LOCUS       NM_001401137            5657 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus TBC1 domain family member 8B (Tbc1d8b), mRNA.
ACCESSION   NM_001401137 XM_003749480
VERSION     NM_001401137.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5657)
  AUTHORS   Dorval,G., Kuzmuk,V., Gribouval,O., Welsh,G.I., Bierzynska,A.,
            Schmitt,A., Miserey-Lenkei,S., Koziell,A., Haq,S., Benmerah,A.,
            Mollet,G., Boyer,O., Saleem,M.A. and Antignac,C.
  TITLE     TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic
            Syndrome via Defective Trafficking Pathways
  JOURNAL   Am J Hum Genet 104 (2), 348-355 (2019)
   PUBMED   30661770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Feb 2, 2022 this sequence version replaced XM_003749480.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1629157.1,
                                           SRR26360172.2355655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000021.1  108107799-108108120
            323-433             JAXUCZ010000021.1  108125485-108125595
            434-552             JAXUCZ010000021.1  108134570-108134688
            553-778             JAXUCZ010000021.1  108136004-108136229
            779-1019            JAXUCZ010000021.1  108136869-108137109
            1020-1227           JAXUCZ010000021.1  108140812-108141019
            1228-1392           JAXUCZ010000021.1  108141810-108141974
            1393-1542           JAXUCZ010000021.1  108154668-108154817
            1543-1693           JAXUCZ010000021.1  108155556-108155706
            1694-1908           JAXUCZ010000021.1  108156173-108156387
            1909-2026           JAXUCZ010000021.1  108168489-108168606
            2027-2312           JAXUCZ010000021.1  108170134-108170419
            2313-2442           JAXUCZ010000021.1  108172865-108172994
            2443-2541           JAXUCZ010000021.1  108173537-108173635
            2542-2610           JAXUCZ010000021.1  108178452-108178520
            2611-2851           JAXUCZ010000021.1  108178673-108178913
            2852-2917           JAXUCZ010000021.1  108179847-108179912
            2918-3001           JAXUCZ010000021.1  108181946-108182029
            3002-3058           JAXUCZ010000021.1  108183035-108183091
            3059-3156           JAXUCZ010000021.1  108191643-108191740
            3157-5657           JAXUCZ010000021.1  108193244-108195744
FEATURES             Location/Qualifiers
     source          1..5657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..5657
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /note="TBC1 domain family member 8B"
                     /db_xref="GeneID:315912"
                     /db_xref="RGD:1563084"
     exon            1..322
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..3549
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /note="TBC1 domain family, member 8B (with GRAM domain)"
                     /codon_start=1
                     /product="TBC1 domain family member 8B"
                     /protein_id="NP_001388066.1"
                     /db_xref="GeneID:315912"
                     /db_xref="RGD:1563084"
                     /translation="MWLKPEEVLLKNALKLWLMERSNEYFVLQRRRGYGEEGGGGLTG
                     LLVGTLDSVLDSTAKVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTL
                     SVFDSNEDITNFVQGKIRGLIAEEGKQSFAKEDDPEKFREALLKFEKSFGLPEQEKLV
                     TYYSCSYWRGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDAISKLEKTSSVIVAE
                     SIHVCSQGENHYFSMFLHINETYLLMEQLTNYAIKRLFDKETFDNDPVLDDPLQITKR
                     GLEYRAHSEQFKAFFRLPKEETLKEVHECFLWVPFSHFSTHGKMCISENYICFASQDG
                     NLCSVIIPLREVLAVDKTDDSSRSVIISIKGKTAFRFNEVKDFEQLVAKLRLKCRAAS
                     TQDDGSTEVAISSDSTGLSENFEEQPLTFPKECSKTVNTEALMTVFHPQNLENLDSKM
                     LKEKMKEQSWNILFSECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMAA
                     NPGYYAEVVEQSLGTSNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNP
                     KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELI
                     RDHLPQLTDHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGL
                     AILDYNLDKLLTCKDDAEAVTALNRFFDNVINKDSPLPSNVQQGSNINDGKSNHAKVD
                     ITDLIRESNEKYGSIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKMSLQEL
                     DELYVIFKKELFISCYWYLSCPGLKHHDPSLSYLEQYQIDCQQFRVLFHLLCPWAHSA
                     NRDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVI
                     SKTSSKGDELSTEELLYFSQLQVSKPADGKETELGRKSPEKGKGKIDIQAYLSQWQDE
                     LLKKEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEEALYQAIAIVTNLLLRMEEVGR
                     KLHSPASSAKGLSSVACDSGPSEGNTESSVKKDPSSPREEHQWSFAFEQILASLLNEP
                     ALVRFFERPLDLKAKLEKAKSSQLRSRTKM"
     exon            323..433
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            434..552
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            553..778
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1019
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1227
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1392
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1542
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1693
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1908
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2026
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2312
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2442
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2541
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2610
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2851
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2917
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3001
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3058
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3156
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..5657
                     /gene="Tbc1d8b"
                     /gene_synonym="RGD1563084"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcactctct ctgcctacgt gggagagaag gcacggttgg gggaagtgtg gaaaacctcc
       61 ggaggcgccg ccgccgccgc caacggaaga cttggtagga ggagaagtag aggggtaaag
      121 acaggctggg ttggggggag gtaaggagga caaataggtc gccgcttctg aggcggcaca
      181 aagttcttcg agatgtggct gaagcccgag gaagtgttgt tgaaaaatgc gctgaagctg
      241 tggctgatgg aaagatccaa cgagtacttt gtcctgcaaa ggcggcgagg ctacggggaa
      301 gaaggcggag gaggacttac aggtcttttg gttgggactc ttgattccgt cttagactct
      361 actgctaagg tagctccgtt tcgcatccta caccagacac cagattctca agtgtacttg
      421 tcaattgcat gtggagccaa cagagaagaa ataacaaaac attgggactg gttggaacaa
      481 aatatcatga agactttatc tgtgttcgat tcaaatgaag atattactaa ttttgtacaa
      541 ggcaaaataa gaggactaat tgctgaagag ggaaaacaat cttttgctaa agaagatgat
      601 cctgagaaat ttcgagaagc ccttttgaaa tttgaaaaat cttttggttt accagagcag
      661 gagaaactag taacttatta ttcttgcagt tactggagag gacgggttcc ttgtcagggt
      721 tggctctatc taagtaccaa ctttctgagc ttctattctt tcttgctagg atcagaaatt
      781 aaactcataa tctcctggga tgcaatctca aaacttgaaa agacttcaag tgttatagta
      841 gcagagagta ttcacgtatg ttctcaagga gagaaccact atttctcaat gtttttacac
      901 atcaatgaaa cctaccttct tatggaacag ctgacaaact atgccataaa gagacttttt
      961 gataaggaaa catttgataa tgacccagtc cttgatgatc ctctacagat taccaaaaga
     1021 ggtttggaat atcgagccca cagtgagcaa ttcaaagcct tttttaggct acccaaagaa
     1081 gaaactttga aagaagtaca tgaatgtttt ttatgggtac cattcagcca cttcagtact
     1141 catggaaaaa tgtgcatttc agaaaactat atttgctttg ctagccagga tgggaatcta
     1201 tgtagtgtta tcattccatt acgagaggtt ttagctgtag ataaaactga tgactccagc
     1261 agatccgtca tcattagcat caaaggaaaa acagcttttc gtttcaatga ggttaaagac
     1321 tttgagcaac tggtggcaaa gctcaggctc aagtgccggg cagcttcaac tcaagatgat
     1381 ggtagcacag aggttgctat tagttctgac tctacaggcc tatctgagaa ttttgaggaa
     1441 caacctttga catttccgaa ggaatgcagt aaaactgtga acactgaagc cttaatgaca
     1501 gtatttcacc ctcaaaattt ggaaaatctt gattctaaaa tgttaaagga aaagatgaag
     1561 gaacaatcat ggaacatctt attttcagaa tgtggtcgtg gggttagcat gttccggaca
     1621 aaaaagactc gagacctggt tgtaagaggg attccagaga ctttaagagg ggagctctgg
     1681 atgcttttct caggtgctgt taatgacatg gcagctaacc ctggctatta tgctgaagtg
     1741 gttgaacaat ccttagggac ctccaacctg gcaactgaag aaattgagcg tgatttgcgt
     1801 cgctccctgc ctgaacaccc agcatttcag agtgatactg gcatatctgc tctgaggcgg
     1861 gtactgacag cttatgcata taggaatccc aaaataggat actgccaggc aatgaacatt
     1921 ttgacttcag tattgctcct atatgcaaaa gaagaagaag ctttttggct tctggttgct
     1981 gtatgtgaac gaatgttgcc agattatttt aatcgtcgaa tcattggtgc cttggtggat
     2041 caggcagtgt ttgaagaact aatcagggat caccttcctc agctgacaga ccacatgacc
     2101 gacatgactt tcttttcctc agtttctctc tcgtggttcc tcacgctttt cattagtgtg
     2161 cttcctattg aaagtgcagt gaatgtggtg gactgtttct tctatgacgg aatcaaagcc
     2221 attttacaac tgggattggc aatactggac tataatttag acaaacttct gacatgtaaa
     2281 gatgacgctg aagctgtgac agcactaaac aggttctttg acaatgtcat taataaggat
     2341 agcccattgc cttcaaatgt tcagcagggt tcaaatatca atgatggaaa aagcaatcat
     2401 gctaaagtgg atattacaga tttgattaga gagtccaatg agaaatatgg tagtattcgc
     2461 tatgaagata tacatagcat gcgctgtcga aataggttgt atgtgataca gaccctggag
     2521 gaaacaacaa agcagaatgt gttgcgtgtt gtatcacaag atgtgaaaat gagccttcag
     2581 gaattggatg aactttatgt catttttaag aaagagctgt tcatatcttg ttattggtat
     2641 ttgagttgtc caggactgaa gcatcatgac cccagcctgt catatttgga acaatatcag
     2701 attgactgcc agcaattcag agtattgttt cacttgttgt gtccctgggc tcattctgca
     2761 aacagagact ctctagcttt gtggacattc agattgttgg atgagaactc tgattgcctt
     2821 ataaacttca aagaattctc ctctgcaatc gatataatgt acaatggaag ttttactgag
     2881 aagctcaagc tgctttttaa gctgcatatt cctccagctt atactgaagt gatatctaag
     2941 acttcttcaa aaggtgatga gctttcaaca gaagaattac tttatttcag tcagctccaa
     3001 gtttctaagc ctgcagatgg gaaggaaaca gaattgggaa gaaaaagccc tgagaaaggc
     3061 aaaggaaaaa ttgatattca agcctattta agtcaatggc aagatgaact tctcaaaaaa
     3121 gaagagaaca ttaaagattt accaagaatg aatcagtcac aatttattca gttttcaaag
     3181 accctgtata atttatttca tgaggacccc gaagaagagg cgctatatca agccattgct
     3241 attgtaacca accttcttct caggatggaa gaagttggaa ggaaactcca tagcccggcg
     3301 tcatcagcca aaggactgtc cagtgtagcc tgtgattctg gacccagtga gggaaacaca
     3361 gagagcagtg tgaagaaaga tccttcctct cccagagaag aacatcagtg gtcctttgca
     3421 ttcgagcaga ttcttgcttc cctgttaaac gaaccggccc tggtgaggtt ttttgagaga
     3481 cccttagatt taaaagccaa gctagaaaag gcgaaaagct cccagttaag gtctagaacc
     3541 aagatgtaaa tctctgccgt cctccggttt gctaagattc ctgttctatc agcctggctc
     3601 ctgggaatac ttctcaggaa tagattgcat taccaatgtg ctccggggca gaagagaaag
     3661 acactcagaa gcacaatggt tcattgcttt gtattaattg cactttaaaa aattctccca
     3721 ctctatgtca caagataagc atcatcaggg tcacatgctc cgtggaacca ccagagggcg
     3781 ccaccatatc actttagtga gtcactcaca agtttgtact gctgtttcca tgagattact
     3841 ggtgtttcaa aaggtgatga tgtatttatt ttaatgctgt catagcatat tggtaagctt
     3901 tgtttttcaa atcgccccag tcctataaaa ccaccttaga aaactggact tcagaactat
     3961 agccttaatt atctaggaag ttgcctttta gggccctgat tcccaagttc tataactgaa
     4021 agattaactt ctaaaatgta attttattca ggacagtaat acatggtttt taaaatcaac
     4081 ttcttcattc tctgttcctg agggattaag cacttggagg ttaacactat taactctgtt
     4141 gctgataatg caaatcagga agtctaaatt ctgggctgat ataaagaaaa acaacactag
     4201 atttagactt aaatcagata aagccagcat tttgaaaaac aagaaaaggt taggagacag
     4261 ttcagttgac tatctagctc tttcagttag actgagatat aactacaaat tgtttatggc
     4321 ttttgtttca gaatagcgtg tgattgcttg tgtcccagcc ttatgttttt aattttcact
     4381 ggttgtgttt taatttgtag taggtagtgc ggaacagcta cactaagatt gaattgctgt
     4441 actagtctgg caagcatgtg aagtatactt catgtaatac tcactaaggt actatgtgga
     4501 attgccagca cctaccttaa aaaggttcga cttagatgtg caatttttac acactttatg
     4561 cttcttctat ggcggtccat gtaaatatat atggactttg atagcacttt aaaaagaaca
     4621 aaacaaaaaa caagcaaacc acgtggacct gtcctatctt ctgccatttt taacgaatac
     4681 tttatttagc agttgtcctg ggaaatgggg caggaaccat catgtggagc ttgtgtctcc
     4741 acactagact ttgatttcaa gccgttgcct tggctagaag gaaaacaatg aaagggtagc
     4801 cctccttcat ggtgaccaaa gtctcccttt gtgggaagga attggtgtgg tctgccttcc
     4861 acgagaacgt accgtgaata aaaccgagcc gtgttgccat actgcatact attttcaagg
     4921 aagttaagca cttctcacat tttgtctttg aaaattcctg agttggatgt ggtcaaatgc
     4981 tggtagtgtc tttaaggttt gattatgctg ccttttcaag gaaataacta tttaaaagag
     5041 atagtgtaaa actaagcctt tctgcctcaa ttcagaaatg attagctaaa atatgtcccc
     5101 gttttcaatt ttagttaata gtctatgtga gaaccatcac acatctgtca ttatgcaatg
     5161 attgttaaat tatacgacaa tagctctaga aaaacatatg ctccgtgctt gtatacaaag
     5221 acactgttat acacacttgg ttaatatttt gtcagttgta tttacaacac atactttctt
     5281 aagagaatat gttgttaatt tttgatatta ttttagagtc aaaattgtaa agatgactga
     5341 atattgtatt ttagtctaga ttaattaact acttaaagag atttttgagt ttcaagaaga
     5401 ttataaatga aggttagcaa gacaacaatg tattttctga gtctccaaga gaagtgaaac
     5461 atgttatagt tttgtagctg ctgccttgtt aagcaaatga ttattatgag tcacaatatt
     5521 caaaatattt tgttgtgtca aactggacca gtgcactaac gccttttaca ttaaatgtta
     5581 taagatgacg tgtctttata aagctaagta ttaaaaatct attatgttaa atatgaactg
     5641 tttattaaaa agccaaa
//
