LOCUS       NM_001108173            4611 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus T-box transcription factor 18 (Tbx18), mRNA.
ACCESSION   NM_001108173 XM_001063222 XM_236458
VERSION     NM_001108173.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4611)
  AUTHORS   Sanchez,L., Mesquita,T., Zhang,R., Liao,K., Rogers,R., Lin,Y.N.,
            Miguel-Dos-Santos,R., Akhmerov,A., Li,L., Nawaz,A., Holm,K.,
            Marban,E. and Cingolani,E.
  TITLE     MicroRNA-dependent suppression of biological pacemaker activity
            induced by TBX18
  JOURNAL   Cell Rep Med 3 (12), 100871 (2022)
   PUBMED   36543116
  REMARK    GeneRIF: MicroRNA-dependent suppression of biological pacemaker
            activity induced by TBX18.
REFERENCE   2  (bases 1 to 4611)
  AUTHORS   Foster,D.B., Gu,J.M., Kim,E.H., Wolfson,D.W., O'Meally,R.,
            Cole,R.N. and Cho,H.C.
  TITLE     Tbx18 Orchestrates Cytostructural Transdifferentiation of
            Cardiomyocytes to Pacemaker Cells by Recruiting the
            Epithelial-Mesenchymal Transition Program
  JOURNAL   J Proteome Res 21 (10), 2277-2292 (2022)
   PUBMED   36006872
  REMARK    GeneRIF: Tbx18 Orchestrates Cytostructural Transdifferentiation of
            Cardiomyocytes to Pacemaker Cells by Recruiting the
            Epithelial-Mesenchymal Transition Program.
REFERENCE   3  (bases 1 to 4611)
  AUTHORS   Wang,F., Zhao,H., Yin,L., Tang,Y., Wang,X., Zhao,Q., Wang,T. and
            Huang,C.
  TITLE     Transcription Factor TBX18 Reprograms Vascular Smooth Muscle Cells
            of Ascending Aorta to Pacemaker-Like Cells
  JOURNAL   DNA Cell Biol 38 (12), 1470-1479 (2019)
   PUBMED   31633376
  REMARK    GeneRIF: indicated that transcription factor TBX18 could reprogram
            vascular smooth muscle cells into pacemaker-like cells in vitro
REFERENCE   4  (bases 1 to 4611)
  AUTHORS   Gu,J.M., Grijalva,S.I., Fernandez,N., Kim,E., Foster,D.B. and
            Cho,H.C.
  TITLE     Induced cardiac pacemaker cells survive metabolic stress owing to
            their low metabolic demand
  JOURNAL   Exp Mol Med 51 (9), 1-12 (2019)
   PUBMED   31519870
  REMARK    GeneRIF: our data demonstrate that TBX18-iPMs exhibit a low
            metabolic demand that matches their mitochondrial morphology and
            ability to withstand metabolic insult
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4611)
  AUTHORS   Li,Y., Yang,M., Zhang,G., Li,L., Ye,B., Huang,C. and Tang,Y.
  TITLE     Transcription factor TBX18 promotes adult rat bone mesenchymal stem
            cell differentiation to biological pacemaker cells
  JOURNAL   Int J Mol Med 41 (2), 845-851 (2018)
   PUBMED   29207072
  REMARK    GeneRIF: The findings demonstrated that direct conversion of Bone
            mesenchymal stem cells to biological pacemaker cells via TBX18 is a
            feasible method in the field of cardiology.
REFERENCE   6  (bases 1 to 4611)
  AUTHORS   Wiese,C., Grieskamp,T., Airik,R., Mommersteeg,M.T., Gardiwal,A., de
            Gier-de Vries,C., Schuster-Gossler,K., Moorman,A.F., Kispert,A. and
            Christoffels,V.M.
  TITLE     Formation of the sinus node head and differentiation of sinus node
            myocardium are independently regulated by Tbx18 and Tbx3
  JOURNAL   Circ Res 104 (3), 388-397 (2009)
   PUBMED   19096026
REFERENCE   7  (bases 1 to 4611)
  AUTHORS   Trowe,M.O., Maier,H., Schweizer,M. and Kispert,A.
  TITLE     Deafness in mice lacking the T-box transcription factor Tbx18 in
            otic fibrocytes
  JOURNAL   Development 135 (9), 1725-1734 (2008)
   PUBMED   18353863
REFERENCE   8  (bases 1 to 4611)
  AUTHORS   Farin,H.F., Bussen,M., Schmidt,M.K., Singh,M.K.,
            Schuster-Gossler,K. and Kispert,A.
  TITLE     Transcriptional repression by the T-box proteins Tbx18 and Tbx15
            depends on Groucho corepressors
  JOURNAL   J Biol Chem 282 (35), 25748-25759 (2007)
   PUBMED   17584735
REFERENCE   9  (bases 1 to 4611)
  AUTHORS   Airik,R., Bussen,M., Singh,M.K., Petry,M. and Kispert,A.
  TITLE     Tbx18 regulates the development of the ureteral mesenchyme
  JOURNAL   J Clin Invest 116 (3), 663-674 (2006)
   PUBMED   16511601
REFERENCE   10 (bases 1 to 4611)
  AUTHORS   Bussen,M., Petry,M., Schuster-Gossler,K., Leitges,M., Gossler,A.
            and Kispert,A.
  TITLE     The T-box transcription factor Tbx18 maintains the separation of
            anterior and posterior somite compartments
  JOURNAL   Genes Dev 18 (10), 1209-1221 (2004)
   PUBMED   15155583
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063222.1, XM_236458.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4611
                     /gene="Tbx18"
                     /note="T-box transcription factor 18"
                     /db_xref="GeneID:315870"
                     /db_xref="RGD:1309856"
     exon            1..728
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..2257
                     /gene="Tbx18"
                     /note="T-box18"
                     /codon_start=1
                     /product="T-box transcription factor TBX18"
                     /protein_id="NP_001101643.1"
                     /db_xref="GeneID:315870"
                     /db_xref="RGD:1309856"
                     /translation="MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLATE
                     EAAGAVDDAGCSRGGGAREHRCTEADEDPAPPPPAAGSASGPARSCTDAERSCASRGP
                     AGSCEDGFLQGASPLASPGGSPKGSPVPGLARPGTPLPAPQAPRVDLQGAELWKRFHE
                     IGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAG
                     NADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRV
                     HIIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGF
                     RDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNTSSSALLPGTGNGVPAAH
                     PHLLSGSSCSSPAFHLGPNTSQLCSMAPADYSACARSGLALNRYSTSLAETYNRLTNQ
                     SSETFAPPRTPSYVSVSSPSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIIPSP
                     SSNAFAANQTHQGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSG
                     TMTDRQMLPPVEGVHLLGSGNQQSFFDSRTLGSLTLSSSQVSAHMV"
     exon            729..933
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1035
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1207
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1375
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1440
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1535
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..4611
                     /gene="Tbx18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctctcctg cctggaagtg ctgacagatc aaggcaacaa atttcaatta caatccctaa
       61 tttgtgtccg cagagtgttt tttttccccc gtgttagtcc tctcgggcgc atcagtcgag
      121 gcagatcttg gagcagcaag aggaggtgga gggtttggga gtcaaaaagt gcaccactga
      181 gctcgaagga gagacagagg gaaggaaact tggcggccgc gttcctgctt cctcggatcc
      241 caacgccgga gagaaagagg aaacggcaaa tttgtttttg cccgcggcta ggaagggaac
      301 agatctcggg aggcttcggg agctgcggag cgtttggtgg ggccaggagg gcgaacgcgt
      361 gcgtgcgccc cagccgcggg tatatgagag aggggcgggc gggctcgggg cggcggggat
      421 ggcggagaag cggaggggct caccgtgcag catgctaagc ctcaaggcgc atgccttctc
      481 ggtggaggca ctgatcggcg ccgaaaagca gcaacagctt caaaagaagc ggagaaagct
      541 ggccacggaa gaggcggccg gggcggtgga cgacgcaggc tgcagccgtg gcggaggcgc
      601 gagagaacac cgctgcaccg aggccgacga agacccggct cccccgccgc ccgcagccgg
      661 gtcggcgtcc gggccggcgc ggagctgcac ggacgccgaa cggagctgtg cttcccgcgg
      721 acccgcgggc agctgtgagg acggtttctt gcagggcgct tccccgctgg cgtccccggg
      781 aggttccccg aaagggtctc cggtacctgg cctggcacgg ccggggaccc cgctgcccgc
      841 gccacaggcc ccaagagtgg atctgcaagg agcagaactc tggaaacgct ttcacgaaat
      901 aggcaccgag atgatcatca ccaaagccgg caggcgcatg tttccagcga tgcgagtgaa
      961 gatctccggg ttagatcctc accaacaata ttacattgcc atggatattg tgcccgtgga
     1021 caacaaaaga tacagatatg tttaccacag ctctaaatgg atggtggcag gaaatgctga
     1081 ttccccggtg ccaccccgag tatacattca tccagactca ccggcctctg gggagacttg
     1141 gatgagacaa gtgatcagct tcgacaagct gaaacttacc aacaacgaac tggatgacca
     1201 aggccatatc attcttcatt ctatgcacaa ataccaaccg cgagtgcaca tcatccgtaa
     1261 agactgcggg gacgatctgt cccccatcaa gcccgttccc tcgggagagg gagtgaaggc
     1321 gttctccttt ccagaaacag tcttcacaac tgtcactgcc tatcagaatc agcagattac
     1381 tcgcctgaag atagacagga atccatttgc caaaggcttc cgagactctg ggaggaacag
     1441 aatgggtttg gaagctctgg tggagtcata tgcattctgg aggccatcac tacgaactct
     1501 cacctttgaa gatattcctg gaatcccaaa gcaaggcaac acaagttctt cagctctact
     1561 cccaggtact gggaatggcg ttcctgctgc gcaccctcac ctgctgtctg gctcctcctg
     1621 ttcctctcct gccttccatc tggggcccaa caccagccag ctgtgtagta tggctcccgc
     1681 tgactattct gcctgcgccc ggtcaggcct tgctctcaac cgatacagca cgtccttggc
     1741 agagacctac aacaggctta ccaaccagag cagcgagacc tttgccccac ccaggactcc
     1801 ctcctatgtg agtgtgagca gcccctctgt gaacatgtcc atgggcggca cggacgggga
     1861 caccttcagc tgcccgcaga ccagcctgtc catgcagatt tcaggaatgt cccctcaact
     1921 gcagtacatc atcccgtcac catccagcaa tgcctttgct gctaaccaga cccatcaggg
     1981 ttcctacaac actttccgat tgcacagtcc ctgtgccttg tatggatata acttctccac
     2041 atcccccaaa ctggctgcca gtcctgagaa aattgtctct tcccaaggaa gtttcttggg
     2101 gtcgtcaccg agtgggacca tgacggatcg gcagatgttg cccccggtgg aaggagtgca
     2161 cctgctcggc agtgggaacc agcagagttt ctttgactcc aggaccctag gaagcttgac
     2221 tctgtcatct tctcaagtgt ctgcgcatat ggtctgatga ggcctttaag ttaaacgacg
     2281 tttgaatcta atggatcttc cttatttttt tttaaagcaa tatgggaaaa atgtacatat
     2341 ggtagaaaag gaaggctgac tgagtatttt tacttcctca tggcaagatt gtaacacgta
     2401 ttacattatg gtgtgtgcgt atgctgtata tacacagcat gtagcatacg gaagctttct
     2461 ctctgccttg tttattcagt tccacatagc attggcgacg tgtacttcag actctaaagg
     2521 taaaacggta cacttgaaag ttggtactga tgttaccaaa gactcttcta atgcccacat
     2581 gcgaagggat ggggtttatt acagcagttt cctacatacc taaccaaaga tttgtaactt
     2641 catctatcag aagcgtgctc ttagcagtct gtattgaaat gttgatagca ctgcgatctc
     2701 ttttatcctt ggatttgatg tgagaacgtc aaaagtgcaa aagccagtta aatcttagtg
     2761 tatttctgag gtatctaaca ataaaagctt agctttactt tccttctcat tttgttgttt
     2821 ttgtttgttt gtttgttgtt tgagacaggg ttctctgtgg agtttttgct gtcctggaac
     2881 tcactctgtg caccaggttg gtctctaagg cacagttatc agcctgcccc tgcctcccaa
     2941 gtgctgggat tgaaggtgta tgccagcact gcacagccat tcctgtttct tctcactgac
     3001 tgcagacctg gggtctgtca aaatccatag ctgtgctgat gtttgttttc tgaaggaagg
     3061 tggaggacag ccttgtgact ttccactttc taatgaacag aaaatcttac ttcctgcaaa
     3121 aaaaaaaaaa aaagaaatca tatctctgat attttgaaat tgttgcccac ttcatttagt
     3181 ttatcaagaa ggccatgaaa ctgtcacgta aacgttctaa aacgccaata ttcactagtg
     3241 gaggagtagg actgtatggc atgaaaaatt aaaagaaata agcatacttc tcagattctt
     3301 ctgtcccagt gagtaatgtt tattatttat tttttaatca gaggattgaa tagtgttaag
     3361 cagtccttag gcctttgtgt ggcttggttt cttaggctat actttttcat ctttgaactg
     3421 cttgacccct gggctatgag ttaggaaaag gcatgtacac cacttattta tgtctcataa
     3481 ctcctacaaa ttgaaatgtt ccccctccct tgtcttatct ccctgtctga ctcttttcca
     3541 aaacagacac attttgcctt tgtggtgcta gtgctgcgag gaatttcaga gggttatctc
     3601 cggcaatctg tcttgtggtt gtagtcaaag gccaaagtct gtcactagaa aggcctccta
     3661 agaggaccac ggaggaagat actcattatg ataagtgagc tataaaactt ttaacctcaa
     3721 cagcatttta actttggaag tgaagaagtg aaaacaggac tgacctctaa aggttcctaa
     3781 aatgaacgcg tggctcagga gttcagaagc aggaactttg atagtagata aacaggaaag
     3841 agtggagcat ggatggctcc ttctgctggg aatctaaagg gatgtgtctg cccagctgtt
     3901 ctctgcactt cacgtctaac aaacgaagag aatgttttcc ttctgtttat ccacggagtt
     3961 gctctaactt gtccctaatt tggaccggaa ggagtctcca tcccactttc tttctttact
     4021 gaacggaatc actgctgaat attgagggga atgttctgtt tagacagaac acattctgga
     4081 tttgcctctg tttatagttt ctgacaagat tccccatgga ttctgtaaga aggtcatcaa
     4141 atgaatagca aattttaaat ccaagattag tattaaaggg acatgaaata tttgcaatgg
     4201 atagagctag ctaaggcttt atgcgtggta ttattaactt gacagagatt tggaaagaga
     4261 ggctttgaga acgagtctag cctttgggcc attctaattc gcggaagaca gctttccacc
     4321 ctgagagagc atccggtggg gcattttcct tttgctgttg gtcatttgag atgatgccat
     4381 gatgtgagga gacatttcta ttaatcattt tggtaaaacc tagcaatatt gtacaaatgt
     4441 tctttctttt atgttttgct gtaaataata ataatcacca tgtcagccca aagactaata
     4501 accttctatt gttgtgctga atgacacaca tgcattgata attataatta tctatctgta
     4561 ttttattaag aattgcttaa gaaattatat taaagtacat tatgaaacca t
//
