LOCUS       NM_001108920            1726 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus T-box transcription factor 6 (Tbx6), mRNA.
ACCESSION   NM_001108920 XM_001080027 XM_344963
VERSION     NM_001108920.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1726)
  AUTHORS   Chen,M., Maloney,J.A., Kallop,D.Y., Atwal,J.K., Tam,S.J., Baer,K.,
            Kissel,H., Kaminker,J.S., Lewcock,J.W., Weimer,R.M. and Watts,R.J.
  TITLE     Spatially coordinated kinase signaling regulates local axon
            degeneration
  JOURNAL   J Neurosci 32 (39), 13439-13453 (2012)
   PUBMED   23015435
REFERENCE   2  (bases 1 to 1726)
  AUTHORS   Chalamalasetty,R.B., Dunty,W.C. Jr., Biris,K.K., Ajima,R.,
            Iacovino,M., Beisaw,A., Feigenbaum,L., Chapman,D.L., Yoon,J.K.,
            Kyba,M. and Yamaguchi,T.P.
  TITLE     The Wnt3a/beta-catenin target gene Mesogenin1 controls the
            segmentation clock by activating a Notch signalling program
  JOURNAL   Nat Commun 2, 390 (2011)
   PUBMED   21750544
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1726)
  AUTHORS   Pereira,L.A., Wong,M.S., Lim,S.M., Sides,A., Stanley,E.G. and
            Elefanty,A.G.
  TITLE     Brachyury and related Tbx proteins interact with the Mixl1
            homeodomain protein and negatively regulate Mixl1 transcriptional
            activity
  JOURNAL   PLoS One 6 (12), e28394 (2011)
   PUBMED   22164283
REFERENCE   4  (bases 1 to 1726)
  AUTHORS   Takahashi,J., Ohbayashi,A., Oginuma,M., Saito,D., Mochizuki,A.,
            Saga,Y. and Takada,S.
  TITLE     Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism
            underlying the rostro-caudal patterning within a somite
  JOURNAL   Dev Biol 342 (2), 134-145 (2010)
   PUBMED   20346937
REFERENCE   5  (bases 1 to 1726)
  AUTHORS   Lee,D., Park,C., Lee,H., Lugus,J.J., Kim,S.H., Arentson,E.,
            Chung,Y.S., Gomez,G., Kyba,M., Lin,S., Janknecht,R., Lim,D.S. and
            Choi,K.
  TITLE     ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and
            vessel progenitor specification
  JOURNAL   Cell Stem Cell 2 (5), 497-507 (2008)
   PUBMED   18462699
REFERENCE   6  (bases 1 to 1726)
  AUTHORS   White,P.H. and Chapman,D.L.
  TITLE     Dll1 is a downstream target of Tbx6 in the paraxial mesoderm
  JOURNAL   Genesis 42 (3), 193-202 (2005)
   PUBMED   15986483
REFERENCE   7  (bases 1 to 1726)
  AUTHORS   White,P.H., Farkas,D.R. and Chapman,D.L.
  TITLE     Regulation of Tbx6 expression by Notch signaling
  JOURNAL   Genesis 42 (2), 61-70 (2005)
   PUBMED   15864811
REFERENCE   8  (bases 1 to 1726)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   9  (bases 1 to 1726)
  AUTHORS   White,P.H., Farkas,D.R., McFadden,E.E. and Chapman,D.L.
  TITLE     Defective somite patterning in mouse embryos with reduced levels of
            Tbx6
  JOURNAL   Development 130 (8), 1681-1690 (2003)
   PUBMED   12620991
REFERENCE   10 (bases 1 to 1726)
  AUTHORS   Chapman,D.L. and Papaioannou,V.E.
  TITLE     Three neural tubes in mouse embryos with mutations in the T-box
            gene Tbx6
  JOURNAL   Nature 391 (6668), 695-697 (1998)
   PUBMED   9490412
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344963.3, XM_001080027.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680422 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1726
                     /gene="Tbx6"
                     /note="T-box transcription factor 6"
                     /db_xref="GeneID:365371"
                     /db_xref="RGD:1307716"
     exon            1..142
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1335
                     /gene="Tbx6"
                     /note="T-box protein 6; T-box 6"
                     /codon_start=1
                     /product="T-box transcription factor TBX6"
                     /protein_id="NP_001102390.1"
                     /db_xref="GeneID:365371"
                     /db_xref="RGD:1307716"
                     /translation="MYHPRELYPSLGTGYRLGHPQPGADSTFPPALTEGYRYPDLDTS
                     KLDCFLSGIEAAPHTLAAPPPLPLLPSALGPETAPPPPEALHSLPGVSLSLENQELWK
                     EFSAVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGQHWEP
                     SGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQP
                     RIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGR
                     NCKRERDARVKRKLRGPEPVATEACGSGDTPGGPCDSTLGGDIRDSDPEPAPTPQEAA
                     SASAPPCGGPSAEAYLLHPAAFHGAPSHLPARTPSFPEAPDPGRPAPYSAAFLELQPG
                     PGSSAYQTTPSVTPFAPHFIQGAPFPLPYPGPGGYLDMGSKQMY"
     exon            143..377
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            378..645
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            646..792
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            793..863
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1121
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1726
                     /gene="Tbx6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacaaggcca gaagaaacta caacatgtac catccacgag agttataccc ctctctgggg
       61 actggctacc gtctgggaca cccccagcct ggggcagact caaccttccc acctgccctg
      121 acagagggct accgctaccc tgatttggat acttctaaac tggattgctt cctctctggg
      181 attgaggcag ctccccacac tctggctgca ccccctcctt tgccccttct cccatctgct
      241 ctgggccctg agacagcacc gccaccccca gaggcccttc actcgcttcc tggggtcagc
      301 ctgagcttgg agaaccagga actgtggaag gaattcagcg ctgtgggaac agagatgatc
      361 atcaccaagg ctggcaggcg tatgttccct gcttgccgag tatcagtcac aggcctggac
      421 ccggaggccc ggtacttgtt ccttctggat gtggttccag tggatggggc ccgataccgc
      481 tggcagggcc agcactggga gcccagtggc aaggctgagc cccgcctacc cgaccgtgtc
      541 tacattcacc ctgattctcc tgccactggt gcccactgga tgcggcagcc cgtatccttc
      601 caccgtgtta agctcaccaa cagcacgctg gacccccatg gccacctgat cttgcattcc
      661 atgcacaagt accagcctcg cattcacctg gtgagagcca cccaactctg cagccaacac
      721 tgggggggtg tggcctcctt ccgatttcct gagaccacat tcatctcagt gacagcctac
      781 cagaacccta ggatcacaca gctgaagatc gcagccaatc cctttgccaa aggtttccga
      841 gaaaatggca gaaactgtaa gagggagcgg gatgcccgtg tgaagaggaa actccggggc
      901 ccagagccag tggccacaga ggcctgtggg agtggggata caccaggggg tccctgtgac
      961 tccaccctgg gtggggatat tcgagattca gatccagagc cggctcctac cccccaggaa
     1021 gctgcttctg cctcagctcc tccatgtggg ggccccagtg ctgaggccta cctcctgcac
     1081 cctgcagctt ttcatggggc ccccagtcat ctaccagcca ggacccccag cttccctgag
     1141 gctccagacc ctgggcgccc agccccctac tcagctgcat tcctggagct acagcctgga
     1201 ccggggagct ctgcttatca aacgacccca tctgtaacac cctttgcccc tcactttatt
     1261 caaggggccc ccttccctct accataccca ggacctggag gatatctgga catgggatcc
     1321 aagcaaatgt actgagccat ggtgtagtaa gccaagccaa ggcctatgcc agcttccctt
     1381 gatcctccag ctcccttccc cctgcctggt agcatccgca ttgaagtggt accccctccc
     1441 ccccaccaaa tggctggctt gggcctctct tctacccttt agttcacacc ttgatttcac
     1501 tccaccccct ctggcttcaa agctcaggca aggcggctct gagtccagct ggggccagct
     1561 tcccctcagc tctcacctca gtgcgaatgg agggagactc tgcctggcca aatggggccc
     1621 cagcccagta ccctacctcc tgggggcctc ctcatcacta gtgtaagcca cgccaatttg
     1681 ttctcaggat cagagtattt ttgttaataa aactccaaag acatta
//
