LOCUS       NM_001105769            3923 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), mRNA.
ACCESSION   NM_001105769 XM_001057264 XM_220245
VERSION     NM_001105769.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Finelli,M.J., Aprile,D., Castroflorio,E., Jeans,A., Moschetta,M.,
            Chessum,L., Degiacomi,M.T., Grasegger,J., Lupien-Meilleur,A.,
            Bassett,A., Rossignol,E., Campeau,P.M., Bowl,M.R., Benfenati,F.,
            Fassio,A. and Oliver,P.L.
  TITLE     The epilepsy-associated protein TBC1D24 is required for normal
            development, survival and vesicle trafficking in mammalian neurons
  JOURNAL   Hum Mol Genet 28 (4), 584-597 (2019)
   PUBMED   30335140
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Finelli,M.J., Sanchez-Pulido,L., Liu,K.X., Davies,K.E. and
            Oliver,P.L.
  TITLE     The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif
            (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against
            Oxidative Stress
  JOURNAL   J Biol Chem 291 (6), 2751-2763 (2016)
   PUBMED   26668325
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Bakhchane,A., Charif,M., Salime,S., Boulouiz,R., Nahili,H.,
            Roky,R., Lenaers,G. and Barakat,A.
  TITLE     Recessive TBC1D24 Mutations Are Frequent in Moroccan Non-Syndromic
            Hearing Loss Pedigrees
  JOURNAL   PLoS One 10 (9), e0138072 (2015)
   PUBMED   26371875
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Poulat,A.L., Ville,D., de Bellescize,J., Andre-Obadia,N.,
            Cacciagli,P., Milh,M., Villard,L. and Lesca,G.
  TITLE     Homozygous TBC1D24 mutation in two siblings with familial infantile
            myoclonic epilepsy (FIME) and moderate intellectual disability
  JOURNAL   Epilepsy Res 111, 72-77 (2015)
   PUBMED   25769375
REFERENCE   5  (bases 1 to 3923)
  AUTHORS   Azaiez,H., Booth,K.T., Bu,F., Huygen,P., Shibata,S.B.,
            Shearer,A.E., Kolbe,D., Meyer,N., Black-Ziegelbein,E.A. and
            Smith,R.J.
  TITLE     TBC1D24 mutation causes autosomal-dominant nonsyndromic hearing
            loss
  JOURNAL   Hum Mutat 35 (7), 819-823 (2014)
   PUBMED   24729539
REFERENCE   6  (bases 1 to 3923)
  AUTHORS   Falace,A., Buhler,E., Fadda,M., Watrin,F., Lippiello,P.,
            Pallesi-Pocachard,E., Baldelli,P., Benfenati,F., Zara,F.,
            Represa,A., Fassio,A. and Cardoso,C.
  TITLE     TBC1D24 regulates neuronal migration and maturation through
            modulation of the ARF6-dependent pathway
  JOURNAL   Proc Natl Acad Sci U S A 111 (6), 2337-2342 (2014)
   PUBMED   24469796
  REMARK    GeneRIF: findings demonstrate an essential role of TBC1D24 in
            neuronal migration and maturation and highlight the physiological
            relevance of the ARF6-dependent membrane-trafficking pathway in
            brain development.
REFERENCE   7  (bases 1 to 3923)
  AUTHORS   Milh,M., Falace,A., Villeneuve,N., Vanni,N., Cacciagli,P.,
            Assereto,S., Nabbout,R., Benfenati,F., Zara,F., Chabrol,B.,
            Villard,L. and Fassio,A.
  TITLE     Novel compound heterozygous mutations in TBC1D24 cause familial
            malignant migrating partial seizures of infancy
  JOURNAL   Hum Mutat 34 (6), 869-872 (2013)
   PUBMED   23526554
REFERENCE   8  (bases 1 to 3923)
  AUTHORS   Corbett,M.A., Bahlo,M., Jolly,L., Afawi,Z., Gardner,A.E.,
            Oliver,K.L., Tan,S., Coffey,A., Mulley,J.C., Dibbens,L.M.,
            Simri,W., Shalata,A., Kivity,S., Jackson,G.D., Berkovic,S.F. and
            Gecz,J.
  TITLE     A focal epilepsy and intellectual disability syndrome is due to a
            mutation in TBC1D24
  JOURNAL   Am J Hum Genet 87 (3), 371-375 (2010)
   PUBMED   20797691
REFERENCE   9  (bases 1 to 3923)
  AUTHORS   Falace,A., Filipello,F., La Padula,V., Vanni,N., Madia,F., De
            Pietri Tonelli,D., de Falco,F.A., Striano,P., Dagna Bricarelli,F.,
            Minetti,C., Benfenati,F., Fassio,A. and Zara,F.
  TITLE     TBC1D24, an ARF6-interacting protein, is mutated in familial
            infantile myoclonic epilepsy
  JOURNAL   Am J Hum Genet 87 (3), 365-370 (2010)
   PUBMED   20727515
REFERENCE   10 (bases 1 to 3923)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001057264.1, XM_220245.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3923
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /note="TBC1 domain family, member 24"
                     /db_xref="GeneID:287110"
                     /db_xref="RGD:1306143"
     exon            1..49
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     exon            50..159
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     exon            160..1243
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1949
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /codon_start=1
                     /product="TBC1 domain family member 24"
                     /protein_id="NP_001099239.1"
                     /db_xref="GeneID:287110"
                     /db_xref="RGD:1306143"
                     /translation="MDSPGYNCFVDKDKMDASIQDLGPKELNYTELQELKQLARQGYW
                     AQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSSLPLPEFVDNTQVP
                     TYCLNPRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILS
                     CNDPGKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFG
                     ELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDI
                     AKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQKGITVKQKRQFVHLAVHAENF
                     RSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHEPTLLLIKT
                     TQKEVCGAYLSTDWSERNKFGGKLSFFGTGECFVFRLQPEVQRYEWVVIKHPELTKAA
                     SFKSSEAAANPCLISHSVSSDPADRLSPFLAARHFNLPSKTESMFMAGGNDCLIIGGG
                     GGQALYIDGDLNRGRTGHCDTFNNQPLCSESFLIAAVEAWGFQDPDTQ"
     exon            1244..1402
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1466
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1562
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1794
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1969
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..3923
                     /gene="Tbc1d24"
                     /gene_synonym="RGD1306143"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggtccag cggagagctg aagggagcgg tgcggtgcgg cgcgccgagt cgaattttct
       61 agatgcaaga gaaagcagag cggtttggac atttaccaaa gctcacggaa gcggacccct
      121 gtggcattgt tggaccgctc taccatctgg atcagaaagg gtgtgtggga tgacggactg
      181 gttaacagaa aacccccgaa gccggggctg cagggtttag ctgttctttg tccccgccct
      241 ggcagcctgg gacctgccac ctaggcacac ggggcaccat ggactcccca gggtacaatt
      301 gctttgtgga taaggacaag atggacgcgt ccatccagga cctggggcca aaggagctga
      361 actacaccga gctacaggag ctgaagcagc tggcgcggca gggttactgg gctcagagcc
      421 acgccctgcg ggggaaagtg taccagcgtc tgatccggga catcccctgc cgcacggtca
      481 cacccgacgc cagcgtgtac agcgacatcg tggggaagat tgtgggcaag cacagcagca
      541 gtagcttgcc cctgcctgag tttgtagaca acactcaggt gcccacctac tgcctgaacc
      601 cgcggggtga gggggccgtg cgcaagatcc tcctgtgcat cgccaaccag ttccccgaca
      661 tctccttctg ccctgccctg cccgcggtgg tggccttgct gctacactac agcattgacg
      721 aggccgagtg ctttgaaaag gcctgccgca tcttgtcctg caacgacccc ggcaagaagc
      781 tcattgacca gagcttcctg gccttcgagt cttcctgtat gacgtttgga gacctggtga
      841 acaagtactg ccaggcagcc cacaaactga tggtggccgt gtcagaggac gttctgcagg
      901 tctactctga ctggcagaga tggctctttg gggagctgcc cctcaactac tttgcccgcg
      961 ttttcgacgt cttccttgta gaaggctaca aggtactgta ccgagtcgct ctggccatcc
     1021 tcaagttctt ccacaaggtg agagcaggac agccccttga gtcagacaat gtaaagcaag
     1081 acatccggat gtttgtcaag gacattgcca agacagtgtc ccctgagaaa ctactagaga
     1141 aggcctttgc catccgcctg ttttcccgca aggagattca gctcttgcaa atggccaatg
     1201 agaaagccct gaggcagaag ggtattactg tcaaacagaa gaggcagttt gtacacttgg
     1261 ctgtccatgc agagaacttc cgctcagaga ttgtcagtgt gaaggagatg agagacattt
     1321 ggtcctggat ccctgagcgc ttcgccctct gccaacccct cctgctcttc tcgtcgctgc
     1381 agcatgggta cagcctaagc aggttctatt tccagtgcga aggacatgag cccacactcc
     1441 tgctcatcaa gaccactcaa aaggaggttt gtggggctta cctgtcaaca gactggagtg
     1501 agcggaataa gttcggaggc aagctgagct tctttgggac tggagaatgc tttgttttta
     1561 ggctgcagcc ggaggtgcag cgctatgagt gggtggtcat caagcaccca gaactgacca
     1621 aggcagcatc cttcaagtcc tcagaggctg cagccaatcc ttgcctcatc agccactccg
     1681 tctcttcaga ccctgccgac cggctctctc ctttcctggc tgcccggcac ttcaacctgc
     1741 cctccaagac cgagtccatg ttcatggctg ggggcaacga ctgcctcatc attgggggag
     1801 gaggtggcca agcactctac atcgatgggg atctgaaccg agggcgcacc ggacactgtg
     1861 acacgttcaa caaccagccc ctgtgctcgg agagcttcct catcgcggcc gtggaggctt
     1921 ggggcttcca agaccccgac acccagtgac tgacgggccc gcgctgatga gcctgaagct
     1981 cttgctgcac ctcactgcga gtccacacct gaaggtggcc tccggagaga ctttctttga
     2041 ccagcttgac cagtcagctc catttccaga gttcttctca gaactgacta gactcagtga
     2101 ggcctttgcc tcttgtcctt gtggcctctt tgaagttctg tagtcttagt gactcttgtg
     2161 cttccttccc tgtcatgata gtgactgagg cccacacagc atggcatgct tgtccctgtc
     2221 cagcttcccg ccttctcccc agaccctgcg cttctctgga actactcaca cagcatctga
     2281 tacacccttg tgcccccgtc cctcagctct cgctatggct gaccacgtac catatcttct
     2341 gtgtgctatc cctgctccca ttatgacctc taggtctctg gatgtctgtg ctccctgagc
     2401 cctgtaccag cctggtacac agtagatgcc aagagaggtg ctgcctcgag gtatagcaag
     2461 ctccacttcc ccgtgacctc cctcagctgg tcctgagggt ccacagagga agagagcagc
     2521 agtggcccaa atggctgtgc tggggcctag aagtctggat cacaaggcca ggtgcccagt
     2581 tcccacatga ctgtctgtca cgcctgagag tcagcctgtg tcacgccggt ccttgtctcc
     2641 actctgagag tcacttttgc tggggaaggt tcatccttcc ctgttccatc catcggctca
     2701 catcagctct cagcggggcc acagcagcag aagaggcagg gcaggaagga gcctcatcta
     2761 acttgtgcta cctggtaaac acctagaact ttggattccg cacagtggac cagttcctcc
     2821 accatgctgg cttccaggat gggttggcgt gactacagag ggaagagaac tgctgttcct
     2881 cacctccaca gaatggtgta agcctcagcg cccatccccc ctgagcccac tgcccaggcc
     2941 tatacctcca gctttggtgt tttttaacac catcttgatt tttggttatt gttgtttctg
     3001 gcaagacctt actaggtggc ttagctatcc tggaactccc tatgtgaccc aggctagcct
     3061 gctaattgct atgtagccta ggttggcctc aaaaatcatg gtctccctta gcctcctaag
     3121 tgctgggctt ctaggtgtca ggcccagctt tgcactttgc tgttgcgctg actctgggtt
     3181 ctgaggtggg ctccaaccag aaggccccca ggacattccc cggctgtgcc gtcatgctgc
     3241 tcacccatgc attaccacgg agactcaccc tttcagaagc aatgaagtta actaactaac
     3301 gggagtatgt gcagggctct gcagggctcc tgactgagtg gaggatctcc tgctctgtgt
     3361 ggccccactg gcagtctcag gggtctagcc ctaggagact gatggatgct atgcttagtg
     3421 ctgattacat cataagcaaa gttcttagct ttttgcccac aacatactca gttctttaaa
     3481 tttaatgtcc tttattattg acttttctac caaaaggcgt atggttttct ttatattttt
     3541 attcttatca ctgttcttat ctgatactaa gtgttctcac ttagtattta ttttattaat
     3601 gttttctatt atttattagc ttttgatgtt aaaaaagcaa gccaaaacgt gatggcattg
     3661 aacaagaagt tatattttag cagcatttaa acatttgttt ttaaaacaaa taccgaatct
     3721 aatttaagcc cgctcactaa actaagtaag tttgttaaga tgtacaatat gcctttgggg
     3781 cctcagaaaa tcagttcgaa ctttggttta gtttgtgagt ttcatgcagc tcaggctagc
     3841 cttgaactaa ctgcagctga agctgttctt gaattcagct tcctgcttcc tgcttctgtc
     3901 ctctatgtat ttggtgtgcc act
//
