LOCUS       NM_001415033            6103 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus TBC1 domain containing kinase (Tbck), mRNA.
ACCESSION   NM_001415033 XM_008761496
VERSION     NM_001415033.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6103)
  AUTHORS   Wu,J., Li,Q., Li,Y., Lin,J., Yang,D., Zhu,G., Wang,L., He,D., Lu,G.
            and Zeng,C.
  TITLE     A long type of TBCK is a novel cytoplasmic and mitotic
            apparatus-associated protein likely suppressing cell proliferation
  JOURNAL   J Genet Genomics 41 (2), 69-72 (2014)
   PUBMED   24576458
REFERENCE   2  (bases 1 to 6103)
  AUTHORS   Liu,Y., Yan,X. and Zhou,T.
  TITLE     TBCK influences cell proliferation, cell size and mTOR signaling
            pathway
  JOURNAL   PLoS One 8 (8), e71349 (2013)
   PUBMED   23977024
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2022 this sequence version replaced XM_008761496.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.7723.1,
                                           SRR26360172.387119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000002.1  223849807-223850035
            230-451             JAXUCZ010000002.1  223853822-223854043
            452-524             JAXUCZ010000002.1  223868011-223868083
            525-639             JAXUCZ010000002.1  223879643-223879757
            640-713             JAXUCZ010000002.1  223881712-223881785
            714-855             JAXUCZ010000002.1  223888300-223888441
            856-916             JAXUCZ010000002.1  223891952-223892012
            917-978             JAXUCZ010000002.1  223892978-223893039
            979-1040            JAXUCZ010000002.1  223894384-223894445
            1041-1189           JAXUCZ010000002.1  223895213-223895361
            1190-1328           JAXUCZ010000002.1  223896676-223896814
            1329-1428           JAXUCZ010000002.1  223898166-223898265
            1429-1478           JAXUCZ010000002.1  223899141-223899190
            1479-1608           JAXUCZ010000002.1  223899312-223899441
            1609-1707           JAXUCZ010000002.1  223902581-223902679
            1708-1770           JAXUCZ010000002.1  223905464-223905526
            1771-1897           JAXUCZ010000002.1  223905824-223905950
            1898-1948           JAXUCZ010000002.1  223907299-223907349
            1949-2032           JAXUCZ010000002.1  223908597-223908680
            2033-2118           JAXUCZ010000002.1  223912579-223912664
            2119-2155           JAXUCZ010000002.1  223927310-223927346
            2156-2317           JAXUCZ010000002.1  223928490-223928651
            2318-2496           JAXUCZ010000002.1  223948668-223948846
            2497-2672           JAXUCZ010000002.1  223988712-223988887
            2673-2832           JAXUCZ010000002.1  224003283-224003442
            2833-6103           JAXUCZ010000002.1  224018827-224022097
FEATURES             Location/Qualifiers
     source          1..6103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..6103
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /note="TBC1 domain containing kinase"
                     /db_xref="GeneID:295446"
                     /db_xref="RGD:1307816"
     exon            1..229
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            230..451
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2943
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /codon_start=1
                     /product="TBC domain-containing protein kinase-like
                     protein"
                     /protein_id="NP_001401962.1"
                     /db_xref="GeneID:295446"
                     /db_xref="RGD:1307816"
                     /translation="MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQV
                     LKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERRPASHSAVLCIAYEVLE
                     GLQYLNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPE
                     VIAQGIFKSTDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLT
                     LGCVDDTLIVLAEEHGCLDIIKELPENALSILKKCLTFHPPKRPTPDELMKDQVFSEV
                     SPLYTPFIKPASLFSSSLRCADLTLPEDISDVCKDIDDDYLAERSIEEVYYLWCLAGG
                     DLEKELINKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRL
                     KDVGGEAFYPLLEDDQSSLPHSNSNNELSAAASLPLIIRERDTEYQLNRIILFDRLLK
                     AYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVD
                     IPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALA
                     YACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMISFHDPELSNHLNEIGFIPDLYAI
                     PWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF
                     SDLPEIDIERCVRESVNLFCWTPKSATYRQHAQPPRPASESSAVRSSSAPYFSAECTD
                     PPKTDLSRESIPLSDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVV
                     DIRNSEDFLRGHIAGSINIPFSAAFTAEGELSQGPYTTMLHSFKGKVIVIVGHVAKQT
                     SEFAAHLVKMKYPRVCILDGGINKIKPTGLLTVPSPQI"
     exon            452..524
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            525..639
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            640..713
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            714..855
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            856..916
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            917..978
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1040
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1189
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1328
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1428
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1478
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1608
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1707
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1770
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1897
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1948
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2032
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2118
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2155
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2317
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2496
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2672
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2832
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..6103
                     /gene="Tbck"
                     /gene_synonym="RGD1307816; Tbckl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgggtg ctgtcactgg agccaggcgc gcgctcacac acaagttctg agctgtgaac
       61 ctgttcggcc cgcgcggacg gaggcgtgtc gctccggctg tcatcttcca tgggcggcct
      121 cttgtagacg cgcctgaaat gcagaacacg gcccactaaa cactgccagg cacaaccact
      181 gcgtttagga gttcatcccc ctaatctctg cgcccccaga ttcagtcaga tcatcataga
      241 gtacccaaga ctccaaaaat gtttcctttg aaggatgctg aaatgggcgc ctttactttc
      301 tttgcctcag ctcttccaca tgatgtttgt ggaagcaacg gccttcccct cacaccaaac
      361 tccatcaaaa tcttaggtcg ctttcaagtc cttaagacca tcacccatcc cagactgtgt
      421 caatatgtgg atatttctag aggaaagcat gagagactgg tggtggtagc agagcactgt
      481 gagcggagtt tggaagacct tctacgggaa aggagacctg caagtcactc agcagttctg
      541 tgcatagcat atgaggtact tgagggcttg cagtacttga acaagcatgg catagtacac
      601 cgggccttgt ctcctcataa tatcctgttg gatcggaagg gtcacattaa actggctaaa
      661 tttggacttt atcacatgac agcccatggc gatgatgtcg atttcccaat agggtacccc
      721 tcatatctgg ctcctgaggt gattgcacaa ggaattttca aaagcactga tcatgtgccc
      781 agtgaaaagc cattgccctc cggccccaaa tcagatgtat ggtctcttgg gataatttta
      841 tttgagcttt gtgtgggaag aaaattgttt cagagcttgg atatttctga aagactaaaa
      901 tttttgctta ctttgggctg tgtggatgat actctaatcg ttctggctga ggagcacggg
      961 tgtctggaca ttatcaagga gcttcctgaa aatgcgctca gtattttgaa gaagtgcctc
     1021 accttccatc cgcctaagag gccaacccca gatgagctaa tgaaggacca ggtgttcagt
     1081 gaggtgtcac ctttgtacac cccctttatc aagcctgcca gcctgttttc atcttctctg
     1141 agatgcgctg atttaactct gcccgaggat atcagtgacg tgtgcaaaga tatagatgat
     1201 gattacctgg cggagagatc tattgaggaa gtttactacc tttggtgttt ggctggggga
     1261 gacctggaga aggagctgat aaacaaggaa attattcgat ccaaaccacc tatctgcaca
     1321 cttccgaatt ttctctttga agatggagaa agtttcggac aaggtcgaga tagaagctca
     1381 ctcttagatg acaccactgt cacgttgtct ttgtgccagc taagaaacag attaaaagat
     1441 gttggcgggg aagcatttta cccattgctt gaagacgacc agtcaagttt accgcactcg
     1501 aacagcaata acgagttgtc tgcagctgct tccctgcctt taatcatcag agagagggac
     1561 acagagtacc aactaaacag gattattctc tttgacaggc tgttgaaggc ttacccatac
     1621 aaaaaaaatc aaatctggaa agaagcaaga gttgacatcc ctccacttat gcggggttta
     1681 acctgggctg ctcttctggg agttgaggga gctattcacg ccaagtacga tgccattgat
     1741 aaagacactc cgattcccac agacagacaa attgaagtgg atatcccccg ctgtcatcag
     1801 tatgacgaac tcttgtcatc accagaaggc catgcaaagt tccggcgtgt gctgaaagct
     1861 tgggtagttt ctcatcctga tcttgtgtac tggcaaggtc ttgactcact ctgtgctcca
     1921 ttcctgtatc taaatttcaa caatgaagct ttggcgtatg catgcatgtc tgcttttatt
     1981 cccaaatatc tgtataactt cttcttgaaa gacaactcac atgtaataca agagtacctg
     2041 actgtgttct cccagatgat ctccttccat gatccagagc tgagtaatca cctcaacgag
     2101 attggcttca tccctgatct ctacgccatc ccgtggtttc tcaccatgtt cactcatgta
     2161 tttccactgc acaaaatttt ccacctctgg gatacgttat tgcttggaaa ttcctctttc
     2221 ccattctgca ttggggtggc tatcctccag cagctccggg atcgtctttt ggctaatggc
     2281 ttcaatgaat gcatccttct cttctccgac ttaccagaaa ttgacattga acgctgcgtg
     2341 cgagagtcgg tcaatctgtt ttgctggact cctaaaagtg ctacatacag gcagcatgct
     2401 cagcctccaa ggccggcctc tgagagcagt gccgtcagaa gctcatcagc gccttacttc
     2461 tctgccgagt gtactgaccc tccaaaaaca gacctgtcaa gagaatccat ccctttaagt
     2521 gacctgaaat cggaagtgtc accgcggatt tcagcagagg acctgattga tctgtgtgag
     2581 ctcacggtca caggccactt caaaaccccc accaagaaaa ccaagtccag taaacccaag
     2641 ctcctggtgg ttgacatccg aaacagtgag gactttcttc gaggtcacat tgcaggcagc
     2701 atcaacatcc ctttcagcgc agcgttcaca gcggaaggag agctcagcca gggcccttac
     2761 accaccatgc tgcacagctt caaggggaag gtcattgtga ttgtggggca cgtggctaag
     2821 caaacatccg agtttgcagc tcaccttgtg aagatgaaat atccaagagt ctgcattcta
     2881 gatggcggca ttaacaagat caagccaacg ggcctcctca cggtcccctc tcctcagata
     2941 tgaaggactg agtgcctggc tgacaagaca gagtgccatc acccctcaca gcccatctaa
     3001 ctgggacaca agtggacacc cagaccactg cattgtgaca ttttctcatt tacttttata
     3061 aatcgtgact caaatggtca cctatctagg caagaaattt gattatacat gtattgctga
     3121 aagaatttca gtagtgaaat ctgatcatga agtatttcca cactgccaca tacagccaga
     3181 ggaattcagc taacagggca gattgagcac tatcaagagt ccaagatgaa ctgagagagc
     3241 tgccgtccac tgccctgagc agactgtcct aacaaaggtg tgcagagaat ttgatgtatt
     3301 caccacctct tgacagcaaa aattagaaag ctagtcacag tagatgtatt tggtaactca
     3361 caaacaaggg ttgtgtctgt ctgtctgtct gtctgtctgt gtggtgcacg tgtgtttagt
     3421 ccattgtgaa aagtggtagc agattctcag agagtggaat ttcagagtct ggccatattt
     3481 gatagcatat ttgtccacat cctatagcag gaaattgaaa gaatgactca aacagctttt
     3541 ctgatctagc acactcaagt cttcatggac agagactgct tccttaccca cataatggta
     3601 cagagctgat atctcctact gctttactac agaggagttc tcttcttgtg aataaaaaca
     3661 gctccttaga ctggggcaac atacacaggt ctaagccagg tggtctcccg gtgctgagag
     3721 ggggaaatgg acacaagccc tgcccctcac tgagacgcta tctcccgttg ataaccactc
     3781 tcaaagaaac aaatagtttc tccaaaggag tctcactgtg gatacaaacc acacttagag
     3841 tcagactcca tgcccgcagt agatgaccag caaatatgaa ctcaagtgta gttttagatt
     3901 tttttatctg atactgcttt gtttgggcat tttttttcct ttatttttta tatggtatta
     3961 tctctgattt tgtgttttta ttggttttgt ttgtgtgtat gtgtatatat gtgtatttct
     4021 ttgtgctatt tttgtttgtt ttgttttatt ctgatttgtt ttctaaataa tgaaaaagaa
     4081 ggcatagagt tggaagggtg gcaaatggga gacaataagg tagaggaaac tgtgatcaga
     4141 atgaattgaa gaaaaattat tttcaattaa aaaaacctgg ctcctcagct cccatcatta
     4201 tatctgcagt ctagaagaac gaaatgaaag agggaaggag agacagaaag aaggcagaga
     4261 aataaggaag aaacgtcaac agggaaggga agagttattt cccttccctt caaagacatg
     4321 ggctgatgct ggcattctcc ctccacagcc agaatggtgg caggcctgga cacacatgat
     4381 ggcacccagg gaatggtgag ggaagctgag gttgcaggcc ctggctgaaa gccatctccc
     4441 cagctccgaa agccgtctac agtgtgagga gaagaaaaca tgttcaagct ctatagaatc
     4501 taaaaatcca caattgtatg ataccacaaa tatgaaaaca gaaaaactaa ggcatttcat
     4561 catttgtaag aggaactttt ttcagatttc tgaaatggca acgtatataa taagtgaaat
     4621 atgtcctttg actatttgca gtgttgtttc aaaagtggtc actccgtcag tgtgaaggct
     4681 gtctactctg aacagtaact tcaggcccta agccgtgatt tcctgctgct gttgctgtct
     4741 ttattttgtt tgcatctgtt tttaattttg tgagtacgga cgtgtgggtt caggtacctg
     4801 tgcatatggt gtcatctact cattctccaa ctttctttgg tatttttgat gtgggatgta
     4861 gactagaatg ctaattaact taccaatagg ccagcaggac ctgaggtcct gctgtattca
     4921 acctccagca ctaggactac acacatcacc accacgccca actacttatt gggttctggg
     4981 catctgaact caggtcttca tacttgaaag gcaagtgctc tacccactga gccatctcct
     5041 cagcttgcgt ctatgtaaaa atatactttg caaactataa aatttacctt tttattataa
     5101 gtgaatcagt catttattaa ttcgtaacat tgtactgtag ttacctctag tatttgattc
     5161 cagaacattt tcatgacccc aaaccaaaat actgtattta tttgcagcca ttttccaata
     5221 acctctactt ggtctttgat ttcagtttcg tgcttggagt aagacagaga cttttacatg
     5281 aagatatcca ggtcaattaa attatacttg gttattcatc aaacatcttt tgaattatct
     5341 attatgtaag atactaatgt gaccaataac tatcattttg tgatccttac ataatttgta
     5401 aagaaaaaca agcagacttg gaaaaaaatg actaccattg tccaacacca ttttagatca
     5461 acatgaacct tgtcagtgcc cctggttttc ctcggtcttt ggtggtttaa ctgtctccat
     5521 agtaagaatg cagcactgaa aatcacctca gaagaattgc accagatctt aactttctct
     5581 tactgataga gcagagaagg gggaacagag tggccaaggt ttgactgagc agagtgacaa
     5641 atgggagagg acgaagacat gagcattgta agggaaatgt tctaacgtaa cattcagagt
     5701 gtctaatatt gtcaacttga caggctctac tctcacctag gagacactcc tctaggcgtg
     5761 tctgtgaagg agtttccgta ttgggctaat tgaagtggga tgccccaccc taactatgag
     5821 tggtcctatt tcagtagctg cagttcagga tggaacaaag taggaaaaga acactgagct
     5881 ctgtcattca tctccctgtg tcctgactag gatgtaaagt ggccaggctt ctgttatcac
     5941 tactttcctt ctttgaaatt ctgtatgcta aaagtgtgag caaaaatacc ccctattcta
     6001 cgctgtttct gtcatgtttg ccccagaaac agaaaaagta atacagcatg ctaacctgtt
     6061 gcagatcata tcaataaagt tgaccttagc aactgttctt aaa
//
