LOCUS       NM_001113365            4948 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TBC1 domain family, member 14 (Tbc1d14),
            transcript variant 3, mRNA.
ACCESSION   NM_001113365
VERSION     NM_001113365.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4948)
  AUTHORS   Longatti,A., Lamb,C.A., Razi,M., Yoshimura,S., Barr,F.A. and
            Tooze,S.A.
  TITLE     TBC1D14 regulates autophagosome formation via Rab11- and
            ULK1-positive recycling endosomes
  JOURNAL   J Cell Biol 197 (5), 659-675 (2012)
   PUBMED   22613832
REFERENCE   2  (bases 1 to 4948)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   3  (bases 1 to 4948)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   4  (bases 1 to 4948)
  AUTHORS   Yamano,Y., Ohyama,K., Ohta,M., Sano,T., Ritani,A., Shimada,J.,
            Ashida,N., Yoshida,E., Ikehara,K. and Morishima,I.
  TITLE     A novel spermatogenesis related factor-2 (SRF-2) gene expression
            affected by TCDD treatment
  JOURNAL   Endocr J 52 (1), 75-81 (2005)
   PUBMED   15758561
REFERENCE   5  (bases 1 to 4948)
  AUTHORS   Horiba,N., Masuda,S., Takeuchi,A., Saito,H., Okuda,M. and Inui,K.
  TITLE     Gene expression variance based on random sequencing in rat remnant
            kidney
  JOURNAL   Kidney Int 66 (1), 29-45 (2004)
   PUBMED   15200410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB117752.1 and BC099760.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB117752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2309              AB117752.1         1-2309
            2310-4948           BC099760.1         2056-4694
FEATURES             Location/Qualifiers
     source          1..4948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4948
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /note="TBC1 domain family, member 14"
                     /db_xref="GeneID:360956"
                     /db_xref="RGD:1309993"
     exon            1..305
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..360
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2462
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     Up-regulated in nephrectomized rat kidney #2;
                     spermatogenesis-related factor 2"
                     /codon_start=1
                     /product="TBC1 domain family member 14 isoform 3"
                     /protein_id="NP_001106836.1"
                     /db_xref="GeneID:360956"
                     /db_xref="RGD:1309993"
                     /translation="MRLYLDRFWGLMVKVSSWTKMTDGNLSTSMNGVALMGILDGRPG
                     DSLQELQHLSIKAVPRSLSVPDYGPTLKLGALEDRHSLQSVDSGIPTLEIGNPEPVPC
                     SVVHVKRKQSESEIIPERAFQSACPLPSCTPSAPTGSEREQAVRKSSTFPRTGYDSVK
                     LYSPTSKALSRSDDVSVCSVSSLGTELSTTLSVSNEDILDLMVTSNSSAIVTLENDDD
                     PQFTDVTLSSIKETSDLHQQDCVAETEEGRKLRLLQPFSHFFTRNLLARKQNARLDRQ
                     RDLGWKLFGKVPLRETAQKDSKKTQKEYEDKAGRPSRPPSPKQNVRKNLDFEPLSTTA
                     LILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQLEERCKVEESIG
                     NAVLTWNNEILPNWETMWCSKKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDIC
                     LARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYH
                     DMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRV
                     DHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTADIYLIDWIFTLYSKSLPLDLACRI
                     WDVFCRDGEEFLFRTALGILKLFEDILTRMDFIHSAQFLTRLPEDLPADDVFAAISTV
                     QMQSRNKKWAQVLSALQKDSREMEKGSPSLRH"
     exon            361..1102
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1223
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1342
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1425
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1543
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1650
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1731
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1826
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1898
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2027
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2137
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2396
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..4903
                     /gene="Tbc1d14"
                     /gene_synonym="SRF-2; UR-NR#2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatggaga gggaaaggac tgggctgtgg aggggctctg agggccccct ggcctaagac
       61 gctggacaga gacagcaaag tcccagggat tggcatgtga acctactgtg actgtaacca
      121 tgccatgcca ggagccagta gcatgggagg caggtttggg ttgggcagga cctgacctgg
      181 ggacagtggg atagattggt gacaccaagg ctgtgttgct tcacctccca gccctatcct
      241 cctctgtacg gttcgaggca ctgagtgagc ttggcaggtc gtggagatca acttctgtca
      301 cagagactca agttacaatg aggctttatc tagaccgctt ctggggactg atggtaaaag
      361 tttcttcttg gaccaagatg actgatggaa acctttccac ctctatgaat ggtgtagcat
      421 tgatgggcat tctagatggt cggccaggag actcccttca ggaattgcaa caccttagta
      481 tcaaggcagt gcccagatcc ctttcagtgc ctgactatgg acctacacta aaacttggtg
      541 ctttggaaga tcgacacagc cttcagtcag tggactcggg cattcctacc ctggagattg
      601 gcaacccaga gcctgttccc tgcagtgtgg tccatgtgaa gagaaagcag tctgagtcag
      661 agatcatccc ggagcgggcc ttccagagtg cgtgcccctt gccatcctgt acaccctcag
      721 ctcccactgg cagcgaacgg gagcaagctg tgcggaagtc ttccaccttt cccaggacag
      781 gctatgactc agtgaaactc tacagcccca cctccaaagc cttgagccga agtgacgatg
      841 tctctgtctg cagtgtgtct agtcttggca cagaactgtc aaccacattg tcggttagca
      901 atgaggacat cttggacctc atggtcacga gcaattccag tgccattgtg acgctggaga
      961 acgatgatga cccccagttt actgatgtca ccctgagctc catcaaggaa accagtgact
     1021 tacaccagca ggattgtgtt gctgagactg aggaggggag gaaattgagg ctattgcaac
     1081 cattcagcca cttcttcaca aggaatttgc ttgctagaaa gcaaaatgca agacttgata
     1141 gacagagaga tttgggatgg aagctgtttg gaaaagtccc actccgagag actgctcaga
     1201 aagattcaaa gaaaacacaa aaggaatatg aagacaaggc tggaagacca agcaggccgc
     1261 cctctccaaa gcagaatgtg aggaagaacc tggattttga gccactgtcc accacagcgc
     1321 tcatccttga ggacagaccc gcgaatctcc cagcaaagcc agctgaagaa gctcaaaagc
     1381 acagacagca gtatgaagag atggtggtgc aggctaagaa acgagagctt aaagaagccc
     1441 agcggcggaa gaaacagctg gaggaaaggt gcaaggttga agagagcatt ggaaacgccg
     1501 tcctcacctg gaataatgag atcttgccta actgggaaac catgtggtgc tctaagaagg
     1561 ttcgagactt gtggtggcag ggaatccctc cgagtgtaag aggcaaagtt tggagcttgg
     1621 ccattggcaa cgagctgaac atcactcacg agctctttga catctgtctt gctcgggcca
     1681 aggagcggtg gcggtccctc agcactggag gctcagaagt ggagaatgaa gatgctgggt
     1741 tttcagcagc agacagagag gccagtctgg agcttattaa actggacatt tctagaacat
     1801 ttcctaatct ctgcattttc cagcaaggtg gtccatatca tgacatgttg cacagtattt
     1861 tgggcgctta tacttgttac cggccggatg tgggttatgt tcagggcatg tcctttatag
     1921 ctgcagtgtt gatcttgaac ctcgatactg cagatgcctt tattgctttt tctaatcttt
     1981 tgaataaacc ctgtcaaatg gcgtttttcc gagtggacca tggccttatg ttgacttact
     2041 ttgctgcatt tgaggtattc tttgaagaaa acttgccgaa attgtttgcg catttcaaga
     2101 aaaacaactt aactgcagac atctacctaa ttgattggat ttttaccttg tacagtaagt
     2161 ccctgccctt ggacttggcc tgccgcatct gggatgtatt ctgtcgagat ggagaggaat
     2221 ttctcttccg cacagctctg ggcatcctga agctttttga ggatatcctg accaggatgg
     2281 acttcatcca cagtgcccag tttctgacca ggctgcctga ggacctgcca gcagacgacg
     2341 tgttcgcagc tatctctaca gtccagatgc aaagccgcaa caagaaatgg gcacaggtgc
     2401 tgtctgcact gcagaaagac agccgggaaa tggagaaagg aagcccatca ctcagacact
     2461 gaggctcagg gctaactccc acctgccact acagcagagc tcgacatgga cctgtgtgct
     2521 ttcagactga agcctggcat gaacagggct ctttccatgt tggctttctg atgctcaagt
     2581 tggccttaca acaaaacaga attacatcca ggtttagcct taagcagctc agtggaccca
     2641 tgcactgtca ttggtcatgg ctagccgctg cattttctac atgggttcaa gaaagggcag
     2701 gctgtctctg aacctttatt ccagcaacag tcaattaaat tgtaatgcta ttatgccaac
     2761 tactggaagg tacattacaa tctttcttag ccaagatgca tgagaaatgt tattaggaaa
     2821 cctcagagtt gttattggct catatgcttg tgagaaagga attatttagt tactaagata
     2881 agctttccag agatgaaggg tgtgttttaa atctcatacc aaggacaggg taaggaagac
     2941 gggcccttgg agggcagttg ctggtgaatg ctcacaggct tcgaaaatgc acttgacctt
     3001 tgtgctgaca ttgaccctgt tgccttgaca catgagagca agaaggctga gttcatatta
     3061 ggatcctact cttcaaagta gcactcactg catcttggga gccacactgg ttggagcagg
     3121 gaagtcactt gctgcagagg gacagaggcc ggccctgtaa agagagatgt aggacgagac
     3181 tgcaaactct cctcttctta cccgctcgct tctggggagg ctagcatgac agcctctgaa
     3241 aacaccattg tgtaggagat ggtttccttg cttaagctga atgtcccttt ttgcctttgt
     3301 cacctgagta gttggatccc ttctaagtgc cagtgattgt cccctatccc catctggctt
     3361 tagaaaatga gcttcacaca ctgctgaaag gactggagta tggcagtctt ccacattctc
     3421 agtgtcccga gcccttcccc attgcagctg attcctctca gctcattggg gaggtggtgg
     3481 tggttctagc ttttccttga cttaagaact ttgtataaga aatgattatc caaattcaca
     3541 gaagtgaaca gtttctacat agaataggac agtccagtat ctatggaaac gggttacctc
     3601 ctgatcatcc actggcattc tgaaccctga ggtacaggta ggccagtcct agcctagggc
     3661 tgaggacata ttctccagcc aacacctgtg tagtctgtag tgcacagccc tctacagcca
     3721 taccttctac cccagaattc accctctcaa tcggtgtagt ttctgatagc cgtaggggag
     3781 cccttgactg actacagcat gtggcaggga ggcttgggtc agcctcatgg cgctgtgttt
     3841 gcatgggttc ccttcatctg gtgtgcctgt tggtgatcat ctagtgtatc agcaggctgt
     3901 catgttcatg ctattcaccc catgctccca cttttttctt ggagtctcat ttgtagtctg
     3961 tgacttcttc agggaggcca cagagcaccc tccatgtagc tctctgcctt agtgtgaaag
     4021 gctgatgtct gacctcttgg aggaggatgt cttcaccagc catccaatgg cctccagacc
     4081 cagccattct tgacatcaga tactgaatgt agcccaggcc cagctggcca cgagaatcgc
     4141 actacccagc cctgtccgct gtccttcctt gcagatgtac ttagtttcct cccactacat
     4201 gggcatctgt tctctcaaga tgtatatatt ttcttactgt acataaagac attccttaag
     4261 tcatacagaa agtgttgtga caaggggact tgggcacctt gttgtgaatg ccatcgtgga
     4321 attctctgtg tgttcacaac ccagccctta actttttctt gtttgacata aacctgtggg
     4381 catgcatgaa gttctccaac aagactccat gccagccaag cactgactgc atctctagtc
     4441 caaacaaggt ctttatagac tgactggggc tcatgtgagc ctaatgtgcc ctccttcgag
     4501 gctatacagt tccacgttcc tctactttga gggcgtccct catactcctg ttggcaaact
     4561 ggaaactgac cctacagagg tctgcacctc ccatctcaat tgccattgac tttcagtccc
     4621 aaacttgagg gtgctgggca gctggcactc ttaggggagc tttcgggaga ggcttcctgt
     4681 cacttgggag cagtgcttac ttcgaaggta cttctaactg ctcagtttgt gactattttt
     4741 aaacagtttg ccaatagaaa actcctgata acacttgcta catatcatgt tttaattgct
     4801 tgtacagtta acctttaatt ttgtttagta aagtgtatca aactaggact ttttgaattg
     4861 taaatatgtg gttttattaa aataaagtca tgtaaaattg ttaaaaaaaa aaaaaaaaaa
     4921 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
