LOCUS       NM_001394230            2629 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus T-box transcription factor 19 (Tbx19), mRNA.
ACCESSION   NM_001394230
VERSION     NM_001394230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Budry,L., Balsalobre,A., Gauthier,Y., Khetchoumian,K., L'honore,A.,
            Vallette,S., Brue,T., Figarella-Branger,D., Meij,B. and Drouin,J.
  TITLE     The selector gene Pax7 dictates alternate pituitary cell fates
            through its pioneer action on chromatin remodeling
  JOURNAL   Genes Dev 26 (20), 2299-2310 (2012)
   PUBMED   23070814
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Pulichino,A.M., Vallette-Kasic,S., Tsai,J.P., Couture,C.,
            Gauthier,Y. and Drouin,J.
  TITLE     Tpit determines alternate fates during pituitary cell
            differentiation
  JOURNAL   Genes Dev 17 (6), 738-747 (2003)
   PUBMED   12651892
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Liu,J., Lin,C., Gleiberman,A., Ohgi,K.A., Herman,T., Huang,H.P.,
            Tsai,M.J. and Rosenfeld,M.G.
  TITLE     Tbx19, a tissue-selective regulator of POMC gene expression
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8674-8679 (2001)
   PUBMED   11447259
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Lamolet,B., Pulichino,A.M., Lamonerie,T., Gauthier,Y., Brue,T.,
            Enjalbert,A. and Drouin,J.
  TITLE     A pituitary cell-restricted T box factor, Tpit, activates POMC
            transcription in cooperation with Pitx homeoproteins
  JOURNAL   Cell 104 (6), 849-859 (2001)
   PUBMED   11290323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1099741.1,
                                           SRR26360176.2264135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               JAXUCZ010000013.1  80005916-80006343   c
            429-693             JAXUCZ010000013.1  79998060-79998324   c
            694-828             JAXUCZ010000013.1  79996595-79996729   c
            829-890             JAXUCZ010000013.1  79992667-79992728   c
            891-952             JAXUCZ010000013.1  79990462-79990523   c
            953-1141            JAXUCZ010000013.1  79987920-79988108   c
            1142-1277           JAXUCZ010000013.1  79986181-79986316   c
            1278-2629           JAXUCZ010000013.1  79983935-79985286   c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..2629
                     /gene="Tbx19"
                     /note="T-box transcription factor 19"
                     /db_xref="GeneID:304935"
                     /db_xref="RGD:1310145"
     exon            1..428
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1572
                     /gene="Tbx19"
                     /note="T-box 19"
                     /codon_start=1
                     /product="T-box transcription factor TBX19"
                     /protein_id="NP_001381159.1"
                     /db_xref="GeneID:304935"
                     /db_xref="RGD:1310145"
                     /translation="MAMSELATQKSGEGTVSRLLNVVESELQAGREKGDPTEKQLQII
                     LEDAPLWQRFKEVTNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWK
                     YVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLSGGGQIMLN
                     SLHKYEPQVHIVRVGGAHRMVMNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLD
                     AKERNHLKEIPEAVSESQHVTYSHLGGWILSNPDGMCTTGSANYQYATPLPLPAPHTR
                     HGCEHYAGLRGHRQAPYPSAYMHRNHSPSVNLIESSSNNLQVFSGPESWTSLPSAPHG
                     GILSVPHTSGPINPGPSPYPCLWTISNGGGGPVASGSEVHASASGTFLLGSPTVTSPS
                     SLLPTQATTSAGVEVLGEPSLTSIAVSTWTAVASHPLPGWGGPGGAGRHSPSSLDS"
     exon            429..693
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
     exon            694..828
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
     exon            829..890
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
     exon            891..952
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1141
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1277
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..2629
                     /gene="Tbx19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctcccc tctcctccct gctccccaac tgaagcttaa caggtcggtg gtaatttgga
       61 gactttcagg ggtgtcgcac tggaagctta aacaagagcc aaggcatctt gttctcctcc
      121 cagacactga ccagctgggg ttgaaaagct agcaagtgag agaaggaagg agccggaggt
      181 agagaaggtg ggaacggcag ctctcagcaa agtttgacag ggtctatggc catgagcgaa
      241 ctggccacgc agaagtctgg cgaaggcacc gtgtctcgcc tgctcaacgt ggtggaaagt
      301 gagcttcagg cagggaggga gaagggagat cctacagaga agcaacttca gatcatcttg
      361 gaggatgctc cgctctggca gagattcaag gaagtcacta atgaaatgat cgtgaccaag
      421 aatggcaggc ggatgttccc tgttttgaag atcagtgtca cgggactgga ccctaatgct
      481 atgtactccc ttctgttgga cttcgtcccg accgacagtc accgctggaa gtatgtcaac
      541 ggggaatggg tacccgcggg caagccagag gtctccagcc acagctgtgt ctacattcac
      601 cctgactccc ccaactttgg ggctcactgg atgaaagctc ccatctcctt cagcaaagtg
      661 aagctgacca acaagcttag tggaggtggg cagataatgc tgaattctct gcataaatat
      721 gaacctcagg ttcacatagt gcgcgtcgga ggcgcccatc gaatggtcat gaactgctca
      781 ttccctgaaa ctcagttcat cgctgtgact gcttatcaga acgaggagat aacagctctc
      841 aaaatcaagt acaacccttt cgccaaggcc ttcttggatg ccaaggaaag aaaccacctc
      901 aaggaaattc cagaggctgt ctctgagagc cagcatgtga cctactctca cctgggaggc
      961 tggatcttgt ccaatcctga cggcatgtgc acaaccggca gtgccaatta ccagtatgcg
     1021 acgcctttgc ctctgcctgc tccccacaca cgccatggct gtgagcacta cgctggcctc
     1081 cgaggacatc ggcaggctcc ctacccttct gcgtacatgc ataggaacca ttctccctca
     1141 gtaaatttaa tagagagctc aagcaacaat ctgcaagttt tctcggggcc agagagctgg
     1201 acttccttac cctccgcacc ccatggcggc atcctgtctg taccccatac cagtgggccg
     1261 atcaacccag ggcccagccc ctatccgtgt ctgtggacca tcagcaatgg aggtgggggc
     1321 cctgtggcat ccggctcgga ggtgcacgcc agcgcctcag gaacctttct ccttgggagc
     1381 cctactgtca cttcaccttc ctctctgctc cccacccaag caactacgtc agctggcgtg
     1441 gaggtcttgg gtgagccttc gctgaccagc attgccgtgt ccacctggac agccgtggcc
     1501 tcacatcccc tcccaggctg gggtggacca ggtggagctg gacgccattc cccctcttca
     1561 ttggatagtt aggtggggcc ctctgagccg ctgccagcag agaactgtgt atgtatgtgc
     1621 atagcaacct cattgctggt tccaggcagt cgagctcctg ggtctcttca cccagaggcc
     1681 tggaggggtg catggtgatg cccaaaagct tcccaaaaag tggtttagtc tgggtgatgc
     1741 tgattttact acttgcgtct cccactgttt cctgtggttc tctggctctc tctgagttta
     1801 tcttgaccat gcttacattg cagtcagcta tgtctaagtg cccgccctgc ccctgcccct
     1861 tactctcaag tggtcctggg gtcaagcctc ccttcctttt ttctggagtc ggtgcatggt
     1921 gttgaggaga gctcagattc tcccttttga ggctgctgct tcttagcttt gtgcagcctt
     1981 ggaaagcatg tgtggcccta agacctgagc tggctgtgtg gccctaaggt ctgcgctgag
     2041 acccagagaa gacagagcca gtaaagttaa caagagtacg ctagtgcaaa ggcagcccca
     2101 tgttgacaga agtgtgtttg gaattcagga aatgaggtta agccctcaat agtggctccc
     2161 tttgtctaca gagtgaagct ggatgcccct gtattctaag acagcctctc ccatctggcc
     2221 ttcctctgcg cctccagctt tgactctcct tgttgacctc ttagtatcct ccactcaagg
     2281 cagacctctt tccttgctct gaatacttgc ttctgtgcct gaagcatcct ctctcctgcc
     2341 ctacctgtgt gtattatacc agcttggccg ggactggttg aaaggccact ctggtatcaa
     2401 tcacctgagg tgatgtttga ctatctctgt cccctgcttt cccgccattt ttacctcagg
     2461 catagagctc acctcacctc attctgcttt ctatttttgc gagtgtatct gtccccctca
     2521 tagactgtaa gcctctggag ggtgagagct cgccctcctc atcgtgccca tagcccctgg
     2581 tattgtgcct tcaccaccat aggtgcccaa taaacatttg ctgagttga
//
