LOCUS       NM_001401806            3384 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus T-box transcription factor 2 (Tbx2), mRNA.
ACCESSION   NM_001401806 XM_017597309
VERSION     NM_001401806.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Liu,Y., Liu,Y., Chen,G. and Wang,H.
  TITLE     Epigenetic programming of TBX2/CX43 mediates lower sperm quality in
            male offspring induced by prenatal dexamethasone exposure
  JOURNAL   Toxicol Sci (2023) In press
   PUBMED   36790081
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Zhang,R.R., Cai,K., Liu,L., Yang,Q., Zhang,P., Gui,Y.H. and Wang,F.
  TITLE     A regulatory variant in TBX2 promoter is related to the decreased
            susceptibility of congenital heart disease in the Han Chinese
            population
  JOURNAL   Mol Genet Genomic Med 7 (2), e00530 (2019)
   PUBMED   30525309
REFERENCE   3  (bases 1 to 3384)
  AUTHORS   Wang,J., Zhang,R.R., Cai,K., Yang,Q., Duan,W.Y., Zhao,J.Y.,
            Gui,Y.H. and Wang,F.
  TITLE     Susceptibility to congenital heart defects associated with a
            polymorphism in TBX2 3' untranslated region in the Han Chinese
            population
  JOURNAL   Pediatr Res 85 (3), 378-383 (2019)
   PUBMED   30262811
REFERENCE   4  (bases 1 to 3384)
  AUTHORS   Aydogdu,N., Rudat,C., Trowe,M.O., Kaiser,M., Ludtke,T.H.,
            Taketo,M.M., Christoffels,V.M., Moon,A. and Kispert,A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3384)
  AUTHORS   Liu,N., Schoch,K., Luo,X., Pena,L.D.M., Bhavana,V.H.,
            Kukolich,M.K., Stringer,S., Powis,Z., Radtke,K., Mroske,C.,
            Deak,K.L., McDonald,M.T., McConkie-Rosell,A., Markert,M.L.,
            Kranz,P.G., Stong,N., Need,A.C., Bick,D., Amaral,M.D.,
            Worthey,E.A., Levy,S., Wangler,M.F., Bellen,H.J., Shashi,V. and
            Yamamoto,S.
  CONSRTM   Undiagnosed Diseases Network (UDN)
  TITLE     Functional variants in TBX2 are associated with a syndromic
            cardiovascular and skeletal developmental disorder
  JOURNAL   Hum Mol Genet 27 (14), 2454-2465 (2018)
   PUBMED   29726930
REFERENCE   6  (bases 1 to 3384)
  AUTHORS   Borke,J.L., Chen,J.R., Yu,J.C., Bollag,R.J., Orellana,M.F. and
            Isales,C.M.
  TITLE     Negative transcriptional regulation of connexin 43 by Tbx2 in rat
            immature coronal sutures and ROS 17/2.8 cells in culture
  JOURNAL   Cleft Palate Craniofac J 40 (3), 284-290 (2003)
   PUBMED   12733958
  REMARK    GeneRIF: Tbx2 is a negative regulator of connexin 43 expression at
            the transcriptional level in cranial sutures [Tbx2][cx43]
REFERENCE   7  (bases 1 to 3384)
  AUTHORS   Habets,P.E., Moorman,A.F., Clout,D.E., van Roon,M.A., Lingbeek,M.,
            van Lohuizen,M., Campione,M. and Christoffels,V.M.
  TITLE     Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in
            the atrioventricular canal: implications for cardiac chamber
            formation
  JOURNAL   Genes Dev 16 (10), 1234-1246 (2002)
   PUBMED   12023302
REFERENCE   8  (bases 1 to 3384)
  AUTHORS   Brummelkamp,T.R., Kortlever,R.M., Lingbeek,M., Trettel,F.,
            MacDonald,M.E., van Lohuizen,M. and Bernards,R.
  TITLE     TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative
            regulator of p19ARF and inhibits senescence
  JOURNAL   J Biol Chem 277 (8), 6567-6572 (2002)
   PUBMED   11748239
REFERENCE   9  (bases 1 to 3384)
  AUTHORS   Sinha,S., Abraham,S., Gronostajski,R.M. and Campbell,C.E.
  TITLE     Differential DNA binding and transcription modulation by three
            T-box proteins, T, TBX1 and TBX2
  JOURNAL   Gene 258 (1-2), 15-29 (2000)
   PUBMED   11111039
REFERENCE   10 (bases 1 to 3384)
  AUTHORS   He,Ml., Wen,L., Campbell,C.E., Wu,J.Y. and Rao,Y.
  TITLE     Transcription repression by Xenopus ET and its human ortholog TBX3,
            a gene involved in ulnar-mammary syndrome
  JOURNAL   Proc Natl Acad Sci U S A 96 (18), 10212-10217 (1999)
   PUBMED   10468588
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13589]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 25, 2022 this sequence version replaced XM_017597309.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.44548.1,
                                           SRR21887622.889878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-700               JAXUCZ010000010.1  71177082-71177781
            701-968             JAXUCZ010000010.1  71178848-71179115
            969-1115            JAXUCZ010000010.1  71180154-71180300
            1116-1192           JAXUCZ010000010.1  71181408-71181484
            1193-1356           JAXUCZ010000010.1  71181581-71181744
            1357-1994           JAXUCZ010000010.1  71182192-71182829
            1995-3384           JAXUCZ010000010.1  71184886-71186275
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3384
                     /gene="Tbx2"
                     /note="T-box transcription factor 2"
                     /db_xref="GeneID:303398"
                     /db_xref="RGD:1311014"
     exon            1..700
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..2441
                     /gene="Tbx2"
                     /note="T-box 2"
                     /codon_start=1
                     /product="T-box transcription factor TBX2"
                     /protein_id="NP_001388735.1"
                     /db_xref="GeneID:303398"
                     /db_xref="RGD:1311014"
                     /translation="MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALP
                     PGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVE
                     DDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAA
                     DDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDK
                     HGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKI
                     DNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPP
                     PSPSAAPSPLRLHRARAEEKPCAADSDPEPERSGEERAAAPLGRSSSRDASPARLTEP
                     ERSRERRSPERGSKEPTEGGGDGPFSLRSLEKERAEARRKDEGRKDVGEGKEPSLAPL
                     VVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGM
                     GHLLASVAGGGGNSGGAAPGTAAGLDAGGLGPAASAASTATPFPFHLSQHMLASQGIP
                     MPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSP
                     YQIPVTIPPSTSLLTTGLAAESSKGGNSREPSPLPELALRKVGGPSRGALSPSGSAKE
                     AASELQSIQRLVSGLESQRALSPGRESPK"
     exon            701..968
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1115
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1192
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1356
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1994
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..3384
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagggcagg acatgtgaga tagtcacagt tttccagaga tcaggacaag atctaaccag
       61 tcgcgcgtgg tccccggcgc cggagtcggc cagcccagcc cagccccgcg cagagccccc
      121 tccgcccccg cgtccagagc cccgcgcccc ttgaggtgcg cgggacgggg agccgggaga
      181 agccgctgcc gcgcccgccg cccgggccgt ctgtcctccg cgcgcgccgc cgcccgggcc
      241 gggggtccga ggcgcgcgcc cccggccccg gccccggctc ccgggtgcct gggccggatg
      301 tcccgatgag agagccggcg ctggcagcca gcgccatggc ttaccatccg ttccacgcgc
      361 cacggcccgc cgacttcccc atgtccgcct tcctggcggc agcgcagccc tccttcttcc
      421 cggcgctagc gctgccgccc ggcgcgctgg ccaagcctct gcccgacccg ggcctggcgg
      481 gggcggcggc cgcggctgca gcggcggcgg cggcagccga ggcggggctg cacgtctcgg
      541 cactcggccc gcacccgccc gccgcgcatc tgcgctcgct caagagcctg gaacccgagg
      601 acgaggtgga ggacgacccc aaggtgacgc tggaggccaa ggagctgtgg gaccagttcc
      661 acaagctggg caccgagatg gtcatcacca agtccgggag gcggatgttc ccccccttca
      721 aggtgcgagt cagcggcctg gacaagaagg ccaagtacat cctgctgatg gacattgtgg
      781 ctgccgatga ctgccgatat aagtttcaca actcgagatg gatggtggca ggcaaagccg
      841 accccgagat gcctaaacgc atgtacatcc acccggacag tccggccacg ggggagcagt
      901 ggatggccaa gcccgtggcc ttccacaaac tgaagctaac caacaacatt tctgacaagc
      961 atggcttcac catcctgaac tccatgcaca agtaccagcc gcgcttccac atcgtgcgag
     1021 ccaacgacat cttgaagctc ccatacagta cctttcgcac ctatgtcttc ccagagactg
     1081 acttcatcgc tgtcactgcc taccagaatg acaagattac acaactgaag atcgacaaca
     1141 acccttttgc caagggcttc cgggacaccg ggaacggccg tcgggagaaa aggaagcagc
     1201 taacgctgcc cactctccgt ttgtatgagg agcactgtaa accggagcgt gacggcgctg
     1261 aatccgatgc ctcgtcctgc gaccctccgc ctgcgcgcga accaccgccc tcccccagcg
     1321 cagcgcccag ccctctacgc ctgcaccggg cccgagccga ggagaagccg tgcgcagccg
     1381 acagcgaccc tgagccggag cggtcgggcg aggagcgcgc cgcagcgccc ctgggccgca
     1441 gctcttcgcg ggacgccagc cccgctcgcc tgaccgaacc cgaacgctcc cgggagcggc
     1501 gcagcccgga gaggggcagc aaggaaccga cggagggcgg tggggacggc ccatttagtc
     1561 tgcggagcct ggagaaggag cgcgcggagg cccggaggaa ggatgagggg cgcaaggacg
     1621 tgggcgaagg caaggagccc agcctggcgc ctctggtggt gcagacagac agtgcgtccc
     1681 ccctgggtgc gggccatctg cccggcttgg ccttctccag ccacctgcac gggcagcagt
     1741 tctttgggcc gttgggagct ggccagcccc tcttcctgca cccaggacaa tttgccatgg
     1801 gccccggagc cttctccgcc atgggcatgg gtcatctgct agcctcggtg gcaggcggcg
     1861 gtggcaatag cgggggcgct gcgcccggaa ccgcggcggg gctggacgca ggcgggctgg
     1921 gtcccgcagc cagcgcagca agcaccgcga ctcccttccc gttccacctc tcccagcaca
     1981 tgctggcatc tcagggaatc ccaatgccca ctttcggagg cctcttcccc tacccgtaca
     2041 cttacatggc agcagcggcc gccgccgcct ccgctttacc cgccaccagc gctgcagctg
     2101 ccgccgccgc cgccgctggt tctctatcac ggagcccatt tctgggcagt gcccggcccc
     2161 gcctgcgctt cagcccctac cagatcccgg tcaccatccc acctagcact agcctcctta
     2221 ccactgggct ggcggcggag agctccaagg gtggaaatag ccgtgagccc agtccactgc
     2281 ctgagctggc tctccgaaaa gtggggggcc catcccgcgg ggccctatcg cccagcggct
     2341 cagccaaaga ggcggccagt gaactgcaga gcatccagag actggtgagt ggactagaga
     2401 gccagcgagc cctctccccc ggccgggagt ctcccaagtg agggaccgct tggctgctgc
     2461 gctgccacac gagcctgtcg ggctgggctc tctgcctcgg ctgtttggga cgtgtacagc
     2521 acagaatggg tatttattta aataaagaag caaaagcagg cttcagcggt cagaatagac
     2581 cctcgcgtgg caggtcgggg gtctgggccg ctaccctggg gtcttagcga ggaaatcagt
     2641 ctacccggaa cacagtcact ctggagcccc tggatgtgat gcggatttct gttcgagagt
     2701 caactcccag ggcacctcct tctttcaaca ctatgggggt ggcctctttc cggcggtccc
     2761 tttggaagcc aaaaggtgca tagggtagag gtgttcactt cggaaagcat cccaggatcc
     2821 tggccttagg cctgaatgtc gtgcgaaact ggtgtggacg atgctggagg cagggaagcc
     2881 tgaactcagc gtagacttga gctaagagga gtcctgtccg gttggtcttc ccacctctat
     2941 cccacaaaag acaggcgcca ttcctacttc cacttctggg tcagcggagg aagttgcact
     3001 tctgctttga gtccccaggg ggcaaaagat atttatgaaa taaatggtaa tttgtgtaaa
     3061 taagttttaa ggttcccaga agatacaaat tcgtattaat ttattcgaag gtgtacattg
     3121 ctgtgtacat atatttagag attaactcat agcatttaat ttttttttca ttttacatga
     3181 gcatctatat tgtacagggt cccgggatcc ttggctgctg gggtaggggg aggcaccgaa
     3241 ccccagggaa ggcccacccc gcgggcccct cagcctctgc gccccggttt tgcccgccca
     3301 gcccacgggc cccacctcag gttttcactt tttgctccag agggagaacg aagcgagaaa
     3361 ataataaaaa cgctaccatg cgaa
//
