LOCUS       NM_001108941            7757 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TBL1X/Y related 1 (Tbl1xr1), mRNA.
ACCESSION   NM_001108941 XM_001056572 XM_345195
VERSION     NM_001108941.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7757)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7757)
  AUTHORS   Rohm,M., Sommerfeld,A., Strzoda,D., Jones,A., Sijmonsma,T.P.,
            Rudofsky,G., Wolfrum,C., Sticht,C., Gretz,N., Zeyda,M., Leitner,L.,
            Nawroth,P.P., Stulnig,T.M., Berriel Diaz,M., Vegiopoulos,A. and
            Herzig,S.
  TITLE     Transcriptional cofactor TBLR1 controls lipid mobilization in white
            adipose tissue
  JOURNAL   Cell Metab 17 (4), 575-585 (2013)
   PUBMED   23499424
REFERENCE   3  (bases 1 to 7757)
  AUTHORS   Ishii,S., Kurasawa,Y., Wong,J. and Yu-Lee,L.Y.
  TITLE     Histone deacetylase 3 localizes to the mitotic spindle and is
            required for kinetochore-microtubule attachment
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4179-4184 (2008)
   PUBMED   18326024
REFERENCE   4  (bases 1 to 7757)
  AUTHORS   Li,J. and Wang,C.Y.
  TITLE     TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene
            promoter for transcription activation and oncogenesis
  JOURNAL   Nat Cell Biol 10 (2), 160-169 (2008)
   PUBMED   18193033
REFERENCE   5  (bases 1 to 7757)
  AUTHORS   Zhang,X.M., Chang,Q., Zeng,L., Gu,J., Brown,S. and Basch,R.S.
  TITLE     TBLR1 regulates the expression of nuclear hormone receptor
            co-repressors
  JOURNAL   BMC Cell Biol 7, 31 (2006)
   PUBMED   16893456
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7757)
  AUTHORS   Pascual,G., Fong,A.L., Ogawa,S., Gamliel,A., Li,A.C., Perissi,V.,
            Rose,D.W., Willson,T.M., Rosenfeld,M.G. and Glass,C.K.
  TITLE     A SUMOylation-dependent pathway mediates transrepression of
            inflammatory response genes by PPAR-gamma
  JOURNAL   Nature 437 (7059), 759-763 (2005)
   PUBMED   16127449
REFERENCE   7  (bases 1 to 7757)
  AUTHORS   Yoon,H.G., Choi,Y., Cole,P.A. and Wong,J.
  TITLE     Reading and function of a histone code involved in targeting
            corepressor complexes for repression
  JOURNAL   Mol Cell Biol 25 (1), 324-335 (2005)
   PUBMED   15601853
REFERENCE   8  (bases 1 to 7757)
  AUTHORS   Perissi,V., Aggarwal,A., Glass,C.K., Rose,D.W. and Rosenfeld,M.G.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
REFERENCE   9  (bases 1 to 7757)
  AUTHORS   Yoon,H.G., Chan,D.W., Huang,Z.Q., Li,J., Fondell,J.D., Qin,J. and
            Wong,J.
  TITLE     Purification and functional characterization of the human N-CoR
            complex: the roles of HDAC3, TBL1 and TBLR1
  JOURNAL   EMBO J 22 (6), 1336-1346 (2003)
   PUBMED   12628926
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473961.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345195.3, XM_001056572.1.
FEATURES             Location/Qualifiers
     source          1..7757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..7757
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /note="TBL1X/Y related 1"
                     /db_xref="GeneID:365755"
                     /db_xref="RGD:1560053"
     exon            1..114
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            115..181
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            182..284
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1771
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /note="transducin (beta)-like 1 X-linked receptor 1; TBL1X
                     receptor 1"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1XR1"
                     /protein_id="NP_001102411.1"
                     /db_xref="GeneID:365755"
                     /db_xref="RGD:1560053"
                     /translation="MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALV
                     PPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDK
                     LAQQHAAAAAAAAAATNQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPN
                     KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGPTQLVLRHCIREG
                     GQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNK
                     KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVC
                     KLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK
                     EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF
                     SPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVC
                     VLDLRK"
     exon            285..430
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            431..653
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            654..786
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            787..928
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            929..992
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1090
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1151
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1273
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1348
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1476
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1642
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1744
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..7757
                     /gene="Tbl1xr1"
                     /gene_synonym="RGD1560053"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccaggtag ggccttcctg aggacacttg tcttaccagt gtttcaccag gagctcctgg
       61 tgaagtacaa actgcactct gttcgtactg aattggtgag gctttccaaa tgatcctcag
      121 caacgtgtga ttggaggttg gacatccggt tgcacatcct cacatcaatg cactgccaat
      181 gggttatgtc ctgtgttgtg acctcatggt ttaagtggga ataaagatga gtataagcag
      241 tgatgaggtc aacttcttgg tatataggta cttgcaagag tcaggatttt ctcattctgc
      301 atttaccttt ggtatagaga gccatataag tcagtccaac ataaatggtg ccctcgtccc
      361 acccgctgca ctcatctcta tcatccagaa aggcctgcaa tatgtagagg cagaagttag
      421 cataaatgag gatggcacct tatttgatgg tcgacccata gagtctctgt ccctgataga
      481 tgctgtcatg cccgatgtcg tccaaacaag acaacaagcc tacagagaca agcttgcaca
      541 gcaacatgca gccgctgctg cagctgctgc cgcagccact aaccagcaag gctctgcgaa
      601 aaatggagag aacacagcca atggggagga gaatggagca cacaccatcg caaataatca
      661 cacggacatg atggaggtgg acggggatgt ggaaatccct cccaataaag cggttgtgct
      721 tcggggccat gaatcggaag ttttcatctg tgcctggaac cctgttagtg atctcctggc
      781 atcagggtct ggagactcca ctgcaagaat atggaacctc agtgagaaca gcacaagtgg
      841 ccccacacag ctggtgctta gacactgcat acgggaagga gggcaggacg ttcccagtaa
      901 caaggatgtc acctctctag attggaatag tgaaggtaca cttctagcaa ctgggtcata
      961 tgacggattt gccagaatat ggactaaaga tggtaatctt gccagcacct tggggcagca
     1021 taaaggtcct atatttgcat taaaatggaa taagaaagga aatttcatcc taagtgctgg
     1081 tgtagacaag accaccatca tttgggatgc gcatactgga gaagccaagc agcagtttcc
     1141 tttccattca gccccagcac tggatgttga ctggcagagc aacaacacct ttgcatcttg
     1201 tagtacagat atgtgcattc acgtctgcaa attaggacaa gacagaccta tcaaaacatt
     1261 ccagggacac acgaatgaag taaatgctat caaatgggac ccaactggca atctcctagc
     1321 ctcctgttca gatgacatga cattgaagat atggagtatg aagcaagata actgtgttca
     1381 tgatttacaa gcacataata aagaaattta tactattaaa tggagtccaa caggaccagg
     1441 gacaaataat ccgaatgcca accttatgct agcaagtgca tcctttgatt ctacagttag
     1501 gttatgggat gtagaccgag ggatttgcat ccatactttg acaaaacatc aagagcctgt
     1561 gtacagtgtg gcttttagtc ctgatggcag gtatctggca agtggttctt ttgacaagtg
     1621 tgtgcacatc tggaacacac agacaggtgc tctagttcac agttacaggg gaacaggtgg
     1681 gatttttgaa gtttgctgga acgcagcagg agacaaagtt ggagccagtg cttcggatgg
     1741 ttcagtttgt gtcttagatc ttcggaaata gcgttactag ttggaagcca tggaccgact
     1801 atgaatgtgt acatagccac aagactatcc ctgacccaca taactgctat agtcccattt
     1861 gaaccatggc cagtccacta cagccaaatc taagagaaat atatacatgc agtgtatatg
     1921 aacacagctg taccctgaag atgacagtct cgtcccagct tgtgaattct gctcaccaag
     1981 tgctgggatc taacctgctg tgcccctaag tagtgtttag aagtttggat atggaaacca
     2041 gaagagaagg aatatgcgtt ataagagcaa accacacatg tcccagtttt gaatatcaat
     2101 gacagccttg tttctcccct ttgaatcagc agacaccatg gattatattt tttccccttc
     2161 agtagtgcgc agtttgtatg tacagagaac atggacttaa cagaagcttg cggcagtagt
     2221 tggttcttgc ttccaagttt gtttttggtt tagattacgg atgcatgaag taagggagtg
     2281 aatcattttc ttgctttttt ttttcctcac cttttaaaca aacaaacaaa aaataatctt
     2341 aaaaatattt tcctgcattc tttggaagag gtagatgttt ggtacatttg atggctccca
     2401 gagcatatac tcaataggtg catattgtgg agggaattgg aataatagga aactgcatga
     2461 cttttgtcat gtcattctct gatacacatc agcaaagggt gttatgttat ctttgttttg
     2521 ggttttttgt tttagttctt tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2581 tgtgtgtgtg tgtgaaagag atggggggct taagtaaaat agtttctttt tggggacgta
     2641 tttctgccaa ttaaagacta gaagggcaca accttttttt taaaaatacc ataaagaaga
     2701 gacttttttt taaaaaaaaa atcttctgat gttttgtagc cataactaaa ttatggttaa
     2761 aatgtgcact attgtgagaa ggagcaacgt agtttggggc ttttatttta tttttttatt
     2821 ttaccatttg tctgttttac tttgtttctt aagagattaa aatatttctg gataaggatt
     2881 agcttctcaa agtgtccatc attctgtata gaagcttaac tatgtaatgt aaccagattc
     2941 cagtgttaaa agtctctcct gttagctttc tttttacaaa gcaagattac agcatataac
     3001 actgccatta catggctaaa tgtttgctac cttcgttttg aaaacagttt ttaaaggctt
     3061 gctttgaggt gtttttggat agcagtgatg gagaatttag gagaagtgtg gccgaggcta
     3121 gccctctgcc tgcgtctatg gcgccaaagc tgcactttgt caagcaacat agatctaagc
     3181 tgctgctgtt tccagtagtc actactatat catgtctttt tactcttgtt tatatcaagt
     3241 attctttttt aaatctaggt atccaatcag atctcttctg ttcagctaaa agtaaaatat
     3301 acctacaaat gttcactaga ggctgtgttt gtgaaggtga tgacaggaca gttgatatta
     3361 atggaagaac ccaggaacat tgattctgga gagagaaaga acagttgtca aatttatatc
     3421 tttaaatttt taattaagaa attgcttagc aaatttataa cactatttgt gtcagtagtt
     3481 gttttgaggc ctttgactca taagtcccac cctgtgttct acgaagcggc tctagcccag
     3541 ccccacagct ttgatgctct gtatttgctg ccttgctctt tacaaaacag cgttgattga
     3601 cgcaggtctt ggcttcacta aggtagggtg gcatttgctt ttggtaaaga agatgaatac
     3661 acttaaattt gacatcgtta tatcttcccc attgttggtg gggactatga tactgtaata
     3721 attttaagag ttgcatccag agaggcagtc atctgtggtt tgtgccaggt gtttttaggg
     3781 ttcgatcaca ttgagatatt tagaacccgt tgctctgtgg ctctgtagga attctaaaat
     3841 gctgagtgtc tggcacttaa gattttgctt ttactgcaag agggtcacat ctgttggcct
     3901 ctattgttta aaaaaaaata ataaaaataa aaaactgtgc aataattttt aaacgtgctc
     3961 ccaggaatag acacaaacgt tttgagtatg cctaagctgc atctccttca gcgatgcatt
     4021 tgtcaattgc actgaatctg aacctgaaag tcagaggtga ttgttgatag tgcttttgta
     4081 ttttgatatg gacattttat tcatttgcat acagtcattg acgttcttcc cagctgattc
     4141 aaagacagtc acaaattcct gaaatacagc tgccggaatg acagctgaat tttctgatat
     4201 tgtcttgctc tctgttgggt gtgtgtttat tggtttgttt tgttctgttt tatttttatt
     4261 tttttcctat ttctttggct attttccttc agcacactag ctgtgataga ttgtctgata
     4321 gaagtgcaga gctttgctat cccagagcct cgggtctttc tctcgcagat gtggctgaag
     4381 acgtccacct ttaggctggt tctccgtgag cgtaggactg tgtgctttgc tgctgctctc
     4441 agtgtcactg tagcctgctg acgtgccaca atgctgctcc acagacacca taccacgtct
     4501 ccacccgagc agtcagatga tcaccggaga ccacacttga gtgttgtcaa gtgctgtcat
     4561 ggggttctca ctttccttct tgtccttttc tgaagatgca aagtccagga gtctttctgt
     4621 ggtgttcatt tagatcattg ttttatatgc tactgtaaag aagtgaggaa ggagagggaa
     4681 atgaatagca ctgattacag tagactggag ggtgcggtct actgccaccc atgaaaggca
     4741 ggaaggaacc tgtgtactcc atgctggaga ctcttgggga cttaggttta ccccactcct
     4801 gttctccatg atcaggtaat atcattgact ttcaaatgat ttaggggtgg taactggaat
     4861 agatattaga gtgtagcaaa ttctgttttc atgagttatc ctctaggtga atatgtttta
     4921 ggattaaaca ccttttacag atactgaaag tgcctccttt tgtggtatac aaaaaacaaa
     4981 ttatggtgca aaaagtaatc aatagattga atcacatgaa gggttttttg ctttttgaca
     5041 taaaaatgtc aagagacagg ccaaagattt gtacttttca cttataaagc actccttttt
     5101 ttccttaaga ttctttctgt cgatcagatt taatgaaaga gtactatttt taaggagcta
     5161 tctgtttatg tagaatgatt ttgttaaaag agtaatgtaa actatgaatg aggagtagag
     5221 gcccgcggag gactgggcct tttgctattt aaaggaatca cggatgacca ggcttctgta
     5281 agcacacacg gcaacttcta ctaagtgcat aggaaaagca tctcatacag tgctgtcttg
     5341 ctcttttaaa gaccatttat gtttttgtaa gcgcattgca catttccaca gaagctggat
     5401 tctcaggagc tcagcggtac ttgcccagtt gccgcagaaa tcctgcctcc gtggaccaac
     5461 atcgtggcac agcagcaaaa gccagcttat gggggctacc agccagccta cagagaccct
     5521 gggggtggtt ttctgtttgt tcttcattcc ctccttttgt ctgaaatcat cagggaggga
     5581 tcagtaatag ctctgaagtg tcacatttaa tatcagtctt ttaatacaca atcctagtca
     5641 aatgtaggag agaaaaaaag gggagtgctc acatttttta atctactcgt ttagaatccg
     5701 gtgtctctac atagcagttc tgaggttttc atggcagtct ttatctctgc ccttctgtga
     5761 cagtgttgaa gcaggatgaa taagtaggct tttgttgtgt tttgttttta aacctagcaa
     5821 ggtgtttcat attttctttg ggatttctca ttaagtttga ggaaacattc tgcatgttct
     5881 atctggtgtg ctttttttca tctcattaca aacaggcaga gttcattgtg tatctctgcc
     5941 atccttaaat acagaagtga ttttctttcc tgactttgac attgttgcta tatataatgt
     6001 tttcatttga gtttttgcaa atcatttggg tctaattctg tgagcctacc ttagtactgg
     6061 gtgacgatgt ctgcagcctt tctttagttc cacagttaac tttaaagctg ttgtagaagt
     6121 gtaaaccagc ccatgacagt ttttttgtac acgcttaaga actttattgt tcaattttca
     6181 tgatgattgt gtaaggaaga ctgatacaga tgtctatctc tcctggacca tgtcaatgac
     6241 acttacgatg tattttggtt ccacatcaca gtgatttgtc cccgatgacc ctttgaccct
     6301 ttccaggcac attttgtgtg tgtgtgtgtg ttgttgttgt tgcagttttc cctttgcatt
     6361 gtattgcttt gacaactgta atttgaatca gatctgaaag aggtccagaa taaaatatat
     6421 tttgatatta tgttggctgt gtacgtatat aaaacctttg ctatctatgt ggtttgtaaa
     6481 gactagtcga gtaaggagag ggatggtgtt tgtttacaat ttcctgttta catttcaatt
     6541 gcgtttatcc cccactattc agtgtagaat agataatttt gcttccagag tcttccctac
     6601 tacagcctat ctgtcctagc tcttactatc tccagtgaat ataactgcca tgggaatcac
     6661 tgttttcata aacattgttt ccaagatgta tactttaaag aagcccatag atgaatttaa
     6721 agtttttgct attttattac ttcttgcagg ggataagatt ttttaaaatg aagggattat
     6781 tttctatatt tgttaaataa tagcatgtac tcagctaagg gtaatgatga ctcctgagtg
     6841 attttgaaat actgatagtt tatttagagg acttcacaca tgaactaata agacttcaga
     6901 ttcactgtta gcttagcatc cagtagcaca aggcacacca agtatgtggc cgacggcttt
     6961 cagcacagga gctctgccct tcctgctgca ctcctatcca tgccaaccaa acatgccaca
     7021 gtggtttcca cctgtagctg attgctgacc ttactacaaa tctagtaaca gatgaggaac
     7081 atcccaaggc accatccagc ctcagttact gccaactcct atagatcgtt tccttggtca
     7141 agttgccttc tccatgccct ccgcctttct tctgttttct tggtagatac aggctgctgt
     7201 agccttgttg tgctctcatt gcaactgcta aagctagcaa cctttagttg tcaaggggtt
     7261 catttctatt gcatggcata ggttgttaat gacattctgt ttttacactt ctccagaaag
     7321 cattgggccg ccaaggatta gagtccactt gagcctaaag ttaagcagaa gttcattgag
     7381 ccaccattgc agagaggtta cttttgattt catagttctt atactttatc atgaattaga
     7441 tttcttacct actataatat gtagctgatt aaagtttact ggtttttttt ttttttccta
     7501 tatattcatc tgaaaacgac agtagaggaa aagccattat ggacacttga ttttgtggtg
     7561 cttttctctg ctgtaccgag gcactgtcaa cagtaaaaat gttaacccta tgctaccttt
     7621 ccctgcatgc ttctttaaat gtcatctacc aatgcttaat tgtcctaact tgtaatattt
     7681 ttgtataaaa ttttttagga gttccttgta atttctttat aatttaaaat atattaaaca
     7741 caaagtgttt agtaaag
//
