LOCUS       NM_032056               2446 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transporter 2, ATP binding cassette subfamily B
            member (Tap2), mRNA.
ACCESSION   NM_032056 XM_003751929 XM_006256032
VERSION     NM_032056.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Tuncel,J., Haag,S., Yau,A.C., Norin,U., Baud,A., Lonnblom,E.,
            Maratou,K., Ytterberg,A.J., Ekman,D., Thordardottir,S.,
            Johannesson,M., Gillett,A., Stridh,P., Jagodic,M., Olsson,T.,
            Fernandez-Teruel,A., Zubarev,R.A., Mott,R., Aitman,T.J., Flint,J.
            and Holmdahl,R.
  CONSRTM   EURATRANS Consortium
  TITLE     Natural polymorphisms in Tap2 influence negative selection and
            CD4ratioCD8 lineage commitment in the rat
  JOURNAL   PLoS Genet 10 (2), e1004151 (2014)
   PUBMED   24586191
  REMARK    GeneRIF: Variants of Tap2 have previously been shown to influence
            the antigenicity of MHC class I molecules . Our results show that a
            restricted peptide repertoire on MHC class I molecules leads to
            reduced negative selection of CD8SP cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Kim,J.H., Park,B.L., Pasaje,C.F., Bae,J.S., Park,J.S., Park,S.W.,
            Uh,S.T., Kim,M.K., Choi,I.S., Cho,S.H., Choi,B.W., Park,C.S. and
            Shin,H.D.
  TITLE     Genetic association analysis of TAP1 and TAP2 polymorphisms with
            aspirin exacerbated respiratory disease and its FEV1 decline
  JOURNAL   J Hum Genet 56 (9), 652-659 (2011)
   PUBMED   21796142
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Feng,M., Yin,B., Shen,T., Ma,Q., Liu,L., Zheng,J., Zhao,Y., Qian,K.
            and Liu,D.
  TITLE     TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis
            in genetically homogenous Chinese Han population
  JOURNAL   Hum Immunol 70 (4), 257-261 (2009)
   PUBMED   19480848
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Liu,Q., Hao,C., Su,P. and Shi,J.
  TITLE     Down-regulation of HLA class I antigen-processing machinery
            components in esophageal squamous cell carcinomas: association with
            disease progression
  JOURNAL   Scand J Gastroenterol 44 (8), 960-969 (2009)
   PUBMED   19492245
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Masserano,G., Montanaro,M., Poggi,G., Rusca,L. and Vignali,F.
  TITLE     [Rehabilitative evaluation of 18 cases of anterior cruciate
            ligament lesions surgically treated by the Kenneth-Jones technique]
  JOURNAL   Minerva Med 83 (12 Suppl 1), 89-91 (1992)
   PUBMED   1300480
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Powis,S.J., Deverson,E.V., Coadwell,W.J., Ciruela,A.,
            Huskisson,N.S., Smith,H., Butcher,G.W. and Howard,J.C.
  TITLE     Effect of polymorphism of an MHC-linked transporter on the peptides
            assembled in a class I molecule
  JOURNAL   Nature 357 (6375), 211-215 (1992)
   PUBMED   1350326
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   Attaya,M., Jameson,S., Martinez,C.K., Hermel,E., Aldrich,C.,
            Forman,J., Lindahl,K.F., Bevan,M.J. and Monaco,J.J.
  TITLE     Ham-2 corrects the class I antigen-processing defect in RMA-S cells
  JOURNAL   Nature 355 (6361), 647-649 (1992)
   PUBMED   1538753
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Kelly,A., Powis,S.H., Kerr,L.A., Mockridge,I., Elliott,T.,
            Bastin,J., Uchanska-Ziegler,B., Ziegler,A., Trowsdale,J. and
            Townsend,A.
  TITLE     Assembly and function of the two ABC transporter proteins encoded
            in the human major histocompatibility complex
  JOURNAL   Nature 355 (6361), 641-644 (1992)
   PUBMED   1538751
REFERENCE   10 (bases 1 to 2446)
  AUTHORS   Caillat-Zucman,S., Bertin,E., Timsit,J., Boitard,C., Assan,R. and
            Bach,J.F.
  TITLE     TAP1 and TAP2 transporter genes and predisposition to insulin
            dependent diabetes mellitus
  JOURNAL   C R Acad Sci III 315 (13), 535-539 (1992)
   PUBMED   1300236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X63854.1 and BC091140.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006256032.1, XM_003751929.1, NM_032056.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X75305.1, X75306.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               X63854.1           1-101
            102-2422            BC091140.1         35-2355
            2423-2446           X63854.1           2423-2446
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2446
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /note="transporter 2, ATP binding cassette subfamily B
                     member"
                     /db_xref="GeneID:24812"
                     /db_xref="RGD:3818"
     exon            1..81
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            82..582
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2201
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /EC_number="7.4.2.14"
                     /note="APT2; ATP-binding cassette sub-family B member 3;
                     Transporter 2 ABC (ATP binding cassette); transporter 2
                     ATP-binding cassette sub-family B; transporter 2,
                     ATP-binding cassette, sub-family B (MDR/TAP)"
                     /codon_start=1
                     /product="antigen peptide transporter 2"
                     /protein_id="NP_114445.2"
                     /db_xref="GeneID:24812"
                     /db_xref="RGD:3818"
                     /translation="MALSYPRPWASLLLVDLALLGLLQRSLGTLLPPGLPGLWLEGTL
                     RLGVLWGLLKVGGLLRLVGTFLPLLCLTTPLFFSLRALVGSTMSTSVLRVASASWGWL
                     LAGYVAAALSLAVWAVLSPAGAQEKEPGQENNRALMIRLLRLSKPDLPFLIVAFIFLA
                     MAVWGETLIPHYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSLSAGCRGGSFLFTM
                     SRINLRIREQLFSSLLRQDLAFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLV
                     KVVGLYYFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDVVAKAGQVVRE
                     AVGGLQTVRSFGAEEQEVSRYKEALERCRQLWWRRDLEKELYLVIRRVMALGMQVLIL
                     NCGVQQILAGEVTRGGLLSFLLYQEEVGHHVRNLVYMYGDMLSNVGAAEKVFSYLDRR
                     PNLPKPGTLAPPRVEGRVEFQDVSFSYPSRPEKPVLQGLTFTLHPGKVTALVGPNGSG
                     KSTVAALLQNLYQPTGGKVLLDGEPLVQYDHHYLHRQVVLVGQEPVLFSGSVKDNIAY
                     GLRNCEDAQVMAAAQAACADDFIGEMTNGINTEIGERGSQLAVGQKQRLAIARALVRN
                     PRVLILDEATSALDAECEQALQTWRSQEDRTMLVIAHRLHTVQNADQVLVLKQGQLVE
                     HDQLRDEQDVYAHLVQQRLEA"
     exon            583..697
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            698..828
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1034
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1232
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1361
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1550
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1724
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1884
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2021
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2426
                     /gene="Tap2"
                     /gene_synonym="Abcb3; Cim"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcgctgcg cacccagaag acccagtttg ggaggaagca gatttcagaa gctctcctga
       61 ggtgccgctc cgcagccgca gaccccacca tggcgctgtc ctacccgagg ccctgggcct
      121 ctctgctgct ggtggacctg gctttacttg ggttgctaca aagatctctg ggaactctgc
      181 ttcccccggg gctgccagga ttatggctgg agggcaccct gcgacttgga gtgctgtggg
      241 gactgctaaa agtgggaggg ctgctgagac ttgtggggac ctttctgccc ttgctctgcc
      301 tgaccacccc cctgtttttc tcgctgagag ccctggtggg aagcaccatg agcacctcag
      361 tactcagagt ggcttctgcc tcttggggct ggctgcttgc tggctatgta gccgcggcgt
      421 tgagccttgc cgtgtgggct gtgctgagcc ccgctggagc acaggagaag gaaccaggcc
      481 aggagaacaa cagagcactc atgatacggt tgctgaggct gtccaagccg gatctgcctt
      541 tcctcattgt tgccttcatc tttcttgcga tggctgtgtg gggggagacg ttaatccctc
      601 attattcggg tcgtgtgatt gacatcctgg gaggtgattt tgacccagac gcctttgcga
      661 gcgccatctt tttcatgtgc ttattctctg ttgggagctc cctctctgca ggctgccgag
      721 gaggctcctt cctcttcacc atgtccagga tcaaccttcg catacgagag cagcttttct
      781 catctttgtt gcgccaagac cttgcattct tccaggagac caagacaggg gagctgaact
      841 cacggctgag ctcggacacc tccctgatga gccgctggct ccctttcaat gccaatatcc
      901 tgctgcggag cctggtgaag gtggtggggc tgtactactt catgctccag gtctccccga
      961 gactcacctt cctctccctg ctggacctgc ccctcacaat agcagccgag aaggtgtaca
     1021 acccccgcca tcaggctgtg ctaaaggaga tccaggatgt agtggcgaag gcagggcagg
     1081 tggtgcgtga ggccgtagga gggctgcaga ccgtgagaag ctttggcgcg gaggagcagg
     1141 aagtcagccg ctacaaggag gccctggagc gatgtcgaca gctgtggtgg cgccgagacc
     1201 tggaaaaaga attgtattta gtcatacgga gggtaatggc cttgggcatg caggtgctga
     1261 ttctgaactg cggtgtgcag cagatcctgg ctggggaggt cacccggggc ggcctgctct
     1321 ccttcttgct gtatcaggag gaagtggggc accatgtccg gaacctggta tacatgtatg
     1381 gggatatgct gagcaacgtg ggtgccgcgg aaaaggtttt ttcctacttg gaccgaaggc
     1441 caaatctgcc gaagcctggt accctggccc ctcccagggt ggaggggcgc gtggaatttc
     1501 aagatgtctc cttctcgtac cccagtcgcc ccgagaagcc tgtgctccag ggcctgacgt
     1561 ttaccctgca tcctggaaag gtgaccgcgt tggtgggacc caatgggtca gggaagagca
     1621 ccgtggccgc cctgctgcag aacctgtacc agccaaccgg gggcaaggtg ctcctggatg
     1681 gcgagcccct ggtccagtac gatcaccact acctgcaccg ccaggtggtt ctggtggggc
     1741 aggagcctgt gctgttctcc ggttctgtca aggacaatat tgcctatggc ctgaggaact
     1801 gtgaggatgc tcaagtgatg gctgctgccc aggcggcctg tgcagacgac ttcatagggg
     1861 aaatgacgaa cggaataaac acagaaatcg gggagagagg gagccagtta gctgtgggac
     1921 agaagcaacg tctggccatt gcccgggccc ttgtgcggaa cccgcgggtc ctcatcctgg
     1981 atgaggctac cagtgccctg gacgccgagt gcgagcaggc tcttcagacc tggagatcgc
     2041 aggaggacag gacgatgctg gtcattgctc accggctgca cacggttcag aatgctgacc
     2101 aagttctggt gctcaagcag gggcagctgg tggagcacga ccagctcagg gatgagcagg
     2161 atgtctacgc tcacttggta cagcagcggc tggaagcgtg aggcctccag acactgagcc
     2221 ctctcaggac tgtggccagg atctgaccca cagggactgt gctggaggct agcgtcagga
     2281 taaagattgg gaccctttgg actttgttta ttttggtggg cttggtgggt gagggccagg
     2341 ggatgggatg gttgctgggt ggggtgggtg gtttaaacat tatttttttc taaatataaa
     2401 aataataaat atatatataa tactttaaaa aaaaaaaaaa aaaaaa
//
