LOCUS       NM_001014040            2400 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus threonyl-tRNA synthetase 2, mitochondrial
            (Tars2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001014040 XM_227448
VERSION     NM_001014040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Wang,Y., Zhou,X.L., Ruan,Z.R., Liu,R.J., Eriani,G. and Wang,E.D.
  TITLE     A Human Disease-causing Point Mutation in Mitochondrial
            Threonyl-tRNA Synthetase Induces Both Structural and Functional
            Defects
  JOURNAL   J Biol Chem 291 (12), 6507-6520 (2016)
   PUBMED   26811336
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079154.1.
            
            On Apr 20, 2005 this sequence version replaced XM_227448.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079154.1, SRR8487230.80665.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2400
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /note="threonyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:310672"
                     /db_xref="RGD:1308283"
     exon            1..96
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2187
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /EC_number="6.1.1.3"
                     /note="threonyl-tRNA synthetase, mitochondrial; thrRS;
                     threonyl-tRNA synthetase-like 1; threonyl-tRNA synthetase
                     2, mitochondrial (putative)"
                     /codon_start=1
                     /product="threonine--tRNA ligase, mitochondrial"
                     /protein_id="NP_001014062.1"
                     /db_xref="GeneID:310672"
                     /db_xref="RGD:1308283"
                     /translation="MGLCLRWRRLGFPLPGFRRCELHTVREAPIPTPPHWLAERFGLF
                     EELWTAQVKRLASMTQKKARTIKISLPEGQKVDAVAWNTTPYQLAQQISSTLADTAVA
                     AEVNGELYDLDRPLETDCHLRFLTFDSPEGKAVFWRSSAHVLGAAAEQHLGAVLCRGP
                     STESGFYLDFFLGKERTVRSTELPTLERICQEIITAAQPFRRLEASRGQLRQLFKDNH
                     FKLHVIEEKVTGTTATVYGCGMSVDLCQGPHLRHTGQIGALKLLTNSSALWRSSEAPE
                     TLQRVSGISFPKAELLRNWEARREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGT
                     RIYNALVAFIRAEYARRGFSEVKTPTLFSTKLWEQSGHWEHYRAHMFSLKPPGTDGVD
                     SSQSGHPARCPKDTLALKPMNCPAHCLMFAHRPRSWRELPVRLADFGVLHRAEASGSL
                     GGLTRLWRFQQDDAHIFCAPSQLEAEIRGCLDFLRSVYSVLGFSFHLALSTRPPGFLG
                     EPHLWDQAEKVLQQALEEFGEPWNLNPGDGAFYGPKIDVHLHDALGRPHQCGTIQLDF
                     QLPLRFDLQYKGPAGAPECPVLIHRAVLGSVERLLGVLAESCGGRWPLWLSPFQVVVI
                     PVRTEQEDYARQVQQCLQAAGLVSDLDADCGLTLSRRVRRAQLAHYNFQFVVGQREQS
                     QMSVNVRTRDNRQLGERGLAESVQRLLELQDARVPNAEELF"
     exon            97..293
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..417
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..542
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..660
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..725
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..804
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..951
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1050
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1268
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1431
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1569
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1647
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1748
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1850
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1923
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2038
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2377
                     /gene="Tars2"
                     /gene_synonym="RGD1308283; Tarsl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgacttgag gcagcatggg tctctgtctg aggtggcgcc ggcttgggtt cccactcccg
       61 gggttccgcc gctgcgagct ccacacagtg cgtgaggccc ctataccaac tcctccacat
      121 tggttggcag aacgatttgg cctttttgag gagctatgga ctgctcaggt gaagagatta
      181 gcaagtatga cacagaagaa agcccggact attaagatat cacttcctga aggccagaag
      241 gtagatgctg ttgcatggaa tacaacccct tatcaactgg cccagcagat cagttcgaca
      301 ctggctgata ctgcagtggc tgctgaagta aatggagaac tttacgatct ggaccgaccc
      361 ttggagacag attgtcacct cagatttctg acatttgatt ccccagaggg caaagcggtg
      421 ttctggcgct ctagtgccca cgttctgggt gcagcagctg agcaacatct gggtgctgtt
      481 ctctgcagag gtccaagtac agaatctggc ttttaccttg atttcttcct gggaaaagaa
      541 cggacagtcc gcagcacgga gttgcccact ttagagcgga tttgccagga gatcataact
      601 gctgcacagc ctttccgaag gctagaggct tcccggggtc agcttcgcca gctcttcaag
      661 gataaccact ttaagcttca tgtgatcgag gagaaagtga caggcacgac agcaacagtg
      721 tacgggtgtg gcatgtcggt tgacctgtgc cagggccccc atcttcggca cacaggacag
      781 attggagcac tgaagctgct cacgaactcc tcggccttgt ggaggtcctc cgaagcgcct
      841 gagacactgc agagggtatc aggaatttct ttccccaagg cagagttact gaggaattgg
      901 gaagctcgaa gggaggaagc agagttaaga gatcacagac gcatcgggaa ggaacaggag
      961 ctcttcttct tccatgagct gagccctggg agctgctttt tcctgccacg agggacaaga
     1021 atttataacg ccctggtggc ttttatcagg gctgagtatg cccgacgagg tttctcagag
     1081 gtgaaaactc ccacgctgtt ttctacaaaa ctctgggaac agtcagggca ctgggagcat
     1141 tatagggcac acatgttttc cctaaagccc ccaggcactg atggtgtcga cagctcccag
     1201 agtggccatc ctgccaggtg tcccaaagac acacttgctc taaagcccat gaactgccct
     1261 gcacactgcc tgatgtttgc ccaccggccc agatcctggc gagaactgcc tgtgcggctg
     1321 gctgatttcg gagtcctgca tcgtgcggag gcctctggca gtctgggagg attgacgcgg
     1381 ctgtggcgct tccagcagga tgatgctcac atcttttgtg cgcccagtca gctggaagca
     1441 gagatccggg gctgccttga ttttctccgg tctgtctact cggttcttgg tttctccttc
     1501 cacctggctt tgtctacccg accacccggc ttcctagggg agcctcacct atgggaccag
     1561 gctgagaagg tcctacaaca agccttggaa gagtttggag aaccctggaa cctcaaccct
     1621 ggagatgggg cgttctatgg gcctaagatt gatgtgcacc tccatgatgc ccttggccgg
     1681 ccccatcaat gcggaacaat ccagcttgac ttccagctgc cactgagatt tgacctacag
     1741 tacaaggggc cggcgggggc ccccgagtgt ccagtcctta ttcatcgggc agtgctgggg
     1801 tctgtggaaa ggctcttggg agtgctggca gaaagctgtg gggggagatg gcccctgtgg
     1861 ctgtccccgt tccaggtggt ggtcatccct gtgaggacag agcaagagga ctatgccagg
     1921 caggtgcaac agtgcctgca ggccgcaggg cttgtgagtg acctcgatgc ggactgtgga
     1981 ctgaccctca gccggagagt ccgccgggcc cagcttgccc actacaattt tcagtttgtg
     2041 gttggccaga gagagcagag tcaaatgtca gtgaacgtgc gcactcgaga taaccggcag
     2101 ctgggggagc gaggcctggc tgagtcagtg cagaggctgc tggagttaca ggacgccagg
     2161 gtccccaacg cagaagaact gttctgagtg atgttccctg gtgacgtcca ctcgtgagag
     2221 ccgtccacct tttccacagg agaccctatc ccacatggtc gcccagcatg ttcccgagtc
     2281 atcagaactg ctctctgaaa atagacatgg tgtagggctc ccacgggaag gaatgctgta
     2341 tcgcttagat agaaggagaa taaaaaataa acttgaaaaa aaaaaaaaaa aaaaaaaaaa
//
