LOCUS       NM_001271266            2978 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus taste 1 receptor member 2 (Tas1r2), mRNA.
ACCESSION   NM_001271266 XM_003750067 XM_003754109
VERSION     NM_001271266.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2978)
  AUTHORS   Song,L., Chen,K., Yan,J., Zhang,Y., Mao,X., Lu,B. and Sun,B.
  TITLE     Maternal high-fat diet during gestation and lactation increases
            conditioned aversion threshold for sucrose and alters sweet taste
            receptors expression in taste buds in rat offspring
  JOURNAL   Physiol Behav 212, 112709 (2019)
   PUBMED   31655082
  REMARK    GeneRIF: Maternal high-fat diet during gestation and lactation
            increases conditioned aversion threshold for sucrose and alters
            sweet taste receptors expression in taste buds in rat offspring.
REFERENCE   2  (bases 1 to 2978)
  AUTHORS   Feng,R., Qian,C., Liu,Q., Jin,Y., Liu,L., Li,S., Liao,Y., Zhou,H.,
            Liu,W., Rayner,C.K. and Ma,J.
  TITLE     Expression of sweet taste receptor and gut hormone secretion in
            modelled type 2 diabetes
  JOURNAL   Gen Comp Endocrinol 252, 142-149 (2017)
   PUBMED   28782537
  REMARK    GeneRIF: Sweet taste molecules of T1R2, T1R3, alpha-gustducin and
            TRPM5 in ileum were dramatically higher than those in duodenum
            (P<0.01 for each).
REFERENCE   3  (bases 1 to 2978)
  AUTHORS   Kotani,T., Toyono,T., Seta,Y., Kitou,A., Kataoka,S. and
            Toyoshima,K.
  TITLE     Expression of synaptogyrin-1 in T1R2-expressing type II taste cells
            and type III taste cells of rat circumvallate taste buds
  JOURNAL   Cell Tissue Res 353 (3), 391-398 (2013)
   PUBMED   23636420
  REMARK    GeneRIF: A subset of synaptogyrin-1-immunoreactive taste cells also
            expressed phospholipase Cbeta2, gustducin, or sweet taste receptor
            (T1R2).
REFERENCE   4  (bases 1 to 2978)
  AUTHORS   Wu,S.V., Chen,M.C. and Rozengurt,E.
  TITLE     Genomic organization, expression, and function of bitter taste
            receptors (T2R) in mouse and rat
  JOURNAL   Physiol Genomics 22 (2), 139-149 (2005)
   PUBMED   15886333
REFERENCE   5  (bases 1 to 2978)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 2978)
  AUTHORS   Li,X., Staszewski,L., Xu,H., Durick,K., Zoller,M. and Adler,E.
  TITLE     Human receptors for sweet and umami taste
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4692-4696 (2002)
   PUBMED   11917125
REFERENCE   7  (bases 1 to 2978)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   8  (bases 1 to 2978)
  AUTHORS   Hoon,M.A., Adler,E., Lindemeier,J., Battey,J.F., Ryba,N.J. and
            Zuker,C.S.
  TITLE     Putative mammalian taste receptors: a class of taste-specific GPCRs
            with distinct topographic selectivity
  JOURNAL   Cell 96 (4), 541-551 (1999)
   PUBMED   10052456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 13, 2022 this sequence version replaced NM_001271266.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF127390.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000005.1  157192799-157193020
            223-523             JAXUCZ010000005.1  157194922-157195222
            524-1300            JAXUCZ010000005.1  157198091-157198867
            1301-1510           JAXUCZ010000005.1  157200599-157200808
            1511-1634           JAXUCZ010000005.1  157206122-157206245
            1635-2978           JAXUCZ010000005.1  157207594-157208937
FEATURES             Location/Qualifiers
     source          1..2978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2978
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /note="taste 1 receptor member 2"
                     /db_xref="GeneID:100270683"
     exon            1..222
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2563
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /note="G protein-coupled receptor 71; sweet taste receptor
                     T1R2; taste receptor TR2; aldehyde dehydrogenase 4 family,
                     member A1; taste receptor, type 1, member 2"
                     /codon_start=1
                     /product="taste receptor type 1 member 2 precursor"
                     /protein_id="NP_001258195.1"
                     /db_xref="GeneID:100270683"
                     /translation="MGPQARTLCLLSLLLHVLPKPGKLVENSDFHLAGDYLLGGLFTL
                     HANVKSISHLSYLQVPKCNEFTMKVLGYNLMQAMRFAVEEINNCSSLLPGVLLGYEMV
                     DVCYLSNNIHPGLYFLAQDDDLLPILKDYSQYMPHVVAVIGPDNSESAITVSNILSHF
                     LIPQITYSAISDKLRDKRHFPSMLRTVPSATHHIEAMVQLMVHFQWNWIVVLVSDDDY
                     GRENSHLLSQRLTKTSDICIAFQEVLPIPESSQVMRSEEQRQLDNILDKLRRTSARVV
                     VVFSPELSLYSFFHEVLRWNFTGFVWIASESWAIDPVLHNLTELRHTGTFLGVTIQRV
                     SIPGFSQFRVRRDKPGYPVPNTTNLRTTCNQDCDACLNTTKSFNNILILSGERVVYSV
                     YSAVYAVAHALHRLLGCNRVRCTKQKVYPWQLLREIWHVNFTLLGNRLFFDQQGDMPM
                     LLDIIQWQWDLSQNPFQSIASYSPTSKRLTYINNVSWYTPNNTVPVSMCSKSCQPGQM
                     KKSVGLHPCCFECLDCMPGTYLNRSADEFNCLSCPGSMWSYKNDITCFQRRPTFLEWH
                     EVPTIVVAILAALGFFSTLAILFIFWRHFQTPMVRSAGGPMCFLMLVPLLLAFGMVPV
                     YVGPPTVFSCFCRQAFFTVCFSICLSCITVRSFQIVCVFKMARRLPSAYSFWMRYHGP
                     YVFVAFITAIKVALVVGNMLATTINPIGRTDPDDPNIMILSCHPNYRNGLLFNTSMDL
                     LLSVLGFSFAYMGKELPTNYNEAKFITLSMTFSFTSSISLCTFMSVHDGVLVTIMDLL
                     VTVLNFLAIGLGYFGPKCYMILFYPERNTSAYFNSMIQGYTMRKS"
     exon            223..523
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1300
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1510
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1634
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2978
                     /gene="Tas1r2"
                     /gene_synonym="Aldh4a1; Gpr71; T1r2; Tr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcatcctc tacggctgtc actttgctgt catgggtccc caggcaagga cactctgctt
       61 gctgtctctc ctgctgcatg ttctgcctaa gccaggcaag ctggtagaga actctgactt
      121 ccacctggcc ggggactacc tcctgggtgg cctctttacc ctccatgcca acgtgaagag
      181 catctcccac ctcagctacc tgcaggtgcc caagtgcaat gagttcacca tgaaggtgtt
      241 gggctacaac ctcatgcagg ccatgcgttt cgctgtggag gagatcaaca actgtagctc
      301 cctgctaccc ggcgtgctgc tcggctacga gatggtggat gtctgttacc tctccaacaa
      361 tatccaccct gggctctact tcctggcaca ggacgacgac ctcctgccca tcctcaaaga
      421 ctacagccag tacatgcccc acgtggtggc tgtcattggc cccgacaact ctgagtccgc
      481 cattaccgtg tccaacattc tctctcattt cctcatccca cagatcacat acagcgccat
      541 ctccgacaag ctgcgggaca agcggcactt ccctagcatg ctacgcacag tgcccagcgc
      601 cacccaccac atcgaggcca tggtgcagct gatggttcac ttccaatgga actggattgt
      661 ggtgctggtg agcgacgacg attacggccg cgagaacagc cacctgttga gccagcgtct
      721 gaccaaaacg agcgacatct gcattgcctt ccaggaggtt ctgcccatac ctgagtccag
      781 ccaggtcatg aggtccgagg agcagagaca actggacaac atcctggaca agctgcggcg
      841 gacctcggcg cgcgtcgtgg tggtgttctc gcccgagctg agcctgtata gcttctttca
      901 cgaggtgctc cgctggaact tcacgggttt tgtgtggatc gcctctgagt cctgggctat
      961 cgacccagtt ctgcataacc tcacggagct gcgccacacg ggtacttttc tgggcgtcac
     1021 catccagagg gtgtccatcc ctggcttcag tcagttccga gtgcgccgtg acaagccagg
     1081 gtatcccgtg cctaacacga ccaacctgcg gacgacctgc aaccaggact gtgacgcctg
     1141 cttgaacacc accaagtcct tcaacaacat ccttatactt tcgggggagc gcgtggtcta
     1201 cagcgtgtac tcagcagttt acgcggtggc ccatgccctc cacagactcc tcggctgtaa
     1261 ccgggtccgc tgcaccaagc aaaaggtcta cccgtggcag ctactcaggg agatctggca
     1321 cgtcaacttc acgctcctgg gtaaccggct cttctttgac caacaagggg acatgccgat
     1381 gctcttggac atcatccagt ggcagtggga cctgagccag aatcccttcc aaagcatcgc
     1441 ctcctattct cccaccagca agaggctaac ctacattaac aatgtgtcct ggtacacccc
     1501 caacaacacg gtccctgtct ccatgtgttc caagagctgc cagccagggc aaatgaaaaa
     1561 gtctgtgggc ctccaccctt gttgcttcga gtgcttggat tgtatgccag gcacctacct
     1621 caaccgctca gcagatgagt ttaactgtct gtcctgcccg ggttccatgt ggtcctacaa
     1681 gaacgacatc acttgcttcc agcggcggcc taccttcctg gagtggcacg aagtgcccac
     1741 catcgtggtg gccatactgg ctgccctggg cttcttcagt acactggcca ttcttttcat
     1801 cttctggaga catttccaga cacccatggt gcgctcggcc ggtggcccca tgtgcttcct
     1861 gatgctcgtg cccctgctgc tggcgtttgg gatggtgccc gtgtatgtgg ggccccccac
     1921 ggtcttctca tgcttctgcc gacaggcttt cttcaccgtc tgcttctcca tctgcctatc
     1981 ctgcatcacc gtgcgctcct tccagatcgt gtgtgtcttc aagatggcca gacgcctgcc
     2041 aagtgcctac agtttttgga tgcgttacca cgggccctat gtcttcgtgg ccttcatcac
     2101 ggccatcaag gtggccctgg tggtgggcaa catgctggcc accaccatca accccattgg
     2161 ccggaccgac ccggatgacc ccaacatcat gatcctctcg tgccacccta actaccgcaa
     2221 cgggctactg ttcaacacca gcatggactt gctgctgtct gtgctgggtt tcagcttcgc
     2281 ttacatgggc aaggagctgc ccaccaacta caacgaagcc aagttcatca ctctcagcat
     2341 gaccttctcc ttcacctcct ccatctccct ctgcaccttc atgtctgtgc acgacggcgt
     2401 gctggtcacc atcatggacc tcctggtcac tgtgctcaac ttcctggcca tcggcttggg
     2461 atactttggc cccaagtgtt acatgatcct tttctacccg gagcgcaaca cctcagccta
     2521 tttcaatagc atgatccagg gctacaccat gaggaagagc tagctccgcc caccggcctc
     2581 agcagcagag cccccggcca cgttaatggt gttcctctgc cattctctgc agcgtagcta
     2641 tttttaccca catagcgctt aaaataccca tgatgcactc tcccccgacc cccaagccat
     2701 ttcactggcc aggacctacc acccacttat agatgaaacc accaaggcgc cctatggggc
     2761 tccaaggatg gcctaccact gccatctggt ggtcacagtg agcacctgcg ggccgtggcc
     2821 catggctccc agccagctgg tggctagtgg ctgtgaggcc agatgtctgt gtatctgagt
     2881 tcctgggaag cagagactgg ggctcctgtg ttctaatggt cagatgggca tcatgggccc
     2941 ttcattattg cttacgaata aacttccctc cggtgaaa
//
