LOCUS       NM_001415704            3281 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus T-box transcription factor 1 (Tbx1), transcript
            variant 1, mRNA.
ACCESSION   NM_001415704 XM_006248619
VERSION     NM_001415704.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3281)
  AUTHORS   Wu,Y., Xia,Y., Yue,C., Xin,T., Wang,Q., Zhang,H., Shen,C., Shen,M.,
            Gu,Y. and Shen,J.
  TITLE     Brachyury positively regulates extracellular matrix synthesis via
            directly promoting aggrecan transcription in nucleus pulposus
  JOURNAL   FASEB J 37 (6), e22976 (2023)
   PUBMED   37227215
  REMARK    GeneRIF: Brachyury positively regulates extracellular matrix
            synthesis via directly promoting aggrecan transcription in nucleus
            pulposus.
REFERENCE   2  (bases 1 to 3281)
  AUTHORS   Alghamdi,M., Al Khalifah,R., Al Homyani,D.K., Alkhamis,W.H.,
            Arold,S.T., Ekhzaimy,A., El-Wetidy,M., Kashour,T. and Halwani,R.
  TITLE     A Novel TBX1 Variant Causing Hypoparathyroidism and Deafness
  JOURNAL   J Endocr Soc 4 (2), bvz028 (2019)
   PUBMED   32110744
  REMARK    Erratum:[J Endocr Soc. 2020 Jun 11;4(6):bvaa036. PMID: 32548537]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3281)
  AUTHORS   Cao,M.L., Zhu,B.L., Sun,Y.Y., Qiu,G.R., Fu,W.N. and Jiang,H.K.
  TITLE     MicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by
            Targeting TBX1 through the JAK2/STAT1 Pathway
  JOURNAL   Cytogenet Genome Res 159 (4), 190-200 (2019)
   PUBMED   31982878
  REMARK    GeneRIF: MiR-144 acts as a proliferation inhibitor in
            cardiomyocytes via the TBX1/JAK2/STAT1 axis
REFERENCE   4  (bases 1 to 3281)
  AUTHORS   Funato,N. and Yanagisawa,H.
  TITLE     Deletion of the T-box transcription factor gene, Tbx1, in mice
            induces differential expression of genes associated with cleft
            palate in humans
  JOURNAL   Arch Oral Biol 95, 149-155 (2018)
   PUBMED   30121012
REFERENCE   5  (bases 1 to 3281)
  AUTHORS   Jaouadi,A., Tabebi,M., Abdelhedi,F., Abid,D., Kamoun,F.,
            Chabchoub,I., Maatoug,S., Doukali,H., Belghuith,N., Ksentini,M.A.,
            Keskes,L.A., Triki,C., Hachicha,M., Kamoun,S. and Kamoun,H.
  TITLE     A novel TBX1 missense mutation in patients with syndromic
            congenital heart defects
  JOURNAL   Biochem Biophys Res Commun 499 (3), 563-569 (2018)
   PUBMED   29596833
REFERENCE   6  (bases 1 to 3281)
  AUTHORS   Vitelli,F., Morishima,M., Taddei,I., Lindsay,E.A. and Baldini,A.
  TITLE     Tbx1 mutation causes multiple cardiovascular defects and disrupts
            neural crest and cranial nerve migratory pathways
  JOURNAL   Hum Mol Genet 11 (8), 915-922 (2002)
   PUBMED   11971873
REFERENCE   7  (bases 1 to 3281)
  AUTHORS   Lindsay,E.A., Vitelli,F., Su,H., Morishima,M., Huynh,T.,
            Pramparo,T., Jurecic,V., Ogunrinu,G., Sutherland,H.F.,
            Scambler,P.J., Bradley,A. and Baldini,A.
  TITLE     Tbx1 haploinsufficieny in the DiGeorge syndrome region causes
            aortic arch defects in mice
  JOURNAL   Nature 410 (6824), 97-101 (2001)
   PUBMED   11242049
REFERENCE   8  (bases 1 to 3281)
  AUTHORS   Jerome,L.A. and Papaioannou,V.E.
  TITLE     DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
  JOURNAL   Nat Genet 27 (3), 286-291 (2001)
   PUBMED   11242110
REFERENCE   9  (bases 1 to 3281)
  AUTHORS   Merscher,S., Funke,B., Epstein,J.A., Heyer,J., Puech,A., Lu,M.M.,
            Xavier,R.J., Demay,M.B., Russell,R.G., Factor,S., Tokooya,K.,
            Jore,B.S., Lopez,M., Pandita,R.K., Lia,M., Carrion,D., Xu,H.,
            Schorle,H., Kobler,J.B., Scambler,P., Wynshaw-Boris,A.,
            Skoultchi,A.I., Morrow,B.E. and Kucherlapati,R.
  TITLE     TBX1 is responsible for cardiovascular defects in
            velo-cardio-facial/DiGeorge syndrome
  JOURNAL   Cell 104 (4), 619-629 (2001)
   PUBMED   11239417
REFERENCE   10 (bases 1 to 3281)
  AUTHORS   Sinha,S., Abraham,S., Gronostajski,R.M. and Campbell,C.E.
  TITLE     Differential DNA binding and transcription modulation by three
            T-box proteins, T, TBX1 and TBX2
  JOURNAL   Gene 258 (1-2), 15-29 (2000)
   PUBMED   11111039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 23, 2022 this sequence version replaced XM_006248619.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.44037.1,
                                           SRR22582419.827574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-911               JAXUCZ010000011.1  95915404-95916314
            912-1257            JAXUCZ010000011.1  95917438-95917783
            1258-1359           JAXUCZ010000011.1  95919180-95919281
            1360-1531           JAXUCZ010000011.1  95920074-95920245
            1532-1687           JAXUCZ010000011.1  95920794-95920949
            1688-1755           JAXUCZ010000011.1  95921435-95921502
            1756-1856           JAXUCZ010000011.1  95921585-95921685
            1857-3281           JAXUCZ010000011.1  95921968-95923392
FEATURES             Location/Qualifiers
     source          1..3281
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3281
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /note="T-box transcription factor 1"
                     /db_xref="GeneID:360737"
                     /db_xref="RGD:1307734"
     exon            1..911
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             728..2320
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     transcription factor TBX1"
                     /codon_start=1
                     /product="T-box transcription factor TBX1 isoform 1"
                     /protein_id="NP_001402633.1"
                     /db_xref="GeneID:360737"
                     /db_xref="RGD:1307734"
                     /translation="MDARSPLSARASAFSIASLVAAEASEGTAHRGPRPSDRAKLRRL
                     PGSPAGMHFSTVTRDMEAFAASSLSGLGAPSPGADPFGPREPPPPRYDPCTAAPGAPG
                     PPPPPRAYPFAPAPGAASSSAAESEGPGASRAAAAKAPVKKNPKVASVSVQLEMKALW
                     DEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSS
                     WLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHR
                     YQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKG
                     FRDCDPEDWPRNHRPGALPLVSAFARSRNPVASPTQPNGADKDVAEARREFDRDSGPA
                     ALGDATHPPQLLARVLSPALPGPGGLVPLPGGSGGRHSPPHADLRLEAPGASEPLHHH
                     PYKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHPHAHPHAHPHHHHHPAVNPAAAAAA
                     AAAANVYSSAAAPPGAYDYCPR"
     exon            912..1257
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1359
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1531
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1687
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1755
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1856
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..3281
                     /gene="Tbx1"
                     /gene_synonym="T-box 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcgggc ggtgcgcgcg gggtgcgcgt gacgctgggg ctcccggtct tgtgcggcct
       61 gggcggcgtc ccacggctcg cttccccacc acgaaagcaa gctgacccaa ggggcctgta
      121 ggggcaattg ttggtgaggt ccagctctgc ggcacggagg gacggaggac tccgcagccc
      181 tggggctatc tgcctgtggc ttttgcgaga gccggagccg ctctcttacc caggtgcagg
      241 ggccgctggg gaggaggtgg aggcaggtgg ggccaagggc agggctagac tcaggcagcc
      301 cctcagtgcc tcgtcagtgc cctgccatct cagactggga ctgagtgctc gagacataga
      361 aacttctcct ttggggctgt agactctggt ggtggcttcg ccgaatagag gggacgccca
      421 acctctgcag aagctgcagg atgttcaagg ggcgttggtc acacagggcc ccgggaggag
      481 agaccaggga cagagagctt gcaaggcagg agggccctga atttccaggg cgctccaact
      541 gttcggactc ccgggccaat attggctgaa aatggggggg tctcatgacg ccataatccc
      601 ttgagccctg gaccggcggc tgtgagtggc accacaggcc cccgcccccg ggccccctgc
      661 gctgggctgg gcgcggtgcg gcagggcgta cgcagtcgga ggcggcgccg gtcaggcccg
      721 ggcgcctatg gacgcgcgga gcccgctgtc tgcccgggcc agcgcattca gcatcgcctc
      781 tcttgttgca gccgaggcct cggagggcac cgcccaccgg ggccccaggc cctcggaccg
      841 ggcgaaactt cgccggctac caggatcccc agccgggatg cacttcagta cagtcaccag
      901 ggacatggaa gccttcgcgg ccagcagtct gagcggcctg ggagccccgt cgcctggcgc
      961 cgacccgttc ggccctcggg agccgccgcc accgcgctac gacccgtgca ccgctgcccc
     1021 cggtgccccg ggcccgccgc ctccgccgcg cgcctaccct ttcgcgcccg cccccggggc
     1081 ggctagcagc tcggcggcgg agtccgaggg tcctggggct agccgcgcgg ccgcggccaa
     1141 ggcgccggtg aagaagaacc caaaggtggc cagcgtgagc gtgcagctgg aaatgaaggc
     1201 gctatgggac gagttcaatc agctgggcac cgagatgatc gtcaccaagg caggcagacg
     1261 aatgttcccc accttccaag tgaagctttt tggaatggac ccgatggctg actacatgct
     1321 cctcatggac tttgtgcctg tggatgacaa gcgctaccgg tacgctttcc acagctcctc
     1381 ctggctggtg gctggcaagg cagatcctgc cacccctggc cgagtgcact accacccgga
     1441 ctcgcccgcg aagggcgcgc agtggatgaa gcagatcgta tctttcgaca agctgaagct
     1501 caccaataac ctgctggacg acaatggcca cattattctt aactccatgc acagatacca
     1561 gccccgtttc catgttgttt atgtggaccc tcgaaaagac agcgagaaat acgcagagga
     1621 gaacttcaaa acttttgtgt ttgaggagac acgcttcact gcagtcaccg cctaccagaa
     1681 tcaccggatc acgcagctta agattgccag caaccccttc gccaaaggct tccgggactg
     1741 cgacccggag gactggcccc gaaaccaccg gcccggagcg ctgccgcttg taagtgcctt
     1801 tgctcgctct cggaatcccg tggcttcccc cacgcagccc aacggagcgg acaaagatgt
     1861 ggcagaagcc cggcgcgagt tcgaccgtga ctctggaccc gcagcgctcg gcgacgccac
     1921 gcacccgccg cagctgctgg cgcgcgtgct gagccccgca ctgcctgggc ctggtggcct
     1981 cgtcccgcta cctggcggat ccggaggccg ccacagtccc ccgcacgctg atctgcgcct
     2041 ggaggctccg ggcgcatccg aaccgctgca ccaccatccc tacaagtacc cggcggccgc
     2101 ctacgaccac tacctcgggg ccaagagccg gccggcgccc tacccgctgc caggcctgcg
     2161 cggccacggc taccacccac atgcgcaccc gcacgcgcac ccgcaccacc accaccaccc
     2221 ggcggtgaac ccggccgccg ccgccgccgc agcagcagca gccaacgtgt actcctcggc
     2281 ggccgcgccg cccggtgcct acgactactg ccccagatag tgcgcccgcg cgcgggcccc
     2341 aagggccacc caaggacgtg ttccccatct ggggagccat gcgggcctcc cgcccgccag
     2401 tgccaaagct ctcgtccgag gcggaaggaa atggtattta ttgttctccg cgagaccgcg
     2461 tcgcctccgg cccggccggc aatagcagtg tagacgaccc gagtgagccc cgcctgcggg
     2521 cggtgtagat acatgtagat atcttgtaga tactgtagat actgcaccgg cgccgatttc
     2581 ataaacggtt tcgcctcttt tggaaactgc cggtgtggct attcttttgc atctaattcg
     2641 attgggctgg gcgtctttgg ggcagagggc ttagtcttct cagccctggt caccggtgtg
     2701 agcgtggagc aagggtctcc ctcccttctc tcccctgggg ctcactgcct cccttccgca
     2761 gctcctccgg tccactacag gctgggcgcg cggtttaccc agggcagaca cctgcagctg
     2821 gtggggcagg atttgggcct gaacgctggc ctgtttacag gactagacca taagtttttc
     2881 cgtgaaagcc gggaatgata ttcgggacag gacactgtcc atccggcctc ggatggcatg
     2941 cggaaagcag tgggctcgac tcttccagcg ttgccctggc ctggcaccag cccagaattg
     3001 tgtttccccc tgtttattga ctttattccc tgaatgtccc cacagagtga tggggagcgg
     3061 gggtcgcaca atgacagtgg tcatgagtca tcttgaaact cccggtgaag caatttttcc
     3121 caggccaggt ggctgggtga cctgtctcca ttaactcaac actatcatag tggccaaagg
     3181 aaccctttga tccctccctt cctgcgcccc agcaggaagg gccaaccgaa ggccagccag
     3241 agttaaggct ggcttatgcc tcaaataaat gggaaatgtc a
//
