LOCUS       NM_001106937            4875 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Rattus norvegicus T-box transcription factor 22 (Tbx22), transcript
            variant 2, mRNA.
ACCESSION   NM_001106937 XM_001059931 XM_228489
VERSION     NM_001106937.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Andreou,A.M., Pauws,E., Jones,M.C., Singh,M.K., Bussen,M.,
            Doudney,K., Moore,G.E., Kispert,A., Brosens,J.J. and Stanier,P.
  TITLE     TBX22 missense mutations found in patients with X-linked cleft
            palate affect DNA binding, sumoylation, and transcriptional
            repression
  JOURNAL   Am J Hum Genet 81 (4), 700-712 (2007)
   PUBMED   17846996
REFERENCE   2  (bases 1 to 4875)
  AUTHORS   Braybrook,C., Lisgo,S., Doudney,K., Henderson,D., Marcano,A.C.,
            Strachan,T., Patton,M.A., Villard,L., Moore,G.E., Stanier,P. and
            Lindsay,S.
  TITLE     Craniofacial expression of human and murine TBX22 correlates with
            the cleft palate and ankyloglossia phenotype observed in CPX
            patients
  JOURNAL   Hum Mol Genet 11 (22), 2793-2804 (2002)
   PUBMED   12374769
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473969.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059931.1, XM_228489.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..4875
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /note="T-box transcription factor 22"
                     /db_xref="GeneID:302369"
                     /db_xref="RGD:1589764"
     exon            1..39
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     exon            40..216
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1598
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /note="isoform 2 is encoded by transcript variant 2; T-box
                     transcription factor TBX22; T-box 22"
                     /codon_start=1
                     /product="T-box transcription factor TBX22 isoform 2"
                     /protein_id="NP_001100407.1"
                     /db_xref="GeneID:302369"
                     /db_xref="RGD:1589764"
                     /translation="MALSSRAHAFSVEALMGRPSKRKAQDPREEMQPELQEEQFIEEG
                     EEILSSPSGDSEQPEKRPKAESSKTVFSCSDNESNSLESLLEESIIQVELQGSDLWKR
                     FHDIGTEMIITKAGRRMFPSVRIKVKGMDPVKQYYVILDVVPVDSKRYRYVYHSSQWM
                     VAGNTDHSCITPRFYVHPDSPCSGENWMRQIISFDRVKLTNNEMDDKGHIILQSMHKY
                     KPRVHVVEEDSRIDLSLIQSFPTEGVKTFSFKETEFTTVTAYQNQQITKLKIDRNPFA
                     KGFRDPGRNRGVLDGFLETYPWRPSFTMDFKPFVPDTQNGSSGSSPVTSSGGAPSPLN
                     SLLSPSCSPPTVYIPPSSIGMTHPETYLHNVNVPFCYRICPTNYWRPQPFVLPTPERL
                     PSFNSSQSFPPLMMEVPLVSSRGFINSNSGLHEDCNGHCLQASHSTSQMLYGLQNPGN
                     IFHPNPIAQEAICCPFHPPNGCYRYNVSMPPRLENVANHLSENGTNQISFTGGSCDHS
                     HWYPAINHYF"
     exon            217..391
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     exon            392..493
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     exon            494..668
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     exon            669..833
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     exon            834..898
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     exon            899..984
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
     exon            985..4875
                     /gene="Tbx22"
                     /gene_synonym="Tbx 22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctgccagg tcccagaatc aaggatttca gaactgatgg gatggctctg agctctcgag
       61 cgcacgcctt ctcggtggag gccttgatgg ggagacccag caaaagaaaa gctcaagacc
      121 caagagagga gatgcagcct gagctgcagg aggagcagtt catagaggaa ggggaggaga
      181 tactgagcag cccttctggg gacagtgagc agcccgaaaa acgacccaag gcagaatctt
      241 caaaaactgt tttctcctgc tctgacaacg agagcaacag cctggaaagt ctgctggagg
      301 aaagcattat ccaagtggag cttcagggat ctgacctatg gaagagattc cacgacattg
      361 gcactgagat gatcattacc aaagcgggca gacgtatgtt tccttctgtt cggatcaagg
      421 tgaaagggat ggaccctgtg aagcagtact atgtgatttt ggacgtggta ccggtggatt
      481 ccaaacgcta taggtatgtg tatcacagtt cacagtggat ggtagctgga aatactgatc
      541 attcatgcat cactcccaga ttttatgtcc acccggactc cccttgctca ggagaaaact
      601 ggatgcgtca aatcatctct tttgatcgag taaaactcac caacaatgag atggacgaca
      661 agggccatat cattctgcag tccatgcata agtacaaacc ccgtgtgcac gtggtggagg
      721 aggacagcag gattgacctg tccctgattc agtcctttcc tactgaagga gttaaaacat
      781 tctcctttaa agaaactgaa ttcactacag tgacagctta ccaaaaccag cagattacca
      841 aactgaaaat agacaggaat ccttttgcca aaggatttag agatcctggg agaaaccggg
      901 gtgtactgga tggattttta gagacctacc cctggaggcc ttctttcact atggatttta
      961 aaccttttgt cccagacaca caaaatggaa gtagtggttc atctccagtg acatctagtg
     1021 gaggagctcc ctctcctttg aactccttac tttctccatc ttgttctcca cctacggttt
     1081 acataccacc aagctccatt gggatgaccc atccagagac gtacctgcac aatgtcaacg
     1141 tgcccttctg ctacagaatt tgtccaacta attattggcg accacaacct tttgtcttac
     1201 ctactcctga aagactacca agcttcaaca gctctcagtc ctttccccca ctcatgatgg
     1261 aagtccccct ggtatcctcc aggggcttca tcaattcaaa cagtggctta catgaagact
     1321 gcaatggcca ttgtctacaa gcatctcatt ctaccagtca aatgttatat ggattacaga
     1381 atcctggaaa cattttccat ccaaacccca ttgcccaaga agcaatctgt tgtccttttc
     1441 atcctcccaa tggctgttat aggtacaatg tttccatgcc acctagattg gaaaatgttg
     1501 ccaatcacct cagtgaaaat ggtaccaatc aaatttcttt tactggaggc agctgtgatc
     1561 attcccattg gtatccagca atcaaccatt acttttaata tgacaacatc cacattttaa
     1621 gacgttcaca tgtaagcatc tattttcttt atttttaaca tacataaaaa acatttctta
     1681 aaaacttcct taccaaaaag cattgctttg ttttgctttt aaagtaactt aacaaatgtt
     1741 tgcaagaatt tctatataat gtcatctgtg acctgtaata atatgacatt ataataacct
     1801 tggtcttcaa gtaagttact taataaatac tatttgataa gatgtgccat cagtgataat
     1861 taatgccaga agattaagtc tccaattata acattattaa ttcactataa tctgtacatt
     1921 acacaattaa ctaaggccaa aaaaagagat gggtataatt catataaaaa gaataaaagt
     1981 atttcagcct tatctatgaa cattggctac actataaaca gctatcaagc aattatggga
     2041 attcaaaatt caatcatttt gtccatttat attttgccaa tagaagaaat agtaattaca
     2101 attttaaggt gtaaatagtt ttcaaatatt gttttccatt aacctgtgta ccttgaataa
     2161 tatttaatac tgaagggatg taaaattcac ttgaaaacta tctgatagct tatatgtaat
     2221 tacttcatta agtgacaaga agttatttaa ctgaaaatta aataacatct ctgagttttt
     2281 taattactat actagagaag atattaattt tatagttgtt ccactatgtg tatatatata
     2341 tatcaatgct ttagatatca gataattttg ttatgtgtta cagttttaaa tctaagcata
     2401 tataattaaa ctagcaatag taattaataa aaagaggcaa cattttaaat gctacaagtt
     2461 tggcatttat cttattttac tttgtaaata gttcgtaaat catcctttgg cacttttaat
     2521 tatattaaac aagggaaacc ttcatacaaa attagacttt gaagaaacct aaatcaagta
     2581 gcctattttc cttaaactag gctgtcaaat tggccaaggt ttccacctgt ttggcatata
     2641 tatatatggc atatatatat atatatatgg catatatata tatatggcat atatatataa
     2701 atatatatat atacatatat atatatatgg ttttgaacct gtcctggtat ctgatttcct
     2761 caaaataaac ctagagaaat aaaccttgtg tcaatttaat aaaatttgca cactgagtca
     2821 ggaaataagc gaacgatatt ttatccttgc agagctctca atcaagctta gacctgtagt
     2881 cagattccct ggtcaggaag gtattttgtg gaacagtcag tcaagctgaa atcaatgaca
     2941 aaagttgaac ttagttgaag gtctaagtag acagattgtt ttattacatt gttcattaca
     3001 ctttaaacat taatataaga ctttatgtaa cagaatttag aacattcagt gtatggtgcc
     3061 taaactatat ggatattata ttttggaaga ccaaagtata actttataac gttttatatt
     3121 acatactttt agaatcttaa aattaactaa tgtcattgct tctatttagt gtgttttgaa
     3181 aatgaagagg cttcttcaaa actccccagc tgtaaagaga tggatggttc acactggcat
     3241 aagttctcca tatggtctga agatggacat gaattcatat ttttgtgagg ttgaagtgtg
     3301 tttgtggcag gaaaaggagt gaattcttag tgaaagcaat tggtgactca atggataatc
     3361 agtctttgaa ctaacaatat cttatgtgct gaccacacga cacaggtgtc agcaacgcat
     3421 aaagacaagc atctgcactg gacattatga aagattcttc ttaaattctc ctaatcattt
     3481 ctatttcgca ccttggggaa atcatggcac agaaagcaaa taaatacaaa tgtagctttt
     3541 aaaaattgtc gatgtgccag tcagttttct ggctgagcca gaatgtatct gaaataaatg
     3601 tgttgtataa aaactaaaat atattttgca aaaatttata tgtatgctaa caacaaattt
     3661 agtatgtttg atattacaaa aatgtatata tttatatata ccatgtataa agtaaaacat
     3721 tttgcattat tgtctcctaa tttaatatca ctaacaagtt ttaacgtatg tatatggttt
     3781 tataaattaa agatgtcgct ctaattgtgt ataaatacat aatgtgtgtg tgtgatctcc
     3841 aatgggatat ttacttttct ttaaaaatga tttacagtgt gatttttatc ccactcctaa
     3901 agagagatgc tgtacagaga atttattcag tagacactat caattatgta tacttatgtg
     3961 gagaggcata tttaaatata tttagaaatg tctaattgca tatgctatac tttgagaatt
     4021 gaattgacat ggtagaagta caatgcttta taatccaatt taaagatacg ttgttgcttt
     4081 tctgctaata aatattaaac cagtcaaaat aacaacaata ttcgagtata taacaacagt
     4141 ttaccagttg attccactgg aatttagcat gcctattgga ggagttagaa acaaacccaa
     4201 tagcttggtc actggtggta gttgctttga tataactaac ttggtatacg tttaatcttc
     4261 ttagatttga tctgcaattt tatactattt tgtattaaaa ctgtataaat aaatatggtt
     4321 tggacggcaa cataaaagag aatgaagaga taacatagaa catttgaaac atactccata
     4381 ggtaaaacta tttacacaag tggggactgg ccaaattcaa catgttgttt caataaaaaa
     4441 ttgagtaaaa agatgagtat catttcctct caaagtttca aatgttcatg tttacaaatt
     4501 tgtcctgcac attaatatgt aaacatacat tatggtgagc agatgtacag gaaaatgtta
     4561 tcgtatcttt gtatttagtt gaaatgtata tatatatata tatttattgg atcacttttg
     4621 actgcttaaa agagttacaa cagttaaagt taaatatgat agaaaattct gagagtataa
     4681 tacaatgcat tgtagcaatt aaacacttca gtcaaatatt atattattat taacacgaaa
     4741 gaattatgac tttgatttaa tatcacattc ttatgaactt gattatataa tgtaatattt
     4801 tagctacaaa acctgtaatt aacaatttaa tgtcttacta atatgaaaag gaataaaatc
     4861 atgatcttaa gttag
//
