcaacgcatg atcaccagcc actgctttcc cgagacccag ttcatagcag
      841 tgactgccta ccagaatgag gagattacgg cccttaaaat taaatacaac ccgtttgcta
      901 aagccttcct tgatgcaaaa gaaagaaatg accacaaaga tgtaatggag gagccagggg
      961 actgccagca gccgggatat tcccaatggg ggtggcttgt tcctggagct ggcaccctct
     1021 gtccacctgc cagctcccat cctcagtttg gaggttcgct ctctctcccc tccacacatg
     1081 gctgtgagag gtacccgact ctgaggaacc accggtcatc gccctacccc agcccttatg
     1141 ctcatcggaa caactctcca acctatgccg acaattcatc tgcatgcctg tccatgctgc
     1201 agtcccatga caactggtct agcctcggag tgcctgccca caccagcatg ctgcccgtga
     1261 gtcataatgc cagcccacct actggctcta gccagtaccc cagcctctgg tctgtgagca
     1321 atggtaccat caccccaggc tcccagacag ctggggtgtc caacgggctg ggagcccagt
     1381 tctttagagg ctcccctgca cactacgcac ccctgacgca cacggtctca gccgccacgt
     1441 cctcatcctc tggctccccg atgtatgaag gggctgctac cgtcacagac atttctgaca
     1501 gccagtatga cacagcccaa agccttctca tagcctcgtg gacacctgtg tcgcctccat
     1561 ccctgtgaat tgaactctcc tccatgtgct gagacttgta gacaactgga tcttctaggc
     1621 acaacatggc aggctcttgg gacaagggga gaaaaagctc tattttcaaa taagagcaac
     1681 agtacatgtc ttattatctt gtctcacaac cttttgctta acacctgcag tagtgatgcc
     1741 aggaacagag acgaggctgt ggtccaattt cctgtgactg caagctagag tcctttgcct
     1801 agggtcctat accttgtatt tctcttcaac atagaagtga cttggaaata ctggaatttg
     1861 tcctacttta gtgagacaca aggcacactt ctaatgtcct cccttgtcgc tttagagtag
     1921 ttaatttggg gacagaaaca ccatagccag cggattgtaa ctgaaccgga aactgttctg
     1981 ccctctggaa gatgcctact ttaagcacgt gtagcttttt gtgttgggaa gtcaactgtg
     2041 tgatactttt ctgttgacaa agtaaccaaa gacaatctgc gggaagcctt ttctgcacaa
     2101 taaaggcaat atacagca
//
