LOCUS       NM_001107043            2428 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus T-box transcription factor 21 (Tbx21), mRNA.
ACCESSION   NM_001107043 XM_001081363 XM_220914
VERSION     NM_001107043.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Ma ZG, Dai J, Yuan YP, Bian ZY, Xu SC, Jin YG, Zhang X and Tang QZ.
  TITLE     T-bet deficiency attenuates cardiac remodelling in rats
  JOURNAL   Basic Res Cardiol 113 (3), 19 (2018)
   PUBMED   29564567
  REMARK    GeneRIF: T-bet knockout could attenuate pressure overloadinduced
            hypertrophy, fibrosis, and inflammation, providing direct evidence
            that the Th1 subset contributes to cardiac remodelling and can
            serve as a therapeutic target for pathological cardiac remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2428)
  AUTHORS   Li J, Li M, Su L, Wang H, Xiao K, Deng J, Jia Y, Han G and Xie L.
  TITLE     Alterations of T helper lymphocyte subpopulations in sepsis, severe
            sepsis, and septic shock: a prospective observational study
  JOURNAL   Inflammation 38 (3), 995-1002 (2015)
   PUBMED   25403265
REFERENCE   3  (bases 1 to 2428)
  AUTHORS   Wang C, Liu X, Peng Q, Li D, Ji Q, Wang C and Li Z.
  TITLE     [Imbalance in the expression of Foxp3, T-bet and GATA-3 is
            correlated with inflammation of chronic obstructive pulmonary
            disease]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30 (7), 704-712 (2014)
   PUBMED   25001933
  REMARK    GeneRIF: Data indicate there is a relationship between inflammation
            and imbalance in the expression of fork head-like transcription
            factor 3 (Foxp3), T box expressed in T cells (T-bet) and GATA
            binding protein 3 (GATA3) in chronic obstructive pulmonary disease.
REFERENCE   4  (bases 1 to 2428)
  AUTHORS   Jang EJ, Park HR, Hong JH and Hwang ES.
  TITLE     Lysine 313 of T-box is crucial for modulation of protein stability,
            DNA binding, and threonine phosphorylation of T-bet
  JOURNAL   J Immunol 190 (11), 5764-5770 (2013)
   PUBMED   23616576
REFERENCE   5  (bases 1 to 2428)
  AUTHORS   Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P,
            Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM,
            Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E,
            Kivioja T and Taipale J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   6  (bases 1 to 2428)
  AUTHORS   Suzuki K, Kaminuma O, Hiroi T, Kitamura F, Miyatake S, Takaiwa F,
            Tatsumi H, Nemoto S, Kitamura N and Mori A.
  TITLE     Downregulation of IL-13 gene transcription by T-bet in human T
            cells
  JOURNAL   Int Arch Allergy Immunol 146 Suppl 1, 33-35 (2008)
   PUBMED   18504404
REFERENCE   7  (bases 1 to 2428)
  AUTHORS   Bian T, Yin KS, Jin SX, Meng ZL, Zhou JY, Ma XQ, Hu JJ and De W.
  TITLE     [Imbalanced T cell-specific transcription factors T-bet and GATA-3
            and relationship to airway inflammation in asthmatic rats]
  JOURNAL   Zhonghua Jie He He Hu Xi Za Zhi 29 (3), 176-180 (2006)
   PUBMED   16677481
  REMARK    GeneRIF: Imbalance of transcription factors T-bet and GATA-3 may
            play a key role in the formation of airway inflammation in asthma.
REFERENCE   8  (bases 1 to 2428)
  AUTHORS   Yoshihara S, Omichi K, Yanazawa M, Kitamura K and Yoshihara Y.
  TITLE     Arx homeobox gene is essential for development of mouse olfactory
            system
  JOURNAL   Development 132 (4), 751-762 (2005)
   PUBMED   15677725
REFERENCE   9  (bases 1 to 2428)
  AUTHORS   Hwang ES, Szabo SJ, Schwartzberg PL and Glimcher LH.
  TITLE     T helper cell fate specified by kinase-mediated interaction of
            T-bet with GATA-3
  JOURNAL   Science 307 (5708), 430-433 (2005)
   PUBMED   15662016
REFERENCE   10 (bases 1 to 2428)
  AUTHORS   Gerth AJ, Lin L and Peng SL.
  TITLE     T-bet regulates T-independent IgG2a class switching
  JOURNAL   Int Immunol 15 (8), 937-944 (2003)
   PUBMED   12882831
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081363.1, XM_220914.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2428
                     /gene="Tbx21"
                     /note="T-box transcription factor 21"
                     /db_xref="GeneID:303496"
                     /db_xref="RGD:1308264"
     exon            1..632
                     /gene="Tbx21"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1731
                     /gene="Tbx21"
                     /note="T-box 21"
                     /codon_start=1
                     /product="T-box transcription factor TBX21"
                     /protein_id="NP_001100513.1"
                     /db_xref="GeneID:303496"
                     /db_xref="RGD:1308264"
                     /translation="MGIVEPGCGDMLTGTEPIPSDEGRGTGADQQHRFFYPESGAQDP
                     TDRRAVSSLGSSYSGSALVPAPPGRFLGAYAYPPRAQATGFPGPGESFPPPAGAEGYP
                     PVDGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVALSNHLLWSKFNQHQTEMIITK
                     QGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRL
                     YVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVND
                     GEPEAACSANTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVD
                     TSVPSPPGPNCQLLGGDPYSPLLSNQYPVSSRFYPDLPGQPKDMVSQSYWLGTPREPS
                     YETEFRAVSVKPTFLPSAPGTTVPYYRGPDVLAPGAGWPMAPQYPPKMSPAGWFRTMR
                     TLPMDPGLGSSEEQGSPSLWTEVTSLQPEPSDSGLGEGDTKRRRISPYPSSGDSSSPA
                     GAPSPFDKETEGQFYNYFPN"
     exon            633..787
                     /gene="Tbx21"
                     /inference="alignment:Splign:2.1.0"
     exon            788..909
                     /gene="Tbx21"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1065
                     /gene="Tbx21"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1127
                     /gene="Tbx21"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2428
                     /gene="Tbx21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaacgcgc gctcaggagc taggcgtccc ggctccggct cgggtggagt tccactggtc
       61 cccggacccc gccccccgtc gccctagccc caaagaccct cgggtctctt cgacggctgc
      121 gggaaggcgc ccagcccgcc tcgaatgggc atcgtggagc cgggctgcgg agacatgctg
      181 accggcaccg agccgatacc gagtgacgag ggccggggga ccggagcgga ccagcagcat
      241 cgcttctttt atccggagtc gggcgcacag gacccgaccg atcgccgggc agttagcagc
      301 ctggggtcgt cctattctgg gagcgccttg gtgcctgccc cgcccggtcg cttcctcgga
      361 gcctacgcct acccgccccg ggcccaggcg actggcttcc ccgggcctgg cgagtccttc
      421 ccgccgcccg cgggtgcgga gggctacccg ccggtggatg gctacgctgc cccggacccg
      481 cgcgccgggc tctatccagg gccccgcgag gactacgcat tgcccgcggg gttggaggtg
      541 tcggggaagc tgagagtcgc gctcagcaac cacctgttgt ggtccaagtt caaccagcac
      601 cagacagaga tgatcatcac taagcaagga cggagaatgt tcccattcct gtccttcact
      661 gtggccgggc tggagcccac gagccattac aggatgtttg tggatgtagt cttggtggac
      721 cagcaccact ggcggtacca gagtggcaag tgggtgcagt gtgggaaggc cgaaggcagt
      781 atgccaggga accgcttata cgtccaccca gactccccca acactggagc ccactggatg
      841 cgacaggaag tttcatttgg gaaactaaag cttaccaaca acaagggggc ttccaacaat
      901 gtgacccaga tgatcgtcct gcagtccctc cataagtacc agccgcggct ccacatcgtg
      961 gaggtgaatg acggtgagcc agaggcggcc tgcagtgcta acactcacat ctttaccttc
     1021 caagagaccc agttcattgc cgtgactgcc taccagaatg cagagatcac tcagctgaaa
     1081 atcgacaaca acccctttgc caaaggattc cgggagaact ttgagtccat gtatacatcg
     1141 gttgatacga gtgttccctc gccacctgga cccaactgtc aactgcttgg gggagacccc
     1201 tactcacctc ttctgtcgaa ccagtatcct gtctccagcc gtttctaccc tgaccttcca
     1261 ggccagccca aagatatggt ctcacagtct tactggctgg gaacacctcg ggaacccagt
     1321 tatgaaacag agttccgagc agtgagcgtg aagcccacat tcctaccctc tgctcctggg
     1381 accactgtgc cctactaccg gggcccagat gtcctggctc ctggagctgg ttggcccatg
     1441 gcgcctcagt atcctcctaa gatgagccca gctggctggt tccgaaccat gcgaactctg
     1501 cccatggacc cgggcctggg atcctcagag gaacagggtt ccccttcgct gtggactgag
     1561 gtcacctccc tccagcccga gcccagcgac tcaggactag gcgagggaga cactaagagg
     1621 aggagaatat ccccctatcc ttccagtggc gacagctcct ctcccgctgg ggccccctct
     1681 ccttttgata aggaaaccga aggccagttt tataactatt ttcccaactg aggaaacgct
     1741 gcggaattgg aaggtgcccg actaacttag aaaacagaca cggggcggag agccccgagc
     1801 tctcgctgtc ccttccctgt acagagatta gttggggaag aagaggggca aggaggattc
     1861 tggggttcac ttgtttcctg gcccacaagg gaatatgaca gaagtgtccc ctgccccttc
     1921 ctctgcccga actacagtca cgtaccaggt gctgcttctg accgatggtt ccgtggagag
     1981 tggagaacgg actccagaaa gtttaggacc cagagggact tccggagagg tggaggggtc
     2041 agccgggagt ccaggactgg agagctgctc tcttccccag cccagtaaca ttcaactgtt
     2101 ggtctaacac ctgtgttaat ctctgatctg aaaaataaag acacatgcat ttttataacg
     2161 gagagacgga cagacagaca gggagaagac tcaggtgacg gcgggtggac tgggtcacct
     2221 gcgagtagac aagagagtgg gtgcagagga agggtttgag gggcgcgcat ctcaccaggt
     2281 gagatcactt tgaactggtg tgcacgcaac tgcttgtttc ttttttttta tttcttcggg
     2341 aggggaggct atttattgtt gagagagtgg tgtctggatg tatttcttct gttttgcatc
     2401 actttctgaa aataaacgtg gaactgat
//
