LOCUS       NM_001106786            2987 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus TANK-binding kinase 1 (Tbk1), mRNA.
ACCESSION   NM_001106786 XM_001079249 XM_216902
VERSION     NM_001106786.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2987)
  AUTHORS   Zeng Y, Ng JPL, Wang L, Xu X, Law BYK, Chen G, Lo HH, Yang L, Yang
            J, Zhang L, Qu L, Yun X, Zhong J, Chen R, Zhang D, Wang Y, Luo W,
            Qiu C, Huang B, Liu W, Liu L and Wong VKW.
  TITLE     Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via
            inhibition of TBK1-IRF3 innate immune response
  JOURNAL   Inflamm Res 72 (12), 2199-2219 (2023)
   PUBMED   37935918
  REMARK    GeneRIF: Mutant p53[R211*] ameliorates inflammatory arthritis in
            AIA rats via inhibition of TBK1-IRF3 innate immune response.
REFERENCE   2  (bases 1 to 2987)
  AUTHORS   Wen H, Zuo Y, Li L, Zhan L, Xue J, Sun W and Xu E.
  TITLE     Hypoxic postconditioning restores mitophagy against transient
            global cerebral ischemia via Parkin-induced posttranslational
            modification of TBK1
  JOURNAL   Neurobiol Dis 179, 106043 (2023)
   PUBMED   36805078
  REMARK    GeneRIF: Hypoxic postconditioning restores mitophagy against
            transient global cerebral ischemia via Parkin-induced
            posttranslational modification of TBK1.
REFERENCE   3  (bases 1 to 2987)
  AUTHORS   Jia YF, Jeeva S, Xu J, Heppelmann CJ, Jang JS, Slama MQ, Tapadar S,
            Oyelere AK, Kang SM, Matveyenko AV, Peterson QP and Shin CH.
  TITLE     TBK1 regulates regeneration of pancreatic beta-cells
  JOURNAL   Sci Rep 10 (1), 19374 (2020)
   PUBMED   33168920
  REMARK    GeneRIF: TBK1 regulates regeneration of pancreatic beta-cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2987)
  AUTHORS   Hegde RN, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L,
            Auwerx J, Landles C, Bates GP, Singh-Bains MK, Dragunow M, Curtis
            MA, Faull RL, Ross CA, Caricasole A and Lashuel HA.
  TITLE     TBK1 phosphorylates mutant Huntingtin and suppresses its
            aggregation and toxicity in Huntington's disease models
  JOURNAL   EMBO J 39 (17), e104671 (2020)
   PUBMED   32757223
  REMARK    GeneRIF: TBK1 phosphorylates mutant Huntingtin and suppresses its
            aggregation and toxicity in Huntington's disease models.
REFERENCE   5  (bases 1 to 2987)
  AUTHORS   Shang J, Xia T, Han QQ, Zhao X, Hu MM, Shu HB and Guo L.
  TITLE     Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a
            Positive Regulator of SeV-Induced Innate Immunity
  JOURNAL   Proteomics 18 (2) (2018)
   PUBMED   29251827
REFERENCE   6  (bases 1 to 2987)
  AUTHORS   Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ,
            Takeuchi O and Akira S.
  TITLE     IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I
            interferon induction
  JOURNAL   Nat Immunol 6 (10), 981-988 (2005)
   PUBMED   16127453
REFERENCE   7  (bases 1 to 2987)
  AUTHORS   O'Connell RM, Vaidya SA, Perry AK, Saha SK, Dempsey PW and Cheng G.
  TITLE     Immune activation of type I IFNs by Listeria monocytogenes occurs
            independently of TLR4, TLR2, and receptor interacting protein 2 but
            involves TNFR-associated NF kappa B kinase-binding kinase 1
  JOURNAL   J Immunol 174 (3), 1602-1607 (2005)
   PUBMED   15661922
REFERENCE   8  (bases 1 to 2987)
  AUTHORS   Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G,
            Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C,
            Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M,
            Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB,
            Joberty G, Neubauer G, Rick J, Kuster B and Superti-Furga G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   9  (bases 1 to 2987)
  AUTHORS   Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K and
            Akira S.
  TITLE     Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta
            (TRIF) associates with TNF receptor-associated factor 6 and
            TANK-binding kinase 1, and activates two distinct transcription
            factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like
            receptor signaling
  JOURNAL   J Immunol 171 (8), 4304-4310 (2003)
   PUBMED   14530355
REFERENCE   10 (bases 1 to 2987)
  AUTHORS   Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y,
            Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H and Sugano S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216902.4, XM_001079249.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2987
                     /gene="Tbk1"
                     /note="TANK-binding kinase 1"
                     /db_xref="GeneID:299827"
                     /db_xref="RGD:1588588"
     exon            1..40
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..186
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2289
                     /gene="Tbk1"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TBK1"
                     /protein_id="NP_001100256.1"
                     /db_xref="GeneID:299827"
                     /db_xref="RGD:1588588"
                     /translation="MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNIS
                     FLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS
                     NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA
                     ARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGS
                     LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQAL
                     LTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTALKIYIHSYNTAAV
                     FHELVYKQTKIISSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSREQLNSIGL
                     RYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTAGTLLLYQELMRKGVRWLIELV
                     KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVSLDAAELGEISDIHTKLLRL
                     SSSQGTIESSLQDINSRLSPGGSLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQF
                     KKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVRKYEAFKDTSEEWMRKML
                     HLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQKMLAASSGIKHTVAPIYPSSNT
                     LVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL"
     exon            187..327
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..457
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..639
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..800
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..911
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1091
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1288
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1347
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1439
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1541
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1620
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1742
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1819
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1859
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1961
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2058
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2165
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2237
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2987
                     /gene="Tbk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgggagc cgcgggctgt acgcggcgga cgctcgctgg cgtacatgca aatctcttct
       61 tcccccttat cgtgaggaga agcgtctgac caagccgaga tgcagagcac ttccaaccat
      121 ctgtggcttt tgtctgatat cctaggccaa ggggctactg caaatgtctt ccgaggaagg
      181 cataagaaaa ctggtgatct ctatgctgtc aaagtattta ataacataag cttccttcgc
      241 ccagtggatg ttcaaatgag agaatttgaa gtgttaaaaa agctcaatca caaaaacatt
      301 gtcaaattat ttgctattga agaagagaca acaacaagac ataaagtact tatcatggag
      361 ttctgtccct gtgggagttt atacactgtg ttagaggagc catccaatgc ctatggactg
      421 ccagaatcag agtttttaat tgttttacga gatgtggtgg gcggaatgaa tcatctccga
      481 gagaacggca tagtgcaccg tgatatcaag ccagggaaca tcatgcgcgt cataggagaa
      541 gacggacagt ctgtgtacaa actcacagac tttggtgccg ctagagagtt agaggacgat
      601 gagcagttcg tgtctctgta tggcacagaa gagtatttgc acccggacat gtatgagagg
      661 gcagtgctaa ggaaggacca tcagaagaag tacggagcca ccgttgatct gtggagtgtc
      721 ggagtcacat tctaccacgc agccacgggg tcgctgccct ttagaccctt cgaggggcct
      781 cggaggaaca aagaagtaat gtataaaata atcactggga agccttctgg tgcaatatct
      841 ggagtacaga aagcagaaaa cggaccaatt gactggagtg gagacatgcc tctttcttgt
      901 agtctttctc agggtcttca ggcactgctt accccagttc ttgcaaacat acttgaagct
      961 gatcaggaga agtgctgggg ctttgaccag ttctttgcag agactagtga tgtgctgcac
     1021 cgaatggtaa tccatgtttt ctcgctacag cacatgacag cgcttaagat ctatattcat
     1081 agctataaca cagctgctgt gttccatgaa ctggtctata aacaaaccaa gattatttct
     1141 tcaaatcaag aacttatcta cgaaggacga cgcttggtcc tagaacttgg aagactagcc
     1201 cagcatttcc ctaaaaccac agaagaaaat cctatctttg tcacaagccg ggaacaactc
     1261 aattccatag gtctgagata tgaaaaaatt tccctaccta aaatacatcc acgctatgac
     1321 ctggacgggg acgccagcat ggccaaggca gtgaccgggg ttgtgtgcta cgcctgcaga
     1381 actgctggca ccctgctgct ctatcaagaa ctaatgcgga agggggtgcg gtggctgatt
     1441 gaactagtta aagacgacta caatgagact gtccacaaga agacagaagt tgtgatcaca
     1501 ctggatttct gcatcagaaa cattgagaag actgtgaaag tatatgagaa gttgatgaag
     1561 gtcagcctgg acgccgcaga gctgggtgag atttcagaca tacacaccaa gctgctgaga
     1621 ctttccagct ctcagggaac aatagagagc agtcttcagg acatcaacag caggctgtcc
     1681 ccagggggat cgctggctga cacctgggca catcaggaag gcactcatcc aagagacagg
     1741 aatgtagaaa agctacaagt cttgttgaat tgcatcacag agatttacta tcagtttaaa
     1801 aaggacaagg cagagcgcag actagcgtat aatgaagaac agatccacaa gtttgataaa
     1861 caaaaattgt attaccatgc aacaaaagca atgacccact ttaccgatga atgtgtcagg
     1921 aagtatgaag catttaaaga cacgtctgaa gaatggatgc gaaagatgct tcatcttcgg
     1981 aaacagctgc tatcactgac taatcagtgt tttgacatcg aagaggaggt gtccaagtat
     2041 caagactaca ctaacgagtt acaagaaact ctgcctcaga aaatgcttgc agcctccagt
     2101 ggaatcaagc acaccgtggc cccgatctac cccagttcta acaccttagt ggagatgact
     2161 ctcggtatga agaagctgaa ggaggagatg gagggcgtgg tcaaggagct ggccgaaaac
     2221 aatcatattt tagaaaggtt tgggtctttg acaatggatg gtggcctccg caatgtggac
     2281 tgtctttagc ttcttcggga gtctgggaag ttctagtttg cacaagaaga tgacactggg
     2341 gcacgaagtg aatgccttta tgaatggcat tcttatttct acaattcagt atttgatgag
     2401 gtcgtgtaaa tatgtacagt ttgtaaatac atatacatat atatatatga atttttggct
     2461 gctgtaagta aacaagacag attgacctca gtgagctgta gaagaaagcc atgaccagcc
     2521 aatgctttgg ggtgctctcc ctaattcttc acatgaggct ggagaaatct atgcttggtg
     2581 cctaaagaaa gtattttttg aattggcgtc cttaaaattt tgaaaggact gatagttgac
     2641 acagttgtga atggaggaga cacagggctt tgtgatagga accgaaccac ggttttacta
     2701 gggtcagttc ctctgacaag gatgaagcgg cattatttca tttgacgagg tgcccaaatc
     2761 tgttttcctc gtatgtttca tttcaggtga attattgagc aaaaacttta aagtgaattc
     2821 attgtttaaa ctattcattt ttcgtttggt cacaatgtgt aattgtcatt cagatcctcg
     2881 tatcatttca attgtcttaa gatgtatatt tctgtacttt aattctgctg tttcatgaaa
     2941 aattctgcct actatttcat gaaaaataaa tttctcaatt ttaatgt
//
