LOCUS       NM_001004199            2925 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus Tax1 binding protein 1 (Tax1bp1), mRNA.
ACCESSION   NM_001004199 XM_342687
VERSION     NM_001004199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2925)
  AUTHORS   Sarraf,S.A., Shah,H.V., Kanfer,G., Pickrell,A.M., Holtzclaw,L.A.,
            Ward,M.E. and Youle,R.J.
  TITLE     Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate
            Accumulation in the Brain
  JOURNAL   Mol Cell 80 (5), 779-795 (2020)
   PUBMED   33207181
  REMARK    GeneRIF: Loss of TAX1BP1-Directed Autophagy Results in Protein
            Aggregate Accumulation in the Brain.
            Erratum:[Mol Cell. 2022 Apr 7;82(7):1383-1385. doi:
            10.1016/j.molcel.2022.03.020.. PMID: 35395199]
REFERENCE   2  (bases 1 to 2925)
  AUTHORS   Chen,J. and Chen,Z.J.
  TITLE     Regulation of NF-kappaB by ubiquitination
  JOURNAL   Curr Opin Immunol 25 (1), 4-12 (2013)
   PUBMED   23312890
  REMARK    Review article
REFERENCE   3  (bases 1 to 2925)
  AUTHORS   Mesentier-Louro,L.A., Coronel,J., Zaverucha-do-Valle,C.,
            Mencalha,A., Paredes,B.D., Abdelhay,E., Mendez-Otero,R. and
            Santiago,M.F.
  TITLE     Cell therapy modulates expression of Tax1-binding protein 1 and
            synaptotagmin IV in a model of optic nerve lesion
  JOURNAL   Invest Ophthalmol Vis Sci 53 (8), 4720-4729 (2012)
   PUBMED   22695963
  REMARK    GeneRIF: The increased expression of Tax1BP1 in optic nerve crush
            eyes displays the possible neuroprotective effect of bone marrow
            mononuclear cell treatment
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2925)
  AUTHORS   Harhaj,E.W. and Dixit,V.M.
  TITLE     Deubiquitinases in the regulation of NF-kappaB signaling
  JOURNAL   Cell Res 21 (1), 22-39 (2011)
   PUBMED   21119682
  REMARK    Review article
REFERENCE   5  (bases 1 to 2925)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (bases 1 to 2925)
  AUTHORS   Shembade,N., Harhaj,N.S., Parvatiyar,K., Copeland,N.G.,
            Jenkins,N.A., Matesic,L.E. and Harhaj,E.W.
  TITLE     The E3 ligase Itch negatively regulates inflammatory signaling
            pathways by controlling the function of the ubiquitin-editing
            enzyme A20
  JOURNAL   Nat Immunol 9 (3), 254-262 (2008)
   PUBMED   18246070
REFERENCE   7  (bases 1 to 2925)
  AUTHORS   Iha,H., Peloponese,J.M., Verstrepen,L., Zapart,G., Ikeda,F.,
            Smith,C.D., Starost,M.F., Yedavalli,V., Heyninck,K., Dikic,I.,
            Beyaert,R. and Jeang,K.T.
  TITLE     Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through
            selective NF-kappaB activation
  JOURNAL   EMBO J 27 (4), 629-641 (2008)
   PUBMED   18239685
REFERENCE   8  (bases 1 to 2925)
  AUTHORS   Ulrich,M., Seeber,S., Becker,C.M. and Enz,R.
  TITLE     Tax1-binding protein 1 is expressed in the retina and interacts
            with the GABA(C) receptor rho1 subunit
  JOURNAL   Biochem J 401 (2), 429-436 (2007)
   PUBMED   16999686
  REMARK    GeneRIF: C-terminal region of Tax1BP1 bound to an intracellular
            domain of the rho1 subunit, but not to other subunits of GABA(C),
            GABA(A) or glycine receptors. Tax1BP1 & GABA(C) receptors were
            co-expressed in both synaptic layers of the retina.
REFERENCE   9  (bases 1 to 2925)
  AUTHORS   De Valck,D., Jin,D.Y., Heyninck,K., Van de Craen,M., Contreras,R.,
            Fiers,W., Jeang,K.T. and Beyaert,R.
  TITLE     The zinc finger protein A20 interacts with a novel anti-apoptotic
            protein which is cleaved by specific caspases
  JOURNAL   Oncogene 18 (29), 4182-4190 (1999)
   PUBMED   10435631
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081949.1.
            
            On Sep 10, 2004 this sequence version replaced XM_342687.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081949.1, SRR8487231.170348.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2925
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2925
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /note="Tax1 binding protein 1"
                     /db_xref="GeneID:246244"
                     /db_xref="RGD:708579"
     exon            1..77
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            78..246
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2526
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /note="TRAF6-binding protein homolog; liver
                     regeneration-related protein 2; Tax1 (human T-cell
                     leukemia virus type I) binding protein 1; liver
                     regeneration-related protein LRRG004"
                     /codon_start=1
                     /product="tax1-binding protein 1 homolog"
                     /protein_id="NP_001004199.1"
                     /db_xref="GeneID:246244"
                     /db_xref="RGD:708579"
                     /translation="MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHP
                     HSKDWVGIFKVGWSTARDYYTFLWSPMPEQYVEGSTVNCVLAFQGYYLPNDDGEFYQF
                     CYVTHKGEIRGASTPFQFRAASPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTLKE
                     KEELLKLVSVLEKETAQLREQVGRMERELSHEKSRCEQLQAEQKGLLEVSQSLRVENE
                     EFMKRYSDATSKAHQLEEDIVSVTHKAVEKETELDSLKDKLRKAQQEKEQLECQLKTE
                     KDEKELYKVHLKNTEIENTKLVSEIQTLKNVDGNKESMITHFKEEIGKLQSCLADKEN
                     LHRALLLTTSNKEDTLLLKEQLRKAEEQVQATRQELIFLAKELSDAVNVRDKTMADLH
                     TARLENERVKKQLADTLAELQLHAVKTDQEKTDTLEHELRREVEDLKLRLQMAADHYK
                     EKFKECQRLQKQINKLSDQSASSNGVFTKRMGSQQKVNDASINTDPAASASAVDVKPA
                     ASCAAETDFDMSAKDHVCEVTKEMAEKVEKYNKCKQLLQDEKAKCNKYADELAQMELK
                     WKEQVRIAENVKLELAELEDSYSLQLAEKDKEINCLASFLENLSREKELTKSLEDQKG
                     RKMEGQSPQQVSRCLNTCSEQSGLLPTLPAAQPVLQYGNPYTAHETRDGADGAFYPDE
                     IQRPPVRGPSWEDNVVCSQPARNLSRPDGLEDPEDSREDENVPIPPDPANQHLRGHGA
                     GFCFDSSFDVHKKCPLCELMFPPNYDQIKFEEHVESHWKVCPMCSEQFPPDYDQQGFE
                     RHVQTHFDQNVLNFD"
     exon            247..349
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            350..537
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            538..696
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            697..845
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            846..936
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1122
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1347
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1494
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1621
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1725
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1851
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1923
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2098
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2241
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2324
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2900
                     /gene="Tax1bp1"
                     /gene_synonym="Aa1076"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtctcggct gagaggctgt ggcggtggct gctgaactcc ggagccggcg tagcgtgccg
       61 ggcggagacc ctgacggatt cacaatgaca tcctttcaag aagtcccatt gcagacttcc
      121 aactttgccc atgtcatctt tcaaaatgtg gctaaaagtt accttcctaa tgcacacttg
      181 gagtgtcatt acaccttaac tccgtatatt catcctcatt ccaaagattg ggttggtata
      241 ttcaaggttg gatggagtac tgctcgtgac tattacacat ttttatggtc tcctatgcct
      301 gaacagtatg tggaaggatc aacagtcaac tgtgtactag catttcaagg atattacctt
      361 ccaaatgatg atggagaatt ttatcagttc tgttacgtca cccataaggg tgaaattcgt
      421 ggagccagta ctcctttcca gtttcgagct gcttctccag ttgaagagct gctcactatg
      481 gaagatgaag gaaattctga tatgttggtg gtgaccacaa aagctggcct tcttgagctg
      541 aaaattgaaa agaccctgaa agaaaaagaa gaattgttaa agttggtttc tgttcttgaa
      601 aaagaaacag cacagctgag agaacaagtt ggaagaatgg agagagaact cagccatgag
      661 aaaagccggt gtgagcaatt gcaggcagag cagaagggcc ttcttgaagt atcccagagt
      721 ttgagagtgg aaaatgaaga gtttatgaag agatacagtg acgctacatc taaagctcat
      781 cagcttgaag aagacattgt atcagtgaca cataaagcag ttgagaaaga aactgagcta
      841 gacagtttga aggataaact caggaaagca cagcaagaaa aagaacaact tgaatgtcag
      901 ctgaagacag aaaaggatga gaaggagctt tataaggtac atttgaagaa cacagaaata
      961 gaaaatacca agcttgtgtc agagatacag actttaaaga atgtagatgg aaacaaagaa
     1021 agcatgatta ctcatttcaa agaagagatt ggcaaactgc agtcttgctt ggctgacaag
     1081 gaaaatttgc acagagctct cctgcttaca acctcaaata aagaagatac attacttcta
     1141 aaggaacaac ttcgcaaagc ggaggaacaa gtccaggcaa cacggcaaga acttatcttt
     1201 ctggctaaag agctcagtga tgcagtgaat gtgcgagata aaacaatggc agatctacat
     1261 accgcacgct tggaaaatga gagagtgaag aagcagctgg ccgacacgct ggcagagctc
     1321 cagttacatg ctgtaaagac agatcaggaa aagactgata cactggaaca tgaactgaga
     1381 agagaagttg aagatctgaa actccggctt cagatggctg cagatcatta caaagaaaag
     1441 tttaaggaat gccagaggct ccaaaaacaa ataaacaaac tttcagacca gtcagccagt
     1501 tctaacggtg tcttcacaaa gagaatgggg agtcagcaga aagtgaatga tgcttcaata
     1561 aacacagacc cagctgcttc tgcttctgcc gtggatgtaa agccagcagc atcttgtgca
     1621 gcagagacag attttgacat gtcagcaaag gatcatgtct gtgaagtgac taaagaaatg
     1681 gctgagaaag tagagaagta taataagtgt aaacaactct tgcaggatga gaaagccaaa
     1741 tgcaataaat atgctgatga acttgcgcaa atggagctga agtggaaaga gcaagtgaga
     1801 attgctgaga atgtaaaact cgaactcgct gagctagagg acagttacag tctacagttg
     1861 gcagagaaag acaaagaaat aaattgcctg gcttcatttt tggaaaatct ctcaagggag
     1921 aaggaactta caaagagttt agaagatcaa aaaggaagga aaatggaagg ccagagccct
     1981 caacaagtct cacggtgtct taacacctgc tctgagcaga gtgggctcct ccctacactg
     2041 ccggctgccc agccagttct tcagtatggg aacccttaca ccgcacacga gacaagagat
     2101 ggagcagatg gtgcttttta tccagatgaa atccagaggc cacctgtgcg cggcccatct
     2161 tgggaagaca acgttgtctg tagccagcct gctcgaaacc ttagcaggcc agatggttta
     2221 gaagacccgg aggatagcag agaagatgag aatgtgccca ttcctcctga tccagcaaat
     2281 cagcatttac gaggtcatgg agcaggcttt tgctttgatt ccagctttga tgttcacaag
     2341 aagtgccccc tctgtgaatt aatgttccct cctaactatg atcagatcaa atttgaagaa
     2401 cacgttgaaa gtcactggaa ggtgtgccca atgtgcagcg agcagttccc acctgactac
     2461 gaccagcagg gctttgaaag gcatgttcag acccattttg atcagaatgt tctcaacttc
     2521 gactagtttt tagtgagagg tagtaaaatt tagcagttaa aaaacaaccc aaaactcaga
     2581 tagaggctaa ggagactgcg ggcctgatgc cctgattgag aactttagag cgagctgtca
     2641 atagggccag ggtacagctt tgactacaat aaatacaggt ttaatctgtt aaccttgtct
     2701 gctttaagga aagagtttct gcatttctat ctctaccctg ttagcaaaag tgtatgaaga
     2761 acacaggagt tattttaatg ttaaaattga aaacatatat gtaatagtta attacctagc
     2821 acaatcagat ttacaagttc ctgttcacct tggtgattga gcatgactac tattatgtaa
     2881 taaaagcatt gatcataaca aaaaaaaaaa aaaaaaaaaa aaaaa
//
