LOCUS       NP_001177999             681 aa            linear   ROD 01-APR-2024
DEFINITION  T-box brain protein 1 [Rattus norvegicus].
ACCESSION   NP_001177999 XP_001056898
VERSION     NP_001177999.2
DBSOURCE    REFSEQ: accession NM_001191070.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 681)
  AUTHORS   Chao,M.W., Chen,C.P., Yang,Y.H., Chuang,Y.C., Chu,T.Y. and
            Tseng,C.Y.
  TITLE     N-acetylcysteine attenuates lipopolysaccharide-induced impairment
            in lamination of Ctip2-and Tbr1- expressing cortical neurons in the
            developing rat fetal brain
  JOURNAL   Sci Rep 6, 32373 (2016)
   PUBMED   27577752
  REMARK    GeneRIF: An increase in fetal cortical thickness was noted in the
            LPS-treated group. In the enlarged fetal cortex, laminar
            positioning of the early born cortical cells expressing Tbr1 and
            Ctip2 was disrupted, with a scattered distribution
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 681)
  AUTHORS   Deriziotis,P., O'Roak,B.J., Graham,S.A., Estruch,S.B.,
            Dimitropoulou,D., Bernier,R.A., Gerdts,J., Shendure,J.,
            Eichler,E.E. and Fisher,S.E.
  TITLE     De novo TBR1 mutations in sporadic autism disrupt protein functions
  JOURNAL   Nat Commun 5, 4954 (2014)
   PUBMED   25232744
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 681)
  AUTHORS   Huang,T.N., Chuang,H.C., Chou,W.H., Chen,C.Y., Wang,H.F., Chou,S.J.
            and Hsueh,Y.P.
  TITLE     Tbr1 haploinsufficiency impairs amygdalar axonal projections and
            results in cognitive abnormality
  JOURNAL   Nat Neurosci 17 (2), 240-247 (2014)
   PUBMED   24441682
REFERENCE   4  (residues 1 to 681)
  AUTHORS   Srinivasan,K., Leone,D.P., Bateson,R.K., Dobreva,G., Kohwi,Y.,
            Kohwi-Shigematsu,T., Grosschedl,R. and McConnell,S.K.
  TITLE     A network of genetic repression and derepression specifies
            projection fates in the developing neocortex
  JOURNAL   Proc Natl Acad Sci U S A 109 (47), 19071-19078 (2012)
   PUBMED   23144223
REFERENCE   5  (residues 1 to 681)
  AUTHORS   Bedogni,F., Hodge,R.D., Elsen,G.E., Nelson,B.R., Daza,R.A.,
            Beyer,R.P., Bammler,T.K., Rubenstein,J.L. and Hevner,R.F.
  TITLE     Tbr1 regulates regional and laminar identity of postmitotic neurons
            in developing neocortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 13129-13134 (2010)
   PUBMED   20615956
REFERENCE   6  (residues 1 to 681)
  AUTHORS   Wang,V.Y., Rose,M.F. and Zoghbi,H.Y.
  TITLE     Math1 expression redefines the rhombic lip derivatives and reveals
            novel lineages within the brainstem and cerebellum
  JOURNAL   Neuron 48 (1), 31-43 (2005)
   PUBMED   16202707
REFERENCE   7  (residues 1 to 681)
  AUTHORS   Wang,T.F., Ding,C.N., Wang,G.S., Luo,S.C., Lin,Y.L., Ruan,Y.,
            Hevner,R., Rubenstein,J.L. and Hsueh,Y.P.
  TITLE     Identification of Tbr-1/CASK complex target genes in neurons
  JOURNAL   J Neurochem 91 (6), 1483-1492 (2004)
   PUBMED   15584924
REFERENCE   8  (residues 1 to 681)
  AUTHORS   Shin,D.M., Korada,S., Raballo,R., Shashikant,C.S., Simeone,A.,
            Taylor,J.R. and Vaccarino,F.
  TITLE     Loss of glutamatergic pyramidal neurons in frontal and temporal
            cortex resulting from attenuation of FGFR1 signaling is associated
            with spontaneous hyperactivity in mice
  JOURNAL   J Neurosci 24 (9), 2247-2258 (2004)
   PUBMED   14999075
REFERENCE   9  (residues 1 to 681)
  AUTHORS   Hevner,R.F., Miyashita-Lin,E. and Rubenstein,J.L.
  TITLE     Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and
            Pax6 mutant mice: evidence that cortical and thalamic axons
            interact and guide each other
  JOURNAL   J Comp Neurol 447 (1), 8-17 (2002)
   PUBMED   11967891
REFERENCE   10 (residues 1 to 681)
  AUTHORS   Hsueh,Y.P., Wang,T.F., Yang,F.C. and Sheng,M.
  TITLE     Nuclear translocation and transcription regulation by the
            membrane-associated guanylate kinase CASK/LIN-2
  JOURNAL   Nature 404 (6775), 298-302 (2000)
   PUBMED   10749215
  REMARK    Erratum:[Nature 2002 May 9;417(6885):205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and BF281828.1.
            
            On Aug 7, 2016 this sequence version replaced NP_001177999.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no transcript was available for the
            full length of the gene. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     Protein         1..681
                     /product="T-box brain protein 1"
                     /note="T-box brain gene 1; T-box, brain, 1-like"
                     /calculated_mol_wt=73779
     Region          203..393
                     /region_name="T-box_TBR1"
                     /note="DNA-binding domain of T-box brain protein 1 and
                     related T-box proteins; cd20204"
                     /db_xref="CDD:410330"
     Site            order(231..232,265,267,310,313,329..330,370,372,378,381,
                     385..387,390..391)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410330"
     Site            order(249,251,284..286,292..293,323,342,356)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410330"
     Region          418..679
                     /region_name="T-box_assoc"
                     /note="T-box transcription factor-associated; pfam16176"
                     /db_xref="CDD:465042"
     CDS             1..681
                     /gene="Tbr1"
                     /coded_by="NM_001191070.2:256..2301"
                     /db_xref="GeneID:680427"
                     /db_xref="RGD:1591773"
ORIGIN      
        1 mqlehclsps imlskkflnv sssyphsggs elvlhdhpii sttdnlerss plkkitrgmt
       61 nqsdtdnfpd skdspgdvqr sklspvldgv selrhsfdgs aadryllsqs sqpqsaatap
      121 samfpypgqh gpahpafsig spsrymahhp vitngaynsl lsnsspqgyp tagypypqqy
      181 ghsyqgapfy qfsstqpglv pgkaqvylcn rplwlkfhrh qtemiitkqg rrmfpflsfn
      241 isgldptahy nifvdvilad pnhwrfqggk wvpcgkadtn vqgnrvymhp dspntgahwm
      301 rqeisfgklk ltnnkgasnn ngqmvvlqsl hkyqprlhvv evnedgtedt sqpgrvqtft
      361 fpetqfiavt ayqntditql kidhnpfakg frdnydtiyt gcdmdrltps pndsprsqiv
      421 pgaryamags flqdqfvsny akarfhpgag agpgpgtdrs vphtngllsp qqaedpgaps
      481 pqrwfvtpan nrldfaasay dtatdfagna atllsyaaag vkalplqaag ctgrplgyya
      541 dpsgwgarsp pqycgaksgs vlpcwpnsaa aaarmaganp ylgeeaegla aersplapaa
      601 edakpkdlsd sswietpssi ksidssdsgi yeqakrrris padtpvsess splksevlaq
      661 rdcekncakd iggyygfysh s
//
