LOCUS       NM_012668               2037 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus tyrosine aminotransferase (Tat), mRNA.
ACCESSION   NM_012668
VERSION     NM_012668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2037)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2037)
  AUTHORS   Hunter,S.R., Vonk,A., Mullen Grey,A.K. and Riddick,D.S.
  TITLE     Role of Glucocorticoid Receptor and Pregnane X Receptor in
            Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor
            Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase
  JOURNAL   Drug Metab Dispos 45 (2), 118-129 (2017)
   PUBMED   27856527
REFERENCE   3  (bases 1 to 2037)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2037)
  AUTHORS   Mehere,P., Han,Q., Lemkul,J.A., Vavricka,C.J., Robinson,H.,
            Bevan,D.R. and Li,J.
  TITLE     Tyrosine aminotransferase: biochemical and structural properties
            and molecular dynamics simulations
  JOURNAL   Protein Cell 1 (11), 1023-1032 (2010)
   PUBMED   21153519
REFERENCE   5  (bases 1 to 2037)
  AUTHORS   Smith,C., Wilson,N.W., Louw,A. and Myburgh,K.H.
  TITLE     Illuminating the interrelated immune and endocrine adaptations
            after multiple exposures to short immobilization stress by in vivo
            blocking of IL-6
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 292 (4), R1439-R1447 (2007)
   PUBMED   17170234
  REMARK    GeneRIF: Tat activity in skeletal muscle and liver was determined
            24h after the last psychological stress and immobilization stress.
REFERENCE   6  (bases 1 to 2037)
  AUTHORS   Natt,E., Kida,K., Odievre,M., Di Rocco,M. and Scherer,G.
  TITLE     Point mutations in the tyrosine aminotransferase gene in
            tyrosinemia type II
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9297-9301 (1992)
   PUBMED   1357662
REFERENCE   7  (bases 1 to 2037)
  AUTHORS   Pan,C.J., Shelly,L.L., Rabin,D.S. and Chou,J.Y.
  TITLE     Inhibition of tyrosine aminotransferase gene expression by retinoic
            acid
  JOURNAL   Mol Endocrinol 6 (4), 572-580 (1992)
   PUBMED   1350056
REFERENCE   8  (bases 1 to 2037)
  AUTHORS   Metelko,Z., Roglic,G. and Skrabalo,Z.
  TITLE     Diabetes in time of armed conflict: the Croatian experience
  JOURNAL   World Health Stat Q 45 (4), 328-333 (1992)
   PUBMED   1299072
REFERENCE   9  (bases 1 to 2037)
  AUTHORS   Lorber,B., Dietrich,J.B. and Kern,D.
  TITLE     Isolation and characterization of active N-terminal truncated apo-
            and holoenzyme of mammalian liver tyrosine aminotransferase
  JOURNAL   FEBS Lett 291 (2), 345-349 (1991)
   PUBMED   1682164
REFERENCE   10 (bases 1 to 2037)
  AUTHORS   Morozov,I.V., Mishin,V.P., Zelenin,S.M., Popova,V.S. and
            Mertvetsov,N.P.
  TITLE     Nucleotide sequence of rat liver tyrosine aminotransferase gene
            fragment
  JOURNAL   DNA Seq 1 (2), 151-155 (1990)
   PUBMED   1983704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089813.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012668.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2037
                     /gene="Tat"
                     /note="tyrosine aminotransferase"
                     /db_xref="GeneID:24813"
                     /db_xref="RGD:3820"
     exon            1..32
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            33..279
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1409
                     /gene="Tat"
                     /EC_number="2.6.1.5"
                     /note="L-tyrosine:2-oxoglutarate aminotransferase"
                     /codon_start=1
                     /product="tyrosine aminotransferase"
                     /protein_id="NP_036800.1"
                     /db_xref="GeneID:24813"
                     /db_xref="RGD:3820"
                     /translation="MDSYVIQTDVDDSLSSVLDVHVNIGGRNSVQGRKKGRKARWDVR
                     PSDMSNKTFNPIRAIVDNMKVQPNPNKTVISLSIGDPTVFGNLPTDPEVTQAMKDALD
                     SGKYNGYAPSIGYLSSREEVASYYHCHEAPLEAKDVILTSGCSQAIELCLAVLANPGQ
                     NILIPRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLVVNNPS
                     NPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKYEPLANLSTNVPILSCG
                     GLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILQRT
                     PQEFYHDTLSFLKSNADLCYGALAAIPGLQPVRPSGAMYLMVGIEMEHFPEFENDVEF
                     TERLIAEQAVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQE
                     ECDK"
     exon            280..384
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            385..452
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            453..611
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            612..750
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            751..803
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            804..956
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1085
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1169
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1268
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1994
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgggagg ctgctttgcc tggacttgga aggcttcgag aggcatggac tcctacgtga
       61 ttcagacgga tgtcgacgac agcttgtcct cagttctgga tgtgcatgtc aatattggtg
      121 ggagaaactc ggtacaagga agaaagaaag gcaggaaggc cagatgggac gtgagaccct
      181 ctgacatgtc caataagacc ttcaatccca tccgagccat cgtggacaac atgaaggtgc
      241 agcccaatcc gaacaagacc gtgatttctc tgtcaattgg ggaccctact gtgtttggga
      301 acctgcctac agaccctgaa gttacccaag ccatgaaaga tgccctggac tcggggaagt
      361 acaatggcta tgccccgtcc atcggctacc tatccagtcg ggaggaggtc gcttcttact
      421 accactgtca tgaggctcct ctggaagcta aggatgtcat tctgacaagc ggctgcagtc
      481 aggccattga gctatgtcta gctgtgttgg ccaatcctgg acaaaacatc ctcattccaa
      541 ggcccgggtt ttccctctat aggactttgg ctgagtctat gggaattgag gtcaagctct
      601 acaatctcct gcccgagaag tcttgggaaa ttgacctaaa acaactggaa tctctgatcg
      661 atgaaaaaac agcgtgtctt gttgtcaaca acccatccaa tccctgtggc tccgtgttca
      721 gtaagcggca ccttcagaag attttggcag tggctgaaag gcagtgtgtc cccatcttag
      781 ctgacgagat ctatggtgac atggtgtttt cagattgcaa atacgaacca ctggccaacc
      841 tcagcaccaa tgttcccatc ctgtcctgtg gtgggctggc caagcgctgg ctggttcctg
      901 gctggaggtt gggctggatc ctcattcatg atcgaagaga catttttggc aatgagattc
      961 gagacgggct ggtgaaactg agtcagcgga tcctgggacc atgcaccata gtccagggtg
     1021 ctctgaagag catccttcag cgaacccctc aggagttcta tcacgacacg ttaagcttcc
     1081 tcaagtccaa tgcggacctc tgctatgggg cactggctgc catccctgga ctccagccgg
     1141 tccgcccttc tggagccatg taccttatgg tgggaattga gatggagcat ttcccggaat
     1201 tcgagaacga cgtggagttc acagagcggt tgattgcgga gcaggctgtc cactgtctcc
     1261 cagcaacgtg cttcgagtac ccaaatttct tccgagtggt catcacagtc cccgaggtga
     1321 tgatgctgga ggcttgtagc cggatccagg agttctgtga acagcactac cactgtgctg
     1381 aaggcagcca ggaggagtgt gacaaataag ccctcacccg tcctcctgaa gacatgtccc
     1441 acgcaaggac ggttggactg gaccgctcct cctcagggag ccaaatgtct ctgatgggag
     1501 aggaacctct aaagcaccgc atgaagactt gaagatcatt tctccttccc ccagtttcac
     1561 ccaacgcacg cctggaaacc cagacccctc cctactcagt tctgctggag ccatgagctc
     1621 actgcccccc accccccact tccttatcct gagggtatca gaccaattta ccagaaagaa
     1681 gctgggccaa gaaaagagag agctcaggat gagagaagca gaagacggag gatgcctctc
     1741 ccacccattt cctcgtgctg acatcctctt cagtcaggtc ggaagtcacc tcagttgctg
     1801 cctcacttca ggcaaacctc actcctcgtg gtacagctac accagagaga agtcgaggac
     1861 ttgtgaattc agttaattgt attctaaaca catcaggaaa cttgatgttt aaaggatccc
     1921 tgacagaatt tttattttta ttttttgtaa aggattattt tgcggtgcaa ataaatacca
     1981 gcttcctaaa ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
