LOCUS       NM_001034941            1495 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Tarbp2 subunit of RISC loading complex (Tarbp2),
            mRNA.
ACCESSION   NM_001034941 XM_343339
VERSION     NM_001034941.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1495)
  AUTHORS   Byun,S.H., Kim,J., Han,D., Kwon,M., Cho,J.Y., Ng,H.X.,
            Pleasure,S.J. and Yoon,K.
  TITLE     TRBP maintains mammalian embryonic neural stem cell properties by
            acting as a novel transcriptional coactivator of the Notch
            signaling pathway
  JOURNAL   Development 144 (5), 778-783 (2017)
   PUBMED   28174252
REFERENCE   2  (bases 1 to 1495)
  AUTHORS   Ding,J., Nie,M., Liu,J., Hu,X., Ma,L., Deng,Z.L. and Wang,D.Z.
  TITLE     Trbp Is Required for Differentiation of Myoblasts and Normal
            Regeneration of Skeletal Muscle
  JOURNAL   PLoS One 11 (5), e0155349 (2016)
   PUBMED   27159388
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1495)
  AUTHORS   Wilson,R.C., Tambe,A., Kidwell,M.A., Noland,C.L., Schneider,C.P.
            and Doudna,J.A.
  TITLE     Dicer-TRBP complex formation ensures accurate mammalian microRNA
            biogenesis
  JOURNAL   Mol Cell 57 (3), 397-407 (2015)
   PUBMED   25557550
REFERENCE   4  (bases 1 to 1495)
  AUTHORS   Acevedo,R., Orench-Rivera,N., Quarles,K.A. and Showalter,S.A.
  TITLE     Helical defects in microRNA influence protein binding by TAR RNA
            binding protein
  JOURNAL   PLoS One 10 (1), e0116749 (2015)
   PUBMED   25608000
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1495)
  AUTHORS   Lee,H.Y., Zhou,K., Smith,A.M., Noland,C.L. and Doudna,J.A.
  TITLE     Differential roles of human Dicer-binding proteins TRBP and PACT in
            small RNA processing
  JOURNAL   Nucleic Acids Res 41 (13), 6568-6576 (2013)
   PUBMED   23661684
REFERENCE   6  (bases 1 to 1495)
  AUTHORS   Lee,Y., Hur,I., Park,S.Y., Kim,Y.K., Suh,M.R. and Kim,V.N.
  TITLE     The role of PACT in the RNA silencing pathway
  JOURNAL   EMBO J 25 (3), 522-532 (2006)
   PUBMED   16424907
REFERENCE   7  (bases 1 to 1495)
  AUTHORS   Maniataki,E. and Mourelatos,Z.
  TITLE     A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
  JOURNAL   Genes Dev 19 (24), 2979-2990 (2005)
   PUBMED   16357216
REFERENCE   8  (bases 1 to 1495)
  AUTHORS   Chendrimada,T.P., Gregory,R.I., Kumaraswamy,E., Norman,J.,
            Cooch,N., Nishikura,K. and Shiekhattar,R.
  TITLE     TRBP recruits the Dicer complex to Ago2 for microRNA processing and
            gene silencing
  JOURNAL   Nature 436 (7051), 740-744 (2005)
   PUBMED   15973356
REFERENCE   9  (bases 1 to 1495)
  AUTHORS   Bannwarth,S., Talakoub,L., Letourneur,F., Duarte,M., Purcell,D.F.,
            Hiscott,J. and Gatignol,A.
  TITLE     Organization of the human tarbp2 gene reveals two promoters that
            are repressed in an astrocytic cell line
  JOURNAL   J Biol Chem 276 (52), 48803-48813 (2001)
   PUBMED   11641396
REFERENCE   10 (bases 1 to 1495)
  AUTHORS   Zhong,J., Peters,A.H., Lee,K. and Braun,R.E.
  TITLE     A double-stranded RNA binding protein required for activation of
            repressed messages in mammalian germ cells
  JOURNAL   Nat Genet 22 (2), 171-174 (1999)
   PUBMED   10369260
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104690.1.
            
            On Oct 21, 2005 this sequence version replaced XM_343339.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104690.1, FQ228813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1495
                     /gene="Tarbp2"
                     /note="Tarbp2 subunit of RISC loading complex"
                     /db_xref="GeneID:363006"
                     /db_xref="RGD:1307375"
     exon            1..156
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1201
                     /gene="Tarbp2"
                     /note="TAR (HIV) RNA binding protein 2; TAR (HIV-1) RNA
                     binding protein 2; TARBP2, RISC loading complex RNA
                     binding subunit"
                     /codon_start=1
                     /product="RISC-loading complex subunit TARBP2"
                     /protein_id="NP_001030113.1"
                     /db_xref="GeneID:363006"
                     /db_xref="RGD:1307375"
                     /translation="MSEEDQGSGSTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGK
                     TPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLE
                     PALEDSSSFSLLDSSVPEDTAVIAAEAAAPVPSALLTRSPPMEMQPPVSPQQSECNPV
                     GALQELVVQKGWRLPEYMVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAA
                     KMLLRVHTVPLDARDGNEAEPDDDHFSIGVSSRLDGLRNRGPGCTWDSLRNSVGEKIL
                     SLRNCSVGSLGSLGSACCSILSELSAEQAFHVSYLDIEELSLSGLCQCLVELSTQPAT
                     VCYGSATTREAARGDAARRALQYLRIMAGSK"
     exon            157..326
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..429
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..522
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..595
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..713
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..841
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1043
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1472
                     /gene="Tarbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggccgcga ctccgggctt ggccccggcc ctagctcgtc ggcggtgtac tggggtgcgt
       61 ggagactgta gtcacggtgg cgcccgcggg gacggaggag ggaatgagtg aagaggatca
      121 gggctccggc tctactacag gctgcgggct gcccagcata gagcaaatgc tggccgccaa
      181 cccgggcaag accccgatca gccttcttca ggagtatggg accagaatag ggaagacgcc
      241 cgtgtacgac cttctcaaag ccgagggcca agcccatcaa cctaatttca ccttccgggt
      301 caccgttggc gacaccagct gcactggtca gggccccagc aagaaggcag ccaagcacaa
      361 ggcagctgag gtggccctca aacacctcaa aggggggagc atgctggaac cagccctgga
      421 ggacagcagt tctttttctc tcctagactc ttcagtgcct gaggacactg ctgtcattgc
      481 tgcagaagct gctgcccctg ttccatctgc tttactaacc aggagccctc ccatggagat
      541 gcagccccct gtctctcctc agcagtctga gtgcaaccct gttggtgctc tgcaggagct
      601 ggtggtgcag aaaggctggc gtttgccaga gtacatggtg acccaggagt ctgggcctgc
      661 tcaccgcaaa gagttcacca tgacctgccg ggtggagcgt ttcattgaga ttggcagtgg
      721 gacctccaag aagctggcaa agcgcaacgc ggcagctaag atgctgcttc gagtgcacac
      781 ggtacctctg gatgcccgcg acggcaacga ggctgaacct gatgacgatc atttttccat
      841 tggcgtgagc tcccgcctgg atggactaag gaaccgtggg ccaggctgca cctgggattc
      901 cttacggaat tctgtgggag aaaagatcct gtcccttcgc aattgctccg tgggctctct
      961 ggggtctttg ggctctgcct gctgcagcat cctcagtgag ctctctgcgg agcaggcttt
     1021 ccatgtcagc tatctggata ttgaggaact gagcctgagt gggctctgcc agtgtctagt
     1081 ggagctgtcc acgcagccag ccactgtgtg ttatggttct gccactacca gggaggcagc
     1141 ccgaggtgat gctgctcgcc gcgcactaca gtacctcagg atcatggccg gtagcaaata
     1201 gcacccacta cagtgatgga tatctgttac ttcttgctcc ttctgccctg ggtctatgcg
     1261 tctgcctagc tctggtgccc tccagaggtg ccatctctac ctctgacaca gcttgcctgc
     1321 cttgagactg aggaaggcaa aggcaagcaa ggagccatga accacagggc cccagccagc
     1381 gcagggtttg ccctcattcc atggatgatg aatgaaagga aattggaatt ctattggaat
     1441 ccagaataaa tgctgctctt tggcttctta aaaaaaaaaa aaaaaaaaaa aaaaa
//
