LOCUS       NM_001371895            3777 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus TBC1 domain family, member 23 (Tbc1d23),
            transcript variant 1, mRNA.
ACCESSION   NM_001371895 XM_006221097 XM_006248214
VERSION     NM_001371895.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3777)
  AUTHORS   Navarro Negredo,P., Edgar,J.R., Manna,P.T., Antrobus,R. and
            Robinson,M.S.
  TITLE     The WDR11 complex facilitates the tethering of AP-1-derived
            vesicles
  JOURNAL   Nat Commun 9 (1), 596 (2018)
   PUBMED   29426865
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3777)
  AUTHORS   Shin,J.J.H., Gillingham,A.K., Begum,F., Chadwick,J. and Munro,S.
  TITLE     TBC1D23 is a bridging factor for endosomal vesicle capture by
            golgins at the trans-Golgi
  JOURNAL   Nat Cell Biol 19 (12), 1424-1432 (2017)
   PUBMED   29084197
  REMARK    Erratum:[Nat Cell Biol. 2018 Feb;20(2):222. doi:
            10.1038/s41556-017-0026-7. PMID: 29311657]
REFERENCE   3  (bases 1 to 3777)
  AUTHORS   Ivanova,E.L., Mau-Them,F.T., Riazuddin,S., Kahrizi,K., Laugel,V.,
            Schaefer,E., de Saint Martin,A., Runge,K., Iqbal,Z., Spitz,M.A.,
            Laura,M., Drouot,N., Gerard,B., Deleuze,J.F., de Brouwer,A.P.M.,
            Razzaq,A., Dollfus,H., Assir,M.Z., Nitchke,P., Hinckelmann,M.V.,
            Ropers,H., Riazuddin,S., Najmabadi,H., van Bokhoven,H. and
            Chelly,J.
  TITLE     Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar
            Hypoplasia and Alter Cortical Development
  JOURNAL   Am J Hum Genet 101 (3), 428-440 (2017)
   PUBMED   28823707
REFERENCE   4  (bases 1 to 3777)
  AUTHORS   Marin-Valencia,I., Gerondopoulos,A., Zaki,M.S., Ben-Omran,T.,
            Almureikhi,M., Demir,E., Guemez-Gamboa,A., Gregor,A., Issa,M.Y.,
            Appelhof,B., Roosing,S., Musaev,D., Rosti,B., Wirth,S., Stanley,V.,
            Baas,F., Barr,F.A. and Gleeson,J.G.
  TITLE     Homozygous Mutations in TBC1D23 Lead to a Non-degenerative Form of
            Pontocerebellar Hypoplasia
  JOURNAL   Am J Hum Genet 101 (3), 441-450 (2017)
   PUBMED   28823706
REFERENCE   5  (bases 1 to 3777)
  AUTHORS   De Arras,L., Yang,I.V., Lackford,B., Riches,D.W., Prekeris,R.,
            Freedman,J.H., Schwartz,D.A. and Alper,S.
  TITLE     Spatiotemporal inhibition of innate immunity signaling by the
            Tbc1d23 RAB-GAP
  JOURNAL   J Immunol 188 (6), 2905-2913 (2012)
   PUBMED   22312129
REFERENCE   6  (bases 1 to 3777)
  AUTHORS   Xiao,H.S., Huang,Q.H., Zhang,F.X., Bao,L., Lu,Y.J., Guo,C.,
            Yang,L., Huang,W.J., Fu,G., Xu,S.H., Cheng,X.P., Yan,Q., Zhu,Z.D.,
            Zhang,X., Chen,Z., Han,Z.G. and Zhang,X.
  TITLE     Identification of gene expression profile of dorsal root ganglion
            in the rat peripheral axotomy model of neuropathic pain
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8360-8365 (2002)
   PUBMED   12060780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1 and BG673671.1.
            
            On or before Jul 25, 2019 this sequence version replaced
            XM_006248214.3, XM_006221097.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1428172.1,
                                           SRR26360190.2943317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000011.1  56772476-56772672
            198-309             JAXUCZ010000011.1  56787660-56787771
            310-415             JAXUCZ010000011.1  56793870-56793975
            416-620             JAXUCZ010000011.1  56795785-56795989
            621-744             JAXUCZ010000011.1  56799563-56799686
            745-869             JAXUCZ010000011.1  56802291-56802415
            870-916             JAXUCZ010000011.1  56802502-56802548
            917-1020            JAXUCZ010000011.1  56802866-56802969
            1021-1143           JAXUCZ010000011.1  56807815-56807937
            1144-1236           JAXUCZ010000011.1  56809189-56809281
            1237-1407           JAXUCZ010000011.1  56811287-56811457
            1408-1450           JAXUCZ010000011.1  56814783-56814825
            1451-1557           JAXUCZ010000011.1  56816580-56816686
            1558-1697           JAXUCZ010000011.1  56818035-56818174
            1698-1742           JAXUCZ010000011.1  56819556-56819600
            1743-1831           JAXUCZ010000011.1  56822979-56823067
            1832-1967           JAXUCZ010000011.1  56826412-56826547
            1968-2162           JAXUCZ010000011.1  56827612-56827806
            2163-3764           JAXUCZ010000011.1  56829023-56830624
            3765-3777           BG673671.1         704-716
FEATURES             Location/Qualifiers
     source          1..3777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..3777
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /note="TBC1 domain family, member 23"
                     /db_xref="GeneID:304019"
                     /db_xref="RGD:1307925"
     exon            1..197
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2244
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="TBC1 domain family member 23 isoform 1"
                     /protein_id="NP_001358824.1"
                     /db_xref="GeneID:304019"
                     /db_xref="RGD:1307925"
                     /translation="MAEGEDLLPLSTSGGDSWEKDLEEALEAGGCDLETLRNIIQGRP
                     LPAELRAKVWKIALNVAGKGDSLASWDGILDLPEQNSIHKDCLEFIEQLSVPEEKAAE
                     LLLDIESVITFYCKSRSVKYSTSLSWTHLLKPLVCLQLPRSDLYNCFYAIMNKYIPRD
                     CSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFAHYCSIEVTQAIW
                     DGYLQQADPFFIYFLMLIILVNTKEVILAQESDSKEEVIHFLENTPSSLNLEDIEDLF
                     SLAQYYCSKTPTSFRKDNHHLFGSTLLGIKDDEADLSQALCLAVSVSEILQANQLQGE
                     GVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQRQSIESGSI
                     AGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLSDINVEGPE
                     SGYGHWIASTSGSRGSISSVDGESCNGSNDRGMKSLVNKMTVALKTKSVNVREKVISF
                     IENTSTPVDRMSFNLPWPDRSCTERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEID
                     SSSMSDDDRKEVVNIQTWINKPDIKHHFPCKEVKESGHMFPSHLLVTATHMYCLREIL
                     SRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDA
                     TRAIKQQIMKVLDALES"
     exon            198..309
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            310..415
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            416..620
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            621..744
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            745..869
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            870..916
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1020
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1143
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1236
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1407
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1450
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1557
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1697
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1742
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1831
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1967
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2162
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..3765
                     /gene="Tbc1d23"
                     /gene_synonym="RGD1307925"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgcatcct tctagttcca agctctttag ctctggtgga gtctcaagtc tcagacttca
       61 taactccttt tacgacactg agtctctgag gcagtctcgg cgccaggtcc acttttcggc
      121 taagtgacgt ggacgtcaac agcaatggcg gaaggagaag atcttctgcc actgtcaacg
      181 tcgggcgggg acagctggga aaaagacctt gaagaagccc tggaagcagg aggttgtgat
      241 cttgaaactt tgagaaatat aattcaaggg agaccactgc ctgctgaact gagggccaag
      301 gtttggaaga ttgctctgaa cgttgcagga aaaggtgata gtttggcatc atgggatggt
      361 attttagact tgcccgaaca gaacagtatt cataaagatt gccttgagtt tattgagcag
      421 ctctcagtac cagaggagaa ggcagcagaa ttactcctgg atattgaatc tgtaattact
      481 ttttactgta aatcacgcag tgttaaatac agcacatccc tgagctggac tcatctactg
      541 aaaccactgg tctgtctcca gctgcctcgc agcgacctat acaactgctt ctatgccatc
      601 atgaataagt acattcccag ggattgttcc ctgaagggga ggccatttca tctcttccga
      661 ttgctcatcc agtaccatga gcctgagctt tgttcttttc ttgatacaaa gaaaatcact
      721 ccagactcct atgcactcaa ctggctcgga agcctttttg cacattactg ttccatcgaa
      781 gtcacccagg ccatatggga cggatatctt cagcaagcgg atccgttttt tatttatttc
      841 ttaatgttaa ttatccttgt taatacgaaa gaagttattt tagcacaaga gtctgacagc
      901 aaagaagaag ttatccactt tttggaaaat actccatcca gcttgaatct ggaagacata
      961 gaagaccttt tctctttggc tcagtattac tgtagtaaaa cgcccacttc ttttaggaag
     1021 gataatcatc acctctttgg tagtactctg ttggggatca aggacgatga ggcagatctg
     1081 agccaggctc tgtgtctggc tgtttcagta tccgagatcc ttcaagcaaa tcagctgcaa
     1141 ggggaaggag tccggttctt cgtggtggac tgccgtcctg cagaacagta caatgcgggc
     1201 catttgtcaa ctgcgttcca cttagactca gacttgatgc tgcagaatcc atccgagttt
     1261 gcacagtcag taaagtcctt gctagaagcg cagagacagt ccattgagtc cggttccatc
     1321 gctggtgggg agcacctgtg ttttatgggc agtggcagag aggaagaaga catgtatatg
     1381 aacatggtcc tcgcacactt cttgcagaaa aacaaagaat atgttagtat tgccagtgga
     1441 ggatttatgg ccctgcagca gcacctgtca gacataaatg tggagggacc ggaaagtgga
     1501 tacggccatt ggattgccag cacctcaggg tcaaggggca gcatcagctc tgtggatggt
     1561 gaatcttgta acggctcaaa tgatagaggg atgaagtccc ttgtcaataa aatgactgtg
     1621 gctctaaaga caaaatctgt taatgttagg gaaaaggtca tcagtttcat tgagaacacg
     1681 tcaactcctg tggaccgaat gtctttcaat cttccttggc cagacagatc atgtacagag
     1741 cggcatgtga gcagcagtga cagagtgggc aagccttacc gtggagtgaa gcctgtgttc
     1801 agcattggcg atgaagagga atacgacaca gatgagatcg acagctcttc catgtcagat
     1861 gatgatagaa aggaagtcgt aaacatccag acctggatca acaagccaga catcaagcac
     1921 cattttcctt gtaaagaagt aaaagaaagc gggcatatgt ttcccagtca tctgttggtt
     1981 acggccacac atatgtactg cttaagggag attctttcga ggaaaggact ggcttatatc
     2041 cagtctcgac aagcactaaa ttctgtagtt aaaattacgt ccaaaaaaaa acatcctgag
     2101 ctaattacct tcaagtatgg aaacagcagt gcttccggga tagaaatctt ggctatcgaa
     2161 aggtatttga ttcccaatgc aggagatgct accagagcca taaaacagca gatcatgaaa
     2221 gtgttggatg ctttggaaag ttaatgtaaa agaaagttat ttaagagaaa ttaaggcaac
     2281 gaagagaaac atgaaaatat atttcctgac tcaatactaa ccagagacct ttgatttgct
     2341 cacggggtgc ctgaggagag ggtctaaatg caaattattg taatcaatct cgggatgggt
     2401 acactttttt aaaaatttct tttgcatctt tggttttata tgatgattta ttataaaggt
     2461 cagttattaa atgactttta agtaactggc cttgtgccct atggatcaag ggcttagaat
     2521 gcagttctgt tttgaagagc tgttttaaag acatgcatca ttttcggttc taaaacaact
     2581 gtacacatac gtatttgcaa tgtcttcact gaaatttatg gatagaatta gttgaagaga
     2641 tttaattgct acattgagtt ttactacaat gagcattatt ggaaaataaa tggttagatt
     2701 cataattagc tcactgtttc tgttcttaaa aagattgaag tctgtttgat agaatggatg
     2761 gagatcatag caactccagt acagtcccta ggagaccctg aagtgtcagc ttcgccccat
     2821 ctttgctcca gtgggtaatt attcagagac aattgactca gagacagaga gcctcatccc
     2881 agggtttgct aaggaacagt taacagcatt agaagtaagt aggcatgtta ggttaaaatt
     2941 agcactcggg ggacagaatt gtatctgtaa gaatgtcatg ggtcatttgg tctaggctgt
     3001 ttcaaatgtt ttgaacacac tgattatcct ccttgaaatg atcacctgtg accacactaa
     3061 tgtccagttt aaaaatagat aatcagagag ctacagaaat tttattgttt ttctatcact
     3121 ttctaaaaaa ttttttggtt ttgtcttctc agtaaaatct cagtagttga aacttttttt
     3181 tcattcttgt actctgggaa aaaaaaaaaa agccagaagc ggcctgcttg ttttgcagct
     3241 tgctcagatt aatttctgtg gcccatatta gccactgtgc tgagagatcc agaacatctt
     3301 tggaccatgg gatgattttt ataaaatctg tttgaaaaat agtaaacata acctgccaag
     3361 tcatacaatg tcatagattt tctccaaggg gttggttgat agaagtatct aggtgtaccc
     3421 cactagtagc cagtgtttta atttgcataa tggaaatcaa gtgaataaaa gataacataa
     3481 ttaaaagaac tctattctga tatctaaata aaaacagtgt atttgagtgg ttgaagacat
     3541 ttgcatgaga ttgcaccctg tgaggtactt gatatttata actcttctcc caaactgttg
     3601 tatttcattt cttccatttt cttgacaccc tctttgaaat gtcctgaagt ctcatttttc
     3661 aaccatctca gctatgggac ttttttcata atattaatgt aaagatgttt gtgttactgt
     3721 ttataaatta caattgtaaa taaactgata caagtttgct caaaaaaaaa aaaaaaa
//
