LOCUS       NP_001099679             436 aa            linear   ROD 23-JUL-2024
DEFINITION  T-box transcription factor T [Rattus norvegicus].
ACCESSION   NP_001099679 XP_001069590 XP_217890
VERSION     NP_001099679.1
DBSOURCE    REFSEQ: accession NM_001106209.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 436)
  AUTHORS   Xia,Y., Wu,Y., Gong,Y., Yue,C., Tao,L., Xin,T., Shen,C., Zhu,Y.,
            Shen,M. and Shen,J.
  TITLE     Brachyury promotes extracellular matrix synthesis through
            transcriptional regulation of Smad3 in nucleus pulposus
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1384-C1397 (2024)
   PUBMED   38690917
  REMARK    GeneRIF: Brachyury promotes extracellular matrix synthesis through
            transcriptional regulation of Smad3 in nucleus pulposus.
REFERENCE   2  (residues 1 to 436)
  AUTHORS   Postma,A.V., Alders,M., Sylva,M., Bilardo,C.M., Pajkrt,E., van
            Rijn,R.R., Schulte-Merker,S., Bulk,S., Stefanovic,S., Ilgun,A.,
            Barnett,P., Mannens,M.M., Moorman,A.F., Oostra,R.J. and van
            Maarle,M.C.
  TITLE     Mutations in the T (brachyury) gene cause a novel syndrome
            consisting of sacral agenesis, abnormal ossification of the
            vertebral bodies and a persistent notochordal canal
  JOURNAL   J Med Genet 51 (2), 90-97 (2014)
   PUBMED   24253444
REFERENCE   3  (residues 1 to 436)
  AUTHORS   Roselli,M., Fernando,R.I., Guadagni,F., Spila,A., Alessandroni,J.,
            Palmirotta,R., Costarelli,L., Litzinger,M., Hamilton,D., Huang,B.,
            Tucker,J., Tsang,K.Y., Schlom,J. and Palena,C.
  TITLE     Brachyury, a driver of the epithelial-mesenchymal transition, is
            overexpressed in human lung tumors: an opportunity for novel
            interventions against lung cancer
  JOURNAL   Clin Cancer Res 18 (14), 3868-3879 (2012)
   PUBMED   22611028
REFERENCE   4  (residues 1 to 436)
  AUTHORS   David,R., Jarsch,V.B., Schwarz,F., Nathan,P., Gegg,M., Lickert,H.
            and Franz,W.M.
  TITLE     Induction of MesP1 by Brachyury(T) generates the common multipotent
            cardiovascular stem cell
  JOURNAL   Cardiovasc Res 92 (1), 115-122 (2011)
   PUBMED   21632880
REFERENCE   5  (residues 1 to 436)
  AUTHORS   Pereira,L.A., Wong,M.S., Lim,S.M., Sides,A., Stanley,E.G. and
            Elefanty,A.G.
  TITLE     Brachyury and related Tbx proteins interact with the Mixl1
            homeodomain protein and negatively regulate Mixl1 transcriptional
            activity
  JOURNAL   PLoS One 6 (12), e28394 (2011)
   PUBMED   22164283
REFERENCE   6  (residues 1 to 436)
  AUTHORS   Rennebeck,G.M., Lader,E., Chen,Q., Bohm,R.A., Cai,Z.S., Faust,C.,
            Magnuson,T., Pease,L.R. and Artzt,K.
  TITLE     Is there a Brachyury the Second? Analysis of a transgenic mutation
            involved in notochord maintenance in mice
  JOURNAL   Dev Biol 172 (1), 206-217 (1995)
   PUBMED   7589801
REFERENCE   7  (residues 1 to 436)
  AUTHORS   Kispert,A., Koschorz,B. and Herrmann,B.G.
  TITLE     The T protein encoded by Brachyury is a tissue-specific
            transcription factor
  JOURNAL   EMBO J 14 (19), 4763-4772 (1995)
   PUBMED   7588606
REFERENCE   8  (residues 1 to 436)
  AUTHORS   Johnson,L.R., Pilder,S.H., Bailey,J.L. and Olds-Clarke,P.
  TITLE     Sperm from mice carrying one or two t haplotypes are deficient in
            investment and oocyte penetration
  JOURNAL   Dev Biol 168 (1), 138-149 (1995)
   PUBMED   7883069
REFERENCE   9  (residues 1 to 436)
  AUTHORS   Wilson,V., Manson,L., Skarnes,W.C. and Beddington,R.S.
  TITLE     The T gene is necessary for normal mesodermal morphogenetic cell
            movements during gastrulation
  JOURNAL   Development 121 (3), 877-886 (1995)
   PUBMED   7720590
REFERENCE   10 (residues 1 to 436)
  AUTHORS   Lyon,M.F. and Bechtol,K.B.
  TITLE     Derivation of mutant t-haplotypes of the mouse by presumed
            duplication or deletion
  JOURNAL   Genet Res 30 (1), 63-76 (1977)
   PUBMED   924142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_217890.3, XP_001069590.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676789,
                              SAMN16676808 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     Protein         1..436
                     /product="T-box transcription factor T"
                     /note="brachyury protein; brachyury homolog; T brachyury
                     transcription factor"
                     /calculated_mol_wt=47302
     Region          41..219
                     /region_name="T-box_TBXT"
                     /note="DNA-binding domain of T-box transcription factor T
                     and related T-box proteins; cd20202"
                     /db_xref="CDD:410328"
     Site            order(66,69..70,103,147,150,162..163,196,198,204,207..208,
                     211..213,215..217)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410328"
     Site            order(87,129..132,175)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410328"
     CDS             1..436
                     /gene="Tbxt"
                     /coded_by="NM_001106209.2:258..1568"
                     /db_xref="GeneID:292301"
                     /db_xref="RGD:1310141"
ORIGIN      
        1 msspgtesag kslqyrvdhl lsaveselqa gsekgdpter elrvgleese lwlrfkeltn
       61 emivtkngrr mfpvlkvnvs gldpnamysf lldfvaadnh rwkyvngewv pggkpepqap
      121 scvyihpdsp nfgahwmkap vsfskvkltn klngggqiml nslhkyepri hivrvggpqr
      181 mitshcfpet qfiavtayqn eeitalkiky npfakaflda kerndhkdvm eepgdcqqpg
      241 ysqwgwlvpg agtlcppass hpqfggslsl psthgceryp tlrnhrsspy pspyahrnns
      301 ptyadnssac lsmlqshdnw sslgvpahts mlpvshnasp ptgssqypsl wsvsngtitp
      361 gsqtagvsng lgaqffrgsp ahyaplthtv saatssssgs pmyegaatvt disdsqydta
      421 qslliaswtp vsppsl
//
