LOCUS       NM_012687               1849 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus thromboxane A synthase 1 (Tbxas1), mRNA.
ACCESSION   NM_012687
VERSION     NM_012687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Minami,D., Takigawa,N., Kato,Y., Kudo,K., Isozaki,H., Hashida,S.,
            Harada,D., Ochi,N., Fujii,M., Kubo,T., Ohashi,K., Sato,A.,
            Tanaka,T., Hotta,K., Tabata,M., Toyooka,S., Tanimoto,M. and
            Kiura,K.
  TITLE     Downregulation of TBXAS1 in an iron-induced malignant mesothelioma
            model
  JOURNAL   Cancer Sci 106 (10), 1296-1302 (2015)
   PUBMED   26211743
  REMARK    GeneRIF: TBXAS1 gene expression was downregulated in rats with
            iron-induced mesothelioma.
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Majed,B.H. and Khalil,R.A.
  TITLE     Molecular mechanisms regulating the vascular prostacyclin pathways
            and their adaptation during pregnancy and in the newborn
  JOURNAL   Pharmacol Rev 64 (3), 540-582 (2012)
   PUBMED   22679221
  REMARK    Review article
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Park,S.A., Park,B.L., Park,J.H., Lee,T.K., Sung,K.B., Lee,Y.K.,
            Chang,H.S., Park,C.S. and Shin,H.D.
  TITLE     Association of polymorphisms in thromboxane A2 receptor and
            thromboxane A synthase 1 with cerebral infarction in a Korean
            population
  JOURNAL   BMB Rep 42 (4), 200-205 (2009)
   PUBMED   19403042
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Yeh,H.C., Tsai,A.L. and Wang,L.H.
  TITLE     Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid
            catalyzed by human prostacyclin and thromboxane synthases
  JOURNAL   Arch Biochem Biophys 461 (2), 159-168 (2007)
   PUBMED   17459323
REFERENCE   6  (bases 1 to 1849)
  AUTHORS   Nagao,T., Nagamatsu,T. and Suzuki,Y.
  TITLE     Effect of DP-1904, a thromboxane A2 synthase inhibitor, on passive
            Heymann nephritis in rats
  JOURNAL   Eur J Pharmacol 316 (1), 73-80 (1996)
   PUBMED   8982653
REFERENCE   7  (bases 1 to 1849)
  AUTHORS   Takahashi,T.
  TITLE     The effects of thromboxane A2 synthetase inhibitor (OKY-046) on
            complete hepatic ischemia in rats with obstructive jaundice
  JOURNAL   Surg Today 26 (1), 15-20 (1996)
   PUBMED   8680115
REFERENCE   8  (bases 1 to 1849)
  AUTHORS   Tone,Y., Miyata,A., Hara,S., Yukawa,S. and Tanabe,T.
  TITLE     Abundant expression of thromboxane synthase in rat macrophages
  JOURNAL   FEBS Lett 340 (3), 241-244 (1994)
   PUBMED   8131852
REFERENCE   9  (bases 1 to 1849)
  AUTHORS   Ruan,K.H., Wang,L.H., Wu,K.K. and Kulmacz,R.J.
  TITLE     Amino-terminal topology of thromboxane synthase in the endoplasmic
            reticulum
  JOURNAL   J Biol Chem 268 (26), 19483-19490 (1993)
   PUBMED   8366093
REFERENCE   10 (bases 1 to 1849)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012687.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28773.1, D31798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000004.1  68631885-68632102
            219-312             JAXUCZ010000004.1  68663416-68663509
            313-365             JAXUCZ010000004.1  68666729-68666781
            366-462             JAXUCZ010000004.1  68697553-68697649
            463-579             JAXUCZ010000004.1  68717618-68717734
            580-668             JAXUCZ010000004.1  68738645-68738733
            669-817             JAXUCZ010000004.1  68741883-68742031
            818-948             JAXUCZ010000004.1  68743692-68743822
            949-1263            JAXUCZ010000004.1  68747968-68748282
            1264-1355           JAXUCZ010000004.1  68792112-68792203
            1356-1493           JAXUCZ010000004.1  68800427-68800564
            1494-1656           JAXUCZ010000004.1  68803181-68803343
            1657-1849           JAXUCZ010000004.1  68803767-68803959
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..1849
                     /gene="Tbxas1"
                     /note="thromboxane A synthase 1"
                     /db_xref="GeneID:24886"
                     /db_xref="RGD:3826"
     exon            1..218
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1731
                     /gene="Tbxas1"
                     /EC_number="5.3.99.5"
                     /EC_number="4.2.1.152"
                     /note="TXS; thromboxane A synthase 1, platelet; TXA
                     synthase; cytochrome P450 5A1; ThromboxA ane synthase 1;
                     hydroperoxy icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="thromboxane-A synthase"
                     /protein_id="NP_036819.1"
                     /db_xref="GeneID:24886"
                     /db_xref="RGD:3826"
                     /translation="MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGI
                     RHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVE
                     NFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACE
                     LLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFA
                     FSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRG
                     DFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQ
                     AFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPY
                     LDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPET
                     FDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPET
                     QVPLQLESKSALCPKNGVYVKIVSR"
     exon            219..312
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..365
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..462
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..579
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..668
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..817
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..948
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1263
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1355
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1493
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1656
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1849
                     /gene="Tbxas1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatgggatg tttgctcatt acatattcct tccttcactg cctacacaca gctcaggact
       61 cctataaggg caggagatca acacgctctc tcctcctagg aagaacccct ctggggtctc
      121 agaggaaaaa tggaagtgtt ggggcttctc aagttcgaag tcagtggtac cgtagtgact
      181 gtgactctgt ccgtggttct cttggccctc ctgaaatggt actccacatc agcgttctca
      241 agactgagga agttgggcat cagacaccct gagccttctc cttttgttgg aaacttgatg
      301 tttttccgcc agggcttttg ggagagccat ttggagctcc gagagcgata tgggcctctg
      361 tgtgggtact atcttggccg tcggatgtac attgtcattt cagacccaga catgatcaag
      421 gaggtgttgg ttgagaactt cagtaacttt tccaacagaa tggcctcagg tctggaaccc
      481 aagctgatag cagacagtgt cctgatgtta cgtgacagaa gatgggagga agtcagaggt
      541 gccctgatgt ctgcattcag tcctgaaaaa ttgaacgaga tgacacctct catcagccaa
      601 gcctgtgaac ttctcctgtc tcacttaaaa cactctgcgg catccgggga cgcattcgac
      661 atccagaggt gttactgctg ttttaccaca aatgtggtgg ccagtgtggc ctttggcatc
      721 gaggtgaact cccaggatgc tccagaagac ccctttgtgc aacactgcca gcgtgttttt
      781 gctttcagta ccccaaggcc tctcctggct ttaattttat catttccatc cataatggtc
      841 ccattggccc ggattctgcc caataagaac cgagatgaac tgaatggctt ttttaacaca
      901 ctcattagga atgtgattgc cttacgggac aagcaaacag cagaagagag gcggggagac
      961 ttcctgcaga tggtgctgga tgcccagcgt tccatgagct ctgtgggtgt agaagccttt
     1021 gacatggtca cagaagccct gtcctctgct gagtgcatgg gggacccacc ccaaaggtgt
     1081 catcctacat ccacagctaa gcctttaact gtggatgaga ttgccggcca ggctttcctc
     1141 ttcctcatcg ctggccacga gatcaccaca aacacgctct ccttcatcac atacctgctg
     1201 gccacccacc ctgagtgcca ggagaggctt ctgaaagagg tggacctctt catggagaag
     1261 catccagccc ctgagtactg caacctgcag gaaggtctgc cctatctgga catggtggtt
     1321 gcagagaccc tgaggatgta cccaccagct ttcaggttca caagggaggc agcacaggac
     1381 tgtgaggtgc tgggacagca catccctgca ggttctgtgc tggagattgc tgtgggtgcc
     1441 ctacaccacg acccagagca ctggccgaac cctgagacct ttgaccctga aaggtttaca
     1501 gcagaagccc ggcttcagca gaagccattc acatacctgc cttttggagc tggtcccagg
     1561 agctgccttg gagtacggct ggggctgctg gtggtcaagc tgacactgct ccaggtccta
     1621 cacaagttcc gctttgaagc ttgccctgag actcaggttc cacttcagct agaatccaaa
     1681 tctgctctat gccccaaaaa tggagtctac gtcaagattg tgtcacgctg acatagaagg
     1741 caggtgtgaa agaggaagca ctttgtaata gtgacgtctg tgcatcactg ttaggagggc
     1801 gccatttatg tcacagttct aaatgttgaa taaatgtttg tcatgcttc
//
