LOCUS       NP_001385844             442 aa            linear   ROD 28-MAR-2024
DEFINITION  transducin beta-like protein 2 [Rattus norvegicus].
ACCESSION   NP_001385844 XP_003751210
VERSION     NP_001385844.1
DBSOURCE    REFSEQ: accession NM_001398915.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Tsukumo,Y., Tsukahara,S., Furuno,A., Iemura,S., Natsume,T. and
            Tomida,A.
  TITLE     TBL2 is a novel PERK-binding protein that modulates
            stress-signaling and cell survival during endoplasmic reticulum
            stress
  JOURNAL   PLoS One 9 (11), e112761 (2014)
   PUBMED   25393282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Dec 28, 2021 this sequence version replaced XP_003751210.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.80185.1,
                                           SRR26360194.2379457.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     Protein         1..442
                     /product="transducin beta-like protein 2"
                     /calculated_mol_wt=49483
     Region          <72..393
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          89..132
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          187..222
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          228..267
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          278..323
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          371..406
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..442
                     /gene="Tbl2"
                     /coded_by="NM_001398915.1:53..1381"
                     /db_xref="GeneID:686610"
                     /db_xref="RGD:1595038"
ORIGIN      
        1 melpqmpelm glsllvglla lvataavarg wlraeekpsq picqkenesk ksvskkqkqn
       61 qrirkekpqq hnfthpllaa alkshsgnis cmdfssngky latcaddrtv riwstkdflq
      121 rehrsmranv eldhatlvrf spdcrafivw langdtlrvf kmtkredggf tftatpedfp
      181 kkhkapiini giadtgkfim tassdttvli wnlkgqvlst intnqmnnsh avispcsrfv
      241 gscgftpdvk vwevcfgkkg efqevlrafe lkghsasvhs fafsndsrrm asvskdgtwk
      301 lwdtdveykk qqdpyllrtg rfeeastmpc rlalspdthv lalatgtsih lfntrrgeke
      361 eyfecvhgec iadltfditg rflascgdra vrlfhntpgh ravveemqgl lkrassestr
      421 qrlqqqltqa qealkslgal kk
//
