LOCUS       NP_036819                533 aa            linear   ROD 28-MAR-2024
DEFINITION  thromboxane-A synthase [Rattus norvegicus].
ACCESSION   NP_036819
VERSION     NP_036819.1
DBSOURCE    REFSEQ: accession NM_012687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 533)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   2  (residues 1 to 533)
  AUTHORS   Minami,D., Takigawa,N., Kato,Y., Kudo,K., Isozaki,H., Hashida,S.,
            Harada,D., Ochi,N., Fujii,M., Kubo,T., Ohashi,K., Sato,A.,
            Tanaka,T., Hotta,K., Tabata,M., Toyooka,S., Tanimoto,M. and
            Kiura,K.
  TITLE     Downregulation of TBXAS1 in an iron-induced malignant mesothelioma
            model
  JOURNAL   Cancer Sci 106 (10), 1296-1302 (2015)
   PUBMED   26211743
  REMARK    GeneRIF: TBXAS1 gene expression was downregulated in rats with
            iron-induced mesothelioma.
REFERENCE   3  (residues 1 to 533)
  AUTHORS   Majed,B.H. and Khalil,R.A.
  TITLE     Molecular mechanisms regulating the vascular prostacyclin pathways
            and their adaptation during pregnancy and in the newborn
  JOURNAL   Pharmacol Rev 64 (3), 540-582 (2012)
   PUBMED   22679221
  REMARK    Review article
REFERENCE   4  (residues 1 to 533)
  AUTHORS   Park,S.A., Park,B.L., Park,J.H., Lee,T.K., Sung,K.B., Lee,Y.K.,
            Chang,H.S., Park,C.S. and Shin,H.D.
  TITLE     Association of polymorphisms in thromboxane A2 receptor and
            thromboxane A synthase 1 with cerebral infarction in a Korean
            population
  JOURNAL   BMB Rep 42 (4), 200-205 (2009)
   PUBMED   19403042
REFERENCE   5  (residues 1 to 533)
  AUTHORS   Yeh,H.C., Tsai,A.L. and Wang,L.H.
  TITLE     Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid
            catalyzed by human prostacyclin and thromboxane synthases
  JOURNAL   Arch Biochem Biophys 461 (2), 159-168 (2007)
   PUBMED   17459323
REFERENCE   6  (residues 1 to 533)
  AUTHORS   Nagao,T., Nagamatsu,T. and Suzuki,Y.
  TITLE     Effect of DP-1904, a thromboxane A2 synthase inhibitor, on passive
            Heymann nephritis in rats
  JOURNAL   Eur J Pharmacol 316 (1), 73-80 (1996)
   PUBMED   8982653
REFERENCE   7  (residues 1 to 533)
  AUTHORS   Takahashi,T.
  TITLE     The effects of thromboxane A2 synthetase inhibitor (OKY-046) on
            complete hepatic ischemia in rats with obstructive jaundice
  JOURNAL   Surg Today 26 (1), 15-20 (1996)
   PUBMED   8680115
REFERENCE   8  (residues 1 to 533)
  AUTHORS   Tone,Y., Miyata,A., Hara,S., Yukawa,S. and Tanabe,T.
  TITLE     Abundant expression of thromboxane synthase in rat macrophages
  JOURNAL   FEBS Lett 340 (3), 241-244 (1994)
   PUBMED   8131852
REFERENCE   9  (residues 1 to 533)
  AUTHORS   Ruan,K.H., Wang,L.H., Wu,K.K. and Kulmacz,R.J.
  TITLE     Amino-terminal topology of thromboxane synthase in the endoplasmic
            reticulum
  JOURNAL   J Biol Chem 268 (26), 19483-19490 (1993)
   PUBMED   8366093
REFERENCE   10 (residues 1 to 533)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28773.1, D31798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     Protein         1..533
                     /product="thromboxane-A synthase"
                     /EC_number="5.3.99.5"
                     /EC_number="4.2.1.152"
                     /note="TXS; thromboxane A synthase 1, platelet; TXA
                     synthase; cytochrome P450 5A1; ThromboxA ane synthase 1;
                     hydroperoxy icosatetraenoate dehydratase"
                     /calculated_mol_wt=59844
     Site            11..31
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P49430.1)"
     Region          74..527
                     /region_name="cytochrome_P450"
                     /note="cytochrome P450 (CYP) superfamily; cl41757"
                     /db_xref="CDD:477761"
     Site            76..96
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P49430.1)"
     Site            order(132,136,143,190,337..338,341..342,345..346,349,401,
                     410,412,435,471..473,477..481,484..485)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410742"
     Site            order(219..220,337,340..341,345,408..411)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410742"
     Site            224..244
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P49430.1)"
     Site            336..356
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P49430.1)"
     CDS             1..533
                     /gene="Tbxas1"
                     /coded_by="NM_012687.2:130..1731"
                     /db_xref="GeneID:24886"
                     /db_xref="RGD:3826"
ORIGIN      
        1 mevlgllkfe vsgtvvtvtl svvllallkw ystsafsrlr klgirhpeps pfvgnlmffr
       61 qgfweshlel rerygplcgy ylgrrmyivi sdpdmikevl venfsnfsnr masglepkli
      121 adsvlmlrdr rweevrgalm safspeklne mtplisqace lllshlkhsa asgdafdiqr
      181 cyccfttnvv asvafgievn sqdapedpfv qhcqrvfafs tprpllalil sfpsimvpla
      241 rilpnknrde lngffntlir nvialrdkqt aeerrgdflq mvldaqrsms svgveafdmv
      301 tealssaecm gdppqrchpt stakpltvde iagqaflfli agheittntl sfityllath
      361 pecqerllke vdlfmekhpa peycnlqegl pyldmvvaet lrmyppafrf treaaqdcev
      421 lgqhipagsv leiavgalhh dpehwpnpet fdperftaea rlqqkpftyl pfgagprscl
      481 gvrlgllvvk ltllqvlhkf rfeacpetqv plqlesksal cpkngvyvki vsr
//
