LOCUS       NM_001401090            6189 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus T-box transcription factor 20 (Tbx20), transcript
            variant 1, mRNA.
ACCESSION   NM_001401090 XM_006242720
VERSION     NM_001401090.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6189)
  AUTHORS   Gong,J., Sheng,W., Ma,D., Huang,G. and Liu,F.
  TITLE     DNA methylation status of TBX20 in patients with tetralogy of
            Fallot
  JOURNAL   BMC Med Genomics 12 (1), 75 (2019)
   PUBMED   31138201
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6189)
  AUTHORS   Yang,X., Kong,Q., Li,Z., Xu,M., Cai,Z. and Zhao,C.
  TITLE     Association between the promoter methylation of the TBX20 gene and
            tetralogy of fallot
  JOURNAL   Scand Cardiovasc J 52 (5), 287-291 (2018)
   PUBMED   30084275
REFERENCE   3  (bases 1 to 6189)
  AUTHORS   Liu,P., Sun,Y., Qiu,G., Jiang,H. and Qiu,G.
  TITLE     Silencing of TBX20 gene expression in rat myocardial and human
            embryonic kidney cells leads to cell cycle arrest in G2 phase
  JOURNAL   Mol Med Rep 14 (4), 2904-2914 (2016)
   PUBMED   27572266
  REMARK    GeneRIF: Silencing of TBX20 in rat myocardial and human embryonic
            kidney cells significantly inhibited cell proliferation, induced
            cell apoptosis and led to G2/M cell cycle arrest.
REFERENCE   4  (bases 1 to 6189)
  AUTHORS   Yu,L.W., Wang,F., Yang,X.Y., Sun,S.N., Zheng,Y.F., Li,B.B.,
            Gui,Y.H. and Wang,H.Y.
  TITLE     Mild decrease in TBX20 promoter activity is a potentially
            protective factor against congenital heart defects in the Han
            Chinese population
  JOURNAL   Sci Rep 6, 23662 (2016)
   PUBMED   27034249
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6189)
  AUTHORS   Mittal,A., Sharma,R., Prasad,R., Bahl,A. and Khullar,M.
  TITLE     Role of cardiac TBX20 in dilated cardiomyopathy
  JOURNAL   Mol Cell Biochem 414 (1-2), 129-136 (2016)
   PUBMED   26895318
  REMARK    GeneRIF: Cardiac TBX20 expression showed a negative correlation
            with LVEF and a positive correlation with left ventricular
            end-systolic volume. No significant difference in TBX20 CNVs and
            promoter methylation was observed between IDCM patients and control
            group
REFERENCE   6  (bases 1 to 6189)
  AUTHORS   Stennard,F.A., Costa,M.W., Lai,D., Biben,C., Furtado,M.B.,
            Solloway,M.J., McCulley,D.J., Leimena,C., Preis,J.I.,
            Dunwoodie,S.L., Elliott,D.E., Prall,O.W., Black,B.L., Fatkin,D. and
            Harvey,R.P.
  TITLE     Murine T-box transcription factor Tbx20 acts as a repressor during
            heart development, and is essential for adult heart integrity,
            function and adaptation
  JOURNAL   Development 132 (10), 2451-2462 (2005)
   PUBMED   15843414
REFERENCE   7  (bases 1 to 6189)
  AUTHORS   Takeuchi,J.K., Mileikovskaia,M., Koshiba-Takeuchi,K., Heidt,A.B.,
            Mori,A.D., Arruda,E.P., Gertsenstein,M., Georges,R., Davidson,L.,
            Mo,R., Hui,C.C., Henkelman,R.M., Nemer,M., Black,B.L., Nagy,A. and
            Bruneau,B.G.
  TITLE     Tbx20 dose-dependently regulates transcription factor networks
            required for mouse heart and motoneuron development
  JOURNAL   Development 132 (10), 2463-2474 (2005)
   PUBMED   15843409
REFERENCE   8  (bases 1 to 6189)
  AUTHORS   Cai,C.L., Zhou,W., Yang,L., Bu,L., Qyang,Y., Zhang,X., Li,X.,
            Rosenfeld,M.G., Chen,J. and Evans,S.
  TITLE     T-box genes coordinate regional rates of proliferation and regional
            specification during cardiogenesis
  JOURNAL   Development 132 (10), 2475-2487 (2005)
   PUBMED   15843407
REFERENCE   9  (bases 1 to 6189)
  AUTHORS   Plageman,T.F. Jr. and Yutzey,K.E.
  TITLE     Differential expression and function of Tbx5 and Tbx20 in cardiac
            development
  JOURNAL   J Biol Chem 279 (18), 19026-19034 (2004)
   PUBMED   14978031
REFERENCE   10 (bases 1 to 6189)
  AUTHORS   Stennard,F.A., Costa,M.W., Elliott,D.A., Rankin,S., Haast,S.J.,
            Lai,D., McDonald,L.P., Niederreither,K., Dolle,P., Bruneau,B.G.,
            Zorn,A.M. and Harvey,R.P.
  TITLE     Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4,
            and GATA5 in regulation of gene expression in the developing heart
  JOURNAL   Dev Biol 262 (2), 206-224 (2003)
   PUBMED   14550786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 2, 2022 this sequence version replaced XM_006242720.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.22436.1,
                                           SRR26643299.34200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               JAXUCZ010000008.1  31533502-31534009   c
            509-761             JAXUCZ010000008.1  31530296-31530548   c
            762-926             JAXUCZ010000008.1  31529186-31529350   c
            927-1035            JAXUCZ010000008.1  31525399-31525507   c
            1036-1194           JAXUCZ010000008.1  31519392-31519550   c
            1195-1271           JAXUCZ010000008.1  31510178-31510254   c
            1272-1381           JAXUCZ010000008.1  31482812-31482921   c
            1382-6189           JAXUCZ010000008.1  31475963-31480770   c
FEATURES             Location/Qualifiers
     source          1..6189
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..6189
                     /gene="Tbx20"
                     /note="T-box transcription factor 20"
                     /db_xref="GeneID:315497"
                     /db_xref="RGD:1309396"
     exon            1..508
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1722
                     /gene="Tbx20"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     transcription factor TBX20; T-box 20"
                     /codon_start=1
                     /product="T-box transcription factor TBX20 isoform 1"
                     /protein_id="NP_001388019.1"
                     /db_xref="GeneID:315497"
                     /db_xref="RGD:1309396"
                     /translation="MEFTASPKPQLSSRANAFSIAALMSSGGPKEKEAAENTIKPLEQ
                     FVEKSSCAQPLGELTSLDAHAEFGGGGGSSPSSSSLCTEPLIPTTPIIPSEEMAKIAC
                     SLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRY
                     RYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGH
                     IILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLK
                     IDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGEEDVLGEESQTTPNRG
                     SAFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIATPIPHPIQGSLPPYSRL
                     GMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV"
     exon            509..761
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
     exon            762..926
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1035
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1194
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1271
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1381
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..6189
                     /gene="Tbx20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtttagg tcgcgccttg ctgcgctctg cagaggagat ccgattccca ggtttctgca
       61 ccctctagag tcccacggcc gatcgtcacc tctccgagac ctgggccatc ccgcggtccc
      121 aagcagggaa gggagggaga actcagcgcg ggttctgggg accccgcgtt ttgctctgta
      181 ggcttacaca cagttttgag ttcccggctg gtccccaccc tactttcgtg ctggtttgct
      241 ctagtgaact ggagtcccca gtcccgctct tcctgctctt gggaactttg agctgcgttt
      301 tgggtctttg tctcccttcg gggaagctgg actgtgcttt tggcagccca ggtccctgag
      361 aaggaccgca cgctgggaac catggagttc accgcgtcgc ccaagcctca gctctcctct
      421 cgagccaatg ccttctccat cgccgcgcta atgtccagcg gcggccccaa ggagaaggag
      481 gcagcagaga acaccatcaa acccctggaa caatttgtgg agaaatcgtc ctgtgcccag
      541 ccgctgggtg agctaactag cctggatgct cacgcggagt ttggcggcgg cgggggcagc
      601 agcccttcct catcctctct gtgcacagag ccactgatcc ccaccacccc catcatcccc
      661 agcgaagaga tggctaaaat cgcctgcagc ctggaaacga aggagctctg ggacaaattc
      721 catgaactgg gcacggagat gattatcacc aagtctggca ggaggatgtt ccccaccatc
      781 cgcgtgtcat tttctggagt ggatcctgag gccaagtaca tagtcctgat ggacatcgtc
      841 ccggtggaca acaagagata tcgctatgcc tatcaccggt cctcctggct ggtggctggc
      901 aaggctgatc ctcccctgcc agccaggctc tacgtgcatc cagactcccc ctttactggc
      961 gagcagctcc tcaaacagat ggtgtccttt gaaaaggtga agctcaccaa caatgaactg
     1021 gaccaacatg gccatataat tttgaattca atgcataagt accagccgag ggtgcacatc
     1081 ataaagaaga aagaccacac ggcctccttg ctcaatctga agtcggaaga attcaggacg
     1141 ttcatctttc cagagacagt cttcacagca gtcacagcct accagaacca actgataacc
     1201 aagctgaaaa tagacagcaa tccgtttgcc aaaggattcc gggactcctc caggctcact
     1261 gacatcgaga gggagagtgt ggagagcctg atccagaagc attcctatgc ccggtcaccc
     1321 atccgcacct atggagagga ggatgtcctg ggggaggaga gtcagacaac tccgaaccga
     1381 gggtcagcct ttacaacatc tgacaatttg tctctcagtt cctgggtatc atcgtcttcc
     1441 agttttcctg gatttcagca tccacagccc ctgactgctc ttggcaccag tacggcatcc
     1501 atagcaacac caattcctca ccctatccag ggttctctgc caccctacag ccgcctggga
     1561 atgcctctga cgccatctgc aattgccagc tccatgcagg gaagtggccc cacgttccct
     1621 tcattccaca tgcctagata ccaccactac ttccaacagg ggccctatgc tgccatccag
     1681 ggacttcgcc actcttctgc agtgatgaca ccatttgtat gattcttctg agagtggggg
     1741 aagctagata cagagtgtgc aaacggctat gaaaatacag gagagggatg ggtgggtggg
     1801 aagtggggta ttggagcagg gactctccag aaaaacacag gacttataaa agaggagagc
     1861 tggactcaca aaataaaact accggtaagg gagtgcaccg tgggccagga ttcacttgtg
     1921 gttggatcca ggagagaatc agtgtgaagt ttagccaaca aactcctaca actaatagga
     1981 tatcagtttg cccagaaagc ttaataatcc cactggttaa aagttctgtt gatgcagtcc
     2041 tgtataaaat ccacgtgtag aggtttcttt ctgctttcaa caagttcaaa gcatcgtcca
     2101 gaaggcaata ccatgtaacg cattgacacg aaagtccatt tctcccagga gaaaatggaa
     2161 gccagtagct atgtttgtag tgctatagtt taggcatgtt tagtttcctt tgtgtcattt
     2221 actacagaag gggaaaagtt ggtgctagta catcctgtgg cgtgaacgaa tacgtgggaa
     2281 cgcctttacc aaatccctgc cacatccacg ggccatgact ccataaactc tgtcttcagt
     2341 tcctcctttt tcctaataat tctttttctc acaccaaccc tgcagttatg tagtgaaaac
     2401 cctccatctg ccattttaaa gcaagaggct ctgtcatcat caaagaggtt ggctttcaag
     2461 ggctgcatta gtaaataggg atagccactg gggacctgtc cagagcccat gtgatggctg
     2521 agactctctc tcacacgatc aaaatctggt gtctctcttc tgtggggaat ttctctgcca
     2581 tgggaaccaa agtcctcttt gttttcaccc cagcgtcagg aggccttttg catattaaaa
     2641 cacactgggc caattctgat ttttttttat ataaatctgc tttactgttg cttccactat
     2701 tgtctgggat ttgccagtgg ccattctcca tgtgcatggc tcaccacgct ctcgtgtgtg
     2761 ctgatgggta tgaatatgcc ctgtagctga ttcctcctgt ctgactgtat tacatttaca
     2821 gacttctttc catcttcccc ggtccctaat aagaagctgc atgtttactc aatgactccc
     2881 tgacagaaac actaacaagc aggagcttct tccggttttc gctattttct taagctttcc
     2941 ttctatgcgt aagccagagc ttatgttttc cttctatata gccaccgcat tattttcgag
     3001 caacatgtat cttagcattt acagtcaggg tagtgcatct ggtttggcag tagtacattt
     3061 ccctaataga ttagatttat taagtcatta ggctttcagc tttgaagaca gtgtattcca
     3121 cctgtaggat gtgaccagct tgcttcatgt aggtcctctg aactttgttt tatatgtagc
     3181 ttttactcct ctctgctctt acttcaaaag tattgagtgt gtccaatcag agatatggga
     3241 aatagctctc ctgacagtag aagtgtattt aggcataaat gcaatatatt tgccacacca
     3301 ctctgaagtt tgatttggta cctttaatgt tacgcttccc agaccacgtc tagtctatga
     3361 aacgaggcac catacgcagc ctgagtgtgg gatgctgatt ttagattttg cacttgatat
     3421 tctccaccga aagtccatag tttacttaca aagaagcatg aactgttaac agaactattt
     3481 taaactctta tgtcagacac ccagcttttt gtgtgtcttg tagtagtctc cacaagtcat
     3541 tggtttccag acagatgtgc atttctctta aaaacccatt gcaagtgatg tttaaaataa
     3601 atgcccatgg agctagggta gggtattgat atttaataat tggtctctca caaaagaacc
     3661 ttggaataaa gtgttgccat ttaaagcaga aaaacccaag gcaggattgt acagagtgcc
     3721 cctcatgtct cccctggttt atgttgagat tctaaacaca tgcctgtgtt ttcttttcag
     3781 tgaggatgaa aagattgttt taatattgct tttagagttt ctcaaaccgg tgtgcctcac
     3841 agtagctttt tttttaattg ctgttcatct gatcttttgc tggcatctcc tgacctttta
     3901 attttgcttg taattaggca gcatgaggac gagactcact gaaatgcatg atagacagca
     3961 aggcgggctc ttgaacacgt tccccctaaa aggcttcgct gggtgtttgt ttcccctgtt
     4021 ggtattacgt aaaccagaca gaaacctccc aagagaaaca gcaacatgtg agtgcctggc
     4081 acttgagcct ggggccacct gtgcctttct gatttatcct gtcaactttt attaagcctt
     4141 ggggagttta tcacttaaaa tccccaagtt tgttccaccg aaattgatgg taataattag
     4201 atattaattg ataaatccaa tcgaataata atgacgaaga tttataatac atttgaaaca
     4261 gttcagagct ccctccttat ggatattatg ttgtgagaaa gaatggtcga atggagttat
     4321 tgaagaggcc tggccaggct tgctttactg agctctaagg gatgtgctca taacttcacg
     4381 ctctggtttt aaaagatccc tcgataattc caggttgagg tgtgaaccat cccaccctgt
     4441 tcctgtcctt agcggttctt gtagaagtac ttccagttgt gtgtgacaga tcaacagttg
     4501 tcaggtagca ttgtctaacg cagtgacttt ctgctccatc gatggcaccg ccagcttgta
     4561 acactggcgt cctacctaga aagttatgag catttatgtg ggggctacaa gaaggctctc
     4621 catacaggtt cgtcatttag cagagctgca ccgactttgg ggcattctaa gtgcttacct
     4681 ccccagccac tggggataac tgtctgcctc tttgcttctc cagatacaac agcattgtct
     4741 ccccaccccc caaccggaaa aataaaacaa agcaaaagga aaatgaatcc tttccaaact
     4801 caagaaatgt tcttagtagt gaaacctctt gtctcacact gcctatgagc acttcgggga
     4861 gatgttagga tatttatcct atttcttgac ttgagatgaa cttttcaagc tacattgcct
     4921 atgtaagggg caattaggtt gagaaaaata actaaatata tgttaacaaa taaagtggat
     4981 ggcggacttc tcaccccact agctaggtgg gtgagcttag tggtcactaa tgagccggct
     5041 aagataatgt gtttaaattc atgttcttat tctgcatttt accgagtaag aaaagctacg
     5101 tccattatta actgggcagg gagctgatag ttattgcaaa cagaacaata ctcactctga
     5161 caaagcagcc gacaaaagat agaatatttg atttgttcct ccatagagtt actgagggaa
     5221 ggatgggttt tatatacatt ttcatatcat tttagaatga cagacattgc cataaacacc
     5281 aaagttaagg ttacacactt ttaacatttt aaggaagtgt acaagcccct ttaacaaagc
     5341 ttactattct gtagctgtta taaaacacca aacacctttc ctctgcaagc ttaatcgtac
     5401 aaaggcacat ttataagtat tcgatgtgtt aataatccac aagtatttac tagctttctt
     5461 taactgcctc tctctctctc tccctaatat aatttcaatc tcttaaccct ttaagaaagc
     5521 gtcctgcaag gaaaatagtg tggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgagtgtgt
     5581 gtgtatgtgt gtgtgtatgt gtgagtgtgt gtgtgagtgt gtgtatgtgt gtgtgtatgt
     5641 gtgagtgtgt gtgtatgtgt gtgtgagtat atgtgtatgt gtatgtgtgt gtgagtatat
     5701 gtgtatgtgt atgggtgtgt gagtgtgtgt gtgagtgtgt gtgtgtgtgt aaaatactga
     5761 atctggacaa aagatacaat ttgttgtatt ttactttact ctggcgcaaa gacattgtat
     5821 ttagttgctt taaaactttt ttcctcaaaa atctgaaaag gttcttttag ttgctaacgt
     5881 atgagattgt gtaacacctg ctcagtaggc cctgtcacag tttccctgtt tgctgtgtct
     5941 tcatttgatt aacaatttgc gtggaaaagt cactgtaatg cagtgtgcgg ggtgggggaa
     6001 gggcgtggga aatgttttat gggaaaaaat tataagccta atgctatgaa gtaacattta
     6061 ctgaagttct gtttaagtgc aatatattta tttctgccag aaatgtatta tcgaccctat
     6121 gtaatatttg atgcaccaca tcttatttgt aaacagctaa aattatatat tatcccaaat
     6181 tgtacagaa
//
