LOCUS       NM_001009964            1593 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus T-box transcription factor 5 (Tbx5), mRNA.
ACCESSION   NM_001009964 XM_222201
VERSION     NM_001009964.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   Jia,Y., Chang,Y., Guo,Z. and Li,H.
  TITLE     Transcription factor Tbx5 promotes cardiomyogenic differentiation
            of cardiac fibroblasts treated with 5-azacytidine
  JOURNAL   J Cell Biochem 120 (10), 16503-16515 (2019)
   PUBMED   31265161
  REMARK    GeneRIF: Transcription factor Tbx5 promotes cardiomyogenic
            differentiation of cardiac fibroblasts treated with 5-azacytidine.
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Li,M., Zhang,Y.L., Huang,H. and Xiong,Y.
  TITLE     MicroRNA-10-5p regulates differentiation of bone marrow mesenchymal
            stem cells into cardiomyocytes by targeting TBX5
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (2), 479-485 (2019)
   PUBMED   30720154
  REMARK    GeneRIF: The MicroRNA-10-5p regulates BMSCs differentiation into
            cardiomyocytes by binding to TBX5.
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Ono,A., Hirooka,K., Nakano,Y., Nitta,E., Nishiyama,A. and
            Tsujikawa,A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Ghosh,T.K., Aparicio-Sanchez,J.J., Buxton,S., Ketley,A.,
            Mohamed,T., Rutland,C.S., Loughna,S. and Brook,J.D.
  TITLE     Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb
            development
  JOURNAL   J Mol Cell Cardiol 114, 185-198 (2018)
   PUBMED   29174768
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   Wang,D., Zhai,G., Ji,Y. and Jing,H.
  TITLE     microRNA-10a Targets T-box 5 to Inhibit the Development of Cardiac
            Hypertrophy
  JOURNAL   Int Heart J 58 (1), 100-106 (2017)
   PUBMED   28100873
  REMARK    GeneRIF: miR-10a may inhibit cardiac hypertrophy via targeting
            Tbx5.
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Ghosh,T.K., Packham,E.A., Bonser,A.J., Robinson,T.E., Cross,S.J.
            and Brook,J.D.
  TITLE     Characterization of the TBX5 binding site and analysis of mutations
            that cause Holt-Oram syndrome
  JOURNAL   Hum Mol Genet 10 (18), 1983-1994 (2001)
   PUBMED   11555635
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Hiroi,Y., Kudoh,S., Monzen,K., Ikeda,Y., Yazaki,Y., Nagai,R. and
            Komuro,I.
  TITLE     Tbx5 associates with Nkx2-5 and synergistically promotes
            cardiomyocyte differentiation
  JOURNAL   Nat Genet 28 (3), 276-280 (2001)
   PUBMED   11431700
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   Hatcher,C.J., Kim,M.S., Mah,C.S., Goldstein,M.M., Wong,B.,
            Mikawa,T. and Basson,C.T.
  TITLE     TBX5 transcription factor regulates cell proliferation during
            cardiogenesis
  JOURNAL   Dev Biol 230 (2), 177-188 (2001)
   PUBMED   11161571
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Basson,C.T., Bachinsky,D.R., Lin,R.C., Levi,T., Elkins,J.A.,
            Soults,J., Grayzel,D., Kroumpouzou,E., Traill,T.A.,
            Leblanc-Straceski,J., Renault,B., Kucherlapati,R., Seidman,J.G. and
            Seidman,C.E.
  TITLE     Mutations in human TBX5 [corrected] cause limb and cardiac
            malformation in Holt-Oram syndrome
  JOURNAL   Nat Genet 15 (1), 30-35 (1997)
   PUBMED   8988165
  REMARK    Erratum:[Nat Genet 1997 Apr;15(4):411]
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Li,Q.Y., Newbury-Ecob,R.A., Terrett,J.A., Wilson,D.I., Curtis,A.R.,
            Yi,C.H., Gebuhr,T., Bullen,P.J., Robson,S.C., Strachan,T.,
            Bonnet,D., Lyonnet,S., Young,I.D., Raeburn,J.A., Buckler,A.J.,
            Law,D.J. and Brook,J.D.
  TITLE     Holt-Oram syndrome is caused by mutations in TBX5, a member of the
            Brachyury (T) gene family
  JOURNAL   Nat Genet 15 (1), 21-29 (1997)
   PUBMED   8988164
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY859491.1.
            
            On Jan 22, 2005 this sequence version replaced XM_222201.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY859491.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1593
                     /gene="Tbx5"
                     /note="T-box transcription factor 5"
                     /db_xref="GeneID:304514"
                     /db_xref="RGD:1305702"
     exon            1..167
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1574
                     /gene="Tbx5"
                     /note="T-box protein 5; T-box 5"
                     /codon_start=1
                     /product="T-box transcription factor TBX5"
                     /protein_id="NP_001009964.1"
                     /db_xref="GeneID:304514"
                     /db_xref="RGD:1305702"
                     /translation="MADADEGFGLARTPLEPDSKDRSCDSKPESALGAPSKSPSSPQA
                     AFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRQMFPSYKVKVTGLNPKTKYIL
                     LMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKL
                     TNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQ
                     NHKITQLKIENNPFAKGFRGSDDLELHRMSRMRSKEYPVVPRSTVRHKVANHSPFSSE
                     TRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLAQEHSQIYHCTKRKDEECSSTE
                     HPYKKPYMETSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQACMYASSAPPSEPVPSL
                     EDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLG
                     EGMFQHQTSVTHQPVVRQCGPQTGLQSPGSLQPPEFLYTHGVPRTLSPHQYHSVHGVG
                     MVPEWSENS"
     exon            168..262
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            263..382
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            383..530
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            531..683
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            684..775
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            776..999
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1593
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacaggaacc cgggcgcacc atggccgacg cagatgaggg cttcggcctg gcgcgcacgc
       61 ctctggagcc tgattccaaa gacaggtcct gcgattcgaa accagagagt gcgctggggg
      121 ctcccagcaa gtctccatcc tcaccgcagg ccgccttcac ccagcagggc atggaaggaa
      181 tcaaggtgtt tcttcacgaa agagaactgt ggctgaagtt ccacgaagtg ggcacagaaa
      241 tgatcatcac caaggcaggg aggcagatgt ttcctagcta caaagtgaag gtgactggcc
      301 ttaatcccaa gacgaagtac atccttctca tggatattgt acccgcagac gaccacagat
      361 ataaatttgc tgataacaaa tggtccgtaa ctggtaaagc cgagcctgct atgccgggtc
      421 gcctttatgt acatccggac tccccagcaa ccggagcgca ctggatgcga caacttgtct
      481 ccttccagaa actcaagctc accaacaacc acctggaccc attcggacac attatcctga
      541 actccatgca caaataccag ccccgattac acatcgtgaa agcagacgaa aataatgggt
      601 ttggttcaaa gaatactgcg ttttgtaccc acgtctttcc ggagacggct tttatcgctg
      661 tgacttcgta ccagaatcac aagatcacac agctgaaaat tgagaacaac cccttcgcca
      721 aaggctttcg gggcagtgac gacctggagt tacacaggat gtctcggatg cgaagtaaag
      781 agtatcctgt ggttcccagg agcaccgtga ggcacaaagt ggccaaccac agccccttca
      841 gcagcgagac ccgagctctc tccacttcgt ctaacttagg gtcccagtac cagtgtgaga
      901 atggtgtctc cggcccctcc caggaccttc tgcccccacc taacccatac ccactggccc
      961 aggagcacag ccaaatttac cactgtacca agaggaaaga tgaagaatgt tccagcaccg
     1021 agcaccccta taagaagccg tacatggaga cctcccccag cgaggaggac accttctacc
     1081 gctccggcta cccccagcag cagggcctga gtacctcgta caggacagag tcagcccagc
     1141 ggcaggcctg catgtatgcc agctccgctc cacccagcga gcccgtgcct agcctggagg
     1201 acatcagctg taacacatgg cccagcatgc cttcctatag cagctgtaca gttaccactg
     1261 tgcagcccat ggaccgtctc ccctaccagc acttctctgc tcatttcacc tcggggcccc
     1321 tggtccctcg gctagctggc atggccaacc atggttctcc ccagcttggt gaagggatgt
     1381 tccagcacca gacctcagtg acccatcagc ctgtggtcag gcaatgcggg cctcagactg
     1441 gccttcagtc tccaggcagc ctccagcccc ctgagttcct ctacactcac ggcgtgccca
     1501 ggaccctgtc tccccaccag tatcactcgg tacacggcgt cggcatggtg ccagagtgga
     1561 gcgagaatag ctaagggccg acctatgcca gag
//
