LOCUS       NP_001388735             711 aa            linear   ROD 31-MAR-2024
DEFINITION  T-box transcription factor TBX2 [Rattus norvegicus].
ACCESSION   NP_001388735 XP_017452798
VERSION     NP_001388735.1
DBSOURCE    REFSEQ: accession NM_001401806.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 711)
  AUTHORS   Liu,Y., Liu,Y., Chen,G. and Wang,H.
  TITLE     Epigenetic programming of TBX2/CX43 mediates lower sperm quality in
            male offspring induced by prenatal dexamethasone exposure
  JOURNAL   Toxicol Sci (2023) In press
   PUBMED   36790081
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 711)
  AUTHORS   Zhang,R.R., Cai,K., Liu,L., Yang,Q., Zhang,P., Gui,Y.H. and Wang,F.
  TITLE     A regulatory variant in TBX2 promoter is related to the decreased
            susceptibility of congenital heart disease in the Han Chinese
            population
  JOURNAL   Mol Genet Genomic Med 7 (2), e00530 (2019)
   PUBMED   30525309
REFERENCE   3  (residues 1 to 711)
  AUTHORS   Wang,J., Zhang,R.R., Cai,K., Yang,Q., Duan,W.Y., Zhao,J.Y.,
            Gui,Y.H. and Wang,F.
  TITLE     Susceptibility to congenital heart defects associated with a
            polymorphism in TBX2 3' untranslated region in the Han Chinese
            population
  JOURNAL   Pediatr Res 85 (3), 378-383 (2019)
   PUBMED   30262811
REFERENCE   4  (residues 1 to 711)
  AUTHORS   Aydogdu,N., Rudat,C., Trowe,M.O., Kaiser,M., Ludtke,T.H.,
            Taketo,M.M., Christoffels,V.M., Moon,A. and Kispert,A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 711)
  AUTHORS   Liu,N., Schoch,K., Luo,X., Pena,L.D.M., Bhavana,V.H.,
            Kukolich,M.K., Stringer,S., Powis,Z., Radtke,K., Mroske,C.,
            Deak,K.L., McDonald,M.T., McConkie-Rosell,A., Markert,M.L.,
            Kranz,P.G., Stong,N., Need,A.C., Bick,D., Amaral,M.D.,
            Worthey,E.A., Levy,S., Wangler,M.F., Bellen,H.J., Shashi,V. and
            Yamamoto,S.
  CONSRTM   Undiagnosed Diseases Network (UDN)
  TITLE     Functional variants in TBX2 are associated with a syndromic
            cardiovascular and skeletal developmental disorder
  JOURNAL   Hum Mol Genet 27 (14), 2454-2465 (2018)
   PUBMED   29726930
REFERENCE   6  (residues 1 to 711)
  AUTHORS   Borke,J.L., Chen,J.R., Yu,J.C., Bollag,R.J., Orellana,M.F. and
            Isales,C.M.
  TITLE     Negative transcriptional regulation of connexin 43 by Tbx2 in rat
            immature coronal sutures and ROS 17/2.8 cells in culture
  JOURNAL   Cleft Palate Craniofac J 40 (3), 284-290 (2003)
   PUBMED   12733958
  REMARK    GeneRIF: Tbx2 is a negative regulator of connexin 43 expression at
            the transcriptional level in cranial sutures [Tbx2][cx43]
REFERENCE   7  (residues 1 to 711)
  AUTHORS   Habets,P.E., Moorman,A.F., Clout,D.E., van Roon,M.A., Lingbeek,M.,
            van Lohuizen,M., Campione,M. and Christoffels,V.M.
  TITLE     Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in
            the atrioventricular canal: implications for cardiac chamber
            formation
  JOURNAL   Genes Dev 16 (10), 1234-1246 (2002)
   PUBMED   12023302
REFERENCE   8  (residues 1 to 711)
  AUTHORS   Brummelkamp,T.R., Kortlever,R.M., Lingbeek,M., Trettel,F.,
            MacDonald,M.E., van Lohuizen,M. and Bernards,R.
  TITLE     TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative
            regulator of p19ARF and inhibits senescence
  JOURNAL   J Biol Chem 277 (8), 6567-6572 (2002)
   PUBMED   11748239
REFERENCE   9  (residues 1 to 711)
  AUTHORS   Sinha,S., Abraham,S., Gronostajski,R.M. and Campbell,C.E.
  TITLE     Differential DNA binding and transcription modulation by three
            T-box proteins, T, TBX1 and TBX2
  JOURNAL   Gene 258 (1-2), 15-29 (2000)
   PUBMED   11111039
REFERENCE   10 (residues 1 to 711)
  AUTHORS   He,Ml., Wen,L., Campbell,C.E., Wu,J.Y. and Rao,Y.
  TITLE     Transcription repression by Xenopus ET and its human ortholog TBX3,
            a gene involved in ulnar-mammary syndrome
  JOURNAL   Proc Natl Acad Sci U S A 96 (18), 10212-10217 (1999)
   PUBMED   10468588
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13589]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 25, 2022 this sequence version replaced XP_017452798.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.44548.1,
                                           SRR21887622.889878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     Protein         1..711
                     /product="T-box transcription factor TBX2"
                     /note="T-box 2"
                     /calculated_mol_wt=74969
     Region          103..287
                     /region_name="T-box_TBX2_3-like"
                     /note="DNA-binding domain of T-box transcription factor 2
                     and 3, and related T-box proteins; cd20188"
                     /db_xref="CDD:410314"
     Site            order(132..133,210,213,226..227,264..267,272,275..276,
                     279..285)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410314"
     Region          305..379
                     /region_name="TBX"
                     /note="T-box transcription factor; pfam12598"
                     /db_xref="CDD:432659"
     CDS             1..711
                     /gene="Tbx2"
                     /coded_by="NM_001401806.1:306..2441"
                     /db_xref="GeneID:303398"
                     /db_xref="RGD:1311014"
ORIGIN      
        1 mrepalaasa mayhpfhapr padfpmsafl aaaqpsffpa lalppgalak plpdpglaga
       61 aaaaaaaaaa aeaglhvsal gphppaahlr slkslepede veddpkvtle akelwdqfhk
      121 lgtemvitks grrmfppfkv rvsgldkkak yillmdivaa ddcrykfhns rwmvagkadp
      181 empkrmyihp dspatgeqwm akpvafhklk ltnnisdkhg ftilnsmhky qprfhivran
      241 dilklpystf rtyvfpetdf iavtayqndk itqlkidnnp fakgfrdtgn grrekrkqlt
      301 lptlrlyeeh ckperdgaes dasscdpppa repppspsaa psplrlhrar aeekpcaads
      361 dpepersgee raaaplgrss srdasparlt epersrerrs pergskepte gggdgpfslr
      421 slekeraear rkdegrkdvg egkepslapl vvqtdsaspl gaghlpglaf sshlhgqqff
      481 gplgagqplf lhpgqfamgp gafsamgmgh llasvagggg nsggaapgta agldagglgp
      541 aasaastatp fpfhlsqhml asqgipmptf gglfpypyty maaaaaaasa lpatsaaaaa
      601 aaaagslsrs pflgsarprl rfspyqipvt ippstslltt glaaesskgg nsrepsplpe
      661 lalrkvggps rgalspsgsa keaaselqsi qrlvsglesq ralspgresp k
//
