LOCUS       NM_001012161            1817 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tubulin folding cofactor E (Tbce), mRNA.
ACCESSION   NM_001012161 XM_341537
VERSION     NM_001012161.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Sferra,A., Baillat,G., Rizza,T., Barresi,S., Flex,E., Tasca,G.,
            D'Amico,A., Bellacchio,E., Ciolfi,A., Caputo,V., Cecchetti,S.,
            Torella,A., Zanni,G., Diodato,D., Piermarini,E., Niceta,M.,
            Coppola,A., Tedeschi,E., Martinelli,D., Dionisi-Vici,C., Nigro,V.,
            Dallapiccola,B., Compagnucci,C., Tartaglia,M., Haase,G. and
            Bertini,E.
  TITLE     TBCE Mutations Cause Early-Onset Progressive Encephalopathy with
            Distal Spinal Muscular Atrophy
  JOURNAL   Am J Hum Genet 99 (4), 974-983 (2016)
   PUBMED   27666369
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Bommel,H., Xie,G., Rossoll,W., Wiese,S., Jablonka,S., Boehm,T. and
            Sendtner,M.
  TITLE     Missense mutation in the tubulin-specific chaperone E (Tbce) gene
            in the mouse mutant progressive motor neuronopathy, a model of
            human motoneuron disease
  JOURNAL   J Cell Biol 159 (4), 563-569 (2002)
   PUBMED   12446740
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Martin,N., Jaubert,J., Gounon,P., Salido,E., Haase,G., Szatanik,M.
            and Guenet,J.L.
  TITLE     A missense mutation in Tbce causes progressive motor neuronopathy
            in mice
  JOURNAL   Nat Genet 32 (3), 443-447 (2002)
   PUBMED   12389029
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Parvari,R., Hershkovitz,E., Grossman,N., Gorodischer,R., Loeys,B.,
            Zecic,A., Mortier,G., Gregory,S., Sharony,R., Kambouris,M.,
            Sakati,N., Meyer,B.F., Al Aqeel,A.I., Al Humaidan,A.K., Al
            Zanhrani,F., Al Swaid,A., Al Othman,J., Diaz,G.A., Weiner,R.,
            Khan,K.T., Gordon,R. and Gelb,B.D.
  CONSRTM   HRD/Autosomal Recessive Kenny-Caffey Syndrome Consortium
  TITLE     Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism
            and autosomal recessive Kenny-Caffey syndrome
  JOURNAL   Nat Genet 32 (3), 448-452 (2002)
   PUBMED   12389028
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Bartolini,F., Bhamidipati,A., Thomas,S., Schwahn,U., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Functional overlap between retinitis pigmentosa 2 protein and the
            tubulin-specific chaperone cofactor C
  JOURNAL   J Biol Chem 277 (17), 14629-14634 (2002)
   PUBMED   11847227
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Sagot,Y., Dubois-Dauphin,M., Tan,S.A., de Bilbao,F., Aebischer,P.,
            Martinou,J.C. and Kato,A.C.
  TITLE     Bcl-2 overexpression prevents motoneuron cell body loss but not
            axonal degeneration in a mouse model of a neurodegenerative disease
  JOURNAL   J Neurosci 15 (11), 7727-7733 (1995)
   PUBMED   7472523
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089833.1.
            
            On Feb 11, 2005 this sequence version replaced XM_341537.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089833.1, SRR8487227.332367.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..1817
                     /gene="Tbce"
                     /note="tubulin folding cofactor E"
                     /db_xref="GeneID:361255"
                     /db_xref="RGD:1305533"
     exon            1..51
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            52..182
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1657
                     /gene="Tbce"
                     /codon_start=1
                     /product="tubulin-specific chaperone E"
                     /protein_id="NP_001012161.1"
                     /db_xref="GeneID:361255"
                     /db_xref="RGD:1305533"
                     /translation="MSDILPLDVIGRRVEVNGEYATVRFCGAVPPVAGLWLGVEWDNP
                     ERGKHDGSHEGTMYFKCRHPTGGSFVRPNIVNFGEDFLTALKKRYVLTDGPDDDEKSC
                     SLKVGSKQVQTIGFEHITKKQSQLRSLQDISLWKCAVSCAGERGRIAEACPNIRVVDL
                     SKNLLSTWDEVILIAEQLKDLEALDLSENKLQFPSDSPTLTRTFSTLKTLVLNKTGIT
                     WTEVLHCAPSWPVLQELYLKSNGISISERPVNALQNLRLLDLSSNPSIDESQLCLIAY
                     LPRLEHLLLSDIGLSSIHFPDAEIGCKTSMFPALTYLIVNDNQISEWSFINELDKLQS
                     LQALSCARNPLTKGDKAEEIIIAKIGQLKTLNRCQILPEERRGAELDYRKAFGKEWRK
                     AGGHPDPDRNRPSAEFLSAHPRYQLLCCKYGAPEDEELKTQQPFMLKNQLLTLKIKCS
                     NQPEQQILEKQLPDSMTIQKVKGLLSRLLKVPVSELLLSYESSKMPGREIELENDLQP
                     LQFYSVENGDCLLVRW"
     exon            183..267
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            268..453
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            454..542
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            543..642
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            746..822
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            823..918
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            919..983
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1048
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1189
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1343
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1412
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1472
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1564
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1791
                     /gene="Tbce"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcagggt gcgtgagggc ctctgggtgc tgacagaccg gctgaaagaa ggtctcctat
       61 tttgaattcc tgctatctta gaatgagtga catcttgcca ttagatgtca ttggtagaag
      121 agttgaagtt aacggagaat acgcaacagt gcgcttttgt ggtgctgttc ctcctgtggc
      181 aggactctgg ttaggagttg agtgggacaa tcctgagaga ggaaagcatg atgggagcca
      241 cgaaggtact atgtatttta aatgcaggca cccaacagga ggctctttcg ttcgtccaaa
      301 catagttaat tttggagaag actttcttac tgcccttaag aagcgctatg tgctcacaga
      361 tggacctgat gatgatgaaa aatcgtgttc cttaaaagtc ggaagtaaac aagtgcaaac
      421 tattggattt gagcatatta caaagaagca gagtcagctg agatcactgc aggacatttc
      481 cctgtggaag tgtgccgtga gttgtgctgg tgaacgagga agaattgctg aagcctgccc
      541 caatattcga gttgtagatt tatccaaaaa cttgttgtca acttgggatg aagtgattct
      601 tattgcagag cagctcaaag acctggaggc tctggatctc agtgaaaata aactgcagtt
      661 tccctctgac tcaccaactc taactagaac attttctact ctgaagactt tagtcctgaa
      721 caaaacagga ataacgtgga ctgaggtgct gcactgtgcc ccttcatggc cagtcctcca
      781 ggaactttac ctcaagtcta acggtatttc catttcagaa aggccagtga atgccctgca
      841 gaacctgagg ttactagacc tttcttccaa cccatcaatt gatgaaagcc agctgtgcct
      901 gatagcatat ctcccaagat tagaacacct actcctttct gacattggac tttcttctat
      961 acattttcca gatgctgaaa ttgggtgcaa aacatccatg ttcccggcct tgacgtacct
     1021 catagtcaat gacaaccaga tatcagaatg gtcatttatc aatgagctgg ataaattaca
     1081 gagcctgcag gccctgtcct gtgctagaaa ccctttgacc aaaggagaca aagcagagga
     1141 gatcatcatt gccaagattg gtcagctgaa gaccctgaac aggtgtcaga ttcttccaga
     1201 ggaaaggcgt ggtgctgagc ttgattatcg aaaagccttt ggaaaagaat ggagaaaggc
     1261 tggtggacac ccagatccag acagaaacag gccaagtgca gagtttctct cggcccatcc
     1321 aagataccag cttctctgct gcaaatatgg tgcacctgaa gatgaggagc tcaaaacaca
     1381 gcagccattc atgctaaaaa atcagctact aacactgaag ataaaatgct caaatcaacc
     1441 tgaacaacaa atattagaaa agcagttgcc agactccatg acaattcaaa aggtaaaggg
     1501 actgctgtca cgtcttctca aggttcctgt gtcagaactt ctgttgtcct acgaaagttc
     1561 caagatgccg ggcagagaaa tcgaactaga aaatgacctg cagccattac agttttattc
     1621 tgtggagaat ggagactgcc tactggtgcg ctggtagcag gccaaccgtg agagttaagg
     1681 ctggaatgtg tacaccagaa acagaacctc tgccctcaca aatgatgttg ttttgttggg
     1741 aaaagaccat tcggttgttt attaatagaa taataaaggc tttgattact aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaa
//
