LOCUS       NM_001399163            4300 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus TBC1 domain family, member 2 (Tbc1d2), mRNA.
ACCESSION   NM_001399163 XM_006238056
VERSION     NM_001399163.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4300)
  AUTHORS   Frasa,M.A., Maximiano,F.C., Smolarczyk,K., Francis,R.E.,
            Betson,M.E., Lozano,E., Goldenring,J., Seabra,M.C., Rak,A.,
            Ahmadian,M.R. and Braga,V.M.
  TITLE     Armus is a Rac1 effector that inactivates Rab7 and regulates
            E-cadherin degradation
  JOURNAL   Curr Biol 20 (3), 198-208 (2010)
   PUBMED   20116244
REFERENCE   2  (bases 1 to 4300)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006238056.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168982.1, SRR26643292.21605.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               JAXUCZ010000005.1  65726483-65726996   c
            515-656             JAXUCZ010000005.1  65722792-65722933   c
            657-804             JAXUCZ010000005.1  65714540-65714687   c
            805-938             JAXUCZ010000005.1  65708032-65708165   c
            939-1135            JAXUCZ010000005.1  65706399-65706595   c
            1136-1516           JAXUCZ010000005.1  65697088-65697468   c
            1517-1627           JAXUCZ010000005.1  65692700-65692810   c
            1628-1812           JAXUCZ010000005.1  65691456-65691640   c
            1813-2289           JAXUCZ010000005.1  65690386-65690862   c
            2290-2410           JAXUCZ010000005.1  65684988-65685108   c
            2411-2596           JAXUCZ010000005.1  65682132-65682317   c
            2597-2718           JAXUCZ010000005.1  65681657-65681778   c
            2719-4300           JAXUCZ010000005.1  65679670-65681251   c
FEATURES             Location/Qualifiers
     source          1..4300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4300
                     /gene="Tbc1d2"
                     /note="TBC1 domain family, member 2"
                     /db_xref="GeneID:313234"
                     /db_xref="RGD:1306860"
     exon            1..514
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2926
                     /gene="Tbc1d2"
                     /codon_start=1
                     /product="TBC1 domain family member 2A"
                     /protein_id="NP_001386092.1"
                     /db_xref="GeneID:313234"
                     /db_xref="RGD:1306860"
                     /translation="MEDTPERTPSSESIQPPGLAREPEVTSPGDSEGCARPLDPAPKK
                     LCGYLSKFGGKGPIKGWKCRWFFYDERKCHLYYSRTAQDANPLDSIDLSSATFDCKAD
                     AEEEGTFEIKTPSRVITLKAATRQVMLYWLQQLQMKRWEFHNSPPALPATPAAALTEN
                     GPTLHLKLEQEEAELEEFLCPVKTPPGLVGTAAALQPVPAMPSALQNISLKHLGTEIQ
                     NTMYNIRGNKQAQATAHGPPVEESSQSAEPQRGEQPLISDPSIPEKEPEDPPKSAPRS
                     CVPSGPMQKPKRQSNTFPFFSDGLARSRTAQEKVVALEQQVLMLTKELKSQKELVIIL
                     HKALEAAQQEKRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALEQDRERLVHEA
                     GLREQQVQALQQHVQLLMDKNQAKQQVICKLSQKLTEDLAQPQPADATNGDFLSQQER
                     LEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYL
                     AGLRRLQEAAGAEPGDFPELLQQLVQEALQWEAGEASDSVGLSPVSEYDDYGFLTVPD
                     YEVEDLKLLAKIQALEVRSHHLLALEAVERPLRDRWATLTELMPSAELKQLLRAGVPR
                     EHRPRVWRWLVHRRVQHLHSSGCYQELLARGRACEHPAARQIELDLNRTFPTNKHFTC
                     PTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETIL
                     PAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQRHVDLSLITFNWFLVIFADSLI
                     SDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILRLQDSLEIYQYLRFFTKTICDSR
                     KLTSIAFNDMNPFPMKQLRQLRAAHRERLEAELRELELLKAEYLERRASRGRAVPEGC
                     VSEDEGEGDS"
     exon            515..656
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..804
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..938
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1135
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1516
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1627
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1812
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2289
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2410
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2596
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2718
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..4300
                     /gene="Tbc1d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcactctc tccaccgcca gcgcggggct ctccgccttc ttcggggggc tggaccgcat
       61 cggctccgcc tagccaggtg tcgtcggttc ccaggtgctc gccggacctc cggcattccg
      121 gtgccgcagg cctgtgcagc ggccagcagc gatggaggac acccccgagc gcactccttc
      181 ctccgagtcc atacagcctc cgggtctggc cagggagccc gaggtgacat ctcccgggga
      241 ctcagagggc tgcgcccggc ctctagaccc ggcccctaag aaactctgtg ggtatttaag
      301 taagtttggc ggcaaaggac ccatcaaagg ctggaaatgc cgctggttct tctacgatga
      361 gaggaagtgc cacctgtatt attcgcgcac cgctcaggat gctaacccct tggacagcat
      421 cgatctctcc agtgccacct ttgactgtaa ggcggacgct gaggaggagg gcacttttga
      481 aatcaagact cctagccgag ttattaccct caaggctgcc accaggcaag tgatgctcta
      541 ctggctacag cagctgcaga tgaagcgctg ggagttccac aacagcccac ctgcacttcc
      601 tgccacccct gctgccgccc tgactgagaa tgggcccacc ctgcacctca agctagaaca
      661 agaggaggct gagctggagg agttcctgtg ccctgtgaaa acgccccctg gacttgtggg
      721 tacagcagcg gctttgcagc ctgtccctgc catgccctca gcccttcaga acatctccct
      781 gaagcatctg ggaaccgaga tacagaacac catgtacaac atccgaggca acaagcaggc
      841 ccaagcaaca gcccatgggc cacccgtgga agagtcgtca cagagtgcag agcctcaaag
      901 aggggagcag cccttgatct ctgatcccag cattccagaa aaggagccag aggatcctcc
      961 caagtctgca cccaggtcct gcgtgccctc gggtcccatg cagaaaccca agcggcaaag
     1021 caataccttt ccgttttttt ccgacggcct ggctcggagc cgcacagccc aggagaaggt
     1081 ggtggctttg gaacagcagg tgctgatgct caccaaagag ctcaagtcac agaaggagct
     1141 ggtgataatc ctacacaagg ccctggaggc tgcccagcaa gagaagcgag cctccagtgc
     1201 gtacctggca gccaccgagg acagagatcg gctggagctg gtccggcaca aggtgcggca
     1261 gatcgcagag ctgaaccaga gggtggaggc tctggagcag gaccgtgagc gcctggtgca
     1321 cgaggctggc ctgcgggagc agcaggtgca ggcgcttcag cagcatgtgc agctgctcat
     1381 ggacaagaac caggccaagc agcaggtcat ctgcaagctc tcccagaagc tcacggaaga
     1441 ccttgcacaa ccccagcctg ctgatgctac caatggtgac ttcctgagcc agcaggagag
     1501 gttggagcat ctgaaggatg acatggaagc atatcggacc cagaaccgct tcctcaactc
     1561 tgagatccac caggtcacca agatctggag gaaggtggcc gagaaggaga aagccctgct
     1621 gaccaagtgc gcctacctcc aagccaggaa ctgccaggta gaaagcaagt acctggccgg
     1681 acttcgaagg ctgcaggaag cggcaggggc tgagcctggt gacttccctg agctgctgca
     1741 gcagctggtc caggaggcac tgcagtggga agcaggagag gcttccgaca gcgtggggct
     1801 gagccctgtc agcgagtatg atgattatgg cttcctgaca gtgccagact acgaggtgga
     1861 agacctgaaa ctactagcca agatccaggc cttggaagtg cgctcccacc acctgctggc
     1921 cctcgaggcc gtggagaggc cactacggga ccgctgggct actctgaccg agctcatgcc
     1981 ctcagctgaa ctcaagcagc tgctacgggc aggtgtgccc cgagagcacc gcccacgggt
     2041 ctggaggtgg ctggtccacc gccgtgtcca gcacctgcac tcctcaggct gctaccagga
     2101 gcttctggcc cggggccggg catgtgagca ccctgctgct cgtcagatcg agctggacct
     2161 caacagaacc ttccccacca acaagcactt cacctgccct acctccagct tccctgacaa
     2221 gctccgccgt gtgctcctgg ccttctcctg gcagaacccc accattggct actgccaagg
     2281 cttgaacagg ctggcagcca tcgccctgtt ggtcctagag gatgaggaga gtgccttctg
     2341 gtgcctggtg gccattgtgg agaccatact gccggctgag tactacagca agacactgac
     2401 tgcatcccag gtggaccagc gggtgctcca ggacctcctc tcagagaagc tgccccgact
     2461 gactgcgcac ctgggacagc gccatgtaga cctctctctc atcacgttca actggttcct
     2521 cgtgatcttt gccgactctc tcatcagtga catcctcctg cgagtctggg atgccttcct
     2581 gtacgaaggg accaaggtgg tgttccgata tgctctggcc atcttcaagt acaacgagga
     2641 agcgatcctt cgactccagg acagcctgga gatctaccag tacctgcgct tcttcaccaa
     2701 gaccatctgc gacagccgga agctcacaag cattgccttc aatgatatga acccctttcc
     2761 catgaagcaa ctgcggcagc tgcgggcagc ccaccgagag cgactagagg ctgagcttcg
     2821 ggagctagaa ctgctgaagg ctgagtactt ggagagaagg gcatccaggg gcagagcagt
     2881 gcctgagggc tgcgtcagcg aggacgaagg agaaggcgac agctgaccca ccaccctgtt
     2941 cctcaaagcc ttgcttacca ctgctggcag gaagacagaa ttcagtaatg ggccggaggt
     3001 gtgtgtgacc ccggacaagg ccttgtcctc tcccagcatt agcctctcgg gcatgccagc
     3061 ctgtatcaca gccccacaga gcactttaac acacaggaag gaggcaggga tacactctgg
     3121 gtcacccgga accgtctccg aggcaccgcc atctcagttt ggcttggatt tcatcttctg
     3181 accaggcctc ctgggactct tcctgaccct ggactctatg cagttgagcg tggccccgat
     3241 cttcggatcc tcctgtcaga gccatgtcga catacagcaa cgtccctgtg gctgatggct
     3301 ctcccccttg aggacaaaag cagtctcatt accagtgctc ctgggcacaa ggtgtcggga
     3361 atggcaccct ctggctcaag gtcttggcca ccattcctgt ggcaccccaa gttcatctgt
     3421 ctttccaggc agtagcccct ctgagctgct acctagatct gtgttgagac caccctgctt
     3481 atggagacta ttatctgcag tctcatgcct aaaacttgcc ttctgtttac agcccacagg
     3541 ggacatcccg ggggaacccc tgcctgccac cctgaggtac ttgatatggt ttggacagtg
     3601 tgcccccgtc atgtggggcc aatgaggtag gcttgggagg gcgagcatgg cagcagcgca
     3661 cctggctcag cagagagagt tggtaagcag atggagggga catgctaggg ggagaccagc
     3721 tctcccagaa accatcaaaa agccaaaaac aggtcaaact gtgggcacgg gctgctggat
     3781 aaacagtatc ctctctacca ctcccctcac caagccaagg cccccacctc tccttttcct
     3841 cgcctcccta gaagagaatt ctgcctaagc acttgtgctc ctccttggag gaccagagca
     3901 gctttcttac caagctgcac cttgttccag cagtgctggg ccttgtgctc tgtgctcttc
     3961 cttggaggac cagagcagct ttcttaccaa gctgcacctt gttccagcag tgctgggcct
     4021 tgtgctctgt ggctcttgga gcttggagcc gagttctact agccctgggg ggtgagcatt
     4081 ctgggactaa ttgcttcctc ccgcccagac agagctccag tgtcacccag aggggagggc
     4141 gggtctggcc atgactgcct gtggggtgca cccatagtat caacactagg aagagaaaag
     4201 gagtcaggtg tggggtacac acttctgatc ccagcagttc caacagtgga ttacacagcc
     4261 aaacagtgtc tccaaaacca aataaataag agaaaaacga
//
