LOCUS       NM_130818               3480 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus taste 1 receptor member 3 (Tas1r3), mRNA.
ACCESSION   NM_130818
VERSION     NM_130818.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Song,L., Chen,K., Yan,J., Zhang,Y., Mao,X., Lu,B. and Sun,B.
  TITLE     Maternal high-fat diet during gestation and lactation increases
            conditioned aversion threshold for sucrose and alters sweet taste
            receptors expression in taste buds in rat offspring
  JOURNAL   Physiol Behav 212, 112709 (2019)
   PUBMED   31655082
  REMARK    GeneRIF: Maternal high-fat diet during gestation and lactation
            increases conditioned aversion threshold for sucrose and alters
            sweet taste receptors expression in taste buds in rat offspring.
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Feng,R., Qian,C., Liu,Q., Jin,Y., Liu,L., Li,S., Liao,Y., Zhou,H.,
            Liu,W., Rayner,C.K. and Ma,J.
  TITLE     Expression of sweet taste receptor and gut hormone secretion in
            modelled type 2 diabetes
  JOURNAL   Gen Comp Endocrinol 252, 142-149 (2017)
   PUBMED   28782537
  REMARK    GeneRIF: Sweet taste molecules of T1R2, T1R3, alpha-gustducin and
            TRPM5 in ileum were dramatically higher than those in duodenum
            (P<0.01 for each).
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Shi,J., Wang,S., Ke,Q., Lin,J., Zheng,Y., Wu,S., Huang,Z. and
            Lin,W.
  TITLE     T1R1/T1R3 Taste Receptor Suppresses Granulocyte-Mediated
            Neuroinflammation after Spinal Cord Injury
  JOURNAL   J Neurotrauma 34 (15), 2353-2363 (2017)
   PUBMED   28474538
  REMARK    GeneRIF: Our research indicates that the T1R1/T1R3 receptor is an
            anti-inflammatory receptor for infiltrating granulocytes after
            spinal cord injury
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Ogawa,N., Kanki,K., Honda,K., Tomooka,Y., Ryoke,K. and Watanabe,T.
  TITLE     Involvement of glucocorticoid in induction of lingual T1R3 in
            rodents
  JOURNAL   Eur J Pharmacol 761, 262-267 (2015)
   PUBMED   26096555
  REMARK    GeneRIF: Low concentration of endogenous GC is necessary and
            sufficient for induction of T1R3 expression. Higher concentrations
            may inhibit such induction. This inhibitory effect may be due, at
            least in part, to a direct action of GC on taste cells.
REFERENCE   5  (bases 1 to 3480)
  AUTHORS   Medina,A., Nakagawa,Y., Ma,J., Li,L., Hamano,K., Akimoto,T.,
            Ninomiya,Y. and Kojima,I.
  TITLE     Expression of the glucose-sensing receptor T1R3 in pancreatic
            islet: changes in the expression levels in various nutritional and
            metabolic states
  JOURNAL   Endocr J 61 (8), 797-805 (2014)
   PUBMED   24898279
  REMARK    GeneRIF: T1R3 is expressed mainly in beta-cells and the expression
            levels are different depending upon the nutritional and metabolic
            conditions.
REFERENCE   6  (bases 1 to 3480)
  AUTHORS   Behrens,M., Bartelt,J., Reichling,C., Winnig,M., Kuhn,C. and
            Meyerhof,W.
  TITLE     Members of RTP and REEP gene families influence functional bitter
            taste receptor expression
  JOURNAL   J Biol Chem 281 (29), 20650-20659 (2006)
   PUBMED   16720576
REFERENCE   7  (bases 1 to 3480)
  AUTHORS   Jiang,P., Ji,Q., Liu,Z., Snyder,L.A., Benard,L.M., Margolskee,R.F.
            and Max,M.
  TITLE     The cysteine-rich region of T1R3 determines responses to intensely
            sweet proteins
  JOURNAL   J Biol Chem 279 (43), 45068-45075 (2004)
   PUBMED   15299024
REFERENCE   8  (bases 1 to 3480)
  AUTHORS   Ariyasu,T., Matsumoto,S., Kyono,F., Hanaya,T., Arai,S., Ikeda,M.
            and Kurimoto,M.
  TITLE     Taste receptor T1R3 is an essential molecule for the cellular
            recognition of the disaccharide trehalose
  JOURNAL   In Vitro Cell Dev Biol Anim 39 (1-2), 80-88 (2003)
   PUBMED   12892531
REFERENCE   9  (bases 1 to 3480)
  AUTHORS   Li,X., Staszewski,L., Xu,H., Durick,K., Zoller,M. and Adler,E.
  TITLE     Human receptors for sweet and umami taste
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4692-4696 (2002)
   PUBMED   11917125
REFERENCE   10 (bases 1 to 3480)
  AUTHORS   Nelson,G., Hoon,M.A., Chandrashekar,J., Zhang,Y., Ryba,N.J. and
            Zuker,C.S.
  TITLE     Mammalian sweet taste receptors
  JOURNAL   Cell 106 (3), 381-390 (2001)
   PUBMED   11509186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 13, 2022 this sequence version replaced NM_130818.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF456324.1, AY032620.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000005.1  171754786-171754993 c
            209-509             JAXUCZ010000005.1  171754370-171754670 c
            510-1313            JAXUCZ010000005.1  171753480-171754283 c
            1314-1511           JAXUCZ010000005.1  171753160-171753357 c
            1512-1632           JAXUCZ010000005.1  171752957-171753077 c
            1633-3480           JAXUCZ010000005.1  171750937-171752784 c
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3480
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /note="taste 1 receptor member 3"
                     /db_xref="GeneID:170634"
                     /db_xref="RGD:620539"
     exon            1..208
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2594
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /note="G-protein coupled receptor (GPCR); sweet taste
                     receptor T1R3; taste receptor, type 1, member 3"
                     /codon_start=1
                     /product="taste receptor type 1 member 3 precursor"
                     /protein_id="NP_570831.1"
                     /db_xref="GeneID:170634"
                     /db_xref="RGD:620539"
                     /translation="MPGLAILGLSLAAFLELGMGSSLCLSQQFKAQGDYILGGLFPLG
                     TTEEATLNQRTQPNGILCTRFSPLGLFLAMAMKMAVEEINNGSALLPGLRLGYDLFDT
                     CSEPVVTMKPSLMFMAKVGSQSIAAYCNYTQYQPRVLAVIGPHSSELALITGKFFSFF
                     LMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQNFSWNWVAALGSDDDY
                     GREGLSIFSGLANSRGICIAHEGLVPQHDTSGQQLGKVVDVLRQVNQSKVQVVVLFAS
                     ARAVYSLFSYSILHDLSPKVWVASESWLTSDLVMTLPNIARVGTVLGFLQRGALLPEF
                     SHYVETRLALAADPTFCASLKAELDLEERVMGPRCSQCDYIMLQNLSSGLMQNLSAGQ
                     LHHQIFATYAAVYSVAQALHNTLQCNVSHCHTSEPVQPWQLLENMYNMSFRARDLTLQ
                     FDAKGSVDMEYDLKMWVWQSPTPVLHTVGTFNGTLQLQHSKMYWPGNQVPVSQCSRQC
                     KDGQVRRVKGFHSCCYDCVDCKAGSYRKHPDDFTCTPCGKDQWSPEKSTTCLPRRPKF
                     LAWGEPAVLSLLLLLCLVLGLTLAALGLFVHYWDSPLVQASGGSLFCFGLICLGLFCL
                     SVLLFPGRPRSASCLAQQPMAHLPLTGCLSTLFLQAAEIFVESELPLSWANWLCSYLR
                     GPWAWLVVLLATLVEAALCAWYLMAFPPEVVTDWQVLPTEVLEHCRMRSWVSLGLVHI
                     TNAVLAFLCFLGTFLVQSQPGRYNRARGLTFAMLAYFIIWVSFVPLLANVQVAYQPAV
                     QMGAILFCALGILATFHLPKCYVLLWLPELNTQEFFLGRSPKEASDGNSGSSEATRGH
                     SE"
     exon            209..509
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1313
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1511
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1632
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..3480
                     /gene="Tas1r3"
                     /gene_synonym="T1r3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggaaac ttctaccatg ccgggtttgg ctatcttggg cctcagtctg gctgctttcc
       61 tggagcttgg gatggggtcc tctttgtgtc tgtcacagca attcaaggca caaggggact
      121 atatattggg tggactattt cccctgggca caactgagga ggccactctc aaccagagaa
      181 cacagcccaa cggcatccta tgtaccaggt tctcgcccct tggtttgttc ctggccatgg
      241 ctatgaagat ggctgtagag gagatcaaca atggatctgc cttgctccct gggctgcgac
      301 tgggctatga cctgtttgac acatgctcag agccagtggt caccatgaag cccagcctca
      361 tgttcatggc caaggtggga agtcaaagca ttgctgccta ctgcaactac acacagtacc
      421 aaccccgtgt gctggctgtc attggtcccc actcatcaga gcttgccctc attacaggca
      481 agttcttcag cttcttcctc atgccacagg tcagctatag tgccagcatg gatcggctaa
      541 gtgaccggga aacatttcca tccttcttcc gcacagtgcc cagtgaccgg gtgcagctgc
      601 aggccgttgt gacactgttg cagaatttca gctggaactg ggtggctgcc ttaggtagtg
      661 atgatgacta tggccgggaa ggtctgagca tcttttctgg tctggccaac tcacgaggta
      721 tctgcattgc acacgagggc ctggtgccac aacatgacac tagtggccaa caattgggca
      781 aggtggtgga tgtgctacgc caagtgaacc aaagcaaagt acaggtggtg gtgctgtttg
      841 catctgcccg tgctgtctac tcccttttta gctacagcat ccttcatgac ctctcaccca
      901 aggtatgggt ggccagtgag tcctggctga cctctgacct ggtcatgaca cttcccaata
      961 ttgcccgtgt gggcactgtt cttgggtttc tgcagcgcgg tgccctactg cctgaatttt
     1021 cccattatgt ggagactcgc cttgccctag ctgctgaccc aacattctgt gcctccctga
     1081 aagctgagtt ggatctggag gagcgcgtga tggggccacg ctgttcacaa tgtgactaca
     1141 tcatgctaca gaacctgtca tctgggctga tgcagaacct atcagctggg cagttgcacc
     1201 accaaatatt tgcaacctat gcagctgtgt acagtgtggc tcaggccctt cacaacaccc
     1261 tgcagtgcaa tgtctcacat tgccacacat cagagcctgt tcaaccctgg cagctcctgg
     1321 agaacatgta caatatgagt ttccgtgctc gagacttgac actgcagttt gatgccaaag
     1381 ggagtgtaga catggaatat gacctgaaga tgtgggtgtg gcagagccct acacctgtac
     1441 tacatactgt aggcaccttc aacggcaccc ttcagctgca gcactcgaaa atgtattggc
     1501 caggcaacca ggtgccagtc tcccagtgct cccggcagtg caaagatggc caggtgcgca
     1561 gagtaaaggg ctttcattcc tgctgctatg actgtgtgga ctgcaaggca gggagctacc
     1621 ggaagcatcc agatgacttc acctgtactc catgtggcaa ggatcagtgg tccccagaaa
     1681 aaagcacaac ctgcttacct cgcaggccca agtttctggc ttggggggag ccagctgtgc
     1741 tgtcacttct cctgctgctt tgcctggtgc tgggcctgac actggctgcc ctggggctct
     1801 ttgtccacta ctgggacagc cctcttgttc aggcctcagg tgggtcactg ttctgctttg
     1861 gcctgatctg cctaggcctc ttctgcctca gtgtccttct gttcccagga cgaccacgct
     1921 ctgccagctg ccttgcccaa caaccaatgg ctcacctccc tctcacaggc tgcctgagca
     1981 cactcttcct gcaagcagcc gagatctttg tggagtctga gctgccactg agttgggcaa
     2041 actggctctg cagctacctt cggggcccct gggcttggct ggtggtactg ctggccactc
     2101 ttgtggaggc tgcactatgt gcctggtact tgatggcttt ccctccagag gtggtgacag
     2161 attggcaggt gctgcccacg gaggtactgg aacactgccg catgcgttcc tgggtcagcc
     2221 tgggcttggt gcacatcacc aatgcagtgt tagctttcct ctgctttctg ggcactttcc
     2281 tggtacagag ccagcctggt cgctataacc gtgcccgtgg cctcaccttc gccatgctag
     2341 cttatttcat catctgggtc tcttttgtgc ccctcctggc taatgtgcag gtggcctacc
     2401 agccagctgt gcagatgggt gctatcttat tctgtgccct gggcatcctg gccaccttcc
     2461 acctgcccaa atgctatgta cttctgtggc tgccagagct caacacccag gagttcttcc
     2521 tgggaaggag ccccaaggaa gcatcagatg ggaatagtgg tagtagtgag gcaactcggg
     2581 gacacagtga atgacccctg atccaatgac cttaccttta gtgaacccag ccctaccaga
     2641 gatctcctaa gccatcaaac cccaaacagt acttcaacca tagacttgag acactgaaca
     2701 taaactcgga ctccattggc cttagtccta cagtgacacc cccacacact gaaggcctgc
     2761 tgagcacaag atggacccta tgagcccacc tacccctcaa aggcaagatc atccttgatc
     2821 ctgttatgcc tacctaaggc ctccccaggt gaccaggctc tatgatctta gaaaacgacc
     2881 cacaaaaggt tctttgggac tacatagcca tactttgaac ctaggaattc cccaggcaga
     2941 cagaccctgg gaggtcagaa agtactactt gcctgaacat gccaggcggg ggcctcatca
     3001 gtgccctgtc caggcatccc aggaatagaa ggctgggcat gtataggtat tgggacagag
     3061 caagaaagac agcaggcaga gcacactcag gagggaggca acatccagtc ttctccattc
     3121 ctggctgagc cctagcctgg aggagaaaac cgggtcgcca ccagcacctt ggacagagca
     3181 tacacagggg tacgggtcag caccacggcc agcaccagcc acccaggacc cctggaatca
     3241 gcttctagta ccaaggacag aaaagttgcc tgcaaggccc cttactggcc agcaccaggg
     3301 acagagccac atgactaagc ggcaagggac aagggtatct tccatctcca ggcaggatca
     3361 gacctgggtc agttctggac tggcccccac acctgaatcc ggaagcagct tagctggaga
     3421 aaagaaaaat aagccacaca tcagtcccat aaaattaaac gcttttttta gtgtttaaaa
//
