LOCUS       NM_017054               1893 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus thromboxane A2 receptor (Tbxa2r), mRNA.
ACCESSION   NM_017054
VERSION     NM_017054.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Rollins,K.S., Butenas,A.L.E., Felice,K.P., Matney,J.E.,
            Williams,A.C., Kleweno,T.E. and Copp,S.W.
  TITLE     Thromboxane A2 receptors mediate chronic mechanoreflex
            sensitization in a rat model of simulated peripheral artery disease
  JOURNAL   Am J Physiol Heart Circ Physiol 319 (2), H320-H330 (2020)
   PUBMED   32530751
  REMARK    GeneRIF: Thromboxane A2 receptors mediate chronic mechanoreflex
            sensitization in a rat model of simulated peripheral artery
            disease.
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Zhao,Z., Hu,J., Gao,X., Liang,H., Yu,H., Liu,S. and Liu,Z.
  TITLE     Hyperglycemia via activation of thromboxane A2 receptor impairs the
            integrity and function of blood-brain barrier in microvascular
            endothelial cells
  JOURNAL   Oncotarget 8 (18), 30030-30038 (2017)
   PUBMED   28415790
  REMARK    GeneRIF: We conclude that hyperglycemia activates thromboxane A2
            receptor to impair the integrity and function of blood-brain
            barrier via the ROCK-PTEN-Akt-eNOS pathway.
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Gariepy,H., Zhao,J. and Levy,D.
  TITLE     Differential contribution of COX-1 and COX-2 derived prostanoids to
            cortical spreading depression-Evoked cerebral oligemia
  JOURNAL   J Cereb Blood Flow Metab 37 (3), 1060-1068 (2017)
   PUBMED   27178425
  REMARK    GeneRIF: the long-lasting oligemia following cortical spreading
            depression consists of at least two distinct temporal phases,
            mediated by preferential actions of COX-1- and COX-2-derived
            prostanoids: an initial phase mediated by COX-1 that involves TXA2
            followed by a later phase, mediated by COX-2 and PGF2alpha.
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Grann,M., Comerma-Steffensen,S., Arcanjo,D.D. and Simonsen,U.
  TITLE     Mechanisms Involved in Thromboxane A2 -induced Vasoconstriction of
            Rat Intracavernous Small Penile Arteries
  JOURNAL   Basic Clin Pharmacol Toxicol 119 Suppl 3, 86-95 (2016)
   PUBMED   26708952
  REMARK    GeneRIF: Data suggest that thromboxane A2/Tbxa2r-mediated
            vasoconstriction of intracavernous small penile arteries depends on
            Ca2+ influx through L-type calcium channels and TRP (transient
            receptor potential) channels, and ROCK- (Rho kinase)-dependent
            mechanisms in vascular smooth muscle.
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Zhao,Y., Vanhoutte,P.M. and Leung,S.W.
  TITLE     alpha1 -Adrenoceptor activation of PKC-epsilon causes heterologous
            desensitization of thromboxane receptors in the aorta of
            spontaneously hypertensive rats
  JOURNAL   Br J Pharmacol 172 (14), 3687-3701 (2015)
   PUBMED   25857252
  REMARK    GeneRIF: The experiments suggest that in the SHR but not the WKY
            aorta, alpha1 -adrenoceptor activation desensitizes TP receptors
            through activation of PKC-epsilon.
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Abe,T., Takeuchi,K., Takahashi,N., Tsutsumi,E., Taniyama,Y. and
            Abe,K.
  TITLE     Rat kidney thromboxane receptor: molecular cloning, signal
            transduction, and intrarenal expression localization
  JOURNAL   J Clin Invest 96 (2), 657-664 (1995)
   PUBMED   7635958
REFERENCE   7  (bases 1 to 1893)
  AUTHORS   Namba,T., Sugimoto,Y., Hirata,M., Hayashi,Y., Honda,A., Watabe,A.,
            Negishi,M., Ichikawa,A. and Narumiya,S.
  TITLE     Mouse thromboxane A2 receptor: cDNA cloning, expression and
            northern blot analysis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1197-1203 (1992)
   PUBMED   1375456
REFERENCE   8  (bases 1 to 1893)
  AUTHORS   Turner,C.R., Lackey,M.N., Quinlan,M.F., Schwartz,L.W. and
            Wheeldon,E.B.
  TITLE     Therapeutic intervention in a rat model of adult respiratory
            distress syndrome: III. Cyclooxygenase pathway inhibition
  JOURNAL   Circ Shock 34 (2), 270-277 (1991)
   PUBMED   1934328
REFERENCE   9  (bases 1 to 1893)
  AUTHORS   Hori,Y., Hatakeyama,H., Yamada,K. and Kurosawa,A.
  TITLE     Effect of a novel thromboxane A2 receptor antagonist, S-145, on
            collagen-induced ECG changes and thrombocytopenia in rodents
  JOURNAL   Jpn J Pharmacol 50 (2), 195-205 (1989)
   PUBMED   2528013
REFERENCE   10 (bases 1 to 1893)
  AUTHORS   Olanoff,L.S., Cook,J.A., Eller,T., Knapp,D.R. and Halushka,P.V.
  TITLE     Protective effects of trans-13-APT, a thromboxane receptor
            antagonist, in endotoxemia
  JOURNAL   J Cardiovasc Pharmacol 7 (1), 114-120 (1985)
   PUBMED   2580129
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017054.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D32080.1, SRR26643285.26403.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               JAXUCZ010000007.1  9038610-9038905     c
            297-1160            JAXUCZ010000007.1  9035662-9036525     c
            1161-1893           JAXUCZ010000007.1  9034108-9034840     c
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1893
                     /gene="Tbxa2r"
                     /note="thromboxane A2 receptor"
                     /db_xref="GeneID:24816"
                     /db_xref="RGD:3825"
     exon            1..296
                     /gene="Tbxa2r"
                     /inference="alignment:Splign:2.1.0"
     exon            297..1160
                     /gene="Tbxa2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1409
                     /gene="Tbxa2r"
                     /note="TXR2; TXA2-R; prostanoid TP receptor; Thromboxane
                     receptor"
                     /codon_start=1
                     /product="thromboxane A2 receptor"
                     /protein_id="NP_058750.2"
                     /db_xref="GeneID:24816"
                     /db_xref="RGD:3825"
                     /translation="MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLL
                     ALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCR
                     LCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGT
                     LGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVA
                     TLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPS
                     GQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPT
                     QAMLSGP"
     exon            1161..1893
                     /gene="Tbxa2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaccact gcctaccgct cccaacagtg gagacagggc tcaggaatgc aggaccaccc
       61 cacatcccag tgacttcttt ggctcccggg tgtccaaagc tggggtgtgg tggcctgcgc
      121 ctgtcacccc agcttcagaa gctgggggca gatgactctc agggagttcc aggccagcct
      181 ggtctacaca gtcagagtct gcaggaggac aaacagaatt cctgagcctt gacattccca
      241 ggcccaaagc tccttgctgc aaggctgtgg aacctgatag ggcgcagaga caccaagtgc
      301 gccagagcct gcatcagccc aacgtcccag tcacctgcat ctgatggggt gttgaccccc
      361 ttatcacgtc aggctcagga gccatgtggc tcaacagcac ctcgctgggg gcatgcttcc
      421 gcccagtgaa catcacgctg caggagcgac gtgccatcgc gtcgccatgg ttcgcggcat
      481 ccttctgcgc actgggcctg gggtccaacc tgctggcgct gagtgtgctg gccggggcgc
      541 gacctggggc gggaccccgc tcctccttcc tcgctttgct gtgcggcctc gtcctcaccg
      601 acttcctggg gctgctggtc accggcgctg tcgtggcgtc gcaacacgcc gccttgttgg
      661 actggcgtgc cactgatcca ggttgccgcc tttgccactt catgggcgcg gccatggtgt
      721 tcttcgggct gtgtcccctg ctcctggggg ccgcgatggc tgcagagcgc ttcgtgggca
      781 tcacacggcc cttctcacga cccgcagcca cgtcgcgccg cgcctgggcc actgtggggc
      841 tggtgtgggt gggggccggg actctcgggc tgctgccact gctggggctc ggccgctaca
      901 gtgtgcagta ccccggctcc tggtgcttcc tgactcttgg ggcggagcgc ggcgacgtgg
      961 ccttcgggct catgtttgct ctcctgggca gcgtgtccgt ggggctgtcc ctcctgctca
     1021 acaccgtgag cgtggccacg ctctgccgcg tctaccatgc gcgcgaggcc acacagcgcc
     1081 cccgggactg tgaggtggag atgatggttc agctcgtagg catcatggtg gtggccacgg
     1141 tgtgttggat gcccttgctg gtcttcatcc tgcagacctt gctgcagacg ctacctgtca
     1201 tgagcccctc cggacagctg ttgcggacca cggagcgcca actgctcatc tacctacgcg
     1261 tggccacatg gaaccagatc ttggacccct gggtctacat cctcttccgt aggtccgtgc
     1321 ttcgacgcct gcatccaagg ttcacttccc agctccaggc tgtgtccttg cactcacccc
     1381 ccacacaggc catgctcagt ggaccctgaa ggacggtgcc aatcaaagct ggggttcttg
     1441 gtgactgcta acgacctgtc tcctgtccca ggagcctgaa tgtttggtgg gatggagtta
     1501 caacacaggg ctgactcctg tgaactacaa agatacctcc tccatgctag ggagatcctc
     1561 cctggccccc tccccagact acttgtcagc taggaggttg gagcatatgt gggaggtccc
     1621 ttgcaggaat ctatggttac acagagagaa cctggagtgc cgatggcatc tcccatcttg
     1681 ccatagtccg cgtctgtctc agccccgttg tcccggggtt gtcccggggc ttcatgtttg
     1741 ttcctttagg ctcaaggatc atcggccttg ggtgttggaa gcacccactg tggtcccagt
     1801 agctggctct ggagttacca acctctccgt gtttactgag ccccctcccc ccacggctat
     1861 ccaacacaca tgctcaataa atggttgaat gtc
//
