LOCUS       NM_001398915            5626 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus transducin (beta)-like 2 (Tbl2), mRNA.
ACCESSION   NM_001398915 XM_003751162
VERSION     NM_001398915.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5626)
  AUTHORS   Tsukumo,Y., Tsukahara,S., Furuno,A., Iemura,S., Natsume,T. and
            Tomida,A.
  TITLE     TBL2 is a novel PERK-binding protein that modulates
            stress-signaling and cell survival during endoplasmic reticulum
            stress
  JOURNAL   PLoS One 9 (11), e112761 (2014)
   PUBMED   25393282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5626)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Dec 28, 2021 this sequence version replaced XM_003751162.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.80185.1,
                                           SRR26360194.2379457.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000012.1  27168268-27168446   c
            180-301             JAXUCZ010000012.1  27164898-27165019   c
            302-486             JAXUCZ010000012.1  27163654-27163838   c
            487-638             JAXUCZ010000012.1  27161937-27162088   c
            639-765             JAXUCZ010000012.1  27161136-27161262   c
            766-918             JAXUCZ010000012.1  27159325-27159477   c
            919-5626            JAXUCZ010000012.1  27154150-27158857   c
FEATURES             Location/Qualifiers
     source          1..5626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..5626
                     /gene="Tbl2"
                     /note="transducin (beta)-like 2"
                     /db_xref="GeneID:686610"
                     /db_xref="RGD:1595038"
     exon            1..179
                     /gene="Tbl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1381
                     /gene="Tbl2"
                     /codon_start=1
                     /product="transducin beta-like protein 2"
                     /protein_id="NP_001385844.1"
                     /db_xref="GeneID:686610"
                     /db_xref="RGD:1595038"
                     /translation="MELPQMPELMGLSLLVGLLALVATAAVARGWLRAEEKPSQPICQ
                     KENESKKSVSKKQKQNQRIRKEKPQQHNFTHPLLAAALKSHSGNISCMDFSSNGKYLA
                     TCADDRTVRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVF
                     KMTKREDGGFTFTATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVL
                     STINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVCFGKKGEFQEVLRAFELKGHSA
                     SVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKQQDPYLLRTGRFEEASTMPCRLAL
                     SPDTHVLALATGTSIHLFNTRRGEKEEYFECVHGECIADLTFDITGRFLASCGDRAVR
                     LFHNTPGHRAVVEEMQGLLKRASSESTRQRLQQQLTQAQEALKSLGALKK"
     exon            180..301
                     /gene="Tbl2"
                     /inference="alignment:Splign:2.1.0"
     exon            302..486
                     /gene="Tbl2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..638
                     /gene="Tbl2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..765
                     /gene="Tbl2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..918
                     /gene="Tbl2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..5626
                     /gene="Tbl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacgtgag gacgccggcg tcgtaggctg aggtggcagc tgtcccgcag tcatggagct
       61 gccgcagatg ccggagctga tggggctgtc cctcctggtg gggttgctgg ccctggtggc
      121 caccgcggcc gtggcgcggg gctggctgcg ggccgaggag aagcccagcc agcccatctg
      181 tcagaaagaa aacgaatcta agaagtcagt atctaagaag cagaaacaga atcagcggat
      241 tcgtaaggag aagcctcagc agcacaactt cacccacccc ctcctagccg cagcactgaa
      301 gagccacagt gggaatatat cttgcatgga cttcagcagc aacggcaagt atctggccac
      361 ctgtgcagat gaccgcactg tccgtatctg gagcaccaaa gatttccttc agcgggaaca
      421 ccgcagcatg agagccaacg tggagctgga ccatgccacc ttggtgcgct tcagccctga
      481 ctgcagagcc ttcattgttt ggctggcaaa tggggatact ctccgtgttt ttaagatgac
      541 caagcgagaa gacgggggct ttactttcac agccacccca gaggatttcc ctaaaaaaca
      601 caaggcaccc attatcaaca tcggcattgc tgacacaggg aaattcatca tgactgcctc
      661 cagtgacacg actgtcctca tatggaatct gaaaggtcag gtgctgtcca caatcaacac
      721 caaccagatg aacaacagtc acgctgttat ctccccatgt agcaggtttg tgggttcgtg
      781 tggcttcacc cccgatgtga aggtctggga ggtctgcttc gggaagaagg gagagttcca
      841 ggaggtgctg cgagcctttg aactgaaagg tcactctgcg tctgtccact ctttcgcctt
      901 ctccaatgac tctcggagga tggcctctgt ctccaaggat ggcacatgga agctatggga
      961 cacagatgtg gaatacaaga agcaacagga cccctacttg ctaaggacag gccgctttga
     1021 agaggcgagt accatgcctt gccgcctggc actctcccct gacacccatg tcctggcctt
     1081 ggccactggc accagtattc atctcttcaa cacacggcgt ggggagaagg aggagtactt
     1141 tgagtgtgtg catggggagt gtattgctga cttgactttt gacatcacag gccgcttcct
     1201 ggcctcctgt ggggaccgtg cagttcgact cttccacaac acccctggcc accgggctgt
     1261 ggtggaggag atgcagggcc tcctgaagcg ggcatccagc gaaagtaccc gccagaggct
     1321 gcagcaacag ctgacccagg cccaagaggc gctaaagagc ctgggtgccc tgaagaagtg
     1381 actctggctc tggatgggtc tcgctgtctg ctccagtgac cacttcctcc caggtgcccc
     1441 tgggatggag acctggagga acctcccaat tttcttcctg gtggccccta ttttttccta
     1501 ttgaaactat tcttgcatac tccgattctt ttctctctgt ctctctctct ctccttgttt
     1561 gactcttcct agactgaaag gtgctgtttt ctcacaggcc caagggggga tccatcttca
     1621 cctagcactg agaaaagtaa tagaaaaaga cagaacaaag ctcttgacag tttggcaaaa
     1681 gaccctgaga cccaaagaag tttgtcagtg tagaagtttg tcaccaggag cacgttgctg
     1741 ttttagaaga gtacagatgt gttttataat gctgcacggt gagcctccat ctggaccagg
     1801 ttactcatag tagcaagaag taattaagga ctggtctttg tcggcattgg tctgtaatct
     1861 cagcactcta caggcaaagg caagagatca gtggttcaaa gccagcttgg actacatagt
     1921 gaattctagg tcctcctggg ctccgtatgg acagaaacct tgatgagatt gtttttccct
     1981 gggcttcagt tttcttattt gtaaaatggg gaacgatgct ctctgtggcc ttcctgcaaa
     2041 gctgctgtga ggctaagagt gtgttcccac acacggagcg tagcagtgct gtccagtgtc
     2101 attaactacc aggtaaacat gggacgaaac cggcgttctg caagccagct gggtagagcc
     2161 acagcccttg tgaaggccgg gtttcctagg gctctgcgtg ctcattcatc ttggataaat
     2221 ctggtgctct ggttcacgtg cctcgagaag taatgccgtc tcaagatggc gctcctctct
     2281 cttggagact tcttgaactc atcacttgag tgcctgcttc atgggactag ctagtgatgc
     2341 tggctaacac agacaagact gggcctgctg ccaaggataa aagctggtgg gaggacctag
     2401 aggctggtgt ctgtgacgtg ctttttgttc attgacagct gcaggggagg tggtagacgt
     2461 aaggcttgac cttagtgaat ccaggacaat aatggggaat gaaggaaata cacccactaa
     2521 taaattgggt ctcagccata tacatttgaa gactgcttgg atccaagggg tgaggaagat
     2581 gtcaggaatc taggaaggct tgaatctagc aaaaagtacc catccctgtt agttttgatg
     2641 ctcacttaaa agtaagacct cttcctgccg tcctcaatgc tacaggatgt ttagaacaag
     2701 gcacaaccct gaagttgacc ttgatggctc ccttgtcacc ctctccttcc accactgctg
     2761 ctacatccag atggcctgca gcatctgctg tctctcccac tcttctgtta ccatcccggt
     2821 cttagccact gtcctgtact ttgtggatag tacttgtttc caaccgcatt acttcaagtc
     2881 accttctaca tagtttagcc agccttggga aaacaaaaat ggcgttttgg atcacgccat
     2941 tccccaaagg tctccctctc ttcttggaat gaaaccccaa accctccttg tggcctgcat
     3001 agtgtcgtga aatttagcct ctcttgtgat ctttctttgc cgtggtccat cccaccccat
     3061 tcttcctgtt cttcactaac aggcagttgg caggctccag gtatgctgcc agcatttttc
     3121 ctttctgttg gcagacttgt caatgcgatt cagtccttgt aactttctct tgaaaacagt
     3181 tgtctccctt acccacttcc tccgaagtag ccctttccac caatcctgtc ccacctggtg
     3241 ccctggtgtt tttccttctt ttgtatgact tggtgctttc tgaaaccatc ttgtctggct
     3301 atgtgtttgc tccagtgtca gtgacaaggg cagtcgagtg gggagcagga gtgggaatta
     3361 ggcccgttac ctggttgtga gatgggagga aacggtagag actgtactgg gcttctgtct
     3421 attgtcctgg ctgcacagtg ggtaggagcc actacttcct gttaagaatc ccgaaaaagt
     3481 tgccagtttc agagaagtta gatgttggca ctgcccttct caaggaggca ccattgtgaa
     3541 ttacactaaa ccctgacagg aggaggtaac tcagcaaggc ttcttccttg cttttccttt
     3601 tgcagtcctg ggaatggaac ccagggcctc atgcagggga gacaaagagc tctgctgcga
     3661 gccatgcctc aacccctcac tgggaggctc tctgctcagc cccagccctc actgggcaaa
     3721 tgctttgcca ctggccctct agcaccagtt tgtgaaattg ctgacgaatt tgttggagca
     3781 gaatccttgt tagtgtgcct tgctctgggt cccaagtcaa ctagcaggac gaagtaagct
     3841 ctcaataaat ggaactcaga ccagaagcag tgaccgaact tttgatattt ttttttctgc
     3901 actctgctct ctattgtgga ttcaggtttc tgatgagatc agtcatactg agggttgtgt
     3961 gacggtcaca cgtggtttgg gcttccgact acacagccgt gcctcagact tgtgtgtgca
     4021 tgtggggtct ggggggcatc tgccctggct gtcggaggca gcttgaaaac gcctgcactt
     4081 gcttctgcac tcctttccag aagtaacagg cgttgtggct gcagagtagt gaacccaagc
     4141 ctagtgaagt aggaatctgt tcctgaatcg gccaagtcac tgacctgtgg cctagagtcc
     4201 actaatcaca gaggttgcca gagtttgtct cctcatctgt aaaatgggaa taaatgttgt
     4261 tctgctacct tgccatgttg attctttgct tatgtattac acaggattag acatgtggtc
     4321 ttgccgcaac cccatttttt gtgtgtattg gagacaatga ctcactttgt agtcttggct
     4381 agcctggaat tcatagaaat ccacctgctt ggcttcctga gtgcttggtt ttaaggtatg
     4441 tgccgccata cacaggtctt tttgcctgta ttttgagcta atgtttcagt aagttgcctt
     4501 tgatcttgag attctctagc ttgacacccc cctgagtagc agggctgaca ggcctgcatc
     4561 tccatccctg ggagccctga gttcctaatg agctgagcat tacaaagggt cactgcccag
     4621 actgcccagg gatagaatag agctgttctt gttgccctag gaaaaatgtc tggctattaa
     4681 tagagactgc caagctttta tgatcctcaa agcagaggca gcattgatct acacaaggtg
     4741 tggcggcgca tgcttggagc ccgagtactt gtcaggttga agaaccatga gtcagctctg
     4801 catagactga ctaaaacagt tcatttactt tggctttttg agacagggtt tctctcactc
     4861 tgtagaccag gctggcctca aactttacaa tgacccactt gcctctgcct cccaagtact
     4921 gggattaaag gcatatgcca ccactgtccg gatctaaaac acgaaattta atacgaattt
     4981 tgaaactttt taatttttaa ggtgtgggag agctaaacat ggtggtgtaa aggctagcca
     5041 actccaaacc tgggagggaa accacaaagt ccacttaggc aaacacctga tggcaccccc
     5101 cccccatcct cacccttcac cgccaccccc accttagcaa tagccagtca ggctacaaca
     5161 acggggtcaa ggtacacaca gatgagctaa gacatcctgc agagaaaaga taacctaccc
     5221 atcccgcttg tcaggcggtt tggcccccat atttggttcc tagagattat aacagaaatg
     5281 cagcttttag ggctggagag atgtcttaga ggttaagaac actatccgct tttccagagg
     5341 tccagagttc aattcccagc aaccacatgg tggctcatag ccatctataa tgagatctgg
     5401 tgtcctggcc tgtagacata caggtcactg tatacataac ctttcaaaaa aattcagttt
     5461 ttaaaatatt aatttgctga cccggatgga attccccaag cttgctgtag ccacaataca
     5521 taccctgtac ccctagactt gaggctctca tttctgacct gctgtcgatg atggtgagag
     5581 tccttgctct ggagctccta ataaagaccc ttatgtgttt acacca
//
