LOCUS       NM_001271364            3882 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tubulin folding cofactor D (Tbcd), mRNA.
ACCESSION   NM_001271364 XM_002730075
VERSION     NM_001271364.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Edvardson,S., Tian,G., Cullen,H., Vanyai,H., Ngo,L., Bhat,S.,
            Aran,A., Daana,M., Da'amseh,N., Abu-Libdeh,B., Cowan,N.J.,
            Heng,J.I. and Elpeleg,O.
  TITLE     Infantile neurodegenerative disorder associated with mutations in
            TBCD, an essential gene in the tubulin heterodimer assembly pathway
  JOURNAL   Hum Mol Genet 25 (21), 4635-4648 (2016)
   PUBMED   28158450
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Miyake,N., Fukai,R., Ohba,C., Chihara,T., Miura,M., Shimizu,H.,
            Kakita,A., Imagawa,E., Shiina,M., Ogata,K., Okuno-Yuguchi,J.,
            Fueki,N., Ogiso,Y., Suzumura,H., Watabe,Y., Imataka,G., Leong,H.Y.,
            Fattal-Valevski,A., Kramer,U., Miyatake,S., Kato,M., Okamoto,N.,
            Sato,Y., Mitsuhashi,S., Nishino,I., Kaneko,N., Nishiyama,A.,
            Tamura,T., Mizuguchi,T., Nakashima,M., Tanaka,F., Saitsu,H. and
            Matsumoto,N.
  TITLE     Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative
            Encephalopathy
  JOURNAL   Am J Hum Genet 99 (4), 950-961 (2016)
   PUBMED   27666374
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Flex,E., Niceta,M., Cecchetti,S., Thiffault,I., Au,M.G.,
            Capuano,A., Piermarini,E., Ivanova,A.A., Francis,J.W., Chillemi,G.,
            Chandramouli,B., Carpentieri,G., Haaxma,C.A., Ciolfi,A., Pizzi,S.,
            Douglas,G.V., Levine,K., Sferra,A., Dentici,M.L., Pfundt,R.R., Le
            Pichon,J.B., Farrow,E., Baas,F., Piemonte,F., Dallapiccola,B.,
            Graham,J.M. Jr., Saunders,C.J., Bertini,E., Kahn,R.A., Koolen,D.A.
            and Tartaglia,M.
  TITLE     Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor
            D, Perturb Microtubule Dynamics and Cause Early-Onset
            Encephalopathy
  JOURNAL   Am J Hum Genet 99 (4), 962-973 (2016)
   PUBMED   27666370
REFERENCE   4  (bases 1 to 3882)
  AUTHORS   Tian,G., Thomas,S. and Cowan,N.J.
  TITLE     Effect of TBCD and its regulatory interactor Arl2 on tubulin and
            microtubule integrity
  JOURNAL   Cytoskeleton (Hoboken) 67 (11), 706-714 (2010)
   PUBMED   20740604
REFERENCE   5  (bases 1 to 3882)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 3882)
  AUTHORS   Bartolini,F., Bhamidipati,A., Thomas,S., Schwahn,U., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Functional overlap between retinitis pigmentosa 2 protein and the
            tubulin-specific chaperone cofactor C
  JOURNAL   J Biol Chem 277 (17), 14629-14634 (2002)
   PUBMED   11847227
REFERENCE   7  (bases 1 to 3882)
  AUTHORS   Bhamidipati,A., Lewis,S.A. and Cowan,N.J.
  TITLE     ADP ribosylation factor-like protein 2 (Arl2) regulates the
            interaction of tubulin-folding cofactor D with native tubulin
  JOURNAL   J Cell Biol 149 (5), 1087-1096 (2000)
   PUBMED   10831612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 17, 2021 this sequence version replaced NM_001271364.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               JAXUCZ010000010.1  107215667-107215907
            242-292             JAXUCZ010000010.1  107217339-107217389
            293-390             JAXUCZ010000010.1  107223096-107223193
            391-492             JAXUCZ010000010.1  107224176-107224277
            493-639             JAXUCZ010000010.1  107224921-107225067
            640-695             JAXUCZ010000010.1  107225436-107225491
            696-828             JAXUCZ010000010.1  107237648-107237780
            829-874             JAXUCZ010000010.1  107252249-107252294
            875-1007            JAXUCZ010000010.1  107254727-107254859
            1008-1150           JAXUCZ010000010.1  107257578-107257720
            1151-1211           JAXUCZ010000010.1  107258957-107259017
            1212-1286           JAXUCZ010000010.1  107259956-107260030
            1287-1381           JAXUCZ010000010.1  107263458-107263552
            1382-1538           JAXUCZ010000010.1  107300410-107300566
            1539-1596           JAXUCZ010000010.1  107309257-107309314
            1597-1626           JAXUCZ010000010.1  107315902-107315931
            1627-1712           JAXUCZ010000010.1  107319959-107320044
            1713-1793           JAXUCZ010000010.1  107330300-107330380
            1794-1867           JAXUCZ010000010.1  107331796-107331869
            1868-1985           JAXUCZ010000010.1  107332634-107332751
            1986-2046           JAXUCZ010000010.1  107335285-107335345
            2047-2069           JAXUCZ010000010.1  107336419-107336441
            2070-2101           JAXUCZ010000010.1  107340855-107340886
            2102-2164           JAXUCZ010000010.1  107347306-107347368
            2165-2241           JAXUCZ010000010.1  107348116-107348192
            2242-2323           JAXUCZ010000010.1  107349496-107349577
            2324-2442           JAXUCZ010000010.1  107351629-107351747
            2443-2537           JAXUCZ010000010.1  107353893-107353987
            2538-2678           JAXUCZ010000010.1  107354616-107354756
            2679-2762           JAXUCZ010000010.1  107359720-107359803
            2763-2921           JAXUCZ010000010.1  107360720-107360878
            2922-3060           JAXUCZ010000010.1  107360952-107361090
            3061-3182           JAXUCZ010000010.1  107361336-107361457
            3183-3260           JAXUCZ010000010.1  107362965-107363042
            3261-3350           JAXUCZ010000010.1  107365739-107365828
            3351-3438           JAXUCZ010000010.1  107366501-107366588
            3439-3548           JAXUCZ010000010.1  107367154-107367263
            3549-3633           JAXUCZ010000010.1  107368804-107368888
            3634-3882           JAXUCZ010000010.1  107372150-107372398
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..3882
                     /gene="Tbcd"
                     /note="tubulin folding cofactor D"
                     /db_xref="GeneID:100361417"
                     /db_xref="RGD:2320148"
     exon            1..241
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3651
                     /gene="Tbcd"
                     /codon_start=1
                     /product="tubulin-specific chaperone D"
                     /protein_id="NP_001258293.1"
                     /db_xref="GeneID:100361417"
                     /db_xref="RGD:2320148"
                     /translation="MVLSNEPAASAAEEEVEDDALVRASTLEAFGESAETRALLRSLP
                     AVHRERAAREVAEERFRVIMDKYQEQPHLLDPHLEWMMNSLLDIVQDETSLPDLVHLA
                     FKFLYIITKVRGYKVFLRLFPHEVADVQPVLDMFTGQNPKDHETWETRYMLLLWLSVT
                     CLIPFDFSRLDGNLPTQSGETRMPIMDRILQIAQSYLVVSDKARDAAAVLVSKFITRP
                     DVKQRKMASFLDWSLCTLAHSSFQTIDGVITMDGMLQALAQIFKHGKREDCLPYANTV
                     LQCLDGCRLPESSHTLLRKLGVKLVQRLGLTFLKPKVATWRYQRGCRSLAANLQLRAP
                     GKSEQKLLSDSLTSDGDEDYDVPEGVETVIEQLLVGLKDKDTIVRWSAAKGIGRMAGR
                     LPRELADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLSEVVTVILKAL
                     TYDEKRGACSVGANVRDAACYVCWAFARAYEPQELTPFVTAISSALVIAAVFDRNVNC
                     RRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNISNCFLIISVFIAGFQEYTKPMI
                     DHLVSMKINHWDGAIRELSAKALHNLTSLVPEYMATHVFPALLLMTQSPDLHTRHGAI
                     LACAEVTYALYELAAQSNRLVTDYLDEKAVQSLKQIHQQLCDRHLYRGLGGELMRQAV
                     CILIEKLSLSRMPFKGDTVIEGWQWLINDTLRSLHLVSSHSREQIKEVAVSALAAVCN
                     EYYKKEPGEAGSTITEELIPQYLAELRSPEEMTRCGFSSALGALPCFLLRGHLQQVLS
                     GLRRVTCTTSPMDVSFAEARRDGLKAISRICQTVGVNTQGPPDEVICQENISEVYAAL
                     LGCMSDYTTDSRGDVGAWVREASMTSLMDLMLLLAQTEPVLIEAHICERVMCCVAQQA
                     SEKIDRFRAHAARVFLTLLHFDSPPIPHVPHRKELESLFPRSDVATVNWNAPSQAFPL
                     ITQLLGLPTYRYHVLLGLAVSVGGLTESTVRHSTQSLFEYMKGIQKDAQVLESFSETL
                     LKVFEDNLLNDRVSVSLLKMLDQLLANGCFDIFTAEENHPFCVKLLTLCKEEIKKSKD
                     IQKLRSSIAVLCGMVQFSGDVRKKVLLQLFLLLGHPFPVIRKSTASQVYEMVLTYSDL
                     VDAEVLDEVMSVLSDTAWDSELPVVRGQRNHLCDLLGVPRPQLVPKPVPGS"
     exon            242..292
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            293..390
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            391..492
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            493..639
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            640..695
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            696..828
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            829..874
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1007
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1150
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1211
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1286
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1381
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1538
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1596
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1626
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1712
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1793
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1867
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1985
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2046
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2069
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2101
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2164
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2241
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2323
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2442
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2537
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2678
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2762
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2921
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3060
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3182
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3260
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3350
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3438
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3548
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3633
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3882
                     /gene="Tbcd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatctcctt tcttcccggt tgccggtagg gttcttacgg agcctgctac tggcacgatg
       61 gtactgagca acgagccggc tgcgagcgcc gcggaggagg aggtggagga tgatgcgctt
      121 gtccgcgcct ccaccctgga agcgttcggc gagagtgcgg agacccgcgc gctgctccgc
      181 agcttgccgg cggtgcaccg cgagcgcgcg gcccgggagg tggcggagga gcggttccgc
      241 gtaattatgg acaaatacca ggagcagccc cacctcctgg acccacacct cgagtggatg
      301 atgaactcac tgttggacat agtacaggat gagacatctc tgcccgacct tgtacatctg
      361 gcttttaaat ttctgtatat catcaccaag gttcgtggat ataaagtatt tctgcgtctg
      421 tttccccatg aagtagctga tgttcagcct gtgttagata tgttcacagg acagaaccct
      481 aaagaccatg agacatggga aactcgctac atgcttttac tgtggctgtc tgtgacctgc
      541 ttgatccctt ttgatttttc acgccttgat gggaacctgc ccactcaatc tggagaaaca
      601 cggatgccca taatggaccg aattctgcaa atagcacagt cttacttggt ggtcagtgac
      661 aaggcgcgag atgcggctgc tgtccttgtg tccaagttta tcacacgtcc tgatgtcaag
      721 cagagaaaga tggccagctt tctggactgg agcctttgta ccttggccca ctcttccttc
      781 cagaccattg acggtgtcat taccatggat gggatgttgc aggccctggc tcaaatattt
      841 aagcatggaa aacgtgaaga ctgtctaccc tatgccaaca ctgtgctcca gtgccttgat
      901 ggatgtagac tccctgagag cagtcacacc ttactgcgga agcttggtgt gaagcttgtc
      961 cagaggctgg ggctgacttt cctgaagcca aaggtggcca cgtggaggta tcagcgtggc
     1021 tgtcggtctt tggctgccaa cctgcagctc cgtgctccgg gtaagagtga acagaagctg
     1081 ctgtctgata gtttgacctc tgatggtgat gaagactatg atgtcccaga gggggtggaa
     1141 actgtgatag agcaactgct ggttgggctg aaggacaagg acacgatagt gcggtggtct
     1201 gcagctaaag gaattggtag gatggctgga aggcttccca gagagctggc agatgatgtg
     1261 gtggggtccg tgttggactg tttcagcttt caggagacag ataaggcatg gcatggtgga
     1321 tgtctggcac tggcagagct gggtagacga ggcctgttgc tgccatcgag actctcagag
     1381 gttgtcacag tgatcctgaa ggcccttacc tacgatgaga agcggggtgc ctgcagcgtg
     1441 ggggccaacg tcagggatgc tgcctgctat gtgtgctggg cttttgcacg tgcctacgag
     1501 cctcaggagt tgacaccttt cgtgactgcc atttcaagtg ccctggtcat tgctgctgta
     1561 tttgaccgaa acgtgaactg cagaagagca gcctctgctg ccttccagga gaacgtgggg
     1621 agacagggta cttttcctca tggaattgat attttgacta cagcagacta ttttgcagtt
     1681 ggtaacattt ctaactgttt cctgattata agcgtgttta ttgctggctt ccaggaatac
     1741 accaagccaa tgatcgacca cctggtctcc atgaaaatca accactggga tggggccatc
     1801 cgagaactgt ctgcaaaggc actgcacaac ctgacttcac tagtacccga gtacatggcc
     1861 actcacgtat tcccagcact actgctgatg acacagagtc cagatctaca cacgagacat
     1921 ggtgccatcc ttgcctgtgc agaggtcacc tatgccctgt acgagctggc cgcacagagt
     1981 aacaggcttg tcacagacta tctggatgag aaggcagtgc aaagcctgaa gcagatccac
     2041 cagcagcttt gtgatcgcca tctctaccgg ggtctgggag gagagcttat gagacaagca
     2101 gtgtgcatct taatagagaa attgtcactt tccagaatgc cctttaaagg tgacaccgtt
     2161 attgagggat ggcagtggct gataaatgac actctcagga gccttcacct tgtttcaagc
     2221 cattccagag aacagatcaa ggaggtggct gtctctgccc tggctgccgt ctgcaatgaa
     2281 tactacaaga aggagcctgg ggaggcaggc tctaccatca cagaggagct gattccacag
     2341 taccttgctg aactccgaag cccagaggag atgacccgtt gtggcttttc ctcagccttg
     2401 ggtgccctcc cgtgtttcct tctcaggggc catctgcagc aggttctctc aggtctgaga
     2461 agagtcacct gtactacttc tcccatggat gtgagctttg ctgaggccag gagagacggt
     2521 ttgaaagcaa tctcgagaat ttgccagaca gttggtgtga acacacaggg acctccagat
     2581 gaagtcatat gccaagagaa catctctgag gtttatgctg cattgctggg ctgcatgagt
     2641 gattacacca cagacagcag aggcgatgtg ggagcctggg ttcgtgaggc ttccatgacc
     2701 agcctcatgg atttgatgct tttgctggca cagactgagc cagtgctgat tgaggcccac
     2761 atctgtgagc gtgtcatgtg ttgcgttgcc cagcaggcaa gtgagaagat tgatcggttc
     2821 cgtgctcatg ctgcccgggt attcctgact ctcttgcact tcgacagccc tcccattccc
     2881 catgttcccc accgcaagga actggaaagt ctgtttccca ggtctgatgt ggccactgtg
     2941 aactggaatg caccttcaca ggccttccct cttatcaccc agctcttggg actgcctacc
     3001 tatagatacc atgtcctgct ggggctggcc gtgtccgtgg gtggcttgac agagtctacg
     3061 gtcaggcatt ctacacagag cctcttcgag tacatgaagg ggattcagaa ggatgctcag
     3121 gtcctggaga gcttcagtga gaccctccta aaggtctttg aggacaacct cttgaatgac
     3181 agagtgtctg tatcgctgct gaaaatgttg gaccagctgt tggccaatgg gtgctttgac
     3241 atctttactg ccgaggagaa ccaccccttt tgtgtgaagt tgctcacact ttgtaaggaa
     3301 gaaatcaaga agtcaaaaga catccagaaa cttcggtcaa gcattgcagt gctctgtggg
     3361 atggtgcagt tcagtggtga tgtgagaaag aaggttcttc tgcagctctt cctcctcctt
     3421 ggccaccctt ttcctgtgat ccggaagagc acagcaagcc aggtatatga gatggtgctt
     3481 acctatagtg acttggtaga tgctgaggtg cttgatgagg tcatgtctgt gctcagtgac
     3541 acagcctggg actcagagct tcccgttgta agaggacagc ggaatcacct gtgtgacctc
     3601 cttggtgtgc ccagacccca actggttcca aagcctgttc caggaagctg agccttgccc
     3661 gcctagctgg gatgctttgc cctgaggctc cacaacaggc tttaccatca tggaaacttg
     3721 gtgccacaga cttctgagaa aggtagcacc tgctgctaga tggattggga ggccatcccc
     3781 agagagcagc aattcctcat ggatgctgtg ctctggtgac ctggactgcc catacttttg
     3841 ctgtcacaca gatgtgcttc tcattaaatc atgtatcaca ca
//
