LOCUS       NM_001044243            1990 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus taspase 1 (Tasp1), mRNA.
ACCESSION   NM_001044243 XM_001080195 XM_230631
VERSION     NM_001044243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Wunsch,D., Fetz,V., Heider,D., Tenzer,S., Bier,C., Kunst,L.,
            Knauer,S. and Stauber,R.
  TITLE     Chemico-genetic strategies to inhibit the leukemic potential of
            threonine aspartase-1
  JOURNAL   Blood Cancer J 2 (6), e77 (2012)
   PUBMED   22829979
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Khan JA, Dunn BM and Tong L.
  TITLE     Crystal structure of human Taspase1, a crucial protease regulating
            the function of MLL
  JOURNAL   Structure 13 (10), 1443-1452 (2005)
   PUBMED   16216576
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Hsieh JJ, Cheng EH and Korsmeyer SJ.
  TITLE     Taspase1: a threonine aspartase required for cleavage of MLL and
            proper HOX gene expression
  JOURNAL   Cell 115 (3), 293-303 (2003)
   PUBMED   14636557
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105618.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XM_230631.4, XM_001080195.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105618.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1990
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /note="taspase 1"
                     /db_xref="GeneID:311468"
                     /db_xref="RGD:1308591"
     exon            1..209
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1327
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /note="taspase, threonine aspartase 1"
                     /codon_start=1
                     /product="threonine aspartase 1"
                     /protein_id="NP_001037708.1"
                     /db_xref="GeneID:311468"
                     /db_xref="RGD:1308591"
                     /translation="MIMEKGMNSGEGLPSRSSQASAAKITVKELETQQPCKEKRGGFV
                     LVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVMAALVELEDSPFTNAG
                     VGSNLNLLGEIECDASIMDGKSLSFGAVGALSGIKNPVSVAHRLLCEGQKGKLSAGRI
                     PPCFLVGEGAYRWAVDHGIPSCPPSTMTTRFSLAAFKRNKRKLELAERVETDFIQLKR
                     RRQSSAKENDSGALDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAE
                     NTGAHNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLA
                     SEDGVLGGVIVLRSCRCPSESDPSQDKQTLLVEFLWSHSTESMCVGYMSAQDGKAKTH
                     ISRLPPGAVAGQSVAIEGGVCRLESPVN"
     exon            210..277
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            278..346
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            347..467
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            468..552
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            553..632
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            633..739
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            740..859
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            860..938
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1049
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1160
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1234
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1926
                     /gene="Tasp1"
                     /gene_synonym="RGD1308591"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttgcagt ttcttttgca tggaaggatg cttttttcct gatagaagat gataatcttg
       61 gagaatgatc atggagaagg ggatgaattc tggagaagga ctgccttcca gatcctctca
      121 ggcatctgct gctaaaataa cagtcaagga gttagaaaca cagcagccct gtaaggagaa
      181 acgagggggc tttgtgctgg tgcatgcagg tgcaggctat cattctgaat ccaaagccaa
      241 ggagtataaa catgtatgca aacgagcttg tcagaaggca attgagaagc tacaggctgg
      301 tgcccttgcg acagatgcag tgatggctgc tctggtggaa cttgaggatt ctccttttac
      361 aaatgcagga gttggatcta atctaaatct cttaggagag atcgaatgtg atgccagcat
      421 aatggatggg aagtccttaa gcttcggagc cgtaggagca ctgagtggaa tcaagaatcc
      481 agtatcagtt gcacacagac tcttgtgtga agggcagaag ggcaagctgt ctgcaggccg
      541 gattcctcct tgctttttag ttggagaagg agcctacaga tgggcagtgg atcatgggat
      601 accctcttgc cctcctagca ccatgaccac aagattcagc ttagctgcat ttaaaaggaa
      661 caagaggaaa ctagagctgg cagaaagggt ggaaacagac ttcatccagc taaagagaag
      721 aagacaatca agtgcaaagg aaaatgactc gggcgctttg gacacagtgg gtgctgtggt
      781 tgtcgatcat gaagggaatg ttgctgctgc tgtctccagt ggaggcttgg ccttgaaaca
      841 tccagggaga gttgggcagg ctgctcttta tggatgtggc tgctgggctg aaaatactgg
      901 agctcataac ccctactcca cagctgtgag tacctcagga tgtggagagc atcttgtgcg
      961 caccatactg gctagagaat gttcacacgc tttacaagct gaagacgctc accaagctct
     1021 gttggagact atgcaaaaca agtttatcag ttcacctttc cttgccagtg aagacggcgt
     1081 gctcggcggg gtgatcgtcc tccggtcatg cagatgtcct tcagagtctg acccctccca
     1141 agataaacag acattgctcg tggaatttct gtggagccac agtacagaga gcatgtgcgt
     1201 gggctatatg tcagcccagg atggcaaagc caagactcac atttccagac tccctcctgg
     1261 tgctgtggca ggacagtctg ttgcaatcga aggtggggtt tgccgcctgg agagccctgt
     1321 gaactgactc caggctgact acgaagtgtc tgcgaggcat ttcagaacct gagctttggc
     1381 tgttcagttg aagttggatg ttttatcttc cttgttttgt aattcttatt gcaacctcgg
     1441 gcactgcttg ggacacttaa gtgctgctat acttagtgct ggttgacact cgagtcttag
     1501 gcggatgagc ggagcatgtg tgagtgtgtg tccgtgtgca gtgtgtgtgc ttgcttctcc
     1561 ctgatgggat aagatctcct caagtgtaac ctatgaacga gaatgattaa ctctttacaa
     1621 aatgtgtgct ttaactgttt acaagtaaac ctaaagttgt agaaaacttt tatttcataa
     1681 agaggtacca actatggttg atacaatgtg tctgaactga agagtgaatc tgcttgttaa
     1741 aatgacttga ctttgattgt agcccattta atcacaggaa tcaataatct ggtgtcagtt
     1801 taagtggatg gtgtggtaac ttaaatggtt gttctcaccc ctcacacagg gcaattttct
     1861 tgaacacaga gtggtttcag tgaaaccatt ctagcagaga attaaagtca gaacctttta
     1921 aagtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1981 aaaaaaaaaa
//
