LOCUS       NM_001106964            5067 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transducin (beta)-like 1 X-linked (Tbl1x), mRNA.
ACCESSION   NM_001106964 XM_001057805 XM_217623
VERSION     NM_001106964.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5067)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   2  (bases 1 to 5067)
  AUTHORS   Oberoi,J., Fairall,L., Watson,P.J., Yang,J.C., Czimmerer,Z.,
            Kampmann,T., Goult,B.T., Greenwood,J.A., Gooch,J.T.,
            Kallenberger,B.C., Nagy,L., Neuhaus,D. and Schwabe,J.W.
  TITLE     Structural basis for the assembly of the SMRT/NCoR core
            transcriptional repression machinery
  JOURNAL   Nat Struct Mol Biol 18 (2), 177-184 (2011)
   PUBMED   21240272
REFERENCE   3  (bases 1 to 5067)
  AUTHORS   Perissi,V., Scafoglio,C., Zhang,J., Ohgi,K.A., Rose,D.W.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     TBL1 and TBLR1 phosphorylation on regulated gene promoters
            overcomes dual CtBP and NCoR/SMRT transcriptional repression
            checkpoints
  JOURNAL   Mol Cell 29 (6), 755-766 (2008)
   PUBMED   18374649
REFERENCE   4  (bases 1 to 5067)
  AUTHORS   Ishii,S., Kurasawa,Y., Wong,J. and Yu-Lee,L.Y.
  TITLE     Histone deacetylase 3 localizes to the mitotic spindle and is
            required for kinetochore-microtubule attachment
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4179-4184 (2008)
   PUBMED   18326024
REFERENCE   5  (bases 1 to 5067)
  AUTHORS   Li,J. and Wang,C.Y.
  TITLE     TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene
            promoter for transcription activation and oncogenesis
  JOURNAL   Nat Cell Biol 10 (2), 160-169 (2008)
   PUBMED   18193033
REFERENCE   6  (bases 1 to 5067)
  AUTHORS   Yoon,H.G., Choi,Y., Cole,P.A. and Wong,J.
  TITLE     Reading and function of a histone code involved in targeting
            corepressor complexes for repression
  JOURNAL   Mol Cell Biol 25 (1), 324-335 (2005)
   PUBMED   15601853
REFERENCE   7  (bases 1 to 5067)
  AUTHORS   Perissi,V., Aggarwal,A., Glass,C.K., Rose,D.W. and Rosenfeld,M.G.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
REFERENCE   8  (bases 1 to 5067)
  AUTHORS   Yoon,H.G., Chan,D.W., Huang,Z.Q., Li,J., Fondell,J.D., Qin,J. and
            Wong,J.
  TITLE     Purification and functional characterization of the human N-CoR
            complex: the roles of HDAC3, TBL1 and TBLR1
  JOURNAL   EMBO J 22 (6), 1336-1346 (2003)
   PUBMED   12628926
REFERENCE   9  (bases 1 to 5067)
  AUTHORS   Guenther,M.G., Lane,W.S., Fischle,W., Verdin,E., Lazar,M.A. and
            Shiekhattar,R.
  TITLE     A core SMRT corepressor complex containing HDAC3 and TBL1, a
            WD40-repeat protein linked to deafness
  JOURNAL   Genes Dev 14 (9), 1048-1057 (2000)
   PUBMED   10809664
REFERENCE   10 (bases 1 to 5067)
  AUTHORS   Bassi,M.T., Ramesar,R.S., Caciotti,B., Winship,I.M., De Grandi,A.,
            Riboni,M., Townes,P.L., Beighton,P., Ballabio,A. and Borsani,G.
  TITLE     X-linked late-onset sensorineural deafness caused by a deletion
            involving OA1 and a novel gene containing WD-40 repeats
  JOURNAL   Am J Hum Genet 64 (6), 1604-1616 (1999)
   PUBMED   10330347
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473966.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217623.4, XM_001057805.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..5067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..5067
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="transducin (beta)-like 1 X-linked"
                     /db_xref="GeneID:302711"
                     /db_xref="RGD:1563868"
     exon            1..77
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            78..172
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            173..286
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1812
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1X"
                     /protein_id="NP_001100434.1"
                     /db_xref="GeneID:302711"
                     /db_xref="RGD:1563868"
                     /translation="MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLV
                     PPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREK
                     LAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSK
                     PMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG
                     STQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLG
                     QHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT
                     FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK
                     QDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHT
                     LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARG
                     DKVGASASDGSVCVLDLRK"
     exon            287..432
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            433..694
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            695..827
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            828..969
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1033
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1131
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1192
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1314
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1389
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1517
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1683
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1785
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..5067
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaattgaga tagaagacca gtctttaaaa aaagcgggcg gggggggggg gatttgcctg
       61 tatttgcttc tgagcaaggt ggtcctggac tttgtgcaca cctctcaagt tctgtgattg
      121 gatgctgggt agcccactgc tccagaggtc tacacatgca ctcactgtga cgagggtggc
      181 tcacacttga tcgagacgaa gacctcatcg ccgcaaggtg aggctaagat gagcattacc
      241 agcgacgagg tgaactttct ggtatatcgc tacctccagg aatcaggttt ttcccattcc
      301 gccttcacgt ttgggatcga aagccacatt agccagtcca acatcaatgg tacactagtg
      361 ccaccggctg ccctaatctc cattcttcag aaaggactgc aatatgtgga ggcggagatc
      421 agcatcaacg aggatggcac ggtatttgat gggcgtccca ttgagtccct atcgttaatt
      481 gatgctgtga tgcccgatgt ggtacagaca agacagcaag cttttcggga gaagctcgcc
      541 caacagcaag ccaatgcagc agctgcagca gcagcagccg cagccacagc cacaagcaca
      601 gcggccacaa caccagcagc tgctgctcag caaaacccac caaagaatgg agaagccacc
      661 gtgaatgggg aagaaaatgg agcccatgca ataaataatc actcaaaacc aatggaaata
      721 gatggagacg ttgaaattcc accgagtaaa gccacagtcc ttcgaggcca tgagtctgaa
      781 gtgttcattt gtgcctggaa tcctgttagt gacctacttg cttctggatc tggagactct
      841 actgcgagga tatggaacct taatgagaac agcaacgggg gctccacaca gcttgtgctg
      901 aggcactgca tccgtgaagg tggacatgat gttcccagta ataaggatgt cacctcattg
      961 gactggaata gcgatgggac actgttggca acaggttcct atgatggttt tgcaagaata
     1021 tggacagaag atggtaacct agccagcacc ttgggtcaac acaaaggccc catctttgcc
     1081 ttgaagtgga acaaaaaggg gaattatatt ttgagtgctg gtgtagacaa gacaacaata
     1141 atttgggacg cccacacagg agaagccaaa caacagtttc cttttcattc agcacctgcc
     1201 cttgatgtgg actggcagaa caacactacc tttgcctcgt gcagcacaga catgtgcatt
     1261 catgtgtgca ggcttggctg tgatcgccca gtcaaaacct tccaaggaca tactaatgag
     1321 gtcaatgcta tcaaatggga tccttctgga atgttgctag cctcctgctc tgatgacatg
     1381 acattaaaga tctggagtat gaagcaggat gcatgtgtcc atgacctcca agctcacagc
     1441 aaagagatat ataccatcaa gtggagtccc acaggaccag ccaccagcaa cccgaactcc
     1501 aacatcatgt tagcaagtgc ttcatttgac tctacggttc gactgtggga tgtggagcga
     1561 ggcgtttgca tccacacact gaccaagcat caggagcctg tctatagtgt agcgttcagc
     1621 cctgacggaa agtatttggc cagtggatcc tttgacaagt gtgtccatat ctggaatact
     1681 cagagtggaa gtctcgtcca cagctaccga ggaacaggcg gcatatttga ggtgtgctgg
     1741 aatgctcgag gagacaaagt gggtgccagt gcatctgatg gctctgtctg tgttttagat
     1801 ctccgaaagt aaacacaaaa tgtagaaaac aaaaccattc taatggagca gcagtgaatg
     1861 tgtgggattg cagcaccctt tcctatgatg ggctccaaac tgtgtgaact tgacttgttc
     1921 gagtctactt ggaaatcacc tgtccctggc cacaggatta tttccccccc tcccctaatc
     1981 tccatccaga agtttaaaac acaaacaaat acaaagtcat acgcatggtt gtatcacagg
     2041 aatatggttt ctacctagaa tgctcagctg gggaaggatg aagcaagcca tcagctacat
     2101 ggtacatggt tggtttccat ccagaacagg ctctaatgac tgaacaggga aggaagaaca
     2161 caaagctgtg ccaaaaaata atgaaaaggt taaaaaatga aagagaaaaa atgctgtgat
     2221 aaaccaaaag ggaggaaaaa cctgtccctt atggtgtttc cctcctatca atttggatac
     2281 tacagttgct ccaaaagacc agtttgtacc aatgaaatgt gtgactttgt aatcccaacg
     2341 ctgtattttc tagaaccttc tttggtggtt tttctatctg ctaaaattct gtggtctggg
     2401 ggcttcccac ctcagatgaa aactgttttt ggcttattcc ttctgtcctc ccttgttgtt
     2461 tcccacccct tcctctgatg tccttgctct ggtgtggtct cacttctaat gaaatcctgc
     2521 atagatatgg ccacatgcac acagtggatc tttgttggac agcactctcc ttccctctct
     2581 cccactccta cctattgctt actctgtccc tttctcatag ttgcttcaca ttaggtccca
     2641 aaggcacttt cagagcatag taagtgcttt atgtaagaag gcagggatgg ggacttttta
     2701 cagaaaaaaa aagacttact tataagagaa agaacctgga gtattttttg aaaaaaatat
     2761 ttttatgtta aaatgacttt aaaatcctaa aatggccatc agacatagag agttttgtga
     2821 aattcatatt taaaagacta agaagacact ggcagagtct gaggtgtcta attacccctt
     2881 tcccttcagc ttcacgaaag gcagttaggc aagccgtgga ttgggaagcg tcctatggaa
     2941 gaacaagggg attgttttgg cagctggtgg ggaagaaaga gcccactggt taggcatcaa
     3001 gcagaatgct gaactgtttg gtacacattt ccttcagcag ccaataggaa catagtgaag
     3061 aagccaccct gaccaggtgt ggctcatggc acctgccagc tacatctttc tcacaacagt
     3121 gtagctacag atgggcactt ttatcaagag catgcttggt gaatcttgca aaactgaccc
     3181 aaaggcctca gtgtcactca gtcttgtgaa gacagtgagt ctcaagggag actttcaatt
     3241 gtaaaaatga attatgaccc aggtagaatg tcactgatca tttctgccca ctttccaatt
     3301 tctctgacag aagattagga caaagctttc ttttaaaaaa tgagaaaaaa ataggaaaga
     3361 aatttcggct attttttaaa aacaaaataa ggcatagtgt gcctggtaaa gtttgccatc
     3421 attgaatcag gtggcctttg ttcatttctt gtcataactt gacactgact tgtttcttta
     3481 attagtaata ggggacagac cagaaggggg ctgcaagagg cagtatgaag ggtccagtct
     3541 gcagctgagg caagtgttac ttagagaaaa gtatacatat atgaagccaa aaatcaacca
     3601 gcaaggaagg tcaggtgctc cctacacaac aaatgttagc accaaaacat gtattggcct
     3661 ccactttgcc atgtaaatta tgtgagccct caaaatctaa agtgttgtgt attgagttga
     3721 gtggtgaatt tgggttctgc cacctaaatg cttagcaaag taagcccaag ttgtgtggaa
     3781 atttgatcat agcagatgtc tctgtgtcag tggatatgaa gttccctgcc ctgagactgc
     3841 ttttagcttt aggatgtaat tttggaagtc cagataaatc ctatcattgt tccacaaata
     3901 catttctgtt catctctaca gaagatcagc tgttagatgt cagcctattg taaaggtatg
     3961 actttcattt gacaagttct acattgctat atggtggtaa tgggtaggtg gcacatatgg
     4021 ggttcatcag acaatctctg ggtgtccagg ctacaccccc cctagatgaa tctaagccac
     4081 ataagaatta ttattttgga gtcaatggct gtaagactag gacaaaaagg ttcaatctac
     4141 ataaacctga agaccattca tttccctggc cttacagcta aacatggaca ggaacttagt
     4201 gctggccaca caaggaccaa gcagaagaat gcagcccaca cccctgaagt tcatccccat
     4261 aagacagctc agtctgcagc tgtttctgga gcggccagca tttggacgcc atcatttgcc
     4321 tgctgttaca gggcaggtgc atcatctttg tgatcaaggg gtggcccatg tgttatgctg
     4381 ttacctaaca ttgtttataa ctcctaaaaa cattgtgagg aatggttagt cttgtgacca
     4441 aattcaacct tgaaagcagt gtagtcacat agcagccttt ccaggtaatt ttccttgagt
     4501 ttgaagtaac catataccat tcctagcaca tccaggatgc tgcctgtaga ggaccgaagg
     4561 gccagatgga cattacaaag ttcaactctc tgaccccact caacaccata ggacttgact
     4621 ttttgttctg tctgactaag aaatagacca tggagccaag tgaagtgcac tttgtcacat
     4681 gtaaggatct gctttgttcc ttgttgcttt tccctttata aacctttgtt atatctttcc
     4741 attctgtttc ttgtcaaatg cataaatgtc tgttctgcaa ctcactgaag ttttgaattc
     4801 tggcttgtgc agtttttatt gtctgtgtca gacgtacagc cagacatggt cctctttcaa
     4861 cattttccac attctgttaa gcaccatcaa aactcccctc cccctctgtc ctctccccca
     4921 cccccactcc cattcacccc acacgctctt cgagaagaaa aaaaaaagaa tcaccttgtg
     4981 tgttgtagct catttgtttc aagagagaat caacagatca tattcagtgt cttgaataaa
     5041 ttgctctatt ttgatattag agaacat
//
