LOCUS       NM_033098               1563 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus TAP binding protein (Tapbp), mRNA.
ACCESSION   NM_033098
VERSION     NM_033098.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1563)
  AUTHORS   Tuncel J, Haag S, Yau AC, Norin U, Baud A, Lonnblom E, Maratou K,
            Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A,
            Stridh P, Jagodic M, Olsson T, Fernandez-Teruel A, Zubarev RA, Mott
            R, Aitman TJ, Flint J and Holmdahl R.
  CONSRTM   EURATRANS Consortium
  TITLE     Natural polymorphisms in Tap2 influence negative selection and
            CD4ratioCD8 lineage commitment in the rat
  JOURNAL   PLoS Genet 10 (2), e1004151 (2014)
   PUBMED   24586191
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1563)
  AUTHORS   Rizvi SM, Del Cid N, Lybarger L and Raghavan M.
  TITLE     Distinct functions for the glycans of tapasin and heavy chains in
            the assembly of MHC class I molecules
  JOURNAL   J Immunol 186 (4), 2309-2320 (2011)
   PUBMED   21263072
REFERENCE   3  (bases 1 to 1563)
  AUTHORS   Verweij MC, Koppers-Lalic D, Loch S, Klauschies F, de la Salle H,
            Quinten E, Lehner PJ, Mulder A, Knittler MR, Tampe R, Koch J,
            Ressing ME and Wiertz EJ.
  TITLE     The varicellovirus UL49.5 protein blocks the transporter associated
            with antigen processing (TAP) by inhibiting essential
            conformational transitions in the 6+6 transmembrane TAP core
            complex
  JOURNAL   J Immunol 181 (7), 4894-4907 (2008)
   PUBMED   18802093
REFERENCE   4  (bases 1 to 1563)
  AUTHORS   Rufer E, Leonhardt RM and Knittler MR.
  TITLE     Molecular architecture of the TAP-associated MHC class I
            peptide-loading complex
  JOURNAL   J Immunol 179 (9), 5717-5727 (2007)
   PUBMED   17947644
REFERENCE   5  (bases 1 to 1563)
  AUTHORS   Garbi N, Tiwari N, Momburg F and Hammerling GJ.
  TITLE     A major role for tapasin as a stabilizer of the TAP peptide
            transporter and consequences for MHC class I expression
  JOURNAL   Eur J Immunol 33 (1), 264-273 (2003)
   PUBMED   12594855
REFERENCE   6  (bases 1 to 1563)
  AUTHORS   Antoniou AN, Ford S, Pilley ES, Blake N and Powis SJ.
  TITLE     Interactions formed by individually expressed TAP1 and TAP2
            polypeptide subunits
  JOURNAL   Immunology 106 (2), 182-189 (2002)
   PUBMED   12047747
REFERENCE   7  (bases 1 to 1563)
  AUTHORS   Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson
            PO, Sjogren HO, Li S and Wang P.
  TITLE     Association of tapasin and COPI provides a mechanism for the
            retrograde transport of major histocompatibility complex (MHC)
            class I molecules from the Golgi complex to the endoplasmic
            reticulum
  JOURNAL   J Biol Chem 277 (21), 18266-18271 (2002)
   PUBMED   11884415
REFERENCE   8  (bases 1 to 1563)
  AUTHORS   Deverson EV, Powis SJ, Morrice NA, Herberg JA, Trowsdale J and
            Butcher GW.
  TITLE     Rat tapasin: cDNA cloning and identification as a component of the
            class I MHC assembly complex
  JOURNAL   Genes Immun 2 (1), 48-51 (2001)
   PUBMED   11294569
REFERENCE   9  (bases 1 to 1563)
  AUTHORS   Grandea AG 3rd, Golovina TN, Hamilton SE, Sriram V, Spies T,
            Brutkiewicz RR, Harty JT, Eisenlohr LC and Van Kaer L.
  TITLE     Impaired assembly yet normal trafficking of MHC class I molecules
            in Tapasin mutant mice
  JOURNAL   Immunity 13 (2), 213-222 (2000)
   PUBMED   10981964
REFERENCE   10 (bases 1 to 1563)
  AUTHORS   Grandea AG 3rd, Comber PG, Wenderfer SE, Schoenhals G, Fruh K,
            Monaco JJ and Spies T.
  TITLE     Sequence, linkage to H2-K, and function of mouse tapasin in MHC
            class I assembly
  JOURNAL   Immunogenetics 48 (4), 260-265 (1998)
   PUBMED   9716645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB794019.1, FM054278.1, BC062007.1 and CR467474.1.
            
            On Sep 12, 2009 this sequence version replaced NM_033098.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062007.1, AJ400732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               CB794019.1         60-393
            335-617             FM054278.1         326-608
            618-1547            BC062007.1         609-1538
            1548-1563           CR467474.1         3-18                c
FEATURES             Location/Qualifiers
     source          1..1563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1563
                     /gene="Tapbp"
                     /note="TAP binding protein"
                     /db_xref="GeneID:25217"
                     /db_xref="RGD:3819"
     exon            1..60
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1418
                     /gene="Tapbp"
                     /note="tapasin; Tap-binding protein"
                     /codon_start=1
                     /product="tapasin precursor"
                     /protein_id="NP_149089.1"
                     /db_xref="GeneID:25217"
                     /db_xref="RGD:3819"
                     /translation="MKLLPLLVVVALGLATVVVSAGPQTIECWFVEDAGGGGLSKKPA
                     TLLLRHGPRGPPPRPDLDPKLYFKVDDPAGMLLAAFRRYPAGAHAPHCEMSSYIPFPA
                     SAKWARGLSPQQNCSRALDGDWLMVSVSGTVFSLSSLLRPLPEPQREPVFITMATVVL
                     TVLTRHPAPRIHLGKDAVLDLRFAYAPPALEDAPSVASGPPPFGLEWRRQHRGKGHLL
                     LAAIPGLLEKMPPAREKAVAFAAWDDDNDPWGPWTGNGTLWLPAVSPSQEGVYLATVH
                     LPYLQGQVSLELTVHKPPRVSLTPAPIVWAAPGEAPPELLCLVSHFYPEEGLEVEWEL
                     RGGPEGSSRKAEGKTWVSTVRHHSDGSVSQSGHLQLPPVTDKQHGVRYACRVRHPSLP
                     SSGRSAEVTLEVAGFSGPSIEDGIGLFLSAFLLLGLFKALGWMAAYLTIPKILKEKAS
                     ATSLTVPKDEKKSE"
     exon            61..234
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
     exon            235..495
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
     exon            496..897
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1239
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1329
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1406
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1563
                     /gene="Tapbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggtagggg agatcgcagc accatgaagc ttcttcccct gctcgtcgtt gtggcactgg
       61 gcctggcgac cgtggtggtc tcggctggac cacagacgat tgagtgctgg ttcgtggagg
      121 atgcaggtgg gggtggcctg tccaagaaac ctgccacatt gctactgcgc catggaccca
      181 ggggaccgcc gccccggcca gatcttgacc ctaagctata cttcaaggtg gatgacccgg
      241 cgggaatgct cctggctgcc ttcaggcggt accccgcagg cgcccacgcc ccacactgcg
      301 agatgagcag ctacatcccg ttccccgcct cggcgaagtg ggctaggggt ctgagtccgc
      361 agcagaactg ctcgcgggcc ctggacgggg attggctgat ggtcagcgta tccggcacgg
      421 tcttcagcct ctccagcctg ctgcgaccac tgccggagcc tcagcgggag cctgtcttca
      481 tcaccatggc aacagtggta ctgactgtcc tcacacgtca ccccgcccct cggatccatc
      541 tgggaaagga tgcagtgctg gacctgcgtt ttgcctacgc gccccctgct ctggaagatg
      601 ctccctctgt ggcctcaggg cctcctccct ttgggctgga gtggcggcgc cagcacaggg
      661 gaaagggtca cctgctgctg gctgcaattc ctgggctgct tgagaaaatg ccaccagccc
      721 gagaaaaggc tgtggcattt gctgcttggg atgacgacaa tgatccctgg ggcccgtgga
      781 ctgggaatgg gaccttgtgg ctgccagcag tgagcccttc tcaggagggt gtctacctgg
      841 ccaccgtaca tctgccctat ctgcaaggac aggtgtccct ggagctgact gtgcacaagc
      901 ccccgagagt gtctctaaca ccagcaccca ttgtgtgggc tgccccagga gaggcacccc
      961 cagaattgct ctgtcttgtg tcccacttct accctgagga gggcttggag gtggaatggg
     1021 agctcagagg tggcccagaa ggaagttcta gaaaggctga ggggaagact tgggtctcca
     1081 ctgtccgtca ccattctgat ggctctgtca gccagtctgg gcacctgcag ctacccccag
     1141 tcactgacaa gcaacatgga gttcgctatg cctgtcgggt ccgccaccct agcctgccct
     1201 catcggggcg cagtgctgaa gtcactctgg aggtggcagg cttctcaggg ccctccattg
     1261 aggacggcat aggcctcttc ctgtctgctt ttctcctttt gggcctcttc aaggcactag
     1321 gctggatggc tgcctacctg accattccta aaatcttaaa ggagaaggcc tcagctacca
     1381 gcctgaccgt tcccaaagac gaaaagaagt cagagtgaag acactggtct gtggaagcca
     1441 ccctcatctc tggtccaaac gactccagta gcccctgccc cagaacaaga ggggggtgcc
     1501 tcataccctc ttctccctcc attaaatgac tcagggttgt tttttttttc tttttctttt
     1561 taa
//
