LOCUS       NM_001191070            3964 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus T-box brain transcription factor 1 (Tbr1), mRNA.
ACCESSION   NM_001191070 XM_001056898
VERSION     NM_001191070.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3964)
  AUTHORS   Chao,M.W., Chen,C.P., Yang,Y.H., Chuang,Y.C., Chu,T.Y. and
            Tseng,C.Y.
  TITLE     N-acetylcysteine attenuates lipopolysaccharide-induced impairment
            in lamination of Ctip2-and Tbr1- expressing cortical neurons in the
            developing rat fetal brain
  JOURNAL   Sci Rep 6, 32373 (2016)
   PUBMED   27577752
  REMARK    GeneRIF: An increase in fetal cortical thickness was noted in the
            LPS-treated group. In the enlarged fetal cortex, laminar
            positioning of the early born cortical cells expressing Tbr1 and
            Ctip2 was disrupted, with a scattered distribution
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3964)
  AUTHORS   Deriziotis,P., O'Roak,B.J., Graham,S.A., Estruch,S.B.,
            Dimitropoulou,D., Bernier,R.A., Gerdts,J., Shendure,J.,
            Eichler,E.E. and Fisher,S.E.
  TITLE     De novo TBR1 mutations in sporadic autism disrupt protein functions
  JOURNAL   Nat Commun 5, 4954 (2014)
   PUBMED   25232744
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3964)
  AUTHORS   Huang,T.N., Chuang,H.C., Chou,W.H., Chen,C.Y., Wang,H.F., Chou,S.J.
            and Hsueh,Y.P.
  TITLE     Tbr1 haploinsufficiency impairs amygdalar axonal projections and
            results in cognitive abnormality
  JOURNAL   Nat Neurosci 17 (2), 240-247 (2014)
   PUBMED   24441682
REFERENCE   4  (bases 1 to 3964)
  AUTHORS   Srinivasan,K., Leone,D.P., Bateson,R.K., Dobreva,G., Kohwi,Y.,
            Kohwi-Shigematsu,T., Grosschedl,R. and McConnell,S.K.
  TITLE     A network of genetic repression and derepression specifies
            projection fates in the developing neocortex
  JOURNAL   Proc Natl Acad Sci U S A 109 (47), 19071-19078 (2012)
   PUBMED   23144223
REFERENCE   5  (bases 1 to 3964)
  AUTHORS   Bedogni,F., Hodge,R.D., Elsen,G.E., Nelson,B.R., Daza,R.A.,
            Beyer,R.P., Bammler,T.K., Rubenstein,J.L. and Hevner,R.F.
  TITLE     Tbr1 regulates regional and laminar identity of postmitotic neurons
            in developing neocortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 13129-13134 (2010)
   PUBMED   20615956
REFERENCE   6  (bases 1 to 3964)
  AUTHORS   Wang,V.Y., Rose,M.F. and Zoghbi,H.Y.
  TITLE     Math1 expression redefines the rhombic lip derivatives and reveals
            novel lineages within the brainstem and cerebellum
  JOURNAL   Neuron 48 (1), 31-43 (2005)
   PUBMED   16202707
REFERENCE   7  (bases 1 to 3964)
  AUTHORS   Wang,T.F., Ding,C.N., Wang,G.S., Luo,S.C., Lin,Y.L., Ruan,Y.,
            Hevner,R., Rubenstein,J.L. and Hsueh,Y.P.
  TITLE     Identification of Tbr-1/CASK complex target genes in neurons
  JOURNAL   J Neurochem 91 (6), 1483-1492 (2004)
   PUBMED   15584924
REFERENCE   8  (bases 1 to 3964)
  AUTHORS   Shin,D.M., Korada,S., Raballo,R., Shashikant,C.S., Simeone,A.,
            Taylor,J.R. and Vaccarino,F.
  TITLE     Loss of glutamatergic pyramidal neurons in frontal and temporal
            cortex resulting from attenuation of FGFR1 signaling is associated
            with spontaneous hyperactivity in mice
  JOURNAL   J Neurosci 24 (9), 2247-2258 (2004)
   PUBMED   14999075
REFERENCE   9  (bases 1 to 3964)
  AUTHORS   Hevner,R.F., Miyashita-Lin,E. and Rubenstein,J.L.
  TITLE     Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and
            Pax6 mutant mice: evidence that cortical and thalamic axons
            interact and guide each other
  JOURNAL   J Comp Neurol 447 (1), 8-17 (2002)
   PUBMED   11967891
REFERENCE   10 (bases 1 to 3964)
  AUTHORS   Hsueh,Y.P., Wang,T.F., Yang,F.C. and Sheng,M.
  TITLE     Nuclear translocation and transcription regulation by the
            membrane-associated guanylate kinase CASK/LIN-2
  JOURNAL   Nature 404 (6775), 298-302 (2000)
   PUBMED   10749215
  REMARK    Erratum:[Nature 2002 May 9;417(6885):205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and BF281828.1.
            
            On Aug 7, 2016 this sequence version replaced NM_001191070.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no transcript was available for the
            full length of the gene. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-947               JAXUCZ010000003.1  66759803-66760749
            948-1102            JAXUCZ010000003.1  66761324-66761478
            1103-1224           JAXUCZ010000003.1  66762054-66762175
            1225-1298           JAXUCZ010000003.1  66762771-66762844
            1299-1640           BF281828.1         1-342
            1641-3964           JAXUCZ010000003.1  66767303-66769626
FEATURES             Location/Qualifiers
     source          1..3964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..3964
                     /gene="Tbr1"
                     /note="T-box brain transcription factor 1"
                     /db_xref="GeneID:680427"
                     /db_xref="RGD:1591773"
     exon            1..947
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2301
                     /gene="Tbr1"
                     /note="T-box brain gene 1; T-box, brain, 1-like"
                     /codon_start=1
                     /product="T-box brain protein 1"
                     /protein_id="NP_001177999.2"
                     /db_xref="GeneID:680427"
                     /db_xref="RGD:1591773"
                     /translation="MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTD
                     NLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAA
                     DRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSL
                     LSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFH
                     RHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGK
                     ADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQ
                     PRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFR
                     DNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAG
                     AGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAG
                     NAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWP
                     NSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSID
                     SSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS"
     exon            948..1102
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1224
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1383
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1445
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..3964
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctaacca atggcaggag ccgtttcatc ggctgcataa gcagcaagat caaaagtgag
       61 ccttttctga ttgctgcata gtgtcaattg gccaatctct tctcccaggg aaaaaaaaaa
      121 gtaaatcaaa cctttgagaa gcatttgctg gttgaagtgc tttctgtcta gtgaggggtc
      181 tgtggattcc tagtttatga taaacaggac tttaaaaccc agggacggga gggccagcct
      241 tcaggttcta gagctatgca gctggagcat tgcctctctc cttctatcat gctctccaag
      301 aaatttctca atgtgagcag cagctaccca cattcgggcg gatctgagct tgtcttgcat
      361 gatcatccca ttatctcgac cactgacaac ctggagagaa gttcaccttt gaaaaaaatt
      421 accaggggga tgacgaatca gtcagataca gacaattttc ctgactccaa ggactcacca
      481 ggggacgtcc agagaagtaa actctctcct gtcttggacg gggtctctga gcttcgtcac
      541 agtttcgatg gctctgctgc agatcgttac ctcctctctc agtccagcca gccacagtct
      601 gcggccaccg ctcccagtgc catgttcccg taccccggcc agcacggacc ggcgcatccc
      661 gccttctcca tcggcagccc cagtcgctac atggcccacc acccggtcat caccaacgga
      721 gcttacaaca gcctgctgtc caactcttcg ccgcagggct accccaccgc cggctacccc
      781 tacccacagc agtacggcca ctcctaccaa ggagccccat tctaccagtt ctcctccacc
      841 cagcccgggt tggtgcccgg caaggcgcag gtatacctgt gcaacaggcc actttggctg
      901 aaatttcatc ggcatcaaac ggagatgatc atcactaaac agggaaggcg catgtttccc
      961 tttttgagtt ttaacatttc tggtctcgat cccaccgctc attacaatat ttttgtggat
     1021 gtgattttgg cggatcccaa tcactggagg tttcaaggag gcaaatgggt tccttgtggc
     1081 aaagcggaca ccaatgtgca aggaaaccgg gtctatatgc atccggattc ccccaacact
     1141 ggggctcact ggatgcggca agaaatctcg tttggaaaat taaaacttac caacaacaag
     1201 ggagcatcaa acaacaatgg gcagatggtg gttttacagt ccctgcacaa gtaccagccc
     1261 cgtctgcacg tggtggaagt gaatgaggac ggcacagagg acaccagcca gccaggccgc
     1321 gtccagacgt tcactttccc agagactcag ttcatcgctg tcaccgccta tcagaacacc
     1381 gatattacac aactaaaaat agatcataac ccctttgcaa aaggatttcg agataactat
     1441 gacacgatct acacgggctg cgacatggac cgcttgaccc cgtcgcccaa cgactctccg
     1501 cgctctcaga tcgtgcccgg cgctcgctac gccatggccg gctctttcct gcaagatcaa
     1561 ttcgtgagca actacgccaa ggcccgcttc cacccgggcg ccggcgcggg ccccgggcct
     1621 ggcacggacc gcagcgtgcc gcacaccaac gggctactgt ccccgcaaca ggccgaggac
     1681 ccgggcgcgc cgtcgccgca gcgctggttc gtgacgccgg ccaacaaccg gctggacttc
     1741 gcggcctcgg cctacgatac ggccacggac ttcgccggca acgcggccac gctgctgtcg
     1801 tacgcggccg cgggcgtgaa ggcgctgccg ctgcaggccg cgggctgcac gggccgcccg
     1861 ctcggctact acgccgaccc ttccggctgg ggcgcgcgca gccctccgca gtactgcggc
     1921 gccaagtcgg gctccgtgct cccctgctgg cccaacagcg ctgcggccgc cgcgcgcatg
     1981 gcgggcgcca acccctactt aggcgaggag gccgagggcc tggcggccga gcgctctccg
     2041 ctggcgcccg ccgccgagga cgccaagccc aaggacctgt ccgactccag ctggatcgag
     2101 acgccctcct cgatcaagtc catcgactcg agcgactcgg ggatttacga gcaggccaag
     2161 cggaggcgga tctctccggc cgacacgccg gtgtccgaga gctcgtcccc actcaagagc
     2221 gaggtgctgg cccagcggga ctgcgagaag aactgcgcca aggacatagg cggctactat
     2281 ggcttctact cgcacagcta ggccgccagc ccgctcgccc gtgcccccgg cccctcagct
     2341 cggccccacg tcctcctccc caggcccgct cttgcgcact cgctctttca cttgacgctc
     2401 gatgaccgtc tgcggggata agtgcaggtc tcccactatg attttaaaac tttttttttc
     2461 tctttctttc tgcacagcca tctctgcagt tagcgcaccg accttgaacc tggctgtaaa
     2521 ccttgtggtt ttccaacttt tcgtctatga agttatgatc ctcccttttt tatttttctc
     2581 tctccttgtc ccccctcact ctctccttct ttctcttgga atgaaactct tcaactttag
     2641 gagacctggg caatcctgcc aggcgtcagc gattccgacc cgccttgtct tggcctccct
     2701 attaaccgta ggatgttgac tctagaacct gcacccaccc agcgcgtcct ttcttatacc
     2761 cgagtggatg gatggatgga tggatggtag ggatgttaat acttttagtg gaacaaagcc
     2821 tgtgaaatga ttgtatatag tgttaattta ttgtaacgaa tggctagttt ttattctcat
     2881 cgtcaaggca caaaaccagt tcacgcttaa ctttttatac ccttcctttt tttctccttt
     2941 tctttttctc ctctcattct ttctcttccc ccgccccctt tgttttcttg tgagatatta
     3001 aagatattct aagaggctct ggaaacacga aacaacactt catagtggtg gctttctcac
     3061 ttctcagttc gttgcatgat gtaaccacta tgtgccccag tgcacacagc atagctaagg
     3121 agaatccacc tgaacatcta taaaagctag tcgtctgttc ctaggcgagt cgattaagcg
     3181 acatgcttgc cacacagaca taactggagt tgtatgtgtc cctccctccc tccctccctc
     3241 ctgaatggaa tagctccaca tcagcaatat tattttgcct tatttgtttt tccccaaagt
     3301 gccaaatcca ctactggtct gtgcaggtgc caaatatgct gataaactgt ttccgactat
     3361 cttttcagtc cccactccac ctttctatgc tgtaaatctt tgtaatgaat aatctactaa
     3421 tgatagagat gactgaattg ttggtaacta tagtgtagtc tagtgaagat gaattgtgtg
     3481 agttgtatat tttactgcat tttagtttga aaacaattcc cccgccactt agagacagct
     3541 gaaatttgac tttcttggga aaacacttag cattattgca agtaagactg attcccccca
     3601 agtcttgtta tatttgataa ggagcattaa tccccctgga aatagattag taggatttct
     3661 aatgttgtgt agcaaactta tacttttttt gtactttaaa atcaatgtga aatatgcatc
     3721 atacacaata ttcaatctag attccagtct atggggggat ttttcctaat aggaattcag
     3781 ggtctaaacg tgtgtatact ttggctcttc tgtaaatcaa atgttgtgat ttttatattt
     3841 gttttgtttt gtctgtgaat tgaataattt atacaagtac acactccact gagaatcgtt
     3901 ttgttttctg ctcgtttgta tcgtctgtgt ataacaagta aaataaatct ggtaaaacgc
     3961 taaa
//
