LOCUS       NM_001004281            1391 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus TBC1 domain family, member 20 (Tbc1d20), mRNA.
ACCESSION   NM_001004281 XM_342544
VERSION     NM_001004281.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1391)
  AUTHORS   Liegel RP, Handley MT, Ronchetti A, Brown S, Langemeyer L, Linford
            A, Chang B, Morris-Rosendahl DJ, Carpanini S, Posmyk R, Harthill V,
            Sheridan E, Abdel-Salam GM, Terhal PA, Faravelli F, Accorsi P,
            Giordano L, Pinelli L, Hartmann B, Ebert AD, Barr FA, Aligianis IA
            and Sidjanin DJ.
  TITLE     Loss-of-function mutations in TBC1D20 cause cataracts and male
            infertility in blind sterile mice and Warburg micro syndrome in
            humans
  JOURNAL   Am J Hum Genet 93 (6), 1001-1014 (2013)
   PUBMED   24239381
REFERENCE   2  (bases 1 to 1391)
  AUTHORS   Nevo-Yassaf I, Yaffe Y, Asher M, Ravid O, Eizenberg S, Henis YI,
            Nahmias Y, Hirschberg K and Sklan EH.
  TITLE     Role for TBC1D20 and Rab1 in hepatitis C virus replication via
            interaction with lipid droplet-bound nonstructural protein 5A
  JOURNAL   J Virol 86 (12), 6491-6502 (2012)
   PUBMED   22491470
REFERENCE   3  (bases 1 to 1391)
  AUTHORS   Zenner HL, Yoshimura S, Barr FA and Crump CM.
  TITLE     Analysis of Rab GTPase-activating proteins indicates that Rab1a/b
            and Rab43 are important for herpes simplex virus 1 secondary
            envelopment
  JOURNAL   J Virol 85 (16), 8012-8021 (2011)
   PUBMED   21680502
REFERENCE   4  (bases 1 to 1391)
  AUTHORS   Sklan EH, Staschke K, Oakes TM, Elazar M, Winters M, Aroeti B,
            Danieli T and Glenn JS.
  TITLE     A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and
            mediates viral replication
  JOURNAL   J Virol 81 (20), 11096-11105 (2007)
   PUBMED   17686842
REFERENCE   5  (bases 1 to 1391)
  AUTHORS   Haas AK, Yoshimura S, Stephens DJ, Preisinger C, Fuchs E and Barr
            FA.
  TITLE     Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs
            required to maintain a functional Golgi complex in human cells
  JOURNAL   J Cell Sci 120 (Pt 17), 2997-3010 (2007)
   PUBMED   17684057
REFERENCE   6  (bases 1 to 1391)
  AUTHORS   Yoshimura S, Egerer J, Fuchs E, Haas AK and Barr FA.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   7  (bases 1 to 1391)
  AUTHORS   Yanagimachi R, Wakayama T, Kishikawa H, Fimia GM, Monaco L and
            Sassone-Corsi P.
  TITLE     Production of fertile offspring from genetically infertile male
            mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (6), 1691-1695 (2004)
   PUBMED   14757819
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079383.1.
            
            On Sep 10, 2004 this sequence version replaced XM_342544.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1391
                     /gene="Tbc1d20"
                     /note="TBC1 domain family, member 20"
                     /db_xref="GeneID:362237"
                     /db_xref="RGD:1303293"
     exon            1..124
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1266
                     /gene="Tbc1d20"
                     /codon_start=1
                     /product="TBC1 domain family member 20"
                     /protein_id="NP_001004281.1"
                     /db_xref="GeneID:362237"
                     /db_xref="RGD:1303293"
                     /translation="MALRPSEGDGSAGRWNRGSGKADFNAKRKKKVAEIHQALNSDPT
                     DVAALRRMAISEGGLLTDEIRCQVWPKLLNVNTDEPPPMSRKDLRDMSKDYQQVLLDV
                     RRSLRRFPPGMPDEQREGLQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERL
                     ATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALS
                     WLITWFGHVLLDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHH
                     LLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAASTFKDFELASTQQ
                     RPDMVLRQRFRGLLRPEARTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEW
                     APKFQLQLFP"
     exon            125..310
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
     exon            311..391
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
     exon            392..578
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
     exon            579..680
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
     exon            681..822
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1010
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1364
                     /gene="Tbc1d20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgcgtca ggctccgccg ccagccgggg ctcgggctgg ggcccgggcc cccggggatg
       61 gccctccggc cctcagaggg cgacggctcc gccggccgct ggaaccgcgg ctcagggaag
      121 gcagacttta atgccaaaag gaaaaagaag gtggcggaga tacaccaagc tctgaacagt
      181 gatcccaccg atgtggctgc cctccgacga atggctatca gcgagggcgg gctcctgact
      241 gatgagatca ggtgccaagt atggcctaag ctcctcaacg tcaacaccga tgagccaccg
      301 cctatgtcaa ggaaggatct tcgagacatg agcaaggact accagcaagt gctgctggac
      361 gtcaggcggt ctcttcggcg cttccctccg ggcatgccag atgagcagag agaagggctc
      421 caggaagagc taatcgatat catcctcctc gtcttggatc gaaaccctca gctccactac
      481 taccagggct accatgacat tgtggtcact tttctgctgg tggtgggcga gaggctggca
      541 acatccctgg tagaaaaatt gtccacccac cacctcaggg atttcatgga tcccacaatg
      601 gacaacacca agcacatctt aaattacctg atgcccatca ttgaccaagt gaacccagaa
      661 cttcatgact tcatgcagag tgctgaggtg gggaccatct tcgccctcag ctggcttatc
      721 acctggtttg ggcacgtcct gttggacttc aggcatgtgg tgaggttata cgacttcttc
      781 ctggcctgcc acccactcat gcctatttac tttgcagctg tgatcgtgct gtaccgggag
      841 caggaagtgc tggactgtga ctgtgacatg gcctctgttc accacctgtt gtcccagatc
      901 cctcaggacc tgccctatga gacgctcatc agcagagcag gagacctctt tgttcagttt
      961 cccccttctg aactggcaag ggaggcggct gctcagcagg aggcggagag aacggcagcc
     1021 tctactttca aagactttga gctggcgtca actcagcaga ggccagacat ggtgctgcgg
     1081 cagcggtttc ggggacttct gaggcctgag gctcgaacaa aagatgtcct gaccaaacca
     1141 aggaccaacc gctttgtaaa actggcagtg atggggctga cggtggccct aggagcagca
     1201 gcactggcag tggtgaagag tgccctggag tgggccccta agttccagct gcagctgttc
     1261 ccctaaactc agctcaatca gccacttcct cgccagtgca ccaagctctc cccatttccg
     1321 gaaagagggt gcaattgctg tgattaaagg gtttctgtca ggggaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa a
//
